Online citations, reference lists, and bibliographies.
← Back to Search

Malign Plevral Mezotelyoma Prognozunda Yeni Bir Inflamatuar Parametrenin Değeri

Çetin Tanrıkulu, Özlem Abakay, C. Sezgi, A. Abakay, H. Şen, H. Kaya, M. Taylan
Published 2013 · Medicine

Cite This
Download PDF
Analyze on Scholarcy
Objective: Malignant Pleural Mesothelioma (MPM) generally associated with asbestos exposure is a tumor with poor prognosis. Modified Glasgow Prognostic Score (GPS) which may be a prognostic parameter in patients with MPM is a designed based score including increased C-reactive protein (CRP) levels and decreased albumin .In this study we aimed to investigate the effect of GPS score on the prognosis of MPM and the role of other potential factors. Methods: In this retrospective planned study 140 histological diagnosed MPM patients were included. Results: Mean age of 140 MPM patients were 52.92 years (83 male and 57 female). A total of 91 patients had environmental asbestos exposure and exposure time was the 31 years. Symptoms of the patients started approximately 4.8 months before the application. The most frequently seen symptoms were in 125 patients dyspnea, in 94 patients chest pain and in 22 patients weight loss. GPS score of the patients were as follows; 64 patients two, 14 patients one, 22 patients zero. Of the patients, 112 died and 28 were alive. Mean survival time was 14 months. Patients with GPS score 2 lived for 10 months, GPS score 1 lived for 15 and GPS score 0 lived for 18 months. This difference was statistically significant. Furthermore, the male sex and age older than 65 years were found as poor prognostic parameters on the survival. Conclusion: A simple and inexpensive parameter able to be used to estimate the prognosis of MPM patients could not be developed .GPS score increases in inflammatory conditions. GPS is a simple and inexpensive parameter that can be used for detecting the severity of patients with MPM.
This paper references
Survival of pleural malignant mesothelioma in Italy: A population‐based study
F. Montanaro (2009)
Intratumoral T cells, recurrence, and survival in epithelial ovarian cancer.
L. Zhang (2003)
Inflammation-Based Prognostic Indices in Malignant Pleural Mesothelioma
D. Pinato (2012)
Malignant Pleural Mesothelioma Caused by Environmental Exposure to Asbestos in the Southeast of Turkey : CT Findings in 117 Patients
H. Leblebı̇cı̇a (2000)
A Clinical, Radiographic and Laboratory Evaluation of Prognostic Factors in 363 Patients with Malignant Pleural Mesothelioma
A. C. Tanrıkulu (2010)
Prognostic value of the serum tumour markers Cyfra 21-1 and tissue polypeptide antigen in malignant mesothelioma.
H. Schouwink (1999)
Prognostic Effect of Epithelial and Stromal Lymphocyte Infiltration in Non–Small Cell Lung Cancer
K. Al-Shibli (2008)
Incidence of Malignant Pleural Mesothelioma due to Environmental Asbestos Fiber Exposure in the Southeast of Turkey
A. Şenyiğit (2000)
Survival patterns for malignant mesothelioma: The seer experience
R. Spirtas (1988)
Environmental malignant pleural mesothelioma in Southeast Turkey.
A. C. Tanrıkulu (2006)
Assessing quality of life during chemotherapy for pleural mesothelioma: feasibility, validity, and results of using the European Organization for Research and Treatment of Cancer Core Quality of Life Questionnaire and Lung Cancer Module.
A. Nowak (2004)
Factors predictive of survival among 337 patients with mesothelioma treated between 1984 and 1994 by the Cancer and Leukemia Group B.
J. Herndon (1998)
Evaluation of cumulative prognostic scores based on the systemic inflammatory response in patients with inoperable non-small-cell lung cancer
L. M. Forrest (2003)
Prognostic factors in patients with pleural mesothelioma: the European Organization for Research and Treatment of Cancer experience.
D. Curran (1998)
Malignant mesothelioma: diagnostic and management strategies for 1992.
N. Vogelzang (1992)
Prognostic factors for malignant mesothelioma in 142 patients: validation of CALGB and EORTC prognostic scoring systems
J. Edwards (2000)

Semantic Scholar Logo Some data provided by SemanticScholar