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Chronic Fatigue Syndrome: A Working Case Definition.

G. Holmes, J. Kaplan, N. Gantz, A. Komaroff, L. Schonberger, S. Straus, J. F. Jones, R. E. DuBois, C. Cunningham-Rundles, S. Pahwa
Published 1988 · Medicine

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The chronic Epstein-Barr virus syndrome is a poorly defined symptom complex characterized primarily by chronic or recurrent debilitating fatigue and various combinations of other symptoms, including sore throat, lymph node pain and tenderness, headache, myalgia, and arthralgias. Although the syndrome has received recent attention, and has been diagnosed in many patients, the chronic Epstein-Barr virus syndrome has not been defined consistently. Despite the name of the syndrome, both the diagnostic value of Epstein-Barr virus serologic tests and the proposed causal relationship between Epstein-Barr virus infection and patients who have been diagnosed with the chronic Epstein-Barr virus syndrome remain doubtful. We propose a new name for the chronic Epstein-Barr virus syndrome--the chronic fatigue syndrome--that more accurately describes this symptom complex as a syndrome of unknown cause characterized primarily by chronic fatigue. We also present a working definition for the chronic fatigue syndrome designed to improve the comparability and reproducibility of clinical research and epidemiologic studies, and to provide a rational basis for evaluating patients who have chronic fatigue of undetermined cause.
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10.3390/jcm10143017
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D. Araja (2021)
10.1016/j.jpsychores.2021.110417
An exploratory study of discrepancies between objective and subjective measurement of the physical activity level in female patients with chronic fatigue syndrome.
Kuni Vergauwen (2021)
10.28951/RBB.V39I1.533
CHRONIC FATIGUE SYNDROME AND ITS RELATION WITH ABSENTEEISM: ELASTIC-NET AND STEPWISE APPLIED TO BIOCHEMICAL AND ANTHROPOMETRIC CLINICAL MEASUREMENTS
Anderson Cristiano Neisse (2021)
10.1097/PR9.0000000000000887
A clinical primer for the expected and potential post-COVID-19 syndromes
B. Walitt (2021)
10.36315/2021INPACT027
FACTORS CONTRIBUTING TO WELL-BEING: COMPARING FUNCTIONAL SOMATIC SYMPTOM DISORDERS AND WELL-DEFINED AUTOIMMUNE DISORDERS
Kendra A Hebert (2021)
10.3390/medicina57070652
Systematic Review of Mind-Body Interventions to Treat Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
Samaneh Khanpour Ardestani (2021)
10.1001/amajethics.2021.590
The Importance of Listening in Treating Invisible Illness and Long-Haul COVID-19.
Dorothy Wall (2021)
10.1007/978-3-030-59181-6
Medically Unexplained Symptoms: A Brain-Centered Approach
R. Baloh (2021)
10.1186/s12967-020-02683-4
The evidence base for physiotherapy in myalgic encephalomyelitis/chronic fatigue syndrome when considering post-exertional malaise: a systematic review and narrative synthesis
M. Wormgoor (2021)
10.1177/20499361211009385
COVID-19 and post-infectious myalgic encephalomyelitis/chronic fatigue syndrome: a narrative review
S. Poenaru (2021)
10.1097/MD.0000000000025742
The efficacy and safety of moxibustion for chronic fatigue syndrome
Kaiyang Xue (2021)
10.1007/978-3-030-59181-6_8
Fibromyalgia and Chronic Fatigue Syndrome
R. Baloh (2020)
10.1371/journal.pone.0240403
Effect of disease duration in a randomized Phase III trial of rintatolimod, an immune modulator for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
D. Strayer (2020)
10.20944/preprints202007.0754.v1
Dental Care of the Homebound Patient with Myalgic Encephalomyelitis/chronic Fatigue Syndrome
E. Spivack (2020)
10.1186/s12967-020-02506-6
Neuroimaging characteristics of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS): a systematic review
Zack Y. Shan (2020)
10.17816/mechnikov201911447-54
Chronic fatigue syndrome in the routine hematology practice
Vsevolod G. V.G.Potapenko (2020)
10.5772/intechopen.91413
Self-Management of Chronic Fatigue Syndrome in Adolescents
K. Rowe (2020)
10.1038/s41598-020-62157-x
Human Leukocyte Antigen alleles associated with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)
A. Lande (2020)
10.1080/21641846.2020.1757809
Solving the ME/CFS criteria and name conundrum: the aftermath of IOM
L. Jason (2020)
A protocol for systematic review and meta-analysis
Jing Li (2020)
The Invisible Rainbow: A History of Electricity and Life
A. Firstenberg (2020)
10.1016/j.ctim.2019.102246
Efficacy of Korean red ginseng (Panax ginseng) for middle-aged and moderate level of chronic fatigue patients: A randomized, double-blind, placebo-controlled trial.
Won-Suk Sung (2020)
10.13048/jkm.20007
The Effectiveness of Bojungikgi-tang and its modifications on Chronic Fatigue Syndrome: A Systematic Review And Meta-analysis
D. Nam (2020)
10.1186/s40359-020-0380-2
Treating medically unexplained symptoms via improving access to psychological therapy (IAPT): major limitations identified
Keith Geraghty (2020)
10.3329/imcjms.v13i2.45286
Levocarnitine in the management of fatigue in levothyroxine treated hypothyroid patients
Farjana Akhter (2020)
10.1186/s12967-020-02665-6
Potential causal factors of CFS/ME: a concise and systematic scoping review of factors researched
A. Muller (2020)
10.1186/s12967-020-02455-0
Review of case definitions for myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)
Eun-Jin Lim (2020)
10.1111/jan.14312
Associations of occupational stress, workplace violence and organizational support on chronic fatigue symptoms among nurses.
Mengyao Li (2020)
10.1016/B978-0-323-43044-9.00160-6
Chronic Fatigue Syndrome
J. Nowicki (2020)
10.1016/j.ctcp.2020.101210
The effectiveness of cupping therapy on chronic fatigue syndrome: A single-blind randomized controlled trial.
Xiuying Meng (2020)
10.32322/JHSM.660275
Kronik yorgunluk sendromuna genel yaklaşım ve adölesanlarda görülme sıklığı
A. Doğan (2020)
10.1186/s12967-020-02269-0
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