Online citations, reference lists, and bibliographies.
Please confirm you are human
(Sign Up for free to never see this)
← Back to Search

Photochemotherapy For Psoriasis With Orally Administered Methoxsalen.

K. Wolff, T. Fitzpatrick, J. Parrish, F. Gschnait, B. Gilchrest, H. Hönigsmann, M. Pathak, L. Tannenbaum
Published 1976 · Medicine

Save to my Library
Download PDF
Analyze on Scholarcy
Share
Photochemotherapy denotes a therapeutic approach that is based on the interaction of light and a photoactive drug. This study describes the efficacy of photochemotherapy, using orally administered methoxsalen and long-wave ultraviolet light in 91 patients with severe, generalized psoriasis. Oral administration of methoxsalen was followed by exposure to a high-intensity long-wave ultraviolet light source, emitting a continuous spectrum between 320 and 390 nm (peak, 365 nm) and an energy of 5.6 to 7.5 mw/sq cm at 15 cm. There was complete clearing of 82 patients (90%), a 90% to 100% clearing in seven (8%), and a satisfactory improvement in two (2%). A paired comparison study in 54 patients showed photochemotherapy to be far more effective than ultraviolet light emitted by fluorescent bulbs or a xenon source. Eighty-five percent of the patients receiving outpatient maintenance treatment have remained in remission for periods up to 400 days.
This paper references
10.1111/j.1751-1097.1975.tb06680.x
EFFECTS OF 8‐METHOXYPSORALEN‐INDUCED PHOTOTOXIC EFFECTS ON MAMMALIAN EPIDERMAL MACROMOLECULE SYNTHESIS IN VIVO
J. Epstein (1975)
10.1001/ARCHDERM.1973.01620220007001
Methotrexate therapy for psoriasis. Guideline revisions.
H. Roenigk (1973)
10.1001/ARCHDERM.1972.01620110008002
Topical lomustine in the treatment of psoriasis.
G. Peck (1972)
10.1001/ARCHDERM.1966.01600230093025
Hydroquinone and psoralens in the therapy of hypermelanosis and vitiligo.
T. Fitzpatrick (1966)
10.1001/ARCHDERM.1973.01620180012003
Resistant psoriasis. Combined methoxsalen-anthralin therapy.
I. Willis (1973)
10.1038/183728A0
Ultra-Violet Carcinogenesis in Albino and Pigmented Mice Receiving Furocoumarins: Psoralen and 8-Methoxypsoralen
M. Pathak (1959)
10.1001/ARCHDERM.1970.04000110020003
Effects of topical mechlorethamine on skin lesions of psoriasis.
E. Epstein (1970)
10.1038/JID.1958.122
The wave length effect upon erythemal and carcinogenic response in psoralen treated mice.
A. C. Griffin (1958)
10.1038/JID.1959.50
Clinical experiences with methoxsalen in the treatment of vitiligo.
J. Elliott (1959)
10.1038/JID.1963.99
PSORALEN PROPHYLAXIS AGAINST SKIN CANCER: REPORT OF CLINICAL TRIAL I.
E. Macdonald (1963)
10.1001/archderm.1973.01620180017005
Psoriasis with hydroxyurea. An 18-month study of 60 patients.
S. Moschella (1973)
10.1001/ARCHDERM.1971.04000130035004
Methotrexate for psoriasis. A new therapeutic schedule.
G. Weinstein (1971)
Lehrbuch der Hautkrankheiten
F. Herba (1874)
10.1038/JID.1969.174
Photosensitization of the eye by 8-methoxypsoralen.
R. G. Freeman (1969)
10.1001/ARCHOPHT.1960.01840010348005
Photosensitization of the eye with methoxsalen. 1. Acute effects.
T. Cloud (1960)
10.1038/JID.1968.37
Abnormal cell proliferation in psoriasis.
G. Weinstein (1968)
10.1001/ARCHDERM.1972.01620050022003
Topically administered fluorouracil in psoriasis.
T. Tsuji (1972)
10.1001/ARCHDERM.1972.01620060005001
Use of methotrexate in psoriasis.
H. Roenigk (1972)
10.1056/NEJM197412052912301
Photochemotherapy of psoriasis with oral methoxsalen and longwave ultraviolet light.
J. Parrish (1974)
10.1111/j.1365-2133.1958.tb13306.x
THE PROSPECT OF PSORIASIS.
R. Church (1958)
10.1001/ARCHDERM.1973.01620210029007
Psoralen plus black light inhibits epidermal DNA synthesis.
J. Walter (1973)
Psoriasis improved by psoralen plus black light.
J. Walter (1973)
10.1038/JID.1959.62
Part V: Clinical Applications of Psoralens, and Related Materials: Methoxsalen in Ultraviolet Carcinogenesis in the Mouse
A. C. Griffin (1959)
10.1016/0005-2787(70)90119-X
Light-induced cross-linking of DNA in the presence of a furocoumarin (psoralen). Studies with phage lambda, Escherichia coli, and mouse leukemia cells.
Ronald S. Cole (1970)
10.1038/JID.1959.47
Clinical and laboratory tolerance studies in volunteers given oral methoxsalen.
H. Tucker (1959)
10.1016/0005-2787(69)90616-9
Photosensitization of skin in vivo by furocoumarins (psoralens).
M. Pathak (1969)
10.1001/ARCHOPHT.1961.00960010691014
Photosensitization of the eye with methoxsalen. II. Chronic effects.
T. Cloud (1961)
[On statistical research on psoriasis].
J. Janula (1965)
10.1001/ARCHDERM.1960.01580040090016
Erythema and tumor formation in methoxsalen-treated mice exposed to flourescent light.
R. Hakim (1960)
10.1515/9781400879922
Carcinogenesis by Ultraviolet Light
H. F. Blum (1959)
The effect of oxypsoralen upon ultraviolet carcinogenesis in albino mice.
M. A. O'Neal (1957)
10.1111/j.1365-2133.1974.tb06409.x
Combined 8‐methoxypsoralen and black light therapy of psoriasis TECHNIQUE AND RESULTS
G. Weber (1974)
10.1016/0005-2787(72)90260-2
DNA synthesis in normal and xeroderma pigmentosum fibroblasts following treatment with 8-methoxypsoralen and long wave ultraviolet light.
H. Baden (1972)
10.1001/ARCHDERM.1967.01600310008002
Methotrexate for psoriasis.
R. Rees (1967)
10.1001/ARCHDERM.1968.01610140076019
The Goeckerman treatment of psoriasis.
H. Perry (1968)
10.1001/ARCHDERM.1970.04000080016003
Hydroxyurea. A new treatment for psoriasis.
U. Leavell (1970)
10.1038/JID.1959.63
Part V: Clinical Applications of Psoralens, and Related Materials: Modification of Ultraviolet Carcinogenesis by Photoactive Agents1: Preliminary Report
F. Urbach (1959)
10.1111/j.1365-2133.1974.tb06710.x
A y‐year follow‐up study of ninety patients with psoriasis
G. Durham (1974)
10.1001/ARCHDERM.1971.04000150042006
Topically applied mechlorethamine in the treatment of psoriasis.
S. Mandy (1971)
10.1001/ARCHDERM.109.6.833
Report on ultraviolet light sources. Report by the task force on photobiology of the national program for dermatology.
L. Harber (1974)
10.1001/ARCHDERM.1973.01620220015003
Azaribine in the treatment of psoriasis. A low dose, double-blind evaluation.
H. G. Milstein (1973)
10.1001/ARCHDERM.1973.01620220008002
Psoriasis-liver-methotrexate interactions.
G. Weinstein (1973)



This paper is referenced by
10.1111/j.1365-2133.1977.tb15056.x
A dosimeter for long wave ultraviolet radiation
B. Diffey (1977)
10.1111/J.1600-0609.1981.TB00463.X
Morphology and frequency of heterochromatic nuclear sheets in normal circulating human leucocytes and after PUVA therapy.
Karin Ree (1981)
10.1007/978-1-4615-9203-7_26
Photochemotherapy with Furocoumarins (Psoralens)
H. Hönigsmann (1982)
10.1016/j.det.2019.08.002
The Science and (Lost) Art of Psoralen Plus UVA Phototherapy.
E. G. Richard (2020)
10.1007/978-3-642-70025-5_16
Immunsuppressiva und Zytostatika
J. Ring (1985)
10.1111/j.1751-1097.1979.tb07145.x
PSORALEN PLUS ULTRAVIOLET RADIATION‐INDUCED INHIBITION OF DNA SYNTHESIS AND VIABILITY IN HUMAN LYMPHOID CELLS IN VITRO*
K. Kraemer (1979)
10.1007/978-3-642-81412-9_35
Neuere Entwicklungen in der Dermatologie
O. Braun-Falco (1979)
10.1111/j.1440-0960.1980.tb00161.x
THE COMBINATION OF ORAL AND TOPICAL PSORALEN WITH UVA
E. Lobel (1980)
10.2165/00002018-199920040-00001
Risk of Melanoma with Psoralen/Ultraviolet A Therapy for Psoriasis
B. Lindelöf (1999)
10.1111/1523-1747.EP12525311
Dose-response relations in phototoxicity due to 8-methoxypsoralen and UV-A in man.
B. Ljunggren (1981)
10.1001/ARCHDERM.1981.01650100025021
Outpatient phototherapy for psoriasis.
R. Adrian (1981)
10.1001/ARCHDERM.1984.01650450051017
Psoralens and UV-A and UV-B twice weekly for the treatment of psoriasis.
K. M. Diette (1984)
10.1111/j.1365-2133.1978.tb03593.x
PUVA: A REVIEW OF ULTRAVIOLET DOSIMETRY
B. Diffey (1978)
10.1111/j.1440-0960.1977.tb00811.x
CHEMICALS AND PHOTOCARCINOGENESIS *
J. Epstein (1977)
10.1111/j.1365-2230.1981.tb02362.x
Photochemotherapy in psoriasis—clinical response and 8‐MOP plasma concentrations at two dose levels
E. Andrew (1981)
10.1111/1523-1747.EP12514338
Dermatological and ocular examinations in rabbits chronically photosensitized with methoxsalen.
J. Parrish (1979)
10.1016/0009-2614(85)80925-8
Fluorescence lifetimes of furocoumarins. Psoralens
A. Andreoni (1985)
10.1007/bf00447164
Photoaugmentation: Ein photobiologisches Phnomen
H. Spiegel (1978)
10.1007/s13555-016-0129-2
The Patient’s Guide to Psoriasis Treatment. Part 1: UVB Phototherapy
R. Singh (2016)
10.1007/978-3-642-81091-6_44
Photochemotherapie der Psoriasis
K. Wolff (1976)
10.1007/BF00594202
Photopheresis — Extracorporeal irradiation of 8-MOP containing blood — A new therapeutic modality
R. Knobler (2004)
PSORALEN-UVA IN PATIENTS WITH CHRONIC HAND ECZEMA: AN OPEN LABEL RANDOMISED CONTROLLED TRIAL OF EFFICACY
Willeke G Kamphof (2005)
10.1111/1523-1747.EP12544506
Methoxsalen UV-A Therapy Of Psoriasis
J. Parrish (1976)
10.1016/S0190-9622(80)80258-1
Elastic tissue changes in skin following PUVA therapy.
A. Zelickson (1980)
10.1016/S0190-9622(79)70034-X
Melanocyte changes following PUVA therapy.
A. Zelickson (1979)
10.1007/s00105-016-3821-3
Entwicklung und Siegeszug der modernen PUVA-Therapie
P. Lehmann (2016)
10.1007/978-1-4684-1224-6_14
Some Properties of Furocoumarin (FC) Excited States
R. Bensasson (1985)
10.1007/BF00412382
Immunologic implications of PUVA therapy in psoriasis vulgaris
R. Cormane (2004)
10.1111/j.1365-2133.1978.tb01614.x
Dose‐effects of 8‐methoxypsoralen and UVA in cultured human lymphocytes
J. Krueger (1978)
10.1007/BF00418568
Quantification of HTLA-positive lymphocytes during oral photochemotherapy of psoriasis
D. Schmitt (2004)
10.1001/ARCHDERM.1980.01640330061013
Response of psoriatic nails to oral photochemotherapy.
J. Marx (1980)
10.1007/s13555-016-0130-9
The Patient’s Guide to Psoriasis Treatment. Part 2: PUVA Phototherapy
B. Farahnik (2016)
See more
Semantic Scholar Logo Some data provided by SemanticScholar