Online citations, reference lists, and bibliographies.
← Back to Search

Self-Nanoemulsifying Drug Delivery System Of Glimepiride: Design, Development, And Optimization

Sunny R Shah, R. Parikh, J. Chavda, N. Sheth
Published 2013 · Materials Science, Medicine

Cite This
Download PDF
Analyze on Scholarcy
Share
The objective of the present investigation was to develop and characterize the self-nanoemulsifying drug delivery system (SNEDDS) of glimepiride, a poorly soluble drug. Solubility of glimepiride in various vehicles was determined, and ternary phase diagrams were constructed using a suitable oil, surfactant, and cosurfactant system to find out the efficient self-emulsification system. A three factor, three level Box-Behnken statistical design was employed to explore the main and interaction effect of independent variables, namely X1 (amount of Capmul MCM), X2 (amount of Acrysol K 140), and X3 (amount of Transcutol P). Percent transmittance value (Y1), droplet diameter (Y2), and percent drug released at 5 min (Y3) were the dependent variables. Formulation optimization was carried out to optimize the droplet diameter and percent drug dissolved at 5 min. The batch prepared according to the optimized formulation showed a close agreement between observed and predicted values. Box-Behnken statistical design allowed us to understand the effect of formulation variables on the rapid dissolution of drug from SNEDDS and to optimize the formulation to obtain a rapid drug dissolution at 5 min. LAY ABSTRACT: A self-nanoemulsifying drug delivery system of glimepiride has been design, developed, and optimized. A three factor, three level Box-Behnken statistical design was employed to explore the main and interaction effect of independent variables, namely X1 (amount of Capmul MCM), X2 (amount of Acrysol K 140), and X3 (amount of Transcutol P). Percent transmittance value (Y1), droplet diameter (Y2), and percent drug released at 5 min (Y3) were the dependent variables. The Capmul MCM–Akcrysol K 140–Transcutol system was found to be the suitable ternary system that was able to release almost 80% of drug within the first 5 min. The improved dissolution of glimepiride might improve patient compliance.
This paper references
10.1016/J.IJPHARM.2004.03.034
Preparation and in vitro characterization of self-nanoemulsified drug delivery system (SNEDDS) of all-trans-retinol acetate.
E. Taha (2004)
10.1016/j.ijpharm.2011.08.024
Self-nanoemulsifying drug delivery system of persimmon leaf extract: Optimization and bioavailability studies.
Wanwen Li (2011)
10.1208/s12249-008-9057-5
Micellar Solubilization of Some Poorly Soluble Antidiabetic Drugs: A Technical Note
N. Seedher (2008)
10.1016/J.IJPHARM.2006.08.038
Design and evaluation of self-nanoemulsifying drug delivery systems (SNEDDS) for cefpodoxime proxetil.
A. Date (2007)
Insulin, oral hypoglycemic agents and the pharmacology of the endocrine pancreas
J. Hardman (2001)
10.1016/J.IJPHARM.2006.04.002
Implication of inclusion complexation of glimepiride in cyclodextrin-polymer systems on its dissolution, stability and therapeutic efficacy.
H. Ammar (2006)
10.1080/10837450802498894
Co-solvent solubilization of some poorly-soluble antidiabetic drugs
N. Seedher (2009)
10.1021/JE900546Z
A Contribution to the Glimepiride Dissociation Constant Determination
S. Grbić (2010)
Effectiveness of mechanochemical treatment with cyclodextrins on increasing solubility of glimepiride.
M. Iwata (2009)
10.1016/J.IJPHARM.2006.08.022
Novel poloxamer-based nanoemulsions to enhance the intestinal absorption of active compounds.
Carsten Bruesewitz (2007)
10.1385/ENDO:13:1:117
Appropriate timing of glimepiride administration in patients with type 2 diabetes millitus
R. Gomis (2007)
10.3109/03639045.2010.538061
Strategies to improve dissolution and oral absorption of glimepiride tablets: solid dispersion versus micronization techniques
X. Ning (2011)
10.1016/0168-8227(96)01228-4
Clinical profile of the novel sulphonylurea glimepiride.
R. Rosskamp (1996)
10.2174/157341311796196853
Preparation and In Vivo Evaluation of Self-Nanoemulsifying Drug Delivery System (SNEDDS) Containing Ezetimibe
M. Dabhi (2011)
10.1080/10611860903002761
Preparation, in vitro and in vivo evaluation of solid-state self-nanoemulsifying drug delivery system (SNEDDS) of vitamin A acetate
E. Taha (2009)
Food and Drug Administration (USFDA)
10.3109/10837450902882385
Application of Box-Behnken design in understanding the quality of genistein self-nanoemulsified drug delivery systems and optimizing its formulation
Saijie Zhu (2009)
10.1007/s11095-010-0309-1
Nano-emulsions and Micro-emulsions: Clarifications of the Critical Differences
N. Anton (2010)
10.1021/LA991235V
Effect of Glycols on the Self-Assembly of Amphiphilic Block Copolymers in Water. 1. Phase Diagrams and Structure Identification
R. Ivanova (2000)



This paper is referenced by
10.3109/03639045.2014.983113
Self-nanoemulsifying drug-delivery system for improved oral bioavailability of rosuvastatin using natural oil antihyperlipdemic
Hadel A. Abo Enin (2015)
10.1016/B978-0-12-809717-5.00003-8
Systematic Development of Nanocarriers Employing Quality by Design Paradigms
B. Singh (2017)
10.1088/1742-6596/1469/1/012022
Development of self nanoemulsifying drug delivery system for black seed oil (Nigella sativa L.)
Sani Ega Priani (2020)
10.22377/AJP.V14I03.3762
Formulation and Optimization of Fluvastatin Loaded Self-emulsifying Drug Delivery Systems
D. V. R. N. Bhikshpathi (2020)
10.1016/j.jddst.2020.101808
Self-Generating nano-emulsification techniques for alternatively-routed, bioavailability enhanced delivery, especially for anti-cancers, anti-diabetics, and miscellaneous drugs of natural, and synthetic origins
Naseem Akhtar (2020)
10.22270/JDDT.V7I3.1453
SELF-MICRO EMULSIFYING DRUG DELIVERY SYSTEMS (SMEDDS): A REVIEW ON PHYSICO-CHEMICAL AND BIOPHARMACEUTICAL ASPECTS
Sheo Datta Maurya (2017)
10.3109/03639045.2015.1014374
Development and optimization of press coated tablets of release engineered valsartan for pulsatile delivery
Sunny R Shah (2015)
10.3109/10717544.2013.861659
Self-emulsifying drug delivery system and the applications in herbal drugs
Lin Zhang (2015)
10.1016/j.ejps.2015.06.016
A simple and effective method to improve bioavailability of glimepiride by utilizing hydrotropy technique.
H. Li (2015)
10.3109/03639045.2014.983113
Self-nanoemulsifying drug-delivery system for improved oral bioavailability of rosuvastatin using natural oil antihyperlipdemic.
H. A. A. Enin (2015)
10.1155/2013/848043
Formulation Strategies to Improve the Bioavailability of Poorly Absorbed Drugs with Special Emphasis on Self-Emulsifying Systems
S. Gupta (2013)
Semantic Scholar Logo Some data provided by SemanticScholar