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Silicon And Silicon-Related Surfaces For Biosensor Applications

A. Arafat, Muhammad A. Daous
Published 2011 · Materials Science

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Biosensing systems, such as enzyme, immunosensors, and DNA microarrays, are widely used in the field of medical care and medicine manufacturing [Spochiger-Kuller, 1998]. Recent developments in these devices require a high performance integrated micro-multibiosensing system, which can be employed for the recognition of an individual biomolecule and the analysis of bioreactions at the single molecular level. Constructing a highly sensitive biosensing system, precise fabrication of the electrode parts for molecular recognition is of significant importance. In these context, organic monolayers have self-assemble ability onto surfaces [Ulman, 1991]. Monolayer-modified electrode is suitable as the template for ordered immobilization of biomolecules. On the other hand, it is preferable that the detection system can detect the signal immediately, with a high sensitivity. Formation of covalently-bound organic monolayers has been particularly developed in the last two decades. The main benefit of organic monolayers is to add functionality to inorganic surface via the adaptable tailoring of surface properties. These monolayers keep the bulk features of the material (electrical, optical, magnetic, mechanical and structural), while their surface properties (wetting, passivation, bioresistance, biochemical affinity, etc...) can be tuned through a nanometer-sized grafting. This chapter provides substantial information on modification of silicon and silicon-related surfaces by organic monolayers to get the reader acquainted with the different techniques employed in tailoring the surface properties towards biosensing capability.
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