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Alteration Of Adaptive Immunity In A Colorectal Peritoneal Carcinomatosis Model

Rongchen Shi, Wei Xiang, Xia Kang, Lili Zhang, Jinping Wang, Hongming Miao, Fengtian He
Published 2019 · Medicine
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Colorectal cancer (CRC) usually gives rise to transcoelomic spread and ultimately causes peritoneal carcinomatosis (PC). However, mechanism studies, especially the immunological basis of colorectal PC, are rarely revealed due to lack of a suitable PC model. Here we selected a mouse colorectal cancer cell line MC-38 for intraperitoneal inoculation in the C57BL/6 mice to mimic the development of colorectal PC. We demonstrated that the injected CRC cells preferentially and rapidly migrated and colonized in the visceral fat tissues, but not in other visceral organs. With flow cytometric analysis, we found the proportions of spleen T cells and B cells were not affected by PC progression, while the ratios of blood CD4+ and CD8+ T cells were largely influenced. Especially, the quantity or activity of CD4+ and CD8+ T cells in visceral fats were intimately regulated by PC development. Taken together, we successfully constructed a colorectal PC model in immune-competent mice and revealed the alteration of adaptive immunity in PC development. Our study might potentiate the research and therapy strategies of colorectal PC.
This paper references
Peritoneal carcinomatosis from non-gynecologic malignancies: results of the EVOCAPE 1 multicentric prospective study.
B Sadeghi (2000)
In vivo activation of antigen-specific CD4 T cells.
Marc K Jenkins (2001)
Vaccine-instructed intratumoral IFN-γ enables regression of autochthonous mouse prostate cancer in allogeneic T-cell transplantation.
Rodrigo Hess Michelini (2013)
Cancer-associated adipocytes exhibit an activated phenotype and contribute to breast cancer invasion.
Béatrice Dirat (2011)
Improving Anti-Tumor Activity of Curcumin by Polymeric Micelles in Thermosensitive Hydrogel System in Colorectal Peritoneal Carcinomatosis Model.
Wenli Zhang (2015)
Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth
Kristin M Nieman (2011)
Angiopoietin-1 inhibits tumour growth and ascites formation in a murine model of peritoneal carcinomatosis
Oliver Stoeltzing (2002)
CA : A Cancer Journal for Clinicians
Patrizia Agostinis (2011)
Comparison of hyperthermia and adrenaline to enhance the intratumoral accumulation of cisplatin in a murin model of peritoneal carcinomatosis
Olivier Facy (2011)
Cancer immunotherapy using checkpoint blockade
Antoni Ribas (2018)
Pretreatment with VEGF(R)-inhibitors reduces interstitial fluid pressure, increases intraperitoneal chemotherapy drug penetration, and impedes tumor growth in a mouse colorectal carcinomatosis model
Félix Gremonprez (2015)
Hyperthermic intraperitoneal chemoperfusion in the treatment of locally advanced intra-abdominal cancer.
Wim P Ceelen (2000)
Ovarian cancer development and metastasis.
Ernst Lengyel (2010)
Free Colorectal Cancer Cells on the Peritoneal Surface: Correlation With Pathologic Variables and Survival
S. Baskaranathan (2004)
Incidence of free colorectal cancer cells on the peritoneal surface
M J Solomon (1997)
Colorectal Cancer
Jack D. Hardcastle (1993)
Observations concerning cancer spread within the peritoneal cavity and concepts supporting an ordered pathophysiology.
Paul H Sugarbaker (1996)
Colorectal cancer statistics ,
R Siegel (2014)
Blockage of Core Fucosylation Reduces Cell-Surface Expression of PD-1 and Promotes Anti-tumor Immune Responses of T Cells.
Masahiro Okada (2017)
The future of immune checkpoint therapy
Padmanee Sharma (2015)
Establishment and identification of a rabbit model of peritoneal carcinomatosis from gastric cancer
Lie-Jun Mei (2009)
Peritoneal metastases of colorectal origin treated by cytoreduction and HIPEC: An overview.
Alvaro Arjona-Sánchez (2014)
Innate and adaptive immune cells in the tumor microenvironment
Thomas F Gajewski (2013)
Peritoneal carcinomatosis from colorectal cancer.
D. G. Jayne (2002)
Peritonectomy Procedures
Paul H Sugarbaker (2003)
Peritonectomy procedures. Cancer treatment and research
PH Sugarbaker (2007)
Increased metastases are associated with inflammation and matrix metalloproteinase-9 activity at incision sites in a murine model of peritoneal dissemination of colorectal cancer.
In Kyu Lee (2013)
CAR T cell immunotherapy for human cancer
Carl H. June (2018)
AAV-mediated human PEDF inhibits tumor growth and metastasis in murine colorectal peritoneal carcinomatosis model
Qin Wu (2011)
Monoacylglycerol lipase regulates cannabinoid receptor 2-dependent macrophage activation and cancer progression
Wei Xiang (2018)
Prostate cancer cell growth is modulated by adipocyte-cancer cell interaction.
Yuji Tokuda (2003)
Peritoneal Carcinomatosis of Colorectal Origin: Incidence and Current Treatment Strategies
Manuel J. Koppe (2006)
Complete cytoreductive surgery plus intraperitoneal chemohyperthermia with oxaliplatin for peritoneal carcinomatosis of colorectal origin.
Dominique Elias (2009)

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