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Self-Microemulsifying System

M. Shah, A. G. Agrawal
Published 2019 · Medicine

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Oral route is preferred for drug administration; however according to the recent scenario 40% of new drug candidates have poor water solubility and low bioavailability. One of the biggest challenges in drug delivery science is to improve low oral bioavailability problem which is associated with the hydrophobic drugs due to their unprecedented potential as a drug deliver with the broad range of application. Self-emulsifying systems have been proved as highly useful technological innovations to vanquish such bioavailability problem by virtue of their diminutive globule size, higher solubilization tendency for hydrophobic drugs, robust formulation advantages, and easy to scale up. Self-microemulsifying systems are isotropic mixers of oil, surfactant, drug and co-emulsifier or solubilizer, which spontaneously form transparent micro-emulsions with oil droplets ranging between 100 and 250 nm. Micro emulsified drug can be easily absorbed through the lymphatic pathway and it bypasses the hepatic first-pass effect. Self-microemulsifying system is a thermodynamically stable system and overcomes the drawback of layering of emulsions after sitting for a long period of time. The present literature gives exhaustive information on the formulation design and characterization of self-microemulsifying systems.
This paper references
10.1016/J.AJPS.2014.08.003
Enhancement of solubility and therapeutic potential of poorly soluble lovastatin by SMEDDS formulation adsorbed on directly compressed spray dried magnesium aluminometasilicate liquid loadable tablets: A study in diet induced hyperlipidemic rabbits
M. Qureshi (2015)
10.1016/J.BIOPHA.2004.02.001
Self-emulsifying drug delivery systems (SEDDS) for improved oral delivery of lipophilic drugs.
R. N. Gursoy (2004)
10.1016/j.ejpb.2010.01.008
Development of microemulsions to topically deliver 5-aminolevulinic acid in photodynamic therapy.
L. M. P. C. Araújo (2010)
10.1016/J.JDDST.2018.08.003
Development of self-nanoemulsifying drug delivery systems for oil extracts of Citrus aurantium L. blossoms and Rose damascena and evaluation of anticancer properties
R. Nazari-Vanani (2018)
10.1016/j.ijpharm.2019.04.035
In vitro evaluation of intravesical mucoadhesive self-emulsifying drug delivery systems.
Noemi Lupo (2019)
10.1208/s12249-014-0238-0
Spontaneous Emulsification of Nifedipine-Loaded Self-Nanoemulsifying Drug Delivery System
Yotsanan Weerapol (2014)
10.1016/J.EJPB.2006.10.014
Development and bioavailability assessment of ramipril nanoemulsion formulation.
S. Shafiq (2007)
Light scattering measurements on micro-emulsions: Estimation of droplet
C Goddeeris (2006)
10.1208/s12249-019-1335-x
Self-Emulsifying Oral Lipid Drug Delivery Systems: Advances and Challenges
S. Rani (2019)
10.2174/156720106777731118
Applications of microemulsion based drug delivery system.
K. Jadhav (2006)
10.1016/j.ejpb.2007.12.020
Bioavailability of probucol from lipid and surfactant based formulations in minipigs: influence of droplet size and dietary state.
F. S. Nielsen (2008)
10.1021/mp300219h
Identification and molecular interpretation of the effects of drug incorporation on the self-emulsification process using spectroscopic, micropolarimetric and microscopic measurements.
A. Mercuri (2012)
10.3109/03639045.2011.565774
Enhanced oral bioavailability of tacrolimus in rats by self-microemulsifying drug delivery systems
Y. Wang (2011)
10.1016/j.ijpharm.2009.07.015
Self-nanoemulsifying drug delivery systems of tamoxifen citrate: design and optimization.
Y. Elnaggar (2009)
10.1016/j.ijpharm.2019.01.039
Peptide release from SEDDS containing hydrophobic ion pair therapeutic peptides measured by Taylor dispersion analysis
J. Chamieh (2019)
10.1016/S0928-0987(00)00167-6
Lipid formulations for oral administration of drugs: non-emulsifying, self-emulsifying and 'self-microemulsifying' drug delivery systems.
C. Pouton (2000)
10.1016/j.addr.2018.07.001
SEDDS: A game changing approach for the oral administration of hydrophilic macromolecular drugs.
A. Mahmood (2018)
10.1016/j.colsurfb.2014.11.022
Self emulsifying drug delivery system for enhanced solubility and dissolution of glipizide.
A. G. Agrawal (2015)
10.1016/j.ejps.2008.07.004
Formulation and in vitro and in vivo characterization of a phenytoin self-emulsifying drug delivery system (SEDDS).
E. Atef (2008)
10.1016/J.ADDR.2007.10.010
Formulation of lipid-based delivery systems for oral administration: materials, methods and strategies.
C. Pouton (2008)
QbD-based development of cationic selfnanoemulsifying drug delivery systems of paclitaxel with improved biopharmaceutical attributes. AAPS PharmSciTech
S Beg (2019)
10.1016/s0169-409x(96)00423-1
Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings.
C. Lipinski (2001)
Selfemulsifying pharmaceutical composition with enhanced bioavailability
WH Hao (2012)
Self - nano emulsifying drug delivery systems of tamoxifen citrate : Design and optimization
Elnaggar YSR (2009)
Self-emulsifying drug delivery systems for solubility and bioavailability enhancement of poorly water soluble drugs
A. Kumar (2016)
10.3109/10837459609029889
Positively charged self-emulsifying oil formulation for improving oral bioavailability of progesterone.
T. Gershanik (1996)
10.1023/A:1018984731584
Intestinal Permeability Enhancement: Efficacy, Acute Local Toxicity, and Reversibility
E. S. Swenson (2004)
10.1517/17425247.3.1.97
Development of supersaturatable self-emulsifying drug delivery system formulations for improving the oral absorption of poorly soluble drugs
Ping Gao (2006)
10.1016/j.ejpb.2009.06.001
Lipid--an emerging platform for oral delivery of drugs with poor bioavailability.
S. Chakraborty (2009)
10.1208/s12249-014-0280-y
A Self-microemulsifying Drug Delivery System (SMEDDS) for a Novel Medicative Compound Against Depression: a Preparation and Bioavailability Study in Rats
L. Wu (2014)
10.1208/s12249-019-1319-x
QbD-Based Development of Cationic Self-nanoemulsifying Drug Delivery Systems of Paclitaxel with Improved Biopharmaceutical Attributes
S. Beg (2019)
10.1208/s12249-015-0469-8
Preparation and In Vitro/In Vivo Evaluation of Puerarin Solid Self-Microemulsifying Drug Delivery System by Spherical Crystallization Technique
G. Cheng (2015)
10.1080/03639045.2019.1567758
Self-emulsifying drug delivery system for enhanced solubility of asenapine maleate: design, characterization, in vitro, ex vivo and in vivo appraisal
Harani Avasarala (2019)
10.2217/nnm-2017-0354
Self-emulsifying drug-delivery systems modulate P-glycoprotein activity: role of excipients and formulation aspects.
K. AboulFotouh (2018)
10.1016/0378-5173(94)90271-2
Self-emulsifying drug delivery systems (SEDDS) with polyglycolyzed glycerides for improving in vitro dissolution and oral absorption of lipophilic drugs
N. Shah (1994)
10.1016/j.biopha.2018.11.110
Evaluation of a self-nanoemulsifying docetaxel delivery system.
S. Akhtartavan (2019)
10.1208/s12249-009-9281-7
Oral Bioavailability Enhancement of Exemestane from Self-Microemulsifying Drug Delivery System (SMEDDS)
A. Singh (2009)
Pharmaceutical compositions for oral administration of insulin peptides
포거 플로리안앤더스 (2011)
10.3109/9781420017267
Oral Lipid-Based Formulations: Enhancing the Bioavailability of Poorly Water-Soluble Drugs
J. Dressman (2007)
10.1248/BPB.27.1993
Formulation design of self-microemulsifying drug delivery systems for improved oral bioavailability of celecoxib.
N. Subramanian (2004)
Self-emulsifying and self-microemulsifying formulations for the oral administration of taxoids
고델 질베르 (2004)
10.1016/j.ijpharm.2007.12.026
Preparation and evaluation of self-microemulsifying drug delivery system of oridonin.
Ping Zhang (2008)
10.1016/j.addr.2018.10.014
Successful development of oral SEDDS: screening of excipients from the industrial point of view.
I. Nardin (2018)
10.1016/S0939-6411(00)00089-8
Self-dispersing lipid formulations for improving oral absorption of lipophilic drugs.
T. Gershanik (2000)
10.1016/J.IJPHARM.2007.08.057
Stable drug encapsulation in micelles and microemulsions.
A. Narang (2007)
10.1016/0021-9797(75)90035-1
Entropy-induced dispersion of bulk liquids
H. Reiss (1975)
Selfemulsifying drug delivery systems (SEDDS): Formulation development, characterization, and applications
B Singh (2009)
10.1016/j.ejpb.2013.10.015
Resveratrol self-emulsifying system increases the uptake by endothelial cells and improves protection against oxidative stress-mediated death.
A. Amri (2014)
10.1016/J.EJPS.2003.08.005
Lipid drug delivery and rational formulation design for lipophilic drugs with low oral bioavailability, applied to cyclosporine.
J. Odeberg (2003)
10.1016/J.IJPHARM.2006.01.037
Light scattering measurements on microemulsions: estimation of droplet sizes.
C. Goddeeris (2006)
10.1016/j.addr.2019.01.008
Colloidal aspects of dispersion and digestion of self-dispersing lipid-based formulations for poorly water-soluble drugs.
K. Vithani (2019)
10.1080/21691401.2019.1581791
Development and evaluation of doxorubicin self nanoemulsifying drug delivery system with Nigella Sativa oil against human hepatocellular carcinoma
Afreen Usmani (2019)
Selfmicroemulsifying mitotane composition.EP2435022A2
F Battung (2012)
10.1016/0378-5173(85)90081-X
Self-emulsifying drug delivery systems: assessment of the efficiency of emulsification
C. Pouton (1985)
10.1208/s12249-018-1274-y
Development and Characterization of a Self-Nanoemulsifying Drug Delivery System Comprised of Rice Bran Oil for Poorly Soluble Drugs
Georgios K Eleftheriadis (2019)
10.1016/j.jconrel.2008.03.021
Rationalizing the selection of oral lipid based drug delivery systems by an in vitro dynamic lipolysis model for improved oral bioavailability of poorly water soluble drugs.
A. Dahan (2008)
10.1016/j.ejpb.2017.11.003
Measuring the emulsification dynamics and stability of self‐emulsifying drug delivery systems
Teófilo Vasconcelos (2018)
10.1615/CritRevTherDrugCarrierSyst.v33.i1.20
Current Trends in Self-Emulsifying Drug Delivery Systems (SEDDSs) to Enhance the Bioavailability of Poorly Water-Soluble Drugs.
R. Karwal (2016)
10.1208/s12249-009-9340-0
Porous Magnesium Aluminometasilicate Tablets as Carrier of a Cyclosporine Self-Emulsifying Formulation
C. Sander (2009)
NOVEL APPROACHES FOR DEVELOPMENT AND CHARACTERIZATION OF SMEDDS: REVIEW
U. Deokate (2013)
10.1002/JPS.10501
Excipient effects on in vitro cytotoxicity of a novel paclitaxel self-emulsifying drug delivery system.
Neslihan Gursoy (2003)
10.3109/9781420017267-7
Materials, Process, and Manufacturing Considerations for Lipid-Based Hard-Capsule Formats
William J. Bowtle (2007)
Selfemulsifying drug delivery system for enhanced solubility and dissolution of glipizide. Colloids and Surfaces B: Biointerfaces
A Agrawal (2014)
10.1208/s12249-007-9014-8
Design and Evaluation of Self-Microemulsifying Drug Delivery System (SMEDDS) of Tacrolimus
V. Borhade (2007)
10.1016/j.jconrel.2009.10.005
Impact of emulsion-based drug delivery systems on intestinal permeability and drug release kinetics.
Fulden Buyukozturk (2010)
10.1007/s13205-019-1630-y
Wound healing evaluation of self-nanoemulsifying drug delivery system containing Piper cubeba essential oil
F. Shakeel (2019)
Micro - emulsion - based media as novel drug delivery systems
MJ Lawrence (2000)
10.1016/j.addr.2019.04.001
Self-emulsifying drug delivery system: Mucus permeation and innovative quantification technologies.
M. Abdulkarim (2019)
NEDDS containing bioenhancers for improvement of dissolution and oral bsorption of lacidipine . I : Development and optimization mad
B. Basalious (2010)
10.1208/s12249-018-0991-6
Preparation and Optimization of Rivaroxaban by Self-Nanoemulsifying Drug Delivery System (SNEDDS) for Enhanced Oral Bioavailability and No Food Effect
X. Xue (2018)
10.1080/03639040802488089
Preparation and Evaluation of Self-Microemulsifying Drug Delivery System Containing Vinpocetine
Shu-xia Cui (2009)
10.1016/j.drudis.2010.08.007
Self-emulsifying drug delivery systems: an approach to enhance oral bioavailability.
K. Kohli (2010)
10.1159/000104808
Bioavailability Assessment of Vitamin A Self-Nanoemulsified Drug Delivery Systems in Rats: A Comparative Study
E. Taha (2007)
10.1517/17425247.2012.719870
Potentials and challenges in self-nanoemulsifying drug delivery systems
A. W. Khan (2012)
10.1615/CRITREVTHERDRUGCARRIERSYST.V26.I5.10
Self-emulsifying drug delivery systems (SEDDS): formulation development, characterization, and applications.
B. Singh (2009)
10.1038/nrd2197
Lipids and lipid-based formulations: optimizing the oral delivery of lipophilic drugs
C. H. Porter (2007)
ISSN: 2249-0337 Review Article New Approaches for Development and Characterization of SMEDDS
Latika M. Ingle (2013)
10.1208/aapsj0903041
Preparation and in vivo evaluation of SMEDDS (self-microemulsifying drug delivery system) containing fenofibrate
A. Patel (2008)
10.1016/J.FJPS.2017.02.003
SMEDDS of pioglitazone: Formulation, in-vitro evaluation and stability studies
Vikas Pandey (2017)
10.3109/03639045.2014.886695
Formulation of solid self-nanoemulsifying drug delivery systems using N-methyl pyrrolidone as cosolvent
A. G. Agrawal (2015)
10.1002/JPS.20726
Evaluation of hydroperoxides in common pharmaceutical excipients.
Walter R. Wasylaschuk (2007)
10.1016/S0169-409X(96)00490-5
Formulation of self-emulsifying drug delivery systems
C. Pouton (1997)
10.2147/IJN.S149717
Supersaturable solid self-microemulsifying drug delivery system: precipitation inhibition and bioavailability enhancement
Guilan Quan (2017)
10.1016/j.colsurfb.2012.07.017
Optimized nanoemulsifying systems with enhanced bioavailability of carvedilol.
B. Singh (2013)
10.1016/j.ejps.2007.11.001
Reduced food-effect and enhanced bioavailability of a self-microemulsifying formulation of itraconazole in healthy volunteers.
J. Woo (2008)
10.1016/j.drudis.2008.04.006
Development of solid self-emulsifying drug delivery systems: preparation techniques and dosage forms.
B. Tang (2008)
10.1016/j.addr.2012.09.018
Microemulsion-based media as novel drug delivery systems.
M. Lawrence (2000)
10.1016/j.ijpharm.2010.03.008
SNEDDS containing bioenhancers for improvement of dissolution and oral absorption of lacidipine. I: development and optimization.
E. B. Basalious (2010)
Porous magnesium aluminometasilicate tablets as carrier of a cyclosporine selfemulsifying formulation. AAPS PharmSciTech
C Sander (2009)
10.1615/CRITREVTHERDRUGCARRIERSYST.V18.I1.20
Improved drug delivery using microemulsions: rationale, recent progress, and new horizons.
R. Bagwe (2001)
10.1002/CHIN.200637269
Applications of Microemulsion‐Based Drug Delivery System
K. R. Jadhav (2006)
10.1016/j.ijpharm.2011.04.041
Oil based nanocarrier for improved oral delivery of silymarin: In vitro and in vivo studies.
R. Parveen (2011)
10.2147/IJN.S28761
Improved oral bioavailability of poorly water-soluble indirubin by a supersaturatable self-microemulsifying drug delivery system
Zhi-Qiang Chen (2012)
10.1016/J.ADDR.2007.10.012
Biopharmaceutical challenges associated with drugs with low aqueous solubility--the potential impact of lipid-based formulations.
C. O'Driscoll (2008)
10.1155/2013/848043
Formulation Strategies to Improve the Bioavailability of Poorly Absorbed Drugs with Special Emphasis on Self-Emulsifying Systems
S. Gupta (2013)
10.1080/1061186X.2019.1584200
Oral self-emulsifying delivery systems for systemic administration of therapeutic proteins: science fiction?
Thi Nhu Quynh Phan (2019)



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