Online citations, reference lists, and bibliographies.
← Back to Search

Epidemiology Of Mesothelioma In Egypt. A Ten-year (1998-2007) Multicentre Study

Yosri M. Akl, S. Kaddah, Ahmed A. M. Abdelhafeez, R. Salah, M. Lotayef
Published 2010 · Medicine

Cite This
Download PDF
Analyze on Scholarcy
Introduction Mesothelioma is a cancer strongly linked to exposure to carcinogenic minerals, especially asbestos. The aim of the study was to detect the incidence of malignant pleural mesothelioma (MPM) in Egypt, to clarify the impact of occupational and environmental risk factors, and to characterise its demographic features. Material and methods They were 584 cases diagnosed as MPM detected in Cairo University Hospitals and National Cancer Institute from 1998 to 2007. Unfortunately, full epidemiological data were only available for 165 cases due to absence of a reliable registration system. Results A steady increase in the number of cases was detected, from 24 in 1998, peaking at 82 cases in 2005, followed by a gradual decline (though still high) with 68 cases in 2006 and 51 cases in 2007. Male/female ratio was 1.35/1 (p > 0.05). The occupational exposure to asbestos was 13.9%. Residential exposure plays a major role in two regions, Helwan and Shoubra (27.3% and 20.6% respectively), while in Upper and Lower Egypt the level was 12.7% and 17.5% respectively. Kaplan-Meier survival for sex, residence and the pathological types epithelioid, biphasic and sarcomatoid was insignificant. The median survival for different grades and treatment modalities was significant (P < 0.001). Conclusions There was a steady increase in the incidence of MPM from 1998 to 2005 followed by a decline during 2006-2007. Mesothelioma in Egypt is mainly concentrated in areas of high environmental pollution. The decline within the last 2 years may be attributed to recent strict industrial preventive measures. However, a better environmental control programme would benefit Egypt.
This paper references
Prognostic factors of malignant mesothelioma of the pleura
V. de Pangher Manzini (1993)
p27 immunostaining is related to prognosis in malignant mesothelioma
T. Beer (2001)
a population-based study
F Montanaro (2007)
Phase III study of pemetrexed in combination with cisplatin versus cisplatin alone in patients with malignant pleural mesothelioma.
N. Vogelzang (2003)
Gene therapy for malignant mesothelioma: beyond the infant years
R. Most (2006)
Review and update of uncommon primary pleural tumors: a practical approach to diagnosis.
L. Granville (2005)
Malignant mesothelioma: a case presentation and review.
Timothy J. Barreiro (2006)
Epidemic of mesothelioma in Egypt.
R. Gaafar (2005)
Malignant pleural mesothelioma: CT manifestations in 50 cases.
A. Kawashima (1990)
Survival of pleural mesothelioma in Italy : a population - based study
F Montanaro (2009)
Population-based study からみた神経予後不良因子の検討
鮫島 浩 (2009)
Asbestos and mesothelioma in South Africa.
R. Abratt (2004)
O-48 Molecular markers in malignant pleural mesothelioma
R. Gaafar (2003)
Diffuse Pleural Mesothelioma and Asbestos Exposure in the North Western Cape Province
J. Wagner (1960)
Malignant mesothelioma: pronostic variables in a registry of 180 patients, the Dana-Farber Cancer Institute and Brigham and Women's Hospital experience over two decades 19651985
KH Antman (1988)
Computed tomography and malignant mesothelioma
NO Whitley (1987)
Prognostic factors of malignant mesothelioma of the pleura.
A. Anand (1994)
Malignant mesothelioma: prognostic variables in a registry of 180 patients, the Dana-Farber Cancer Institute and Brigham and Women's Hospital experience over two decades, 1965-1985.
K. Antman (1988)
Phase III study of pemetrexed in combination with cisplatin vs. cisplatin alone in patients with malignant pleural mesothelioma
NJ Vogelzang (2003)
Early response evaluation in malignant pleural mesothelioma by positron emission tomography with [18F]fluorodeoxyglucose.
G. Ceresoli (2006)
SV40 oncoproteins enhance asbestos-induced DNA double-strand breaks and abrogate senescence in murine mesothelial cells.
Jodie R. Pietruska (2007)
Epidemiology of mesothelioma in Egypt. A ten-year (1998-2007) multicentre study
Evaluation of simian virus‐40 as a biological prognostic factor in Egyptian patients with malignant pleural mesothelioma
A. Zekri (2007)
Pleural malignancies including mesothelioma.
G. Hillerdal (1995)
Malignant mesothelioma of the pleura with etiological association to asbestos exposure
E De-Capitani (1997)
Diffuse malignant mesothelioma. Prospective evaluation of 69 patients.
A. Chahinian (1982)
[Possibilities of diagnosis and treatment of malignant pleural mesothelioma].
S. Cicėnas (2004)
Diffuse pleural mesotheliomas and asbestos exposure in the Northwestern Cape Province
J Wagner (1960)
Survival of pleural malignant mesothelioma in Italy: A population‐based study
F. Montanaro (2009)
Evaluation of simian virus-40 as a biological prognostic Egyptian patients with malignant pleural mesothelioma
NZ Abdel-Rahman (2007)
molecular markers in malignant pleural mesothelioma
R Gaafar (2003)
Environmental exposure to asbestos and the exposure-response relationship with mesothelioma.
M. Madkour (2009)
A population based study
P. McIntyre (1993)
Mesothelioma Epidemiology, Carcinogenesis, and Pathogenesis
H. Yang (2008)
[Malignant pleural mesothelioma].
Q. Kong (1983)
Environment and occupation as risk factors in a group of mesothelioma patients
K. Mahgoub (1999)

This paper is referenced by
Semantic Scholar Logo Some data provided by SemanticScholar