Online citations, reference lists, and bibliographies.
← Back to Search

A PH-Responsive Host-guest Nanosystem Loading Succinobucol Suppresses Lung Metastasis Of Breast Cancer

Z. Dan, Haiqiang Cao, X. He, Z. Zhang, L. Zou, Lijuan Zeng, Y. Xu, Q. Yin, M. Xu, Dafang Zhong, Haijun Yu, Q. Shen, P. Zhang, Y. Li
Published 2016 · Medicine

Cite This
Download PDF
Analyze on Scholarcy
Share
Cancer metastasis is the leading reason for the high mortality of breast cancer. Herein, we report on a pH-responsive host-guest nanosystem of succinobucol (PHN) with pH-stimuli controlled drug release behavior to improve the therapeutic efficacy on lung metastasis of breast cancer. PHN was composed of the host polymer of β-cyclodextrin linked with multiple arms of N,N-diisopropylethylenediamine (βCD-DPA), the guest polymer of adamantyl end-capped methoxy poly(ethylene glycol) (mPEG-Ad), and the active agent of succinobucol. PHN comprises nanometer-sized homogenous spherical particles, and exhibits specific and rapid drug release in response to the intracellular acidic pH-stimuli. Then, the anti-metastatic efficacy of PHN is measured in metastatic 4T1 breast cancer cells, which effectively confirms the superior inhibitory effects on cell migration and invasion activities, VCAM-1 expression and cell-cell binding of RAW 264.7 to 4T1 cells. Moreover, PHN can be specifically delivered to the sites of metastatic nodules in lungs, and result in an obviously improved therapeutic efficacy on lung metastasis of breast cancer. Thereby, the pH-responsive host-guest nanosystem can be a promising drug delivery platform for effective treatment of cancer metastasis.
This paper references
10.7150/thno.10904
Nanogels from Metal-Chelating Crosslinkers as Versatile Platforms Applied to Copper-64 PET Imaging of Tumors and Metastases
J. Lux (2015)
Cyclodextrins in non-viral gene
WF Lai (2014)
10.1016/j.ctrv.2009.10.001
Novel therapeutic approaches to the treatment of metastatic breast cancer.
Y. Fernández (2010)
10.1038/nrd2372
Strategies for the discovery and development of therapies for metastatic breast cancer
B. Eckhardt (2012)
10.1016/j.addr.2013.05.001
Cyclodextrin-based supramolecular systems for drug delivery: recent progress and future perspective.
J. Zhang (2013)
10.1158/1078-0432.CCR-11-2904
Molecular Pathways: VCAM-1 as a Potential Therapeutic Target in Metastasis
Q. Chen (2012)
10.1021/ja312004m
Multifunctional envelope-type mesoporous silica nanoparticles for tumor-triggered targeting drug delivery.
J. Zhang (2013)
10.1002/ADFM.201403636
Biospecific Self‐Assembly of a Nanoparticle Coating for Targeted and Stimuli‐Responsive Drug Delivery
J. Li (2015)
10.1016/j.biomaterials.2015.07.023
Reversion of multidrug resistance by a pH-responsive cyclodextrin-derived nanomedicine in drug resistant cancer cells.
Qing Shi (2015)
10.1016/j.biomaterials.2013.10.044
Supramolecular self-assembly forming a multifunctional synergistic system for targeted co-delivery of gene and drug.
F. Zhao (2014)
10.1016/j.biomaterials.2013.12.074
The potential of pH-responsive PEG-hyperbranched polyacylhydrazone micelles for cancer therapy.
J. Yu (2014)
10.7150/thno.4756
Gold Nanorods Conjugated with Doxorubicin and cRGD for Combined Anticancer Drug Delivery and PET Imaging
Yuling Xiao (2012)
10.1016/j.ijpharm.2015.01.035
Biological stimuli-responsive cyclodextrin-based host-guest nanosystems for cancer therapy.
Z. Dan (2015)
10.1016/j.biomaterials.2011.06.060
Theranostic systems assembled in situ on demand by host-guest chemistry.
Hyuntae Jung (2011)
10.1002/ANIE.200501625
A highly active anion-selective aminocyclodextrin ion channel.
N. Madhavan (2005)
10.1016/j.biomaterials.2012.06.034
pH-sensitive degradable chimaeric polymersomes for the intracellular release of doxorubicin hydrochloride.
Yinfeng Du (2012)
10.1016/j.biomaterials.2014.03.046
pH-responsive polymer-liposomes for intracellular drug delivery and tumor extracellular matrix switched-on targeted cancer therapy.
Yi-Ting Chiang (2014)
10.1038/nmat3776
Stimuli-responsive nanocarriers for drug delivery.
S. Mura (2013)
10.1002/ADFM.201400279
Stimuli-Responsive Materials for Controlled Release of Theranostic Agents.
Yucai Wang (2014)
10.7150/thno.5411
Superparamagnetic Iron Oxide Nanoparticles: Amplifying ROS Stress to Improve Anticancer Drug Efficacy
G. Huang (2013)
10.1002/adma.201301202
Host-guest supramolecular nanosystems for cancer diagnostics and therapeutics.
L. Wang (2013)
10.1016/j.biomaterials.2013.03.092
Supramolecular pseudo-block gene carriers based on bioreducible star polycations.
Yang Hu (2013)
10.1038/nrc3180
Treating metastatic cancer with nanotechnology
Avi Schroeder (2011)
10.1002/ADFM.201000038
pH‐Activated Near‐Infrared Fluorescence Nanoprobe Imaging Tumors by Sensing the Acidic Microenvironment
C. Li (2010)
10.1002/ADFM.201303687
Highly Efficient Multifunctional Supramolecular Gene Carrier System Self-Assembled from Redox-Sensitive and Zwitterionic Polymer Blocks
Yuting Wen (2014)
Stimuli-responsive nanocarriers for drug
S Mura (2013)
Transferrin - containing , cyclodex - trin polymer - based particles for tumor - targeted gene delivery
NC Bellocq (2003)
10.1021/nn203503h
Overcoming endosomal barrier by amphotericin B-loaded dual pH-responsive PDMA-b-PDPA micelleplexes for siRNA delivery.
Haijun Yu (2011)
10.7150/thno.12938
Pilot Prospective Evaluation of 18F-Alfatide II for Detection of Skeletal Metastases
Baoming Mi (2015)
10.1002/ADMA.201200420
Biologically responsive polymeric nanoparticles for drug delivery.
Y. Colson (2012)
10.1016/j.ccr.2011.08.025
Macrophage binding to receptor VCAM-1 transmits survival signals in breast cancer cells that invade the lungs.
Q. Chen (2011)
10.1016/j.jconrel.2015.01.015
Hydrophobic interaction mediating self-assembled nanoparticles of succinobucol suppress lung metastasis of breast cancer by inhibition of VCAM-1 expression.
Haiqiang Cao (2015)
10.1038/nrc3110
Dysregulated pH: a perfect storm for cancer progression
B. A. Webb (2011)
10.1021/JA045541T
Solutes probe hydration in specific association of cyclodextrin and adamantane.
D. Harries (2005)
10.1021/ar500055s
Cyclodextrin-based host-guest supramolecular nanoparticles for delivery: from design to applications.
Q. Hu (2014)
10.1038/nrd4333
Multifunctional, stimuli-sensitive nanoparticulate systems for drug delivery
V. Torchilin (2014)
10.1038/ncomms4702
Poly-cyclodextrin and poly-paclitaxel nano-assembly for anticancer therapy.
R. Namgung (2014)
10.1016/j.biomaterials.2013.09.061
Cyclodextrins in non-viral gene delivery
W. Lai (2014)
10.1016/j.biomaterials.2015.01.049
Inhibition of metastasis and growth of breast cancer by pH-sensitive poly (β-amino ester) nanoparticles co-delivering two siRNA and paclitaxel.
S. Tang (2015)
10.1002/adma.201402975
Functional supramolecular polymers for biomedical applications.
R. Dong (2015)
10.7150/thno.4443
Monitoring Breast Tumor Lung Metastasis by U-SPECT-II/CT with an Integrin αvβ3-Targeted Radiotracer 99mTc-3P-RGD2
Y. Zhou (2012)
10.1021/BC034125F
Transferrin-containing, cyclodextrin polymer-based particles for tumor-targeted gene delivery.
N. Bellocq (2003)
10.3791/51046
In vitro cell migration and invasion assays.
C. R. Justus (2014)
10.1002/smll.201400799
Nanoassembly of probucol enables novel therapeutic efficacy in the suppression of lung metastasis of breast cancer.
Z. Zhang (2014)
10.1016/j.biomaterials.2011.10.043
In vivo treatment of tumors using host-guest conjugated nanoparticles functionalized with doxorubicin and therapeutic gene pTRAIL.
H. Fan (2012)
10.1016/j.biomaterials.2015.05.040
pH triggered in vivo photothermal therapy and fluorescence nanoplatform of cancer based on responsive polymer-indocyanine green integrated reduced graphene oxide.
S. Sharker (2015)
10.7150/thno.8263
Cyclodextrin and Polyethylenimine Functionalized Mesoporous Silica Nanoparticles for Delivery of siRNA Cancer Therapeutics
J. Shen (2014)



This paper is referenced by
10.1002/adtp.201800053
Progress of Cell‐Derived Biomimetic Drug Delivery Systems for Cancer Therapy
Tianqun Lang (2018)
10.1038/aps.2017.36
Treating breast cancer metastasis with cabazitaxel-loaded polymeric micelles
T. Zhong (2017)
10.7150/thno.19546
pH-Responsive Aerobic Nanoparticles for Effective Photodynamic Therapy
L. Shen (2017)
10.1186/s12951-020-00649-8
Macrophage-cancer hybrid membrane-coated nanoparticles for targeting lung metastasis in breast cancer therapy
Chunai Gong (2020)
10.1016/j.carbpol.2019.115805
Cyclodextrin-based delivery systems for chemotherapeutic anticancer drugs: A review.
Bingren Tian (2020)
10.3389/fonc.2020.00771
Metastatic Breast Cancer Coexisting With HER-2 Amplification and EGFR Exon 19 Deletion Benefits From EGFR-TKI Therapy: A Case Report
Wei Jing (2020)
10.1002/ADFM.201600642
Treatment of Malignant Brain Tumor by Tumor‐Triggered Programmed Wormlike Micelles with Precise Targeting and Deep Penetration
Lijuan Zeng (2016)
10.1021/acs.biomac.7b01693
Hierarchically Self-Assembled Supramolecular Host-Guest Delivery System for Drug Resistant Cancer Therapy.
H. Cheng (2018)
10.1371/journal.pone.0228557
Novel drug combination nanoparticles exhibit enhanced plasma exposure and dose-responsive effects on eliminating breast cancer lung metastasis
Qingxin Mu (2020)
10.1016/j.msec.2018.11.039
Enhanced treatment effect of nanoparticles containing cisplatin and a GSH-reactive probe compound.
Lingjun Zhu (2019)
10.1016/j.colsurfb.2018.05.001
Star-shaped polymer of β‑cyclodextrin-g-vitamin E TPGS for doxorubicin delivery and multidrug resistance inhibition.
Conglian Yang (2018)
10.1021/acsnano.6b03148
Liposomes Coated with Isolated Macrophage Membrane Can Target Lung Metastasis of Breast Cancer.
Haiqiang Cao (2016)
10.2147/IJN.S116347
Lx2-32c–loaded polymeric micelles with small size for intravenous drug delivery and their inhibitory effect on tumor growth and metastasis in clinically associated 4T1 murine breast cancer
Li-qing Chen (2016)
10.1007/s00330-020-07500-6
Computed tomography reveals microenvironment changes in premetastatic lung
Ranran Li (2020)
10.3390/molecules24244565
Thermodynamic Characterization of the Interaction between the Antimicrobial Drug Sulfamethazine and Two Selected Cyclodextrins
Hiba Mohamed Ameen (2019)
10.1038/s41598-020-71854-6
Preclinical efficacy of CIGB-300, an anti-CK2 peptide, on breast cancer metastasic colonization
M. F. Gottardo (2020)
10.1080/15384047.2018.1456599
Breast cancer lung metastasis: Molecular biology and therapeutic implications
Liting Jin (2018)
10.1002/adma.201806158
Cyclodextrin-Based Multistimuli-Responsive Supramolecular Assemblies and Their Biological Functions.
Ying-ming Zhang (2019)
Semantic Scholar Logo Some data provided by SemanticScholar