← Back to Search
FORMULATION AND CHARACTERIZATION OF ROSUVASTATIN CALCIUM NANOPARTICLES
Ramkumar Ponnuraj, K. Janakiraman, S. Gopalakrishnan, Henald John Jeyakumar, V. Venkateswarlu, D. Narayanan
Published 2015 · Materials Science
Download PDFAnalyze on Scholarcy
Article history The aim of this study is to formulate and characterize Rosuvastatin loaded Chitosan nanoparticles prepared by ionic-gelation method. Rosuvastatin Calcium has a low bioavailability (20%) due to poor absorption of the drug. Chitosan is a polymer of linear polysaccharide, which enhances transport of drug across epithelial surfaces and is biocompatible and biodegradable. The nanoparticles obtained were evaluated for percentage yield of drug, drug entrapment efficiency, particle size and morphology using Scanning Electron Microscopy (SEM), compatibility studies using Fourier-Transform Infrared Spectroscopy (FTIR) and Differential Scanning Calorimetry (DSC) and in vitro release kinetics. Among the four different drug to polymer ratios, 1:1 ratio showed high encapsulation efficiency and drug loading. The nanoparticles obtained were spherical in shape with a smooth surface with particle size range between 231.52 ± 24.12 nm to 405.25 ± 17.42 nm. The nanoparticles prepared proved to be a promising dosage form of Rosuvastatin, with improved bioavailability.
This paper references
In-Vitro Dissolution Profile Comparison: Statistics and Analysis, Model Dependent Approach
P. Sathe (2004)
Nanoparticles - A Review
V. Mohanraj (2007)
MECHANISM OF SUSTAINED-ACTION MEDICATION. THEORETICAL ANALYSIS OF RATE OF RELEASE OF SOLID DRUGS DISPERSED IN SOLID MATRICES.
T. Higuchi (1963)
Modelling of dissolution behaviour of controlled release systems
M. Makoid (1993)
A simple equation for the description of solute release. III. Coupling of diffusion and relaxation
N. Peppas (1989)
Multipoint dissolution specification and acceptance sampling rule based on profile modeling and principal component analysis.
Y. Tsong (1997)
Nanoemulsified ethanolic extract of Pyllanthus amarus Schum & Thonn ameliorates CCl4 induced hepatotoxicity in Wistar rats.
V. Deepa (2012)
Novel chitosan-based pH-sensitive interpenetrating network microgels for the controlled release of cefadroxil ☆
K. Rao (2006)
Rosuvastatin calcium in acute coronary syndromes
R. Aggarwal (2013)
Effects of chitosan hydrolysates on lipid absorption and on serum and liver lipid concentration in rats
I. Ikeda (1993)
Dependence of Reaction Velocity upon surface and Agitation
A. Hixson (1931)
Letters to the Editor: Linearization of dissolution rate curves by the Weibull distribution
F. Langenbucher (1972)
FORMULATION AND CHARACTERIZATION OF EPIGALLOCATECHIN GALLATE NANOPARTICLES
Ramkumar Ponnuraj (2015)
Nanocarriers as an emerging platform for cancer therapy.
D. Peer (2007)
Biodegradable polymeric nanoparticles as drug delivery devices.
K. Soppimath (2001)
Reversed chitosan-alginate polyelectrolyte complex for stability improvement of alpha-amylase: optimization and physicochemical characterization.
M. Sankalia (2007)
Effect of particle size on the mechanism controlling n-hexane sorption in glassy polystyrene microspheres
D. Enscore (1977)
Chitosans as absorption enhancers of poorly absorbable drugs. 3: Influence of mucus on absorption enhancement.
N. G. Schipper (1999)
Microstructural imaging and characterization of the mechanical, chemical, thermal, and swelling properties of starch–chitosan blend films
Sindhu Mathew (2006)
Controlled Release of Biologically Active Agents
R. W. Baker (1987)
Modeling and comparison of dissolution profiles.
P. Costa (2001)
Hydrophilic polymeric nanoparticles as drug carriers
P. Ghosh (2000)
Mechanisms of solute release from porous hydrophilic polymers
R. Korsmeyer (1983)
Micronization of cilostazol using supercritical antisolvent (SAS) process: Effect of process parameters
M. Kim (2007)
Synthesis and Biological Activity of Drug Delivery System Based on Chitosan Nanocapsules
M. Gouda (2014)
Improving drug solubility for oral delivery using solid dispersions.
C. Leuner (2000)
Development and characterization of new insulin containing polysaccharide nanoparticles.
B. Sarmento (2006)
Methods to compare dissolution profiles and a rationale for wide dissolution specifications for metoprolol tartrate tablets.
J. Polli (1997)
Pharmacological properties of ZD4522 — A new HMG-CoA reductase inhibitor
G. Smith (2000)
Improved absorption of meloxicam via salt formation with ethanolamines.
H. Han (2007)
Interaction of dietary fiber with lipids--mechanistic theories and their limitations.
I. Furda (1990)
Sonication Parameters for the Preparation of Biodegradable Nanocapsulesof Controlled Size by the Double Emulsion Method
U. Bilati (2003)
Nanocapsules prepared via nanoprecipitation and emulsification-diffusion methods: comparative study.
C. E. Mora-Huertas (2012)
Quantitative calculations in pharmaceutical practice and research
Themistoklēs P. Chatzēiōannou (1993)
Properties and biocompatibility of chitosan films modified by blending with PVA and chemically crosslinked
Ezequiel Souza Costa-Júnior (2009)
Preparation and Characterization of Nanocapsules from Preformed Polymers by a New Process Based on Emulsification-Diffusion Technique
D. Quintanar-Guerrero (2004)
This paper is referenced by
Preparation and characterization of sodium alginate/polyvinyl alcohol hydrogel containing drug-loaded chitosan nanoparticles as a drug delivery system
M. Afshar (2020)
Electrochemical Corrosion Behavior of Nano-coated Ti-6Al-4V Alloy by A Novel Chitosan Nanoparticles/silver Nanoparticles in Artificial Saliva Solution
A. Fekry (2018)
Carboxylate cross‐linked cyclodextrin: A nanoporous scaffold for enhancement of rosuvastatin oral bioavailability
Mai Mahmoud Gabr (2018)
Application of multiple regression analysis in optimization of metronidazole-chitosan nanoparticles
Hazem Abdul Kader Sabbagh (2019)
Preparation of novel phospholipid‐based sonocomplexes for improved intestinal permeability of rosuvastatin: In vitro characterization, dynamic simulation, Caco‐2 cell line permeation and in vivo assessment studies
Wessam H. Abd-elsalam (2018)
Electrospun core-sheath poly(vinyl alcohol)/silk fibroin nanofibers with Rosuvastatin release functionality for enhancing osteogenesis of human adipose-derived stem cells.
Mohammad Mehdi Kalani (2019)
Directly compressed rosuvastatin calcium tablets that offer hydrotropic and micellar solubilization for improved dissolution rate and extent of drug release
Sharonia Butt (2019)
Effect of Different Polymers on Release of Nanoparticle Loaded Capsules of an Anti-Hyperlipidemic Drug
M. Darwish (2020)