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Evaluation Of Nerve Fiber Layer Assessment.
A. Sommer, H. Quigley, A. Robin, N. Miller, J. Katz, S. Arkell
Published 1984 · Medicine
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More than 1,400 eyes with either ocular hypertension glaucomatous visual field loss, or normal pressures and fields (controls) were studied prospectively in standardized, masked fashion. The appearance of the nerve fiber layer was evaluated independently from red-free photographs with the discs blocked-out by two observers. The vast majority of photographs could be evaluated, the proportion varying with the observer and with the age and clinical status of the subject. Sensitivity (proportion of glaucomatous eyes with nerve fiber defects) and specificity (proportion of normal control eyes without defects) averaged 80% to 94%, varying with the observer and with the age, race, and severity of field loss. In two thirds of presumed false-positive eyes, but only 5% of true-positive eyes, the abnormalities were limited to focal slitlike defects. The prevalence of nerve fiber defects in eyes with elevated pressure and normal visual fields was similar to that in control eyes, approximately 10%. However, the proportion of eyes in which these defects included diffuse loss was considerably higher among the hypertensive eyes.
This paper references
The histology of human glaucoma cupping and optic nerve damage: clinicopathologic correlation in 21 eyes.
H. Quigley (1979)
Monochromatic (red-free) photography and ophthalmoscopy of the peripapillary retinal nerve fiber layer.
N. Miller (1978)
The effect of age on the nerve fiber population of the human optic nerve.
A. G. Balazsi (1984)
High-resolution photography of the retinal nerve fiber layer.
A. Sommer (1983)
The earliest observable defect in glaucoma?
W. Hoyt (1972)
[Typical slit-like retinal nerve fiber layer defect and corresponding scotoma (author's transl)].
K. Iwata (1981)
The First Observable Glaucoma Changes after an Optic Disc Haemorrhage
P. Airaksinen (1983)
Clinical evaluation of nerve fiber layer atrophy as an indicator of glaucomatous optic nerve damage.
H. Quigley (1980)
Fundoscopy of nerve fiber layer defects in glaucoma.
W. Hoyt (1973)
The nerve fiber layer in the diagnosis of glaucoma.
A. Sommer (1977)
Optic nerve damage in human glaucoma. III. Quantitative correlation of nerve fiber loss and visual field defect in glaucoma, ischemic neuropathy, papilledema, and toxic neuropathy.
H. Quigley (1982)
Quantitative studies of retinal nerve fiber layer defects.
H. Quigley (1982)
Clinical recognition of glaucomatous cupping.
R. E. Kirsch (1973)
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