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Treatments For Symptomatic Urinary Tract Infections During Pregnancy.

J. C. Vázquez, J. Villar
Published 2000 · Medicine

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BACKGROUND Urinary tract infections, including pyelonephritis, are serious complications that can result in significant maternal and neonatal morbidity and mortality. There is a large number of drugs, and combination of them, available to treat urinary tract infections, most of them tested in non-pregnant women. Attempts to define the optimal antibiotic regimen for pregnancy has, therefore, been problematic. OBJECTIVES The objective of this review was to try to determine, from the best available evidence from randomized control trials, which agent is most effective for the treatment of symptomatic urinary tract infections during pregnancy in terms of cure rates, recurrent infection, incidence of preterm delivery and premature rupture of membranes, admission to neonatal intensive care unit, need for change of antibiotic, and incidence of prolonged pyrexia. SEARCH STRATEGY The Cochrane Pregnancy and Childbirth Group trials register, the Cochrane Controlled Trials Register and reference lists of articles were searched. SELECTION CRITERIA All trials were considered where the intention was to allocate participants randomly to one of at least two alternative treatments for any symptomatic urinary tract infection. DATA COLLECTION AND ANALYSIS Trial quality assessment and data extraction were performed by the two reviewers. MAIN RESULTS Five studies were included. There were no significant differences between studied treatments with regard to cure rates, recurrent infection, incidence of preterm delivery and premature rupture of membranes, admission to neonatal intensive care unit, need for change antibiotic and incidence of incidence of prolonged pyrexia. REVIEWER'S CONCLUSIONS Although antibiotic treatment is effective for the cure of urinary tract infections, there are insufficient data to recommend any specific treatment regimen for symptomatic urinary tract infections during pregnancy. All of the antibiotics studied were shown to be very effective in decreasing the incidence of outcomes measured. Complications were very rare. All included trials had very small sample sizes to try to detect important differences between treatments. Future studies should evaluate the most promising antibiotics, in terms of class, timing, dose, acceptability, maternal and neonatal outcomes and costs.
This paper references
10.4067/S0034-98872000000700007
Estudio prospectivo, randomizado, comparativo de la eficacia, seguridad y costos de cefuroxima vs cefradina en la pielonefritis aguda del embarazo
S. AlfredoOvalle (2000)
10.1016/S0140-6736(75)92294-1
C3 IN CYSTIC FIBROSIS
T. Scanlin (1975)
10.1002/14651858.CD000490.PUB3
Antibiotics for asymptomatic bacteriuria in pregnancy.
F. Smaill (2001)
10.1111/j.1464-410X.1975.tb03978.x
Ampicillin, carbenicillin indanyl ester, and nifuratel in the treatment of urinary infection in domiciliary practice.
B. I. Davies (1975)
10.1002/9780470693926
Systematic Reviews in Health Care
M. Egger (2001)
10.1016/S0029-7844(95)80016-6
Outpatient Treatment of Pyelonephritis in Pregnancy: A Randomized Controlled Trial
L. Millar (1995)
10.11553/antibiotics1968b.29.167
二重盲検法によるPipemidic acidとPiromidic acidの急性下部尿路感染症に対する比較臨床試験
襄次 石神 (1976)
10.1016/S0029-7844(99)00386-5
Outpatient treatment of acute pyelonephritis in pregnancy after 24 weeks.
D. Wing (1999)
10.1016/0002-9378(95)90100-0
Pyelonephritis in pregnancy: once-a-day ceftriaxone versus multiple doses of cefazolin. A randomized, double-blind trial.
L. Sánchez-Ramos (1995)
10.1056/JW199511100000003
OUTPATIENT TREATMENT OF PYELONEPHRITIS IN PREGNANCY.
Tl Schwenk (1995)
10.1056/NEJM197110072851502
Long-Term (10 to 14 Years) Follow-up of Bacteriuria of Pregnancy
S. Zinner (1971)
[Acute cystourethritis during pregnancy].
Ernesto Calderon Jaimes (1989)
10.1016/S0950-3552(87)80040-8
7 Urinary tract infections complicating pregnancy
F. Cunningham (1987)
Treatment of urinary infections in pregnancy using single versus 10-day dosing.
M. Adelson (1992)
10.1093/clinids/12.3.458
Short-term treatment of uncomplicated lower urinary tract infections in women.
S. Norrby (1990)
Acute Pyelonephritis in Pregnancy: A Prospective Study of Oral Versus Intravenous Antibiotic Therapy
Jeffrey L. Angel (1990)
Outpatient treatment of pyelonephritis in pregnancy: a randomized controlled trial.
Beckmann Cr (1996)
10.1128/AAC.27.4.508
Comparative study of amoxicillin-clavulanic acid and cephalexin in the treatment of bacteriuria during pregnancy.
S. Pedler (1985)
10.1016/S0924-8579(00)00351-4
Treatment of lower urinary tract infection in pregnancy.
S. Krcmery (2001)
10.1016/S0029-7844(98)00156-2
A Randomized Trial of Three Antibiotic Regimens for the Treatment of Pyelonephritis in Pregnancy
D. Wing (1998)
10.1159/000238818
Fosfomycin trometamol versus pipemidic acid in the treatment of bacteriuria in pregnancy.
S. Zinner (1990)
10.1155/S1064744996000567
Randomized Clinical Trial of Antibiotic Therapy for Antenatal Pyelonephritis
B. Brost (1996)
10.5694/j.1326-5377.1973.tb111187.x
Trimethoprim-sulphamethoxazole in the treatment of urinary infection.
W. Brumfitt (1973)
Pyelonephritis in pregnancy. The role of in-hospital management and nitrofurantoin suppression.
J. P. van Dorsten (1987)
10.3109/inf.1979.11.issue-4.04
Comparison of pivmecillinam and cephradine in bacteriuria in pregnancy and in acute urinary tract infection.
W. Brumfitt (1979)
10.1136/bmj.2.5815.673
Double-blind Trial to Compare Ampicillin, Cephalexin, Co-trimoxazole, and Trimethoprim in Treatment of Urinary Infection
W. Brumfitt (1972)
10.1345/aph.17227
Single-Dose Treatment of Acute Cystitis with Fosfomycin Tromethamine
G. E. Stein (1998)
10.5694/j.1326-5377.1969.tb107290.x
Subclinical renal infection and prematurity.
Barry G. Wren (1969)
10.5694/j.1326-5377.1972.tb50913.x
Double-blind trial comparing trimethoprim-sulphamethoxazole (bactrim) with ampicillin in treating urinary infections.
Barry G. Wren (1972)
10.1097/00003081-198809000-00006
Infection and preterm labor.
R. Romero (1988)
10.1159/000472874
Urinary tract infections in pregnancy: Monuril single-dose treatment versus traditional therapy.
L. de Cecco (1987)
10.1136/bmj.313.7048.36
Trials to assess equivalence: the importance of rigorous methods
B. Jones (1996)
10.1016/S0095-5108(18)30183-0
Intra-amniotic infection and premature rupture of the membranes.
P. H. Belady (1997)
10.1111/j.1471-0528.1985.tb01355.x
Single‐dose amoxycillin in the treatment of bacteriuria in pregnancy and the puerperium‐a controlled clinical trial
R. Masterton (1985)
10.1159/000281988
Treatment of bacterial infections of the female urinary tract by immunization of the patients.
E. Grischke (1987)
Acute pyelonephritis in pregnancy: a prospective study of oral versus intravenous antibiotic therapy.
L. Sánchez-Ramos (1990)
10.1016/S0140-6736(65)90001-2
BACTERIURIA IN PREGNANCY.
P. Kincaid-Smith (1965)



This paper is referenced by
10.1007/978-1-84628-743-5_16
The Impact of Infection During Pregnancy on the Mother and Baby
H. Jeffery (2007)
10.1016/S1134-2072(13)70571-1
Patología urinaria infecciosa
C. Llor (2013)
10.1016/B978-141602213-8.50016-6
Chapter 13 – Selected Medical Problems Encountered During Pregnancy
Aba Barden-Maja (2007)
Cysticlean And Recurrent Urinary Tract Infection
Mohammad Othman (2013)
COMPASS Therapeutic Notes on the Management of Bacterial Urinary Tract Infections in Adults in Primary Care
Leucocyte Esterase (2007)
10.1111/jep.12454
Factors associated with potentially harmful antibiotic prescription during pregnancy: a population-based study.
Yi-Chen Lee (2016)
HÁBITOS DE HIGIENE GENITAL E INFECÇÃO AUTORREFERIDA NO TRATO URINÁRIO NA GRAVIDEZ
Escola Superior de Enfermagem (2009)
10.1016/j.emc.2018.06.003
The Emergency Department Diagnosis and Management of Urinary Tract Infection.
Brit Long (2018)
Infectious diseases and immune system in infants Risk factors and consequences: The Generation R Study
L. Duijts (2008)
Prevalência e fatores associados à internação hospitalar para tratamento da infecção do trato urinário durante a gestação Prevalence and associated factors with hospitalization for treatment of urinary tract infection during pregnancy
Arnildo Agostinho (2013)
10.7707/HMJ.V6I2.209
Asymptomatic bacteriuria and urinary tract infections in pregnancy – a review of the literature
Anthony Kodzo-grey Venyo (2013)
10.1517/14740338.2014.939580
Safety of antimicrobial treatment during pregnancy: a current review of resistance, immunomodulation and teratogenicity
Harriet F Lamont (2014)
10.1016/j.ajog.2013.12.036
Reports to the Vaccine Adverse Event Reporting System after hepatitis A and hepatitis AB vaccines in pregnant women.
P. Moro (2014)
Sexually transmitted diseases : a practical guide for primary care
Aaenor J. Sawyer (2006)
10.1007/978-90-313-6614-9_50
NHG-Standaard Urineweginfectie
M. V. Haaren (2009)
10.1007/s40620-016-0285-6
A best practice position statement on pregnancy in chronic kidney disease: the Italian Study Group on Kidney and Pregnancy
G. Cabiddu (2016)
10.1016/B978-0-7020-6285-8.00055-1
55 – Complications of Pregnancy: Maternal Perspectives
G. Durand (2017)
Journal of Pharmaceutical and Biological Sciences
Publisher Atom and Cell Publishers (2015)
10.1002/pds.3492
Antibiotics prescribed before, during and after pregnancy in the Netherlands: a drug utilization study.
L. de Jonge (2014)
10.1159/000049840
EAU guidelines for the management of urinary and male genital tract infections. Urinary Tract Infection (UTI) Working Group of the Health Care Office (HCO) of the European Association of Urology (EAU).
K. Naber (2001)
10.1002/9781444323146.CH9
Prophylaxis and Treatment of Urinary Tract Infections in Adults
Sandra J. Matheson (2010)
10.1016/S0246-0335(08)50164-5
Infections urinaires chez la femme enceinte
A. Fournié (2008)
10.1586/EOG.12.21
Understanding urinalysis: clues for the obstetrician–gynecologist
Sarah Coad (2012)
10.1016/J.JGYN.2016.09.029
Prise en charge d’une menace d’accouchement prématuré
Gilles Kayem (2016)
Asymptomatic bacteriuria & obstetric outcome following treatment in early versus late pregnancy in north Indian women
Vaishali Jain (2013)
10.1002/14651858.CD009279.pub3
Interventions for preventing recurrent urinary tract infection during pregnancy.
Caroline Schneeberger (2015)
10.1016/J.SINY.2004.04.002
Epidemiology of preterm birth and neonatal outcome.
S. Wen (2004)
10.5772/24050
Urinary Tract Infections During Pregnancy
Anick Bérard (2011)
10.1016/j.ucl.2015.05.004
Urinary Tract Infection and Bacteriuria in Pregnancy.
A. P. Glaser (2015)
10.1016/S0140-6736(14)60789-3
Midwifery and quality care: findings from a new evidence-informed framework for maternal and newborn care
M. Renfrew (2014)
10.1016/S1283-081X(08)70801-4
Infecciones urinarias en el embarazo
A. Fournié (2008)
10.1038/sc.2016.138
Pregnancy in spinal cord-injured women, a cohort study of 37 pregnancies in 25 women
H. L. Liepvre (2017)
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