Online citations, reference lists, and bibliographies.
← Back to Search

Pathology Of Human Malignant Mesothelioma.

Y. Suzuki
Published 1981 · Medicine

Cite This
Download PDF
Analyze on Scholarcy
Share
The author reviewed 1,517 human malignant mesothelioma cases from 1975 through August 2000. These mesothelioma cases were definite or probable in diagnostic certainty. Sources of these cases varied including asbestos insulation workers, UNARCO workers, Cancer and Leukemia B mesothelioma panel cases and random cases. Pathology materials consisted of autopsy, biopsy and rare cytology specimens. 92.3% of these patients were male, and 85.8% were between 50 and 79 years in age. The major primary site of the tumor was the pleura (73.1%). However, in a group of the asbestos insulation workers, the peritoneum was the more common primary site of malignant mesothelioma, compared to the pleura. Histologically, epithelial cell type was the majority (61.1%), followed by biphasic (22.1%) and fibrosarcomatous (16.4%). A double primary tumor (malignant mesothelioma associated with other cancer) was present in 32 of the 1,517 cases. These 32 cancers included lung cancers, renal cell carcinomas, colorectal cancers, pancreatic cancers and a cancer of the larynx, which are known to be at higher risk among asbestos insulation workers. The latency period of the vast majority (98.1%) of these mesothelioma cases were longer than 20 years. It is well accepted that cigarette smoking does not contribute to the induction of malignant mesothelioma. Indeed, the present study confirmed that 19.9% of these mesothelioma patients had never smoked cigarettes.
This paper references
Pleural mesothelioma; further evidence of its histogenesis.
M. Sano (1950)
HYALURONIC ACID IN THE PLEURAL FLUID ASSOCIATED WITH A MALIGNANT TUMOR INVOLVING THE PLEURA AND PERITONEUM
K. Meyer (1940)
Transplantation of human malignant mesothelioma into nude mice.
A. Chahinian (1980)
Ultrastructure of human malignant diffuse mesothelioma.
Y. Suzuki (1976)
10.1016/0007-0971(76)90039-5
Distant visceral metastases in pleural mesothelioma.
G. H. Roberts (1976)
10.1111/j.1749-6632.1979.tb18744.x
ENVIRONMENTAL MESOTHELIOMA IN TURKEY
Y. Bariş (1979)
10.1002/1097-0142(197705)39:5<2059::AID-CNCR2820390523>3.0.CO;2-2
Malignant fibrous mesothelioma of the tunica vaginalis. A histologic and ultrastructural study
T. Eimoto (1977)
The cytopathology of mesothelioma.
Tao Lc (1979)
10.1002/1097-0142(1967)20:3<462::AID-CNCR2820200315>3.0.CO;2-7
Acid mucopolysaccharide composition of serous effusions. Study of 100 patients with neoplastic and non‐neoplastic conditions
C. W. Castor (1967)
10.1002/1097-0142(197201)29:1<141::AID-CNCR2820290122>3.0.CO;2-P
Ultrastructure and observations on the histogenesis of mesotheliomas “adenomatoid tumors” of the female genital tract
H. Salazar (1972)
10.1111/J.1749-6632.1979.TB18711.X
MORTALITY EXPERIENCE OF INSULATION WORKERS IN THE UNITED STATES AND CANADA, 1943‐1976 *
I. Selikoff (1979)
10.1016/0002-9378(78)90933-X
Benign mesothelioma simulating a uterine leiomyoma.
C. Wood (1978)
10.1038/bjc.1969.70
Mesotheliomas in rats following inoculation with asbestos.
J. Wagner (1969)
The detection of hyaluronic acid in pleural fluids of cases with diffuse pleural mesotheliomas.
J. Harington (1963)
10.1111/j.1749-6632.1965.tb41127.x
TESTS FOR CARCINOGENICITY OF ASBESTOS *
W. E. Smith (1965)
10.1038/bjc.1974.65
The Effects of the Inhalation of Asbestos in Rats
J. Wagner (1974)
10.1093/ANNHYG/11.4.283
Asbestos bodies and mesothelioma.
J. Stumphius (1968)
10.1001/ARCHINTE.1920.00100060070004
PRIMARY MESOTHELIOMA OF THE PLEURA: A CLINICAL AND PATHOLOGIC CONTRIBUTION TO PLEURAL MALIGNANCY, WITH REPORT OF A CASE
Ernest S. du Bray (1920)
10.1002/PATH.1700840109
Histochemical demonstration of hyaluronic acid in pleural mesotheliomas.
J. C. Wagner (1962)
10.1002/1097-0142(196207/08)15:4<691::AID-CNCR2820150403>3.0.CO;2-L
The exfoliative cytology of diffuse pleural mesothelioma
S. Klempman (1962)
Mesotheliomas of the pleura and peritoneum.
Stout Ap (1951)
10.1002/1097-0142(197603)37:3<1478::AID-CNCR2820370333>3.0.CO;2-G
Malignant mesothelioma of the tunica vaginalis propria testis in a patient with asbestos exposure—A case report
Z. Fligiel (1976)
Acute and chronic effects of intraperitoneal injection of two types of asbestos in rats with a study of the histopathogenesis and ultrastructure of resulting mesotheliomas.
M. Shin (1973)
10.1002/1097-0142(197207)30:1<244::AID-CNCR2820300135>3.0.CO;2-C
Observations on benign mesothelioma of the genital tract (adenomatoid tumor).A comparative ultrastructural study
A. Ferenczy (1972)
Malignant uterine mesotheliomas in squirrel monkeys following diethylstilbestrol administration.
Mcclure Hm (1973)
Histochemistry in the diagnosis of malignant mesothelioma.
M. Kannerstein (1973)
[Anatomo-pathological diagnosis of pleural mesothelioma].
Verley Jm (1976)
[Hyaluronic acid in pleural fluids: an additional parameter for clinical diagnosis on diffuse mesotheliomas (author's transl)].
W. Matzel (1979)
10.1056/NEJM196503182721104
RELATION BETWEEN EXPOSURE TO ASBESTOS AND MESOTHELIOMA.
I. Selikoff (1965)
10.1002/1097-0142(196808)22:2<323::AID-CNCR2820220209>3.0.CO;2-M
Ultrastructural evidence of secretory differentiation in a malignant pleural mesothelioma
R. Echevarria (1968)
10.1002/1097-0142(197101)27:1<109::AID-CNCR2820270116>3.0.CO;2-7
The adenomatoid tumor: Fine structural evidence for a mesothelial origin
B. Mackay (1971)
10.1136/oem.17.4.260
Diffuse Pleural Mesothelioma and Asbestos Exposure in the North Western Cape Province
J. Wagner (1960)
Ultrastructural studies of a malignant fibrous mesothelioma of the pleura.
S. Kay (1971)
10.1093/JNCI/48.6.1687
Nitrosamine studies: neoplasms of liver and genital mesothelium in nitrosopyrrolidine-treated MRC rats.
M. Greenblatt (1972)
10.1080/00028896909343117
Experimental pulmonary carcinogenesis with asbestos.
M. Stanton (1969)
Hyaluronic acid analysis and the diagnosis of pleural mesothelioma.
A. Boersma (1980)
10.1136/jcp.25.7.577
Exfoliative cytology of diffuse mesothelioma
G. H. Roberts (1972)
10.1093/JNCI/52.6.1715
Ultrastructure of human mesotheliomas.
J. Davis (1974)
10.1002/1097-0142(197001)25:1<171::AID-CNCR2820250125>3.0.CO;2-2
Ultrastructural comparison of an adenomatoid tumor, lymphangioma, hemangioma, and mesothelioma
J. Marcus (1970)
10.1136/bmj.1.5431.350
Diffuse Mesothelioma of the Pleura and Asbestos
P. Elmes (1965)
A critique of the criteria for the diagnosis of diffuse malignant mesothelioma.
M. Kannerstein (1977)
Cytologic detection of malignant mesothelioma of the pericardium.
Y. Kobayashi (1978)
10.1136/oem.22.4.261
MESOTHELIOMA OF PLEURA AND PERITONEUM FOLLOWING EXPOSURE TO ASBESTOS IN THE LONDON AREA
M. Newhouse (1965)
Mesotheliomas of the Uterine and Tubal Serosa and the Tunica Vaginalis Testis: Report of Four Cases.
N. Evans (1943)
10.1002/1097-0142(197708)40:2<707::AID-CNCR2820400218>3.0.CO;2-8
A scanning electron microscopic study of diffuse mesothelioma and some lung carcinomas
G. Dionne (1977)
10.2214/AJR.99.4.863
Pleural mesotheliomas. Clinical experiences with thirty-seven patients.
E. R. Ratzer (1967)
The cytology of malignant mesothelioma in Western Australia.
D. Whitaker (1978)
10.1002/PATH.1700860204
THE EXFOLIATIVE CYTOLOGY OF DIFFUSE MALIGNANT MESOTHELIOMA.
B. Naylor (1963)
10.1093/JNCI/48.3.797
Mechanisms of mesothelioma induction with asbestos and fibrous glass.
M. Stanton (1972)
10.1177/030089167506100602
Histology of Chemically Induced Mesotheliomas in Mrc-wistar Rats 1
A. Pelfrene (1975)
10.1111/J.1464-410X.1975.TB03949.X
Malignant mesothelioma of the testicular tunica vaginalis.
J. Fishelovitch (1975)
10.1016/0002-9378(74)90370-6
The ovarian mesothelioma.
T. Parmley (1974)
10.1093/JNCI/52.6.1823
Histogenesis and fine structure of peritoneal tumors produced in animals by injections of asbestos.
J. Davis (1974)
10.1164/ARRD.1979.120.3.529
Significance of the quantification and demonstration of hyaluronic acid in tissue specimens for the diagnosis of pleural mesothelioma.
H. Arai (1979)
Distinction between atypical mesothelial cells and malignant cells by scanning electron microscopy.
B. Gondos (1979)
10.1111/j.1749-6632.1976.tb23127.x
HOUSEHOLD‐CONTACT ASBESTOS NEOPLASTIC RISK *
H. Anderson (1976)
10.1002/1097-0142(197305)31:5<1046::AID-CNCR2820310502>3.0.CO;2-P
Electron microscopy in the diagnosis of pleural mesotheliomas
N. Wang (1973)



This paper is referenced by
10.1038/bjc.1985.105
Trend and distribution of mesothelioma in Denmark.
M. Andersson (1985)
10.2169/INTERNALMEDICINE.47.0348
Presence of malignant mesothelial cells in the sputum.
Y. H. Choi (2008)
10.1002/PATH.1711650209
Immunocytochemistry of malignant mesothelioma: OV632 as a marker of malignant mesothelioma
M. Delahaye (1991)
10.1007/s004280050097
Establishment and characterization of spontaneous mesothelioma cell lines derived from F344 rats
M. Kuwahara (1997)
10.1136/ard.44.2.83
Circulating hyaluronate in rheumatoid arthritis: relationship to inflammatory activity and the effect of corticosteroid therapy.
A. Engström-Laurent (1985)
10.1007/0-387-28274-2_24
Clinical Presentation and Natural History of Mesothelioma: Pleural and Pericardial
A. Chahinian (2005)
10.1177/019262338701500205
Spontaneous Mesotheliomas in Fischer Rats—A Histological and Electron Microscopic Study
H. Tanigawa (1987)
10.1007/BF00737290
Ultrastructural observations on the histogenesis of localized fibrous tumours of the pleura (benign mesothehoma)
K. Bürrig (2004)
10.2486/INDHEALTH.40.295
Apportionment in asbestos-related disease for purposes of compensation.
T. Guidotti (2002)
Isolation, propagation, and characterization of rat liver serosal mesothelial cells.
R. Faris (1994)
STUDIES ON MESOTHELIAL DIFFERENTIATION PROGNOSTIC AND THERAPEUTIC APPROACHES TO MALIGNANT MESOTHELIOMA
X. Sun (2005)
10.1016/B978-0-12-405206-2.00016-8
The Pericardium and its Diseases
P. Gupta (2014)
10.1002/JSO.2930250119
Localized fibrous mesothelioma of the pleura
T. G. Weilbaecher (1984)
10.5271/SJWEH.1877
Amosite mesothelioma in a cohort of asbestos workers.
J. Ribak (1989)
All types of asbestos ® ber are associated with the development of asbestos-related scarring [
S. Levin (1999)
PDFlib PLOP: PDF Linearization, Optimization, Protection Page inserted by evaluation version
M. Iri (2002)
10.1007/978-3-642-82873-7_15
Pathology of Tumors of the Pleura and Chest Wall
B. Addis (1988)
Malignant mesothelioma in a cohort of asbestos insulation workers with asbestos or had lived in close vicinity of asbestos mines and mills
R. Lilis ()
10.2482/HAIGAN.26.195
Colony stimulating factor産生悪性胸膜中皮腫の一例
重行 辻 (1986)
10.1016/B978-0-7020-3369-8.00013-6
Chapter 13 – Pleura and chest wall
B. Corrin (2011)
10.1002/1097-0142(19840201)53:3<377::AID-CNCR2820530302>3.0.CO;2-B
Malignant mesothelioma. The university of minnesota experience
N. Vogelzang (1984)
10.1007/978-94-011-7315-5_3
Diffuse Malignant Mesothelioma (of pleura, peritoneum and pericardium)
J. Jones (1985)
10.1016/S0954-6111(96)90286-3
Methods to improve the diagnostic accuracy of malignant mesothelioma.
A. Dejmek (1996)
10.1023/A:1006542301794
Platelet-derived growth factor (PDGF) BB acts as achemoattractant for human malignant mesotheliomacells via PDGF receptor b - integrin a3b1 interaction
J. Klominek (2004)
10.5772/INTECHOPEN.88193
Asbestos-Related Pleural Diseases: The Role of Gene-Environment Interactions
V. Dolžan (2019)
10.3109/15513818809041581
Malignant pleural mesothelioma in a child.
M. R. Dische (1988)
10.1002/(SICI)1097-0274(200001)37:1<6::AID-AJIM3>3.0.CO;2-H
Medical examination for asbestos-related disease.
S. Levin (2000)
10.1007/978-1-4612-4882-8
Computed Tomography of the Gastrointestinal Tract
Alec J. Megibow (1986)
10.1002/1097-0142(19831101)52:9<1662::AID-CNCR2820520919>3.0.CO;2-B
Localized fibrous mesothelioma of the liver. Report of a giant tumor studied by light and electron microscopy
H. Kim (1983)
10.1080/15287398509530695
Early response of the visceral pleura following asbestos exposure: an ultrastructural study.
R. Dodson (1985)
10.1158/1055-9965.EPI-14-0952
Baseline Serum β-carotene Concentration and Mortality among Long-Term Asbestos-Exposed Insulators
D. Hashim (2014)
10.1016/B978-0-407-00299-9.50013-0
7 – Is it a mesothelioma?
F. N. Ghadially (1985)
See more
Semantic Scholar Logo Some data provided by SemanticScholar