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Oronasal Administration Of Lipopolysaccharide Prepartum Modulated Plasma Metabolite Patterns In Periparturient Dairy Cows.

S. Iqbal, Q. Zebeli, D. Mansmann, S. Dunn, B. Ametaj
Published 2013 · Medicine
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The objective of this study was to evaluate whether repeated oronasal administration of LPS before parturition showed effects on metabolic and clinical responses in periparturient dairy cows. Hundred Holstein dairy cows were randomly allocated to two treatment groups (n = 50). Thirty cows out of 100 were randomly assigned for intensive sampling (n = 15) started at 28 d before the expected day of parturition. Cows received an oral and a nasal treatment of 2 mL and 1 mL of sterile saline solution (0.15 M of NaCl), respectively, alone (control), or containing 3 increasing doses of LPS from Escherichia coli 0111:B4 as follows: 1) 0.01 μg/kg body weight (BW) on d ﹣28, 2) 0.05 μg/kg BW on d ﹣25, and ﹣21, and 3) 0.1 μg/kg BW on d ﹣18 and ﹣14. Blood samples were collected from coccygeal vein at different time points around parturition and analyzed for glucose, lactate, non-esterified fatty acids (NEFA), cholesterol, and betahydro-xybutyrate (BHBA). Clinical monitoring of animals was done throughout the experiment at different time points for overall health status, udder edema (UE), manure score, and body condition score (BCS). Results showed that oronasal administration of LPS increased concentrations of glucose and cholesterol in the serum compared to the control group (P 0.05). Oronasal LPS did not influence BCS, manure score or the incidence of UE (P > 0.05). Overall, repeated oronasal administration of LPS modulated some serum metabolites related to energy metabolism around parturition in the treated cows. Further research is warranted to elucidate the mechanisms behind greater glucose and cholesterol status in the serum and their potential effects on long-term metabolic health status of dairy cows.
This paper references
10.4141/A04-043
Strong relationships between mediators of the acute phase response and fatty liver in dairy cows
B. Ametaj (2005)
10.3168/jds.S0022-0302(03)73664-9
Metabolic and lactational responses during recombinant bovine tumor necrosis factor-alpha treatment in lactating cows.
Shiro Kushibiki (2003)
10.1007/s00011-007-6116-4
LPS pretreatment by the oral route protects against sepsis induced by cecal ligation and puncture. Regulation of proinflammatory response and IgM anti-LPS antibody production as associated mechanisms
R. Márquez-Velasco (2007)
10.3168/jds.2012-5403
A metabolomics approach to uncover the effects of grain diets on rumen health in dairy cows.
F. Saleem (2012)
10.1590/S1516-35982010001300048
Nutrition, microbiota, and endotoxin-related diseases in dairy cows
B. Ametaj (2010)
10.2527/1999.7792523x
Effect of a prolonged low-dose lipopolysaccharide infusion on feed intake and metabolism in heifers.
Martine Steiger (1999)
10.1016/S0034-5288(96)90073-9
Characterisation of the acute phase response of heifers to a prolonged low dose infusion of lipopolysaccharide.
Dirk Werling (1996)
10.3168/jds.2008-1634
Performance and metabolic and endocrine changes with emphasis on glucose metabolism in high-yielding dairy cows with high and low fat content in liver after calving.
Harald M Hammon (2009)
10.3168/jds.2007-0256
Feeding high proportions of barley grain stimulates an inflammatory response in dairy cows.
D. G. Emmanuel (2008)
10.1051/vetres:2004062
Dose dependency and individual variability in selected clinical, haematological and blood biochemical responses after systemic lipopolysaccharide challenge in cattle.
Stine Jacobsen (2005)
10.1194/jlr.R300019-JLR200
Effects of infection and inflammation on lipid and lipoprotein metabolism: mechanisms and consequences to the host.
Weerapan Khovidhunkit (2004)
10.1056/NEJM199902113400607
Acute-phase proteins and other systemic responses to inflammation.
Cem Gabay (1999)
10.3168/jds.S0022-0302(03)73949-6
Effect of lipopolysaccharide on indices of peripheral and hepatic metabolism in lactating cows.
M. R. Waldron (2003)
10.3168/jds.S0022-0302(92)77999-5
Evaluation of a system for rating edema in dairy cattle.
Walter B. Tucker (1992)
10.2527/jas.2007-0634
Critical control points in the impact of the proinflammatory immune response on growth and metabolism.
Ted H. Elsasser (2008)
10.3168/jds.2010-3435
Population structure of rumen Escherichia coli associated with subacute ruminal acidosis (SARA) in dairy cattle.
Ehsan Khafipour (2011)
Guide to the care and use of experimental animals
Ernest D. Olfert (1993)
10.1007/s11306-010-0227-6
Metabolomics reveals unhealthy alterations in rumen metabolism with increased proportion of cereal grain in the diet of dairy cows
B. Ametaj (2010)
10.1515/CCLM.1999.059
Reduction of Circulating Cholesterol and Apolipoprotein Levels during Sepsis
P. Fraunberger (1999)
OPEN ACCESS 192 antiLPS antibody production as associated mechanisms
W. Petzl (2011)
10.1177/1753425911434851
Repeated oral administration of lipopolysaccharide from Escherichia coli 0111:B4 modulated humoral immune responses in periparturient dairy cows
B. Ametaj (2012)
10.1016/j.cvfa.2007.04.002
Acidosis in feedlot cattle.
T G Nagaraja (2007)
10.3168/jds.2008-1507
Impact of hyperketonemia in early lactation dairy cows on health and production.
Todd F. Duffield (2009)
10.1186/cc11444
Effects of endotoxin on lactate metabolism in humans
Burkhard Michaeli (2012)
Conjugated primary bile salts reduce permeability of endotoxin through bacteria-stimulated intestinal epithelial cells and synergize with lecithin in suppression of inflammatory cytokine production
Alexandr Parlesak (2007)
10.3945/jn.109.108233
Daily injection of tumor necrosis factor-{alpha} increases hepatic triglycerides and alters transcript abundance of metabolic genes in lactating dairy cattle.
Barry J. Bradford (2009)
10.3168/JDS.2007-0257
Acidosis and lipopolysaccharide from Escherichia coli B:055 cause hyperpermeability of rumen and colon tissues.
D. G. Emmanuel (2007)
10.2307/2533558
Small sample inference for fixed effects from restricted maximum likelihood.
Michael G. Kenward (1997)
10.3168/jds.2011-4194
Intermittent parenteral administration of endotoxin triggers metabolic and immunological alterations typically associated with displaced abomasum and retained placenta in periparturient dairy cows.
Q. Zebeli (2011)
10.15517/AM.V13I1.13244
Estimación lineal de los requerimientos nutricionales del NRC para ganado de leche.
Jorge Alberto Elizondo-Salazar (2014)
10.1177/1753425912461287
Oral challenge with increasing doses of LPS modulated the patterns of plasma metabolites and minerals in periparturient dairy cows
Q. Zebeli (2013)
10.1159/000233710
Different mechanisms of macrophage activation with guinea pig macrophage activation factor, lipopolysaccharide and muramyl dipeptide.
Kikuo Onozaki (1985)
10.2527/1993.713753x
Technical note: an improved method to quantify nonesterified fatty acids in bovine plasma.
Michael M. Johnson (1993)
10.1210/jcem.77.5.8077306
Effects of endotoxin on leucine and glucose kinetics in man: contribution of prostaglandin E2 assessed by a cyclooxygenase inhibitor.
Daniel Bloesch (1993)
10.1177/1753425911422407
Lipopolysaccharide pretreatment of the udder protects against experimental Escherichia coli mastitis
Wolfram Petzl (2012)
10.1016/j.pathophys.2004.09.002
Bile acids in physico-chemical host defence.
Lóránd Bertók (2004)
10.1159/000399574
Problems associated with feeding farm livestock under intensive systems.
Robert Worden Dougherty (1976)
10.1186/1751-0147-44-S1-S141
Bovine Endotoxicosis – Some Aspects of Relevance to Production Diseases. A Review*
Pia Haubro Andersen (2003)
10.3168/jds.2007-0572
Modeling the adequacy of dietary fiber in dairy cows based on the responses of ruminal pH and milk fat production to composition of the diet.
Q. Zebeli (2008)



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