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Management Of Facial Spasm With Clostridium Botulinum Toxin, Type A (Oculinum)

A. W. Biglan, M. May, R. A. Bowers
Published 1988 · Medicine

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One hundred five patients received 391 graded injections of Clostridium botulinum type A toxin (Oculinum) to treat uncontrollable facial muscle spasm. Patients had essential blepharospasm (n = 61), hemifacial spasm (n = 24), or aberrant regeneration of the seventh cranial nerve (n = 20). Muscle spasms were reduced within two days of the first injection of toxin and, in most cases, the drug effect lasted three to four months. Control of facial muscle spasm was achieved in all patients. Complications related to treatment included transient blepharoptosis (n = 7), diplopia (n = 2), and altered facial expression (n = 11). Systemic side effects were not observed. Select chemodenervation of facial muscles with graded injections of botulinum toxin is a useful adjunct to control blepharospasm, hemifacial spasm, and facial spasm due to aberrant regeneration of the facial nerve.
This paper references
10.3928/0191-3913-19840501-06
Botulinum toxin chemo-denervation for strabismus in infants and children.
E. Magoon (1984)
10.1093/MILMED/149.1.12
Botulism--an update.
L. Sellin (1984)
10.1001/ARCHNEUR.1978.00500320001001
Hemifacial spasm. A vascular cause.
J. Maroon (1978)
10.1136/bjo.71.9.664
Long-term results of treatment of idiopathic blepharospasm with botulinum toxin injections.
J. Elston (1987)
10.1001/ARCHOPHT.1985.01050090057031
Hemifacial spasm treated with botulinum A toxin injection.
P. Savino (1985)
10.3171/JNS.1977.47.3.0321
Etiology and definitive microsurgical treatment of hemifacial spasm. Operative techniques and results in 47 patients.
P. Jannetta (1977)
10.1055/S-0028-1090369
Observations on the etiology of trigeminal neuralgia, hemifacial spasm, acoustic nerve dysfunction and glossopharyngeal neuralgia. Definitive microsurgical treatment and results in 117 patients.
P. Jannetta (1977)
10.1016/S0161-6420(86)33785-0
The use of botulinum toxin in the medical management of benign essential blepharospasm.
K. I. Perman (1986)
10.1016/S0161-6420(86)33641-8
Treatment of facial spasm with botulinum toxin. An interim report.
B. Frueh (1986)
10.1001/JAMA.1982.03330230060037
Blinking and blepharospasm. Mechanism, diagnosis, and management.
J. Jankovic (1982)
10.1001/ARCHOPHT.1981.03930011056015
Blepharospasm surgery. An anatomical approach.
W. Gillum (1981)
10.1001/ARCHNEUR.1981.00510030041005
Clinical features of Meige's disease (idiopathic orofacial dystonia): a report of 17 cases.
E. Tolosa (1981)
10.3928/1542-8877-19811101-09
Blepharospasm: a surgical procedure for therapy.
A. Battista (1981)
10.1176/AJP.138.11.1487
Biofeedback in the treatment of blepharospasm: a case study.
G. E. Rowan (1981)
A profile of patients with intractable blepharospasm.
B. Frueh (1976)
10.1016/0002-9394(86)90601-X
Absence of antibody production in patients treated with botulinum A toxin.
A. W. Biglan (1986)
10.3928/0191-3913-19860901-05
Treatment of facial spasm with Oculinum (C. botulinum toxin).
A. W. Biglan (1986)
10.1016/0002-9394(85)90228-4
Treatment of blepharospasm with botulinum toxin.
E. A. Tsoy (1985)
10.3928/1542-8877-19861101-11
Botulinum toxin for the treatment of essential blepharospasm.
J. Shore (1986)
10.1016/S0002-9394(14)77954-1
The use of botulinum toxin in blepharospasm.
N. Shorr (1985)
Pharmacologic weakening of extraocular muscles.
A. B. Scott (1973)
10.1212/WNL.32.3.286
Carbamazepine for hemi facial spasm
G. E. Alexander (1982)
10.1212/WNL.33.9.1237
Blepharospasm associated with brainstem lesions
J. Jankovic (1983)
10.1016/0002-9394(85)90797-4
Sequelae of botulinum toxin injection.
R. Lingua (1985)
10.1016/0002-9394(73)90665-X
Complications in surgery for blepharospasm.
R. Dortzbach (1973)
10.1016/S0161-6420(87)33338-X
Effectiveness of botulinum toxin therapy for essential blepharospasm.
P. Engstrom (1987)
Hemifacial spasm: importance of a complete investigation.
M. Schloss (1976)
10.1001/ARCHOPHT.1984.01040030216030
Treatment of essential blepharospasm. I. Comparison of facial nerve avulsion and eyebrow-eyelid muscle stripping procedure.
C. McCord (1984)
10.3928/0191-3913-19840901-11
Botulinum injections for strabismus.
H. Metz (1984)
Botulinum toxin injection of eye muscles to correct strabismus.
A. B. Scott (1981)
10.1016/0002-9394(68)92217-4
Familial reflex blepharospasm.
A. R. Irvine (1968)
The neurotoxins of Clostridium botulinum and Clostridium tetani.
G. Wright (1955)
10.1001/ARCHOPHT.1985.01050030043017
Botulinum A toxin injection as a treatment for blepharospasm.
A. Scott (1985)
10.1016/0002-9394(65)91994-X
Surgical correction of intractable blepharospasm. Technical improvements.
A. Callahan (1965)
10.1016/S0161-6420(87)33337-8
Use of botulinum toxin in the treatment of one hundred patients with facial dyskinesias.
J. Mauriello (1987)
10.1001/ARCHOPHT.1984.01040031184014
Treatment of blepharospasm with botulinum toxin. A preliminary report.
B. Frueh (1984)



This paper is referenced by
10.1001/ARCHOTOL.1989.01860310120037
Management of facial spasm with Clostridium botulinum toxin.
D. Sanders (1989)
10.1111/J.1524-4725.2004.30556.X
Dry Eyes and Superficial Punctate Keratitis: A Complication of Treatment of Glabelar Dynamic Rhytides with Botulinum Exotoxin A
M. Northington (2004)
10.1016/S0733-8619(18)30311-6
Botulinum toxin therapy.
P. Savino (1991)
10.1046/J.1524-4725.2003.29126.X
Diffusion and Short‐Term Efficacy of Botulinum Toxin A After the Addition of Hyaluronidase and Its Possible Application for the Treatment of Axillary Hyperhidrosis
G. Goodman (2003)
10.2165/00019053-199712060-00009
Costs of Treating Dystonias and Hemifacial Spasm with Botulinum Toxin A
R. Dodel (2012)
10.1007/PL00007813
Botulinum toxin: evidence-based medicine criteria in blepharospasm and hemifacial spasm
W. Jost (2001)
10.1002/lary.27709
Contemporary Review and Case Report of Botulinum Resistance in Facial Synkinesis
J. Shinn (2018)
10.1007/978-3-642-85090-5_122
Hemifacial spasm: evaluation and management options.
R. Wiet (1994)
10.1097/00005537-200008000-00028
Botulinum Toxin for Essential Tremor of the Voice With Multiple Anatomical Sites of Tremor: A Crossover Design Study of Unilateral Versus Bilateral Injection
P. Warrick (2000)
10.1016/S0987-7053(96)85003-9
Mécanisme d'action, indication et résultats des traitements par la toxine botulinique
A. Lagueny (1996)
10.1016/B978-0-323-05283-2.00173-7
Rehabilitation of Facial Paralysis
J. Ridgway (2010)
10.1007/s00702-010-0546-9
Difficulties with differentiating botulinum toxin treatment effects in essential blepharospasm
B. Wabbels (2010)
10.1002/MUS.880150909
Treatment of hemifacial spasm with botulinum toxin
D. Yoshimura (1992)
10.1177/000348949410300105
Treatment of Dysfunction of the Cricopharyngeal Muscle with Botulinum a Toxin: Introduction of a New, Noninvasive Method
I. Schneider (1994)
10.1007/PL00007816
Pharmacology and immunology of botulinum toxin serotypes
K. Aoki (2001)
10.1007/978-3-7091-6829-5_5
(Primary) hemifacial spasm: epidemiological data
A. Vighetto (1997)
10.1177/014556130007901010
Botulinum Toxin in Otolaryngology: A Review of its Actions and Opportunities for Use
M. Neuenschwander (2000)
10.1002/DDR.430240402
Lophotoxins: Irreversible active‐site‐directed inhibitors of nicotinic acetylcholine receptors
S. N. Abramson (1991)
10.1016/S0892-1997(00)80086-7
The treatment of essential voice tremor with botulinum toxin A: a longitudinal case report.
P. Warrick (2000)
10.1007/BF03163766
Indikation zur perioperativen Behandlung des spastischen Entropiums mit Botulinum Toxin-A
A. Kuchar (2009)
10.1076/NOPH.22.1.17.3739
Effect of injection sites of botulinum toxin for blepharospasm treatment: statistical analysis
E. Campos (1999)
Blefarospazm ve Hemifasiyal Spazm Tedavisinde Botulinum Toksin Uygulaması
P. Aydın (2000)
10.1086/510636
Botulinum Toxin Injections as a Method for Chemically Denervating Skeletal Muscle to Test Functional Hypotheses: A Pilot Study in Lepomis cyanellus
M. O'neill (2007)
10.1590/S0004-282X2010000400006
Botulinum toxin type A in the treatment of hemifacial spasm: an 11-year experience.
E. Barbosa (2010)
10.1136/jnnp.59.3.309
Pretarsal application of botulinum toxin for treatment of blepharospasm.
M. Aramideh (1995)
10.1002/MUS.880180708
Five‐year experience in the treatment of focal movement disorders with low‐dose dysportTM botulinum toxin
P. V. D. van den Bergh (1995)
10.5631/jibirin.101.413
Rehabilitation for a Patient with Peripheral Facial Palsy
K. Nakamura (2008)
10.1016/S0194-59980223254-4
Biofeedback Rehabilitation for Prevention of Synkinesis after Facial Palsy
K. Nakamura (2003)
10.1002/mus.20033
Botulinum toxins in neurological disease
C. Comella (2004)
10.1016/S0161-6420(97)30220-6
Blepharospasm and hemifacial spasm. Randomized trial to determine the most appropriate location for botulinum toxin injections.
J. Price (1997)
10.1111/j.1440-0960.1998.tb01272.x
Botulinum toxin for the correction of hyperkinetic facial lines
G. Goodman (1998)
10.1097/00013414-200412000-00009
The Importance of Facial Expression and the Management of Facial Nerve Injury
R. Morgan Stuart (2004)
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