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Silicon And Silicon-Related Surfaces For Biosensor Applications
A. Arafat, Muhammad A. Daous
Published 2011 · Materials Science
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Biosensing systems, such as enzyme, immunosensors, and DNA microarrays, are widely used in the field of medical care and medicine manufacturing [Spochiger-Kuller, 1998]. Recent developments in these devices require a high performance integrated micro-multibiosensing system, which can be employed for the recognition of an individual biomolecule and the analysis of bioreactions at the single molecular level. Constructing a highly sensitive biosensing system, precise fabrication of the electrode parts for molecular recognition is of significant importance. In these context, organic monolayers have self-assemble ability onto surfaces [Ulman, 1991]. Monolayer-modified electrode is suitable as the template for ordered immobilization of biomolecules. On the other hand, it is preferable that the detection system can detect the signal immediately, with a high sensitivity. Formation of covalently-bound organic monolayers has been particularly developed in the last two decades. The main benefit of organic monolayers is to add functionality to inorganic surface via the adaptable tailoring of surface properties. These monolayers keep the bulk features of the material (electrical, optical, magnetic, mechanical and structural), while their surface properties (wetting, passivation, bioresistance, biochemical affinity, etc...) can be tuned through a nanometer-sized grafting. This chapter provides substantial information on modification of silicon and silicon-related surfaces by organic monolayers to get the reader acquainted with the different techniques employed in tailoring the surface properties towards biosensing capability.
This paper references
Photochemical functionalization of hydrogen-terminated diamond surfaces: a structural and mechanistic study.
B. Nichols (2005)
Visible-light attachment of Si-C linked functionalized organic monolayers on silicon surfaces
L. C. D. Smet (2005)
High‐Quality Alkyl Monolayers on Silicon Surfaces
A. Sieval (2000)
Photoreactivity of Unsaturated Compounds with Hydrogen-Terminated Silicon(111)
R. Cicero (2000)
Alkyl Monolayers on Silicon Prepared from 1-Alkenes and Hydrogen-Terminated Silicon
M. R. Linford (1995)
Monolayer-derivative functionalization of non-oxidized silicon surfaces.
Naoto Shirahata (2005)
Well-defined carboxyl-terminated alkyl monolayers grafted onto H-Si(111): packing density from a combined AFM and quantitative IR study.
A. Faucheux (2006)
Simple methods for the direct assembly, functionalization, and patterning of acid-terminated monolayers on Si111.
Mathew Perring (2005)
Covalent assembly and micropatterning of functionalized multiwalled carbon nanotubes to monolayer-modified Si(111) surfaces.
B. Fabre (2008)
“Reagentless” Micropatterning of Organics on Silicon Surfaces: Control of Hydrophobic/Hydrophilic Domains1
James T. C. Wojtyk (2001)
Formation and Structure of Self-Assembled Monolayers.
A. Ulman (1996)
Selective colorimetric detection of polynucleotides based on the distance-dependent optical properties of gold nanoparticles.
R. Elghanian (1997)
Hybridization of DNA at the surface of phospholipid monolayers. Effect of orientation of oligonucleotide chains.
T. Hianik (2003)
Synthesis and characterization of DNA-modified silicon
T. Strother (2000)
Thiol-terminated monolayers on oxide-free Si: assembly of semiconductor-alkyl-S-metal junctions.
T. Böcking (2007)
Detection of DNA hybridization by gold nanoparticle enhanced transmission surface plasmon resonance spectroscopy
Eliza Hutter and (2003)
Patterning by Etching at the Nanoscale (PENs) on Si(111) through the Controlled Etching of PDMS
Mathew Perring (2007)
Microcontact printing directly on the silicon surface
Y. Jun (2002)
Single-step DNA immobilization on antifouling self-assembled monolayers covalently bound to silicon (111).
T. Böcking (2006)
Single-component and mixed ferrocene-terminated alkyl monolayers covalently bound to Si(111) surfaces.
B. Fabre (2006)
Evidence for initiation of thermal reactions of alkenes with hydrogen-terminated silicon by surface-catalyzed thermal decomposition of the reactant.
T. Mischki (2009)
Quantum Dots for Live Cells, in Vivo Imaging, and Diagnostics
X. Michalet (2005)
Y. Xia (1998)
Atomically-Resolved Studies of the Chemistry and Bonding at Silicon Surfaces
R. Hamers (1996)
On the formation and structure of self-assembling monolayers: II. A comparative study of Langmuir—Blodgett and adsorbed films using ellipsometry and IR reflection—absorption spectroscopy
J. Gun (1984)
Importance of monolayer quality for interpreting current transport through organic molecules: alkyls on oxide-free Si.
O. Seitz (2006)
On the formation and structure of self-assembling monolayers. I. A comparative atr-wettability study of Langmuir—Blodgett and adsorbed films on flat substrates and glass microbeads
R. Maoz (1984)
Covalently attached monolayers on crystalline hydrogen-terminated silicon: extremely mild attachment by visible light.
Qiao-yu Sun (2005)
Ellipsometry on thin organic layers of biological interest: characterization and applications
U. HansArwin (2000)
Colorimetric screening of DNA-binding molecules with gold nanoparticle probes.
Min Su Han (2006)
Spontaneously organized molecular assemblies. 1. Formation, dynamics, and physical properties of n-alkanoic acids adsorbed from solution on an oxidized aluminum surface
D. Allara (1985)
Cycloaddition Chemistry at Surfaces: Reaction of Alkenes with the Diamond(001)-2 × 1 Surface
J. S. Hovis (2000)
DNA-Modified Diamond Surfaces
T. Knickerbocker (2003)
Photoactivated Preparation and Patterning of Self-Assembled Monolayers with 1-Alkenes and Aldehydes on Silicon Hydride Surfaces.
F. Effenberger (1998)
Mobile Phospholipid Bilayers Supported on a Polyion/Alkylthiol Layer Pair
L. Zhang (2000)
Direct photopatterning and SEM imaging of molecular monolayers on diamond surfaces: mechanistic insights into UV-initiated molecular grafting.
X. Wang (2007)
Covalently attached monolayers on hydrogen-terminated Si(100): extremely mild attachment by visible light.
Qiao-yu Sun (2004)
Covalent biofunctionalization of silicon nitride surfaces.
A. Arafat (2007)
Microcontact printing onto oxide-free silicon via highly reactive acid fluoride-functionalized monolayers.
Luc Scheres (2010)
Photopatterned Hydrosilylation on Porous Silicon.
M. P. Stewart (1998)
Diamond Surfaces: Just Big Organic Molecules?
J. Buriak (2001)
Near-ideal photodiodes from sintered gold nanoparticle films on methyl-terminated Si(111) surfaces.
Stephen Maldonado (2008)
Surface plasmon resonance study of vesicle rupture by virus-mimetic attack.
S. Chah (2008)
Organometallic chemistry on silicon and germanium surfaces.
J. Buriak (2002)
Submicron patterning of DNA oligonucleotides on silicon.
H. Yin (2004)
Functionalization of acetylene-terminated monolayers on Si(100) surfaces: a click chemistry approach.
S. Ciampi (2007)
How important is the interfacial chemical bond for electron transport through alkyl chain monolayers?
A. Salomon (2006)
A New Method of Preparing Monolayers on Silicon and Patterning Silicon Surfaces by Scribing in the Presence of Reactive Species
T. L. Niederhauser (2001)
Real-time multicolor DNA detection with chemoresponsive diffraction gratings and nanoparticle probes.
R. Bailey (2003)
Semiconductor nanocrystals as fluorescent biological labels.
M. Bruchez (1998)
The compatibility of hepatocytes with chemically modified porous silicon with reference to in vitro biosensors.
S. D. Alvarez (2009)
An Improved Method for the Preparation of Organic Monolayers of 1-Alkenes on Hydrogen-Terminated Silicon Surfaces
A. Sieval (1999)
Functional PEG-modified thin films for biological detection.
A. Anderson (2008)
Self-assembled monolayers of thiolates on metals as a form of nanotechnology.
J. Love (2005)
Advances in silicon carbide processing and applications
S. Saddow (2004)
ADSORPTION OF BIFUNCTIONAL ORGANIC DISULFIDES ON GOLD SURFACES
R. Nuzzo (1983)
Peptide-modified optical filters for detecting protease activity.
Kristopher A. Kilian (2007)
Study of factors affecting the performance of voltammetric copper sensors based on Gly-Gly-His modified glassy carbon and gold electrodes
Guozhen Liu (2006)
Light transmission in quasiperiodic multilayers of porous silicon
R. Nava (2003)
Self-assembled monolayers as a tunable platform for biosensor applications.
N. K. Chaki (2002)
Novel biosensor-based analytic device for the detection of anti-double-stranded DNA antibodies.
A. Buhl (2007)
Controlled loading of oligodeoxyribonucleotide monolayers onto unoxidized crystalline silicon; fluorescence-based determination of the surface coverage and of the hybridization efficiency; parallel imaging of the process by Atomic Force Microscopy
F. Cattaruzza (2006)
Chemical reactivity of hydrogen-terminated crystalline silicon surfaces
R. Boukherroub (2005)
Covalent functionalization of silicon nitride surfaces by semicarbazide group
Y. Coffinier (2007)
Amino-Terminated Organic Monolayers on Hydrogen-Terminated Silicon Surfaces
A. Sieval (2001)
Molecular layer deposition of thiol-ene multilayers on semiconductor surfaces.
Y. Li (2010)
A glucose biosensor based on surface-enhanced Raman scattering: improved partition layer, temporal stability, reversibility, and resistance to serum protein interference.
C. R. Yonzon (2004)
Covalent attachment of organic monolayers to silicon carbide surfaces.
M. Rosso (2008)
Fixation of DNA directly on optical waveguide surfaces for molecular probe biosensor development
M. A. Karymov (1995)
Covalent grafting of organic molecular chains on amorphous carbon surfaces
S. Ababou-Girard (2006)
Formation, characterization, and chemistry of undecanoic acid-terminated silicon surfaces: patterning and immobilization of DNA.
R. Voicu (2004)
Molecular Modeling of Alkyl Monolayers on the Si(111) Surface
A. Sieval (2000)
Nano-chemistry and scanning probe nanolithographies.
R. Garcia (2006)
Monolayers of 1-Alkynes on the H-Terminated Si(100) Surface
A. Sieval (2000)
Recent advances in surface plasmon resonance based techniques for bioanalysis
K. S. Phillips (2007)
Comparing the reactivity of alkynes and alkenes on silicon (100) surfaces.
A. Ng (2009)
Part per trillion determination of atrazine in natural water samples by a surface plasmon resonance immunosensor
M. Farré (2007)
Molecules on si: electronics with chemistry.
A. Vilan (2010)
Tailor-made functionalization of silicon nitride surfaces.
A. Arafat (2004)
What is the Barrier for Tunneling Through Alkyl Monolayers? Results from n‐ and p‐Si–Alkyl/Hg Junctions
A. Salomon (2007)
Conducting ferrocene monolayers on nonconducting surfaces.
F. Hauquier (2008)
Covalently attached organic monolayers on SiC and SixN4 surfaces: formation using UV light at room temperature.
M. Rosso (2009)
Engineering silicon oxide surfaces using self-assembled monolayers.
S. Onclin (2005)
Annealing and deposition effects of the chemical composition of silicon-rich nitride
K. N. Andersen (2005)
Alkyl monolayers covalently bonded to silicon surfaces
M. R. Linford (1993)
Integration of displacement sensor into bulk PZT thick film actuator for MEMS deformable mirror
X. Xu (2008)
Covalently attached saccharides on silicon surfaces.
L. C. P. M. de Smet (2003)
De Smet L.
M. Haine (1986)
Evaluation of two- and three-dimensional streptavidin binding platforms for surface plasmon resonance spectroscopy studies of DNA hybridization and protein-DNA binding.
N. Yang (2007)
Photochemical attachment of organic monolayers onto H-terminated Si(111): radical chain propagation observed via STM studies.
B. J. Eves (2004)
Exciton-mediated hydrosilylation on photoluminescent nanocrystalline silicon.
M. P. Stewart (2001)
Local probe oxidation of self-assembled monolayers on hydrogen-terminated silicon.
M. Yang (2009)
Visualization of DNA hybridization on gold thin film by utilizing the resistance effect of DNA monol
T. Masuda (2005)
Advanced Inorganic Chemistry
F. Cotton (1999)
Determination of organic acids in Vaccinium berry standard reference materials
Melissa M. Phillips (2010)
Kinetic control of the photochemical reactivity of hydrogen-terminated silicon with bifunctional molecules.
Hidehiko Asanuma (2005)
On the performance of different bimetallic combinations in surface plasmon resonance based fiber optic sensors
A. Sharma (2007)
Enzyme Inhibition Assays with an Amperometric Glucose Biosensor Based on a Thiolate Self‐Assembled Monolayer
P. Alexander (2000)
Semicarbazide-functionalized Si(111) surfaces for the site-specific immobilization of peptides.
Y. Coffinier (2005)
Spectroscopic ellipsometry for characterization and monitoring of organic layers
H. Arwin (2001)
Structure and reactivity of alkoxycarbonyl (ester)-terminated monolayers on silicon: sum frequency generation spectroscopy.
Hidehiko Asanuma (2006)
Highly Stable Si−C Linked Functionalized Monolayers on the Silicon (100) Surface
A. Sieval (1998)
Dehydrative cyclocondensation reactions on hydrogen-terminated Si(100) and Si(111): an ex situ tool for the modification of semiconductor surfaces.
T. R. Leftwich (2008)
Ternary monolayers as DNA recognition interfaces for direct and sensitive electrochemical detection in untreated clinical samples.
S. Campuzano (2011)
Thermal behavior of alkyl monolayers on silicon surfaces
M. Sung (1997)
Photochemical Functionalization of Diamond Films
T. Strother (2002)
The Cooperative Molecular Field Effect
D. Cahen (2005)
Molecular simulation study of alkyl monolayers on the Si(111) surface
S. Yuan (2003)
Determination of environmental organic pollutants with a portable optical immunosensor.
E. Mauriz (2006)
Molecularly controlled metal-semiconductor junctions on silicon surface: a dipole effect.
R. K. Hiremath (2008)
Catalytic stamp lithography for sub-100 nm patterning of organic monolayers.
Hidenori Mizuno (2008)
Toward metal-organic insulator-semiconductor solar cells, based on molecular monolayer self-assembly on n-Si
Rotem Har-lavan (2009)
One-step photochemical attachment of NHS-terminated monolayers onto silicon surfaces and subsequent functionalization.
M. Yang (2008)
Arrays of chemomechanically patterned patches of homogeneous and mixed monolayers of 1-alkenes and alcohols on single silicon surfaces.
T. L. Niederhauser (2002)
Si-C linked organic monolayers on crystalline silicon surfaces as alternative gate insulators.
E. Faber (2005)
Truly quantitative XPS characterization of organic monolayers on silicon: study of alkyl and alkoxy monolayers on H-Si(111).
X. Wallart (2005)
The preparation of flat H–Si(111) surfaces in 40% NH4F revisited
P. Allongue (2000)
Insights into the Formation Mechanisms of Si−OR Monolayers from the Thermal Reactions of Alcohols and Aldehydes with Si(111)−H1
R. Boukherroub (2000)
FTIR-ATR detection of proteins and small molecules through DNA conjugation
Wei Liao (2006)
Organic Modification of Hydrogen Terminated Silicon Surfaces
D. Wayner (2002)
Functional nanostructures from surface chemistry patterning.
M. Woodson (2007)
Chemomechanical Functionalization and Patterning of Silicon
L. Yang (2006)
Plasmonic enhancement of molecular fluorescence.
F. Tam (2007)
Self assembled monolayers on silicon for molecular electronics.
D. Aswal (2006)
Covalent Grafting of Organic Layers on Sputtered Amorphous Carbon: Surface Preparation and Coverage Density
S. Ababou-Girard (2007)
Synthesis and Characterization of DNA-Modified Silicon (111) Surfaces
T. Strother (2000)
This paper is referenced by
Hybrids of organic molecules and flat, oxide-free silicon: high-density monolayers, electronic properties, and functionalization.
Y. Li (2012)