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Analysis Of Topical Cyclosporine Treatment Of Patients With Dry Eye Syndrome: Effect On Conjunctival Lymphocytes.

Kathleen S. Kunert, Ann S. Tisdale, Michael E. Stern, Janine A. Smith, Ilene K. Gipson
Published 2000 · Medicine
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OBJECTIVE To study the effect of topical cyclosporine on lymphocyte activation within the conjunctiva of patients with moderate to severe dry eye syndrome (Sjögren and non-Sjögren). METHODS Biopsy specimens were obtained at baseline and after 6 months of cyclosporine treatment from eyes of 32 patients with moderate to severe dry eye syndrome; 19 were cyclosporine treated (0.05% cyclosporine, n = 13; 0.1% cyclosporine, n = 6) and 13 were vehicle treated. Within this group there were 12 with Sjögren syndrome and 20 with non-Sjögren syndrome. Biopsy tissue was analyzed using immunohistochemical localization of binding of monoclonal antibodies to lymphocytic markers CD3, CD4, and CD8 as well as lymphocyte activation markers CD11a and HLA-DR. RESULTS In cyclosporine-treated eyes, biopsy results of conjunctivae showed decreases in the number of cells positive for CD3, CD4, and CD8, while in vehicle-treated eyes, results showed increases in these markers, although these differences were not statistically significant. Following treatment with 0.05% cyclosporine, there was a significant decrease in the number of cells expressing the lymphocyte activation markers CD11a (P<.05) and HLA-DR (P<.05), indicating less activation of lymphocytes as compared with vehicle treatment. Within the Sjögren patient subgroup, those treated with 0.05% cyclosporine also showed a significant decrease in the number of cells positive for CD11a (P<.001) as well as CD3 (P<.03), indicating a reduction in number of activated lymphocytes. CONCLUSION Treatment of dry eye syndrome with topical cyclosporine significantly reduced the numbers of activated lymphocytes within the conjunctiva. Arch Ophthalmol. 2000;118:1489-1496
This paper references
10.1016/S0733-8635(18)30052-4
Cyclosporine: what clinicians need to know.
John Y. M. Koo (1995)
10.1001/archopht.1989.01070020276038
Spontaneous canine keratoconjunctivitis sicca. A useful model for human keratoconjunctivitis sicca: treatment with cyclosporine eye drops.
Renee L. Kaswan (1989)
10.1016/S0161-6420(99)00176-1
Two multicenter, randomized studies of the efficacy and safety of cyclosporine ophthalmic emulsion in moderate to severe dry eye disease1☆
Kenneth Sall (2000)
10.1097/00003226-199311000-00004
Immunological analysis and treatment of Mooren's ulcer with cyclosporin A applied topically.
Jin Cai Zhao (1993)
Flow cytometry in impression cytology specimens. A new method for evaluation of conjunctival inflammation.
Christophe Baudouin (1997)
10.1159/000268003
Flow cytometric analysis of surface antigens on human conjunctival epithelial cells.
Tsutomu Fujihara (1997)
10.1159/000027387
Conjunctival Epithelium Expression of HLA-DR in Dry Eye Patients
Kazuo Tsubota (1998)
10.1136/bjo.68.9.674
Senile atrophy of the human lacrimal gland: the contribution of chronic inflammatory disease.
Bertil E. Damato (1984)
Intraoperative use of mitomycin C and postoperative use of topical cyclosporine A in the treatment of tarsal vernal keratoconjunctivitis
AG Secchi (1997)
10.1001/archopht.1993.01090010023009
Lymphocytic infiltration of the conjunctiva and the salivary gland in Sjögren's syndrome.
Taiichi Hikichi (1993)
10.1007/978-1-4615-5359-5_143
Conjunctival impression cytology from dogs with keratoconjunctivitis sicca. Pre- and post-treatment with topical cyclosporine.
Denise I. Bounous (1998)
Diagnosis and management of dry eye and ocular surface disorders
AJ Lubniewski (1990)
10.1016/S1054-3589(08)60276-8
In vivo pharmacological effects of ciclosporin and some analogues.
J. F. Borel (1996)
10.1111/j.1365-2559.1988.tb02024.x
Conjunctival biopsy in Sjögren's syndrome: correlations between histological and immunohistochemical features.
M Raphael (1988)
10.1097/00003226-199811000-00002
The pathology of dry eye: the interaction between the ocular surface and lacrimal glands.
Michael E. Stern (1998)
Clinical evaluation of 1% cyclosporine for topical treatment of keratoconjunctivitis sicca in dogs.
Dennis K. Olivero (1991)
10.1111/j.1755-3768.1994.tb02792.x
Topical cyclosporin treatment of keratoconjunctivitis sicca in secondary Sjögren's syndrome.
Kaan Gündüz (1994)
10.1046/j.1365-2133.1997.6081584.x
Cyclosporin inhibits intercellular adhesion molecule-1 expression and reduces mast cell numbers in the asebia mouse model of chronic skin inflammation.
Alp Oran (1997)
10.1002/art.1780360309
Preliminary criteria for the classification of Sjögren's syndrome. Results of a prospective concerted action supported by the European Community.
Chiara Vitali (1993)
10.1159/000268041
Topical cyclosporin as an adjunct to topical acyclovir treatment in herpetic stromal keratitis.
Kaan Gündüz (1997)
Conjunctival cytologic features of primary Sjögren's syndrome.
Stephen C. Pflugfelder (1990)
junctival biopsy in Sjögren ’ s syndrome : correlations between histological and immunohistochemical features
M Raphael (1988)
10.1016/0092-8674(94)90335-2
Signals and signs for lymphocyte responses
Charles A. Jr. Janeway (1994)
Ocular disorders associated with systemic diseases
Sanders (1986)
junctival cytologic features of primary Sjögren ’ s syndrome
SC Pflugfelder (1990)
10.1001/archopht.118.5.615
Reliability and validity of the Ocular Surface Disease Index.
Rhett M. Schiffman (2000)
The immunomodulatory effect of topical cyclosporin A in atopic keratoconjunctivitis.
Melanie Hingorani (1999)
10.1016/S0022-1759(97)00207-X
Expression of a soluble form of LFA-1 and demonstration of its binding activity with ICAM-1.
Y Tominaga (1998)
10.1001/archopht.1992.01080130123040
Distribution of lymphocytes and cell adhesion molecules in iris biopsy specimens from patients with uveitis.
Denis Wakefield (1992)
Sjögren's syndrome: cytokine and Epstein-Barr viral gene expression within the conjunctival epithelium.
Dylan T Jones (1994)
10.1097/00003226-199311000-00008
Effect of topical cyclosporin A on conjunctival T cells in patients with secondary Sjögren's syndrome.
William James Power (1993)
10.1016/S0002-9394(14)73872-3
Local therapy of corneal allograft rejection with cyclosporine.
Jin Cai Zhao (1995)
10.1136/bjo.57.11.852
Histology of the lacrimal gland in keratoconjunctivitis sicca.
Jenny Williamson (1973)
10.1097/00003226-199307000-00007
Pilot trial of cyclosporine 1% ophthalmic ointment in the treatment of keratoconjunctivitis sicca.
Robert Laibovitz (1993)
Two multicenter, randomized studies of the efficacy and safety of cyclosporine ophthalmic emulsion in moderate to severe dry eye disease. CsA Phase 3 Study Group.
Kenneth N. Sall (2000)
10.1016/S0161-6420(90)32372-2
Mononuclear cell phenotypes and immunoglobulin gene rearrangements in lacrimal gland biopsies from patients with Sjögren's syndrome.
Jay S. Pepose (1990)
10.1007/978-1-4615-5359-5_91
A unified theory of the role of the ocular surface in dry eye.
Michael E. Stern (1998)
10.1083/jcb.107.1.321
Lymphocyte function-associated antigen-1 (LFA-1) interaction with intercellular adhesion molecule-1 (ICAM-1) is one of at least three mechanisms for lymphocyte adhesion to cultured endothelial cells
Michael L. Dustin (1988)
10.1172/JCI118629
Common T cell receptor clonotype in lacrimal glands and labial salivary glands from patients with Sjögren's syndrome.
Ichie Matsumoto (1996)



This paper is referenced by
on Dry Eye Disease : Diagnosis , Medical Management , Recent Developments , and Future
Suvarna P. Phadatare (2017)
DDDT_A_207743 265..274
Hsin-I Tuan (2020)
10.1097/ICO.0b013e31802b492d
Effect of an oil-in-water emulsion on the tear physiology of patients with mild to moderate dry eye.
Santosh Khanal (2007)
10.1097/ICO.0b013e3181e7845b
The effect of topical cyclosporine A on clinical findings and cytological grade of the disease in patients with dry eye.
Esra Şahlı (2010)
10.1089/jop.2009.0145
A comparison of cyclosporine 0.05% ophthalmic emulsion versus vehicle in Chinese patients with moderate to severe dry eye disease: an eight-week, multicenter, randomized, double-blind, parallel-group trial.
Minjie Chen (2010)
Cornea Tear Interferon-Gamma as a Biomarker for Evaporative Dry Eye Disease
David C Jackson (2016)
How do Functional Tear Tests and Corneal and Anterior Chamber Parameters Change After Topical Cyclosporine -A 0.05% Treatment in Dry Eye Diagnosed Women?
Esra Şahlı (2020)
10.1038/s41419-020-2489-x
FUT1 deficiency elicits immune dysregulation and corneal opacity in steady state and under stress
Kyoung Woo Kim (2020)
10.3109/08820538.2015.1114841
Chronic Ocular Complications of Stevens–Johnson Syndrome and Toxic Epidermal Necrolysis: The Role of Systemic Immunomodulatory Therapy
Victoria S. Chang (2016)
10.1186/s40662-019-0137-2
Dry eye disease immune responses and topical therapy
Charles W. McMonnies (2019)
10.1517/14656560802500613
Ciclosporin use in dry eye disease patients
William H. Ridder (2008)
10.1097/ICL.0b013e31822563be
Effects of topical cyclosporine a plus artificial tears versus artificial tears treatment on conjunctival goblet cell density in dysfunctional tear syndrome.
Elvan Demiryay (2011)
10.1007/s10792-019-01133-5
Association of Ramadan daytime fasting with ocular surface inflammation and dry eye
Brian K. Armstrong (2019)
10.1016/j.jtos.2017.05.006
TFOS DEWS II Management and Therapy Report.
Lyndon Jones (2017)
10.1167/iovs.18-24504
Sleep Deprivation Induces Dry Eye Through Inhibition of PPARα Expression in Corneal Epithelium.
Liying Tang (2018)
Immune profile of squamous metaplasia development in autoimmune regulator-deficient dry eye
Ying-Ting Chen (2009)
10.4068/cmj.2010.46.2.105
Study of Utilization Pattern and Compliance with Topical 0.05% Cyclosporine Emulsion in Korean Dry Eye Patients
Seung Hyun Lee (2010)
Clinical Study Oral Hyaluronic Acid Supplementation for the Treatment of Dry Eye Disease: A Pilot Study
Ye-seul Kim (2019)
10.1007/978-3-030-21162-2_8
Inflammatory Ocular Diseases and Sphingolipid Signaling.
Richard C Grambergs (2019)
Dry Eye Syndrome Limited Revision
Robert S. Feder (2011)
10.1093/intimm/dxy045
Goblet cell-produced retinoic acid suppresses CD86 expression and IL-12 production in bone marrow-derived cells
Yangyan Xiao (2018)
10.1089/jop.2016.0164
Evaluation of Clinical Efficacy and Safety of a Novel Cyclosporin A Nanoemulsion in the Treatment of Dry Eye Syndrome.
Hyun Seung Kim (2017)
10.5772/INTECHOPEN.83821
Sjögren’s Syndrome as an Ocular Problem: Signs and Symptoms, Diagnosis, Treatment
Dorota Kopacz (2019)
10.1167/iovs.15-16555
Correlation Between the Inflammatory Marker HLA-DR and Signs and Symptoms in Moderate to Severe Dry Eye Disease.
Françoise Brignole-Baudouin (2017)
Nanotechnology and Regenerative Medicine A Novel Cyclosporin A Aqueous Formulation for Dry Eye Treatment : In Vitro and In Vivo Evaluation
Claudia Di Tommaso (2012)
10.3181/0711-MR-311
The Importance of the Omega-6/Omega-3 Fatty Acid Ratio in Cardiovascular Disease and Other Chronic Diseases
Artemis P. Simopoulos (2008)
Uso de suero autólogo, heterólogo y suero de cordón umbilical en pacientes con enfermedad autoinmune con síndrome de ojo seco moderado-grave
Gustavo Rodríguez Moreno (2016)
Conjunctiva, Cornea, Lacrimal Gland, and Systemic Blood following Topical Dosing of Cyclosporine to Rabbit, Dog, and Human Eyes, 2 LACRIMAL GLAND, TEAR FILM, AND DRY EYE SYNDROMES
Michael R. Dzwonczyk (2017)
10.1136/bjophthalmol-2020-316196
Late-term topical tacrolimus for subepithelial infiltrates resistant to topical steroids and ciclosporin secondary to adenoviral keratoconjunctivitis
Ceyhun Arici (2020)
A novel cyclosporin A micelle formulation for topical ophthalmic applications: development, biocompatibility, corneal penetration, and efficacy studies
Claudia Di Tommaso (2011)
Flow cytometric analysis of inflammatory markers in KCS: 6-month treatment with topical cyclosporin A.
Françoise Brignole (2001)
Cytofluorimétrie sur empreintes conjonctivales au cours de la kératoconjonctivite sèche: effets de la ciclosporine topique sur l'expression d'antigène HLA DR
Olivier Galatoire (2003)
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