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Monitoring Of Hydroxyapatite Crystal Formation Using Field-effect Transistor

T. Kajisa, T. Sakata
Published 2016 · Physics

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The biomineralization process of hydroxyapatite (HAp) in simulated body fluid (SBF) was monitored in realtime using extended-gate FETs whose gate electrode was modified with a variety of alkanethiol self-assembled monolayers (SAMs). It was found that the gate surface potential of the carboxyl- and amino-group-terminated SAM-coated gate FET was increased in SBF as HAp crystals grew on the gate surface. Moreover, in the carboxyl-group-terminated SAM-coated gate FET, the rate of increase and the shift of gate surface potential of the FET were found to depend on the concentration of calcium ions in the SBF. It was concluded that the process of HAp crystallization at a SAM-modified surface can be detected using FETs. Thus, a FET device that enables the easy detection of ionic charges in a real-time and label-free manner, will be useful for evaluating biomaterials based on biomineralization such as those in the bone regeneration process.
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