Online citations, reference lists, and bibliographies.
← Back to Search

Apolipoprotein E Phenotype Frequency And Cerebrospinal Fluid Concentration Are Not Associated With Creutzfeldt-Jakob Disease.

I. Zerr, M. Helmhold, S. Poser, V. Armstrong, T. Weber
Published 1996 · Medicine

Save to my Library
Download PDF
Analyze on Scholarcy Visualize in Litmaps
Reduce the time it takes to create your bibliography by a factor of 10 by using the world’s favourite reference manager
Time to take this seriously.
Get Citationsy
OBJECTIVE To analyze the distribution of apolipoprotein E (Apo E) phenotypes between patients with Creutzfeldt-Jakob disease (CJD) and control subjects. SETTING University hospital, base of the German National CJD Surveillance Study. DESIGN Prospective case-control study. SUBJECTS Sixty-two patients with definite or probable CJD, 90 patients with initial suspected CJO, and 51 controls matched for age, sex, and place of residence. MAIN OUTCOME MEASURES Phenotyping of Apo E in serum by isoelectric focusing, assessment of the gels by 3 independent investigators, measurement of of Apo E in cerebrospinal fluid using an enzyme-linked immunosorbent assay, and calculation of Kaplan-Meier cumulative survival plots. RESULTS The most frequent phenotype was E 3-3 with 56% in patients and 59% in controls, followed by E 3-4 with a frequency of 29% vs 25%, respectively. The phenotype E 3-2 was much rarer (13% vs 16%, respectively). Patients with definite CJD had a mean (SD) Apo E concentration of 3.4 (2.0) mg/L; patients with probable CJD, 3.1 (1.6) mg/L; patients with possible CJD, 3.8 (2.2) mg/L; and subjects with other diseases, 3.0 (1.7) mg/L. Mean (SD) disease duration for patients with E 3-2 was 11.8 (9.8) months; for patients with E 3-3, 12.0 (9.02) months; and for patients with E 3-4, 14.2 (12.3) months. CONCLUSIONS We found no significant difference in the distribution of Apo E phenotypes between patients with CJD and controls. The concentration of Apo E in cerebrospinal fluid cannot be taken as a biochemical marker for the disease. The Apo E phenotype had no influence on the duration of CJD. Our data do not support an association of Apo E4 with either the duration or time at onset of CJD.
This paper references
Subacute spongiform encephalopathy (Creutzfeldt-Jakob disease). The nature and progression of spongiform change.
C. Masters (1978)
Genetics of the apolipoprotein E system in man.
G. Utermann (1980)
Apolipoprotein E Polymorphism and Coronary Artery Disease
H. Menzel (1983)
Apolipoprotein E: cholesterol transport protein with expanding role in cell biology.
R. Mahley (1988)
Apolipoprotein E phenotypes in Finnish youths: a cross-sectional and 6-year follow-up study.
T. Lehtimäki (1990)
Association of hypercholesterolemia and apolipoprotein E4 in school children
H. Yanagi (1990)
Clinical relevance of the quantification of apolipoprotein E in cerebrospinal fluid.
J. Carlsson (1991)
Neuropathological changes in scrapie and Alzheimer's disease are associated with increased expression of apolipoprotein E and cathepsin D in astrocytes
J. Diedrich (1991)
[Apolipoprotein B immunoreactivity in cerebral amyloid deposits and neurofibrillary tangles in senile dementia of Alzheimer type].
Y. Namba (1991)
Apolipoprotein E polymorphism in a Danish population compared to findings in 45 other study populations around the world
Lars Ulrik Gerdes (1992)
High levels of nervous system-specific proteins in cerebrospinal fluid in patients with early stage Creutzfeldt-Jakob disease.
T. Jimi (1992)
Apolipoprotein E genotypes of normal and hyperlipidemic subjects.
Y. S. Kim (1993)
Apolipoprotein E in sporadic Alzheimer's disease: Allelic variation and receptor interactions
G. W. Rebeck (1993)
Increased amyloid beta-peptide deposition in cerebral cortex as a consequence of apolipoprotein E genotype in late-onset Alzheimer disease.
D. Schmechel (1993)
Association of apolipoprotein E allele ϵ4 with late‐onset familial and sporadic Alzheimer's disease
A. Saunders (1993)
Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families.
E. Corder (1993)
Human prion diseases (spongiform encephalopathies).
H. Kretzschmar (1993)
Binding of human apolipoprotein E to synthetic amyloid beta peptide: isoform-specific effects and implications for late-onset Alzheimer disease.
W. Strittmatter (1993)
Apolipoprotein E Is Localized to the Cytoplasm of Human Cortical Neurons: A Light and Electron Microscopic Study
Seol-Heul Han (1994)
Protective effect of apo epsilon 2 in Alzheimer's disease. Oxford Project to Investigate Memory and Ageing (OPTIMA)
A. Smith (1994)
The apolipoprotein E alleles as major susceptibility factors for Creutzfeldt-Jakob disease
P. Amouyel (1994)
Protective effect of apoE ∈2 in Alzheimer's disease
R. Benjamin (1994)
Cerebrospinal fluid apolipoprotein E is reduced in Alzheimer's disease.
K. Blennow (1994)
Reduced apolipoprotein ϵ4 allele frequency in the oldest old Alzheimer's patients and cognitively normal individuals
G. Rebeck (1994)
Apolipoprotein E in animal models of CNS injury and in alzheimer's disease
J. Poirier (1994)
ApoE polymorphism and predisposition to coronary heart disease in youths of different European populations. The EARS Study. European Atherosclerosis Research Study.
L. Tiret (1994)
Apolipoprotein E epsilon 4 allele frequency in vascular dementia and Alzheimer's disease.
G. Frisoni (1994)
The apolipoprotein E allele epsi;4 is overrepresented in patients with the Lewy body variant of Alzheimer's disease
D. Galasko (1994)
Protection against Alzheimer's disease with apoE ∈2
C. Talbot (1994)
Rapid determination of apolipoprotein E phenotypes from whole plasma by automated isoelectric focusing using PhastSystem and immunofixation.
R. Hackler (1994)
ApoE ϵ4 allelic association with Alzheimer's disease
M. L. Peacock (1994)
Cerebrospinal fluid concentration of neuron-specific enolase in diagnosis of Creutzfeldt-Jakob disease
I. Zerr (1995)
Apolipoprotein E in Creutzfeldt-Jakob disease
Yasushi Nakagawa (1995)
Intra vitam lumbar cerebrospinal fluid and serum and postmortem ventricular immunoreactive apolipoprotein E in patients with Alzheimer's disease.
N. Roesler (1996)

This paper is referenced by
WITHDRAWN: Apolipoprotein E gene polymorphism may increase susceptibility to sporadic Creutzfeldt-Jakob disease in a Korean population.
Seon-mi Park (2015)
APOE gene polymorphisms and susceptibility to Creutzfeldt–Jakob disease
Y. Wei (2014)
Can infections cause Alzheimer's disease?
Francis Mawanda (2013)
Rapidly Progressive Homonymous Hemianopia in the Heidenhain Variant of Creutzfeldt-Jakob Disease
E. Chin (2012)
Genetic Cross-Interaction between APOE and PRNP in Sporadic Alzheimer's and Creutzfeldt-Jakob Diseases
Olga Calero (2011)
Apolipoprotein E in Alzheimer's disease and other neurological disorders
P. Verghese (2011)
Increased frequency of positive family history of dementia in sporadic CJD
A. Krasnianski (2009)
Diagnostic value of CSF protein profile in a Portuguese population of sCJD patients
I. Baldeiras (2009)
About the role of the apolipoprotein E4 polymorphism in dementia : does genetic testing have a place in the assessment of Alzheimer's disease?
E. Aronsen (2009)
Genomic and post-genomic analyses of human prion diseases
M. Pocchiari (2009)
Phenotypic heterogeneity and genetic modification of P102L inherited prion disease in an international series
T. Webb (2008)
ApoE Distribution and Family History in Genetic Prion Diseases in Germany
A. Krasnianski (2007)
Genes and the Environment in Neurodegeneration
F. Coppedè (2006)
Apolipoproteins in Different Amyloidoses
M. Sadowski (2006)
Lipoprotein Genes and Diet in the Evolution of Human Intelligence and Longevity
C. Finch (2003)
Differential diagnosis of neurodegenerative diseases with special emphasis on Creutzfeldt-Jakob disease.
M. Otto (2003)
Detection of apolipoprotein E phenotype in unconcentrated cerebrospinal fluid
P. Mehta (2003)
Characterization of four lipoprotein classes in human cerebrospinal fluid.
S. Koch (2001)
Influence of the prion protein and the apolipoprotein E genotype on the Creutzfeldt–Jakob Disease phenotype
B. Everbroeck (2001)
Decreased β-amyloid1-42 in cerebrospinal fluid of patients with Creutzfeldt-Jakob disease
M. Otto (2000)
Apolipoprotein E4: an allele associated with many diseases
J. Smith (2000)
Apolipoprotein E ϵ4 allele and japanese late-onset depressive disorders
K. Ohara (1999)
APOE in non-Alzheimer amyloidoses
J. Chapman (1998)
The neurobiology of apolipoproteins and their receptors in the CNS and Alzheimer's disease
U. Beffert (1998)
Semantic Scholar Logo Some data provided by SemanticScholar