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Therapies Targeting Cancer Stem Cells: Current Trends And Future Challenges.

D. Dragu, L. Necula, C. Bleotu, C. Diaconu, Mihaela Chivu-Economescu
Published 2015 · Medicine

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Traditional therapies against cancer, chemo- and radiotherapy, have multiple limitations that lead to treatment failure and cancer recurrence. These limitations are related to systemic and local toxicity, while treatment failure and cancer relapse are due to drug resistance and self-renewal, properties of a small population of tumor cells called cancer stem cells (CSCs). These cells are involved in cancer initiation, maintenance, metastasis and recurrence. Therefore, in order to develop efficient treatments that can induce a long-lasting clinical response preventing tumor relapse it is important to develop drugs that can specifically target and eliminate CSCs. Recent identification of surface markers and understanding of molecular feature associated with CSC phenotype helped with the design of effective treatments. In this review we discuss targeting surface biomarkers, signaling pathways that regulate CSCs self-renewal and differentiation, drug-efflux pumps involved in apoptosis resistance, microenvironmental signals that sustain CSCs growth, manipulation of miRNA expression, and induction of CSCs apoptosis and differentiation, with specific aim to hamper CSCs regeneration and cancer relapse. Some of these agents are under evaluation in preclinical and clinical studies, most of them for using in combination with traditional therapies. The combined therapy using conventional anticancer drugs with CSCs-targeting agents, may offer a promising strategy for management and eradication of different types of cancers.
This paper references
10.1186/2001-1326-2-3
Mechanisms of chemoresistance in cancer stem cells
L. N. Abdullah (2013)
10.1007/s11010-012-1401-0
Long-term exposure to imatinib reduced cancer stem cell ability through induction of cell differentiation via activation of MAPK signaling in glioblastoma cells
Yucui Dong (2012)
Molecular pathways: novel approaches
V Justilien (2014)
Targeting CXCR4 with
D Wong (2012)
10.3978/j.issn.2218-6751.2011.11.02
Angiogenesis in cancer: Anti-VEGF escape mechanisms.
G. Prager (2012)
CD44 eradicates human acute myeloid leukemic stem cells
E Marangoni (2006)
10.1038/bjc.2014.152
Novel role of pancreatic differentiation 2 in facilitating self-renewal and drug resistance of pancreatic cancer stem cells
A. P. Vaz (2014)
Identification of a cancer stem cell in human brain tumors.
S. Singh (2003)
10.1016/j.urolonc.2015.02.013
Carbonic anhydrase-IX score is a novel biomarker that predicts recurrence and survival for high-risk, nonmetastatic renal cell carcinoma: Data from the phase III ARISER clinical trial.
K. Chamie (2015)
10.1021/mp200292c
Drug resistance and cellular adaptation to tumor acidic pH microenvironment.
Jonathan W. Wojtkowiak (2011)
10.1074/jbc.M611393200
MicroRNA-21 Targets the Tumor Suppressor Gene Tropomyosin 1 (TPM1)*
S. Zhu (2007)
Targeting cancer stem cells Notch Signaling in Bladder Cancer
C Lobry (2015)
10.1111/resp.12094
Cancer stem cells in lung cancer: Evidence and controversies
M. Alamgeer (2013)
10.1007/s13277-014-1816-1
CXCL12-CXCR4 axis promotes the natural selection of breast cancer cell metastasis
Y. Sun (2014)
10.1038/nrd4233
Can we safely target the WNT pathway?
M. Kahn (2014)
10.3109/1061186X.2012.702767
Role of CD44 in tumour progression and strategies for targeting
L. Negi (2012)
10.1172/JCI61216
Notch1 counteracts WNT/β-catenin signaling through chromatin modification in colorectal cancer.
Hyun-a Kim (2012)
10.1073/pnas.252462599
Preferential induction of apoptosis for primary human leukemic stem cells
M. Guzman (2002)
10.1002/hep.21227
Side population purified from hepatocellular carcinoma cells harbors cancer stem cell–like properties
T. Chiba (2006)
10.1158/1541-7786.MCR-14-0153-T
HIF1α Regulates mTOR Signaling and Viability of Prostate Cancer Stem Cells
M. Marhold (2014)
Efficient tumour formation by single human melanoma cells
Elsa Quintana (2008)
10.3390/cancers6041925
Repositioning of Tyrosine Kinase Inhibitors as Antagonists of ATP-Binding Cassette Transporters in Anticancer Drug Resistance
Yi-Jun Wang (2014)
10.1016/j.jocn.2012.03.012
Orthotopic glioblastoma stem-like cell xenograft model in mice to evaluate intra-arterial delivery of bevacizumab: From bedside to bench
Jan-Karl Burkhardt (2012)
10.1073/pnas.0530291100
Prospective identification of tumorigenic breast cancer cells
M. Al-Hajj (2003)
Overcoming Multidrug Resistance in Cancer: An Update on the Clinical Strategy of Inhibiting P-Glycoprotein
J. Parker (2003)
10.1158/0008-5472.CAN-06-2030
Identification of Pancreatic Cancer Stem Cells
Chenwei Li (2007)
Consequences of Disrupted WJSC|www.wjgnet.com
A Greife (1940)
36 target for improved delivery of cancer therapeutics
G Goodwin Jinesh (2012)
10.4155/fmc.13.17
Hypoxia inducible factor pathway inhibitors as anticancer therapeutics.
S. Burroughs (2013)
10.2147/SCCAA.S58613
Hedgehog signaling in cancer stem cells: a focus on hematological cancers
Victoria L. Campbell (2015)
10.3892/IJMM_00000530
MicroRNA-21 promotes the cell proliferation, invasion and migration abilities in ovarian epithelial carcinomas through inhibiting the expression of PTEN protein.
Yanhui Lou (2010)
10.3892/or.2012.1724
The PI3K/Akt inhibitor LY294002 reverses BCRP-mediated drug resistance without affecting BCRP translocation.
Y. Imai (2012)
10.1016/B978-0-12-394622-5.00002-X
Canonical and noncanonical Hedgehog/GLI signaling in hematological malignancies.
F. Aberger (2012)
10.1002/ijc.23083
Involvement of SDF‐1α/CXCR4 axis in the enhanced peritoneal metastasis of epithelial ovarian carcinoma
H. Kajiyama (2008)
10.1093/neuonc/not149
Blockade of SDF-1 after irradiation inhibits tumor recurrences of autochthonous brain tumors in rats
Shie-Chau Liu (2014)
10.1038/bjc.2014.625
Novel therapeutic strategy targeting the Hedgehog signalling and mTOR pathways in biliary tract cancer
M. Zuo (2015)
10.1016/j.juro.2012.03.113
Systemic buffers inhibit carcinogenesis in TRAMP mice.
Arig Ibrahim-Hashim (2012)
10.1158/1535-7163.MCT-12-1030
Combining Hedgehog Signaling Inhibition with Focal Irradiation on Reduction of Pancreatic Cancer Metastasis
Dongsheng Gu (2013)
10.1111/cas.12271
Alteration of cancer stem cell‐like phenotype by histone deacetylase inhibitors in squamous cell carcinoma of the head and neck
K. Chikamatsu (2013)
10.1016/j.cell.2005.02.034
Stromal Fibroblasts Present in Invasive Human Breast Carcinomas Promote Tumor Growth and Angiogenesis through Elevated SDF-1/CXCL12 Secretion
A. Orimo (2005)
10.1371/journal.pone.0088298
PTEN Regulates BCRP/ABCG2 and the Side Population through the PI3K/Akt Pathway in Chronic Myeloid Leukemia
F. Huang (2014)
10.1038/sj.bjc.6604953
CD44 targeting reduces tumour growth and prevents post-chemotherapy relapse of human breast cancers xenografts
E. Marangoni (2009)
10.1038/nrc1590
Tumour stem cells and drug resistance
M. Dean (2005)
Molecular Pathways Clinical Cancer Research CXCL 12 ( SDF-1 ) / CXCR 4 Pathway in Cancer
B. Teicher (2010)
43 cancer stem cells and their clinical potential
M Athanassiou-Papaefthymiou (2014)
10.1016/j.jhep.2015.04.018
Curcumin effectively inhibits oncogenic NF-κB signaling and restrains stemness features in liver cancer.
J. U. Marquardt (2015)
10.1073/pnas.1318415110
Combining two strategies to improve perfusion and drug delivery in solid tumors
T. Stylianopoulos (2013)
14 characterization of cancer stem cells in human head and neck squamous cell carcinoma
M Alamgeer (2014)
10.4172/2155-9899.S5-007
Targeting Human Cancer Stem Cells with Monoclonal Antibodies
C. Naujokat (2012)
10.1002/ijc.28583
Triptolide reverses hypoxia-induced epithelial–mesenchymal transition and stem-like features in pancreatic cancer by NF-κB downregulation
L. Liu (2014)
10.18632/ONCOSCIENCE.117
Characterization of a murine model of metastatic human non-small cell lung cancer and effect of CXCR4 inhibition on the growth of metastases
A. K. Singla (2015)
Current insights into the regulation of programmed cell death by NF-kappaB.
J. Dutta (2006)
10.1038/cddis.2014.565
The role of hypoxia-inducible factor-2 in digestive system cancers
J. Zhao (2015)
10.1016/j.cytogfr.2008.04.001
Targeting the extrinsic apoptosis pathway in cancer.
A. Ashkenazi (2008)
10.1038/mtna.2014.47
Mir-34: A New Weapon Against Cancer?
G. Misso (2014)
10.18632/ONCOTARGET.2962
By promoting cell differentiation, miR-100 sensitizes basal-like breast cancer stem cells to hormonal therapy
A. Petrelli (2015)
10.1186/1756-9966-29-29
MicroRNA-21 regulates breast cancer invasion partly by targeting tissue inhibitor of metalloproteinase 3 expression
Bao Song (2010)
10.1158/1078-0432.CCR-14-0507
Molecular Pathways: Novel Approaches for Improved Therapeutic Targeting of Hedgehog Signaling in Cancer Stem Cells
V. Justilien (2015)
10.1186/bcr2803
Knockdown of miR-21 in human breast cancer cell lines inhibits proliferation, in vitro migration and in vivo tumor growth
L. Yan (2010)
63 switching an oncogene to a tumor suppressor
C Lobry (2014)
5 and cancer stem cells
L Li (2001)
clinical implications of its inhibition
AA Merchant (2012)
10.1371/journal.pone.0033976
Small Molecule Antagonists of the Wnt/Beta-Catenin Signaling Pathway Target Breast Tumor-Initiating Cells in a Her2/Neu Mouse Model of Breast Cancer
R. Hallett (2012)
10.1172/JCI66024
Cancer stem cells in the development of liver cancer.
T. Yamashita (2013)
10.1016/j.ceb.2009.04.009
Mechanisms of miRNA-mediated post-transcriptional regulation in animal cells.
Marina Chekulaeva (2009)
10.1371/journal.pone.0122439
IL-24 Inhibits Lung Cancer Cell Migration and Invasion by Disrupting The SDF-1/CXCR4 Signaling Axis
J. Panneerselvam (2015)
10.1016/j.ctrv.2014.02.003
Crosstalk between hedgehog and other signaling pathways as a basis for combination therapies in cancer.
Jillian Brechbiel (2014)
10.1158/1078-0432.CCR-0914-3
VX-710 (Biricodar) Increases Drug Retention and Enhances Chemosensitivity in Resistant Cells Overexpressing P-Glycoprotein, Multidrug Resistance Protein, and Breast Cancer Resistance Protein
H. Minderman (2004)
10.1016/j.stemcr.2015.02.005
Targeted Correction and Restored Function of the CFTR Gene in Cystic Fibrosis Induced Pluripotent Stem Cells
A. Crane (2015)
10.1073/pnas.1120068109
Wnt pathway inhibition via the targeting of Frizzled receptors results in decreased growth and tumorigenicity of human tumors
A. Gurney (2012)
10.1038/cddis.2013.407
Acquisition of epithelial–mesenchymal transition and cancer stem cell phenotypes is associated with activation of the PI3K/Akt/mTOR pathway in prostate cancer radioresistance
L. Chang (2013)
10.1240/SAV_GBM_2007_H_002048
Mechanisms of miRNA-mediated gene silencing
E. Izaurralde (2007)
Mechanisms of chemoresistance
LN Abdullah (2015)
10.1039/c5nr00297d
Glutathione- and pH-responsive nonporous silica prodrug nanoparticles for controlled release and cancer therapy.
Z. Xu (2015)
cells: biological and therapeutic perspectives
Y Zhao (2014)
10.1038/sj.leu.2402338
TRAIL (Apo2L) suppresses growth of primary human leukemia and myelodysplasia progenitors
M. Plasilová (2002)
10.1007/s00432-013-1494-1
Breast cancer adaptive resistance: HER2 and cancer stem cell repopulation in a heterogeneous tumor society
N. Duru (2013)
10.1016/j.cell.2009.06.034
Identification of Selective Inhibitors of Cancer Stem Cells by High-Throughput Screening
P. Gupta (2009)
10.1084/JEM.183.4.1797
Isolation and functional properties of murine hematopoietic stem cells that are replicating in vivo
M. Goodell (1996)
10.1158/1078-0432.CCR-13-0877
The Histone Deacetylase Inhibitor Abexinostat Induces Cancer Stem Cells Differentiation in Breast Cancer with Low Xist Expression
M. Salvador (2013)
10.1038/nchembio.258
Eyes wide open.
K. Mueller (2009)
10.1016/j.jss.2012.09.035
Effective inhibition of metastases and primary tumor growth with CTCE-9908 in esophageal cancer.
Astrid Drenckhan (2013)
CXCR 4 / CXCL 12 axis promotes VEGF-mediated tumor angiogenesis through Akt signaling pathway
Z. Liang (2008)
10.1158/0008-5472.CAN-09-1681
Regulation of breast cancer stem cell activity by signaling through the Notch4 receptor.
H. Harrison (2010)
Is NF-kappaB a good target for cancer therapy ? Hopes and pitfalls
V. Baud (2009)
10.3390/ijms150712094
Flavonoids and Wnt/β-Catenin Signaling: Potential Role in Colorectal Cancer Therapies
Nathália G. Amado (2014)
10.1002/hep.25776
Oncogene‐specific formation of chemoresistant murine hepatic cancer stem cells
E. K. Chow (2012)
10.1038/nrc3599
Cancer drug resistance: an evolving paradigm
C. Holohan (2013)
10.1084/jem.20050616
In vivo analysis of the role of aberrant histone deacetylase recruitment and RARα blockade in the pathogenesis of acute promyelocytic leukemia
H. Matsushita (2006)
10.1074/jbc.R800071200
PTEN, Stem Cells, and Cancer Stem Cells*
Reginald Hill (2009)
10.1158/1940-6207.CAPR-15-0063
NOTCH Mutations: Multiple Faces in Human Malignancies
L. Mao (2015)
10.2174/1871520615666150113103439
Development of Fourth Generation ABC Inhibitors from Natural Products: A Novel Approach to Overcome Cancer Multidrug Resistance.
S. Karthikeyan (2015)
10.1186/1741-7015-6-15
MicroRNAs: regulators of oncogenesis and stemness
T. Papagiannakopoulos (2008)
10.1158/1078-0432.CCR-14-1059
Expression of Hedgehog Pathway Mediator GLI Represents a Negative Prognostic Marker in Human Acute Myeloid Leukemia and Its Inhibition Exerts Antileukemic Effects
J. Wellbrock (2015)
Epub ahead of print [PMID: 25535115
D Feng (2014)
10.2147/DDDT.S76602
Wnt blockers inhibit the proliferation of lung cancer stem cells
X. Zhang (2015)
10.1182/BLOOD.V99.2.507
The ABCG2 transporter is an efficient Hoechst 33342 efflux pump and is preferentially expressed by immature human hematopoietic progenitors.
C. Scharenberg (2002)
10.1007/s10616-014-9830-0
Immunobiology and signaling pathways of cancer stem cells: implication for cancer therapy
M. Salem (2014)
10.1111/odi.12309
The opposing roles of NOTCH signalling in head and neck cancer: a mini review.
L. Yap (2015)
10.4161/cc.8.20.9761
Retinoid signaling regulates breast cancer stem cell differentiation
C. Ginestier (2009)
10.1186/s12967-014-0231-0
The impact of microRNA-mediated PI3K/AKT signaling on epithelial-mesenchymal transition and cancer stemness in endometrial cancer
P. Dong (2014)
Solid lipid
SJ Shi (2010)
10.3892/ijo.2011.1085
Cisplatin and TRAIL enhance breast cancer stem cell death.
Shuping Yin (2011)
10.1007/978-1-59745-280-9
Cancer Stem Cells
John E. McNamara (2009)
10.1182/blood-2013-03-493924
The Spiegelmer NOX-A12, a novel CXCL12 inhibitor, interferes with chronic lymphocytic leukemia cell motility and causes chemosensitization.
J. Hoellenriegel (2014)
10.1016/j.exphem.2012.11.004
Plerixafor (AMD3100) induces prolonged mobilization of acute lymphoblastic leukemia cells and increases the proportion of cycling cells in the blood in mice.
R. Welschinger (2013)
10.4252/WJSC.V4.I7.62
MicroRNAs, stem cells and cancer stem cells.
M. Garg (2012)
10.1158/1078-0432.CCR-09-1800
Differentiation Therapy Exerts Antitumor Effects on Stem-like Glioma Cells
B. Campos (2010)
10.1002/asia.201301030
Preparation of a camptothecin prodrug with glutathione-responsive disulfide linker for anticancer drug delivery.
Z. Xu (2014)
10.1517/17425247.2015.960920
Overcoming multidrug resistance with nanomedicines
Assaf Ganoth (2015)
10.1002/stem.1904
Cancer Stem Cell‐Like Phenotype and Survival Are Coordinately Regulated by Akt/FoxO/Bim Pathway
R. Gargini (2015)
10.1016/j.ceb.2013.01.004
Wnt signaling in stem and cancer stem cells.
J. Holland (2013)
10.1158/0008-5472.CAN-06-4180
CD133(+) and CD133(-) glioblastoma-derived cancer stem cells show differential growth characteristics and molecular profiles.
D. Beier (2007)
10.1038/nprot.2012.115
Generation of human induced pluripotent stem cells from urine samples
Ting Zhou (2012)
The microRNA miR
Y Shi (2011)
10.1042/BSR20100114
Epithelial-mesenchymal transition and cancer stemness: the Twist1-Bmi1 connection.
K. Wu (2011)
10.1371/journal.pone.0090022
The microRNA miR-34a Inhibits Non-Small Cell Lung Cancer (NSCLC) Growth and the CD44hi Stem-Like NSCLC Cells
Y. Shi (2014)
10.1007/s11095-011-0514-6
Solid Lipid Nanoparticles Loaded with Anti-microRNA Oligonucleotides (AMOs) for Suppression of MicroRNA-21 Functions in Human Lung Cancer Cells
San-jun Shi (2011)
10.1038/sj.bjc.6605952
TRAIL-expressing mesenchymal stem cells kill the putative cancer stem cell population
M. Loebinger (2010)
10.1084/jem.20111855
Oncogenic and tumor suppressor functions of Notch in cancer: it’s NOTCH what you think
C. Lobry (2011)
NF-kappaB pathway inhibitors preferentially inhibit breast cancer stem-like cells.
J. Zhou (2008)
10.1158/1078-0432.CCR-12-0370
Notch pathway activity identifies cells with cancer stem cell-like properties and correlates with worse survival in lung adenocarcinoma.
K. Hassan (2013)
10.1007/s11010-007-9570-y
Identification of a distinct side population of cancer cells in the Cal-51 human breast carcinoma cell line
M. Christgen (2007)
10.1634/stemcells.2005-0282
Characterization of a Side Population of Cancer Cells from Human Gastrointestinal System
N. Haraguchi (2006)
10.1016/j.cell.2008.03.027
The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells
Sendurai A Mani (2008)
10.1073/pnas.2235846100
A small-molecule antagonist of CXCR4 inhibits intracranial growth of primary brain tumors
J. Rubin (2003)
10.1186/1471-2490-14-12
Targeting CXCR4 with CTCE-9908 inhibits prostate tumor metastasis
D. Wong (2014)
10.1053/j.gastro.2013.12.035
Antibody against CD44s inhibits pancreatic tumor initiation and postradiation recurrence in mice.
L. Li (2014)
10.1517/14728222.2011.617367
Targeting the Hedgehog signaling pathway for cancer therapy
Y. Li (2012)
10.3171/2014.10.JNS132363
RNA interference targeting hypoxia-inducible factor 1α via a novel multifunctional surfactant attenuates glioma growth in an intracranial mouse model.
D. Gillespie (2015)
10.1021/acsmedchemlett.5b00001
Discovery of Clinical Candidate BMS-906024: A Potent Pan-Notch Inhibitor for the Treatment of Leukemia and Solid Tumors.
Ashvinikumar V. Gavai (2015)
The microRNA miR-34 a inhibits prostate cancer stem cells and metastasis by directly repressing CD 44
Can Liu (2010)



This paper is referenced by
10.3389/fgene.2020.00312
Targeting Cancer Stem Cells by Genetically Engineered Chimeric Antigen Receptor T Cells
R. Y. Alhabbab (2020)
10.1002/2211-5463.12226
Licochalcone A specifically induces cell death in glioma stem cells via mitochondrial dysfunction
Kenta Kuramoto (2017)
10.1155/2019/8347595
Scalable Culture Strategies for the Expansion of Patient-Derived Cancer Stem Cell Lines
A. T. Serra (2019)
10.1016/j.wneu.2018.12.067
Association Between CD133, CD44, and Nestin Expression and Prognostic Factors in High-Grade Meningioma.
Dai Kamamoto (2018)
10.1080/10717544.2018.1461276
AKT2 siRNA delivery with amphiphilic-based polymeric micelles show efficacy against cancer stem cells
D. Rafael (2018)
10.1016/j.yexcr.2019.111597
miR-133b suppresses colorectal cancer cell stemness and chemoresistance by targeting methyltransferase DOT1L.
Lv Lv (2019)
10.1007/s13238-017-0394-6
Targeting cancer stem cells by using chimeric antigen receptor-modified T cells: a potential and curable approach for cancer treatment
Yelei Guo (2017)
10.1093/carcin/bgy171
Novel therapies hijack the blood–brain barrier to eradicate glioblastoma cancer stem cells
Raghupathy Vengoji (2019)
Selection and Evaluation of Specific Single Chain Antibodies against CD 90 , a Marker for Mesenchymal and Cancer Stem Cells
Bahareh Moazen (2018)
10.1016/j.compbiolchem.2019.107156
In silico design, synthesis and activity of potential drug-like chrysin scaffold-derived selective EGFR inhibitors as anticancer agents
Sudhan Debnath (2019)
10.1007/978-3-319-64550-6_22
Metastatic Breast Cancer at a Glance: Scenarios of BC Brain- and BC Bone-Metastasis by Illustrations
P. Mehdipour (2017)
10.1111/fcp.12521
Cancer stem cells as therapeutic targets of pancreatic cancer
E. Razi (2019)
10.1007/s00432-019-02892-5
Controlling metastatic cancer: the role of phytochemicals in cell signaling
A. Kapinová (2019)
10.1007/978-3-030-41476-4_3
Cancer Stem Cells
F. Khatami (2020)
10.3892/ol.2019.10004
Low-density lipoprotein receptor expression is involved in the beneficial effect of photodynamic therapy using talaporfin sodium on gastric cancer cells
Tsutomu Kanda (2019)
10.18632/oncotarget.23079
Development of suspension cell culture model to mimic circulating tumor cells
J. Park (2018)
10.1186/s12917-018-1624-8
Notch2 signal is required for the maintenance of canine hemangiosarcoma cancer stem cell-like cells
Keisuke Aoshima (2018)
10.1016/j.jddst.2019.101282
Preclinical Evaluation and Clinical Translation of Magnetite-Based Nanomedicines
Julia V. Nuzhina (2019)
10.1007/s10637-019-00788-2
Pam3CSK4, a TLR2 ligand, induces differentiation of glioblastoma stem cells and confers susceptibility to temozolomide
Javier Megías (2019)
10.1016/j.ijbiomac.2019.10.190
pH RESPONSIVE DOXORUBUCIN LOADED ZEIN NANOPARTICLE CROSSLINKED PECTIN HYDROGEL AS EFFECTIVE SITE-SPECIFIC ANTICANCER SUBSTRATES.
P. Kaushik (2019)
10.21037/sci.2018.02.01
Lung cancer stem cells-origin, characteristics and therapy.
D. Prabavathy (2018)
10.1016/j.semcancer.2018.06.006
Emerging functional markers for cancer stem cell-based therapies: Understanding signaling networks for targeting metastasis.
Stephan Marquardt (2018)
10.3390/cancers11111657
Novel Antrodia cinnamomea Extract Reduced Cancer Stem-Like Phenotype Changes and Resensitized KRAS-Mutant Colorectal Cancer via a MicroRNA-27a Pathway
Tsung-Jen Lin (2019)
10.17219/acem/69135
MiR-181a inhibits human trabecular meshwork cell apoptosis induced by H₂O₂ through the suppression of NF-κB and JNK pathways.
Y. Wang (2018)
10.17925/OHR.2017.13.01.45
Targeting Cancer Stem Cells—A Renewed Therapeutic Paradigm
Catherine L Amey (2017)
10.1055/a-0898-7347
Highlights on Specific Biological Targets; Cyclin-Dependent Kinases, Epidermal Growth Factor Receptors, Ras Protein, and Cancer Stem Cells in Anticancer Drug Development.
M. Hawash (2019)
10.3390/ijms21072327
Calcium Channels as Novel Therapeutic Targets for Ovarian Cancer Stem Cells
Heejin Lee (2020)
Utjecaj retinoične kiseline i inhibitora poli (ADP-ribozil) polimeraze-1 na stanične linije neuroblastoma
Martina Grubar (2017)
10.1021/acsami.9b06155
Co-Delivery of Natural Compounds with Dual-Targeted Nanoparticle Delivery System for Improving Synergistic Therapy in Orthotopic Tumor Model.
P. Chu (2019)
10.1038/cddis.2016.297
Short-term EGFR blockade enhances immune-mediated cytotoxicity of EGFR mutant lung cancer cells: rationale for combination therapies
Charli L Dominguez (2016)
10.3390/diagnostics10090721
The Role of Breast Cancer Stem Cell-Related Biomarkers as Prognostic Factors
Clarence Ching Huat Ko (2020)
10.1016/j.lfs.2019.116952
Hypoxia inducible factors in the tumor microenvironment as therapeutic targets of cancer stem cells.
Farnaz Hajizadeh (2019)
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