Online citations, reference lists, and bibliographies.

Monitoring Of Hydroxyapatite Crystal Formation Using Field-effect Transistor

T. Kajisa, T. Sakata
Published 2016 · Physics

Cite This
Download PDF
Analyze on Scholarcy
The biomineralization process of hydroxyapatite (HAp) in simulated body fluid (SBF) was monitored in realtime using extended-gate FETs whose gate electrode was modified with a variety of alkanethiol self-assembled monolayers (SAMs). It was found that the gate surface potential of the carboxyl- and amino-group-terminated SAM-coated gate FET was increased in SBF as HAp crystals grew on the gate surface. Moreover, in the carboxyl-group-terminated SAM-coated gate FET, the rate of increase and the shift of gate surface potential of the FET were found to depend on the concentration of calcium ions in the SBF. It was concluded that the process of HAp crystallization at a SAM-modified surface can be detected using FETs. Thus, a FET device that enables the easy detection of ionic charges in a real-time and label-free manner, will be useful for evaluating biomaterials based on biomineralization such as those in the bone regeneration process.
This paper references
Molecular-Level Control over Surface Order in Self-Assembled Monolayer Films of Thiols on Gold
C. Bain (1988)
The extended gate chemically sensitive field effect transistor as multi-species microprobe☆
J. D. Spiegel (1983)
Solutions able to reproduce in vivo surface-structure changes in bioactive glass-ceramic A-W.
T. Kokubo (1990)
Detection of Molecular Charges at Cell Membrane
T. Sakata (2008)
Evolution of calcium phosphate crystallization on three functional group surfaces with the same surface density
Zhi-Xu Liu (2012)
Surface-induced mineralization: a new method for producing calcium phosphate coatings.
A. Campbell (1996)
Reversible electrochemical reduction and oxidation of cytochrome c at a bis(4-pyridyl) disulphide-modified gold electrode
I. Taniguchi (1982)
Stability and Self-Exchange in Alkanethiol Monolayers
J. Schlenoff (1995)
Characterization of ion-sensitive extended-gate field effect transistor coated with functional self-assembled monolayer
Taira Kajisa (2015)
Chemical analyses of hydroxyapatite formation on SAM surfaces modified with COOH, NH(2), CH(3), and OH functions.
I. Hirata (2010)
An integrated semiconductor device enabling non-optical genome sequencing
J. M. Rothberg (2011)
Electrical detection of ovum membrane charges using biotransistor
T. Sakata (2008)
The role of surface functional groups in calcium phosphate nucleation on titanium foil: a self-assembled monolayer technique.
Q. Liu (2002)
Isolation of new phosphorylated glycoprotein from mineralized phase of bone that exhibits limited homology to adhesive protein osteopontin.
J. Gorski (1988)
Biomineralization: A crystal-clear view.
H. Cölfen (2010)
Noninvasive monitoring of transporter-substrate interaction at cell membrane.
T. Sakata (2008)
Structures of self-assembled monolayer films of organosulfur compounds adsorbed on gold single crystals: electron diffraction studies
L. Strong (1988)
Surface functional group dependence on apatite formation on self-assembled monolayers in a simulated body fluid.
M. Tanahashi (1997)
Relation between the Inorganic Chemistry and Biochemistry of Bone Mineralization
D. Mcconnell (1961)
Structure, expression, and regulation of the major noncollagenous matrix proteins of bone.
M. Young (1992)
Fundamental Properties of Phenylboronic‐Acid‐Coated Gate Field‐Effect Transistor for Saccharide Sensing
Taira Kajisa (2014)
Osteocalcin and matrix Gla protein: vitamin K-dependent proteins in bone.
P. Hauschka (1989)
DNA Analysis Chip Based on Field-Effect Transistors
T. Sakata (2005)
Adsorption of self-assembling sulfur compounds through electrochemical reactions: Effects of potential, acid and oxidizing agents
Seungwhan Chon (2001)
Extensive H(+) release by bone substitutes affects biocompatibility in vitro testing.
M. Jäger (2006)
Label-free detection of DNA hybridization using carbon nanotube network field-effect transistors.
Alexander Star (2006)
Comparison of the Structures and Wetting Properties of Self-Assembled Monolayers of n- Alkanethiols on the Coinage Metal Surfaces, Cu, Ag, Au'
P. E. Laibinis (1991)
Hypercomplex Gel Changes to Organic/Inorganic Solid Solution by Phase Transition in an Artificial Biomineralization System
T. Iwatsubo (2008)
pH-Dependent Stability of Self-Assembled Monolayers on Gold
Bo-Kyung Kong (2008)
Construction of a new artificial biomineralization system.
T. Iwatsubo (2006)
Osteonectin, a bone-specific protein linking mineral to collagen
J. Termine (1981)
Characterization of fetal porcine bone sialoproteins, secreted phosphoprotein I (SPPI, osteopontin), bone sialoprotein, and a 23-kDa glycoprotein. Demonstration that the 23-kDa glycoprotein is derived from the carboxyl terminus of SPPI.
Q. Zhang (1990)
Control of crystal nucleation by patterned self-assembled monolayers
J. Aizenberg (1999)
Alkanethiol self-assembled monolayers as the dielectric of capacitors with nanoscale thickness
M. A. Rampi (1998)

This paper is referenced by
Semantic Scholar Logo Some data provided by SemanticScholar