Online citations, reference lists, and bibliographies.

Alteration Of Adaptive Immunity In A Colorectal Peritoneal Carcinomatosis Model

Rongchen Shi, Wei Xiang, Xia Kang, Lili Zhang, Jinping Wang, Hongming Miao, Fengtian He
Published 2019 · Medicine
Cite This
Download PDF
Analyze on Scholarcy
Share
Colorectal cancer (CRC) usually gives rise to transcoelomic spread and ultimately causes peritoneal carcinomatosis (PC). However, mechanism studies, especially the immunological basis of colorectal PC, are rarely revealed due to lack of a suitable PC model. Here we selected a mouse colorectal cancer cell line MC-38 for intraperitoneal inoculation in the C57BL/6 mice to mimic the development of colorectal PC. We demonstrated that the injected CRC cells preferentially and rapidly migrated and colonized in the visceral fat tissues, but not in other visceral organs. With flow cytometric analysis, we found the proportions of spleen T cells and B cells were not affected by PC progression, while the ratios of blood CD4+ and CD8+ T cells were largely influenced. Especially, the quantity or activity of CD4+ and CD8+ T cells in visceral fats were intimately regulated by PC development. Taken together, we successfully constructed a colorectal PC model in immune-competent mice and revealed the alteration of adaptive immunity in PC development. Our study might potentiate the research and therapy strategies of colorectal PC.
This paper references
10.1002/(SICI)1097-0142(20000115)88:2<358::AID-CNCR16>3.0.CO;2-O
Peritoneal carcinomatosis from non-gynecologic malignancies: results of the EVOCAPE 1 multicentric prospective study.
B Sadeghi (2000)
10.1146/annurev.immunol.19.1.23
In vivo activation of antigen-specific CD4 T cells.
Marc K Jenkins (2001)
10.1158/0008-5472.CAN-12-3464
Vaccine-instructed intratumoral IFN-γ enables regression of autochthonous mouse prostate cancer in allogeneic T-cell transplantation.
Rodrigo Hess Michelini (2013)
10.1158/0008-5472.CAN-10-3323
Cancer-associated adipocytes exhibit an activated phenotype and contribute to breast cancer invasion.
Béatrice Dirat (2011)
10.1166/JBN.2015.2073
Improving Anti-Tumor Activity of Curcumin by Polymeric Micelles in Thermosensitive Hydrogel System in Colorectal Peritoneal Carcinomatosis Model.
Wenli Zhang (2015)
10.1038/nm.2492
Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth
Kristin M Nieman (2011)
10.1038/sj.bjc.6600598
Angiopoietin-1 inhibits tumour growth and ascites formation in a murine model of peritoneal carcinomatosis
Oliver Stoeltzing (2002)
10.3322/(issn)1542-4863
CA : A Cancer Journal for Clinicians
Patrizia Agostinis (2011)
10.1186/1756-9966-30-4
Comparison of hyperthermia and adrenaline to enhance the intratumoral accumulation of cisplatin in a murin model of peritoneal carcinomatosis
Olivier Facy (2011)
10.1126/science.aar4060
Cancer immunotherapy using checkpoint blockade
Antoni Ribas (2018)
10.18632/oncotarget.5092
Pretreatment with VEGF(R)-inhibitors reduces interstitial fluid pressure, increases intraperitoneal chemotherapy drug penetration, and impedes tumor growth in a mouse colorectal carcinomatosis model
Félix Gremonprez (2015)
10.1046/j.1365-2168.2000.01538.x
Hyperthermic intraperitoneal chemoperfusion in the treatment of locally advanced intra-abdominal cancer.
Wim P Ceelen (2000)
10.2353/ajpath.2010.100105
Ovarian cancer development and metastasis.
Ernst Lengyel (2010)
10.1007/s10350-004-0723-8
Free Colorectal Cancer Cells on the Peritoneal Surface: Correlation With Pathologic Variables and Survival
S. Baskaranathan (2004)
10.1007/BF02050811
Incidence of free colorectal cancer cells on the peritoneal surface
M J Solomon (1997)
10.1007/978-3-642-78225-1
Colorectal Cancer
Jack D. Hardcastle (1993)
10.1007/978-1-4613-1247-5_6
Observations concerning cancer spread within the peritoneal cavity and concepts supporting an ordered pathophysiology.
Paul H Sugarbaker (1996)
Colorectal cancer statistics ,
R Siegel (2014)
10.1016/j.celrep.2017.07.027
Blockage of Core Fucosylation Reduces Cell-Surface Expression of PD-1 and Promotes Anti-tumor Immune Responses of T Cells.
Masahiro Okada (2017)
10.1126/science.aaa8172
The future of immune checkpoint therapy
Padmanee Sharma (2015)
10.1186/1471-2407-10-124
Establishment and identification of a rabbit model of peritoneal carcinomatosis from gastric cancer
Lie-Jun Mei (2009)
10.4251/wjgo.v6.i10.407
Peritoneal metastases of colorectal origin treated by cytoreduction and HIPEC: An overview.
Alvaro Arjona-Sánchez (2014)
10.1038/ni.2703
Innate and adaptive immune cells in the tumor microenvironment
Thomas F Gajewski (2013)
10.1046/j.1365-2168.2002.02274.x
Peritoneal carcinomatosis from colorectal cancer.
D. G. Jayne (2002)
10.1097/00000658-199501000-00004
Peritonectomy Procedures
Paul H Sugarbaker (2003)
Peritonectomy procedures. Cancer treatment and research
PH Sugarbaker (2007)
10.1016/j.jss.2012.04.074
Increased metastases are associated with inflammation and matrix metalloproteinase-9 activity at incision sites in a murine model of peritoneal dissemination of colorectal cancer.
In Kyu Lee (2013)
10.1126/science.aar6711
CAR T cell immunotherapy for human cancer
Carl H. June (2018)
10.1186/1471-2407-12-129
AAV-mediated human PEDF inhibits tumor growth and metastasis in murine colorectal peritoneal carcinomatosis model
Qin Wu (2011)
10.1038/s41467-018-04999-8
Monoacylglycerol lipase regulates cannabinoid receptor 2-dependent macrophage activation and cancer progression
Wei Xiang (2018)
10.1046/j.1464-410X.2003.04218.x
Prostate cancer cell growth is modulated by adipocyte-cancer cell interaction.
Yuji Tokuda (2003)
10.1097/01.sla.0000197702.46394.16
Peritoneal Carcinomatosis of Colorectal Origin: Incidence and Current Treatment Strategies
Manuel J. Koppe (2006)
10.1200/JCO.2008.19.7160
Complete cytoreductive surgery plus intraperitoneal chemohyperthermia with oxaliplatin for peritoneal carcinomatosis of colorectal origin.
Dominique Elias (2009)



This paper is referenced by
Semantic Scholar Logo Some data provided by SemanticScholar