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Combined Vitamin B6-magnesium Treatment In Autism Spectrum Disorder.

C. Nye, A. Brice
Published 2002 · Medicine

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BACKGROUND The use of mega-vitamin intervention began in the early 1950's with the treatment of schizophrenic patients. Pyroxidine (vitamin B6) was first used with children diagnosed with "autism syndrome" when speech and language improvement was observed in some children as a result of large doses of B6. A number of published studies attempted to assess the effects of vitamin B6-Mg (Mg was found to reduce undesirable side effects from B6) on a variety of characteristics such as verbal communication, non-verbal communication, interpersonal skills, and physiological function, in individuals with autism. OBJECTIVES To determine the efficacy of vitamin B6 and magnesium (B6-Mg) for treating social, communication and behavioural responses of children and adults with autism. SEARCH STRATEGY We searched the Cochrane Controlled Trials Register (Cochrane Library, Issue 2, 2002), MEDLINE (1966- January 2002), EMBASE (1980-January 2002), PsychINFO (1887 - January 2002), Dissertation Abstracts International (1861 - January 2002). The search engine FirstSearch was also used (January 2002). Reference lists for all the obtained studies and other review articles were examined for additional studies. SELECTION CRITERIA All studies in which the participants were randomly allocated prior to intervention and in which outcomes were compared to either a placebo or non-treated group were included. DATA COLLECTION AND ANALYSIS Two reviewers independently evaluated all potential studies identified as indicated above for inclusion. MAIN RESULTS Two trials were included in the review. Both studies used a double-blind crossover design. One study (Tolbert 1993) provided insufficient data to conduct an analysis. The senior author was contacted for supporting data but was unable to provide the needed information. The remaining study (Findling, 1997) yielded no significant differences between treatment and placebo group performances following the B6 intervention on measures of social interaction, communication, compulsivity, impulsivity, or hyperactivity. REVIEWER'S CONCLUSIONS Due to the small number of studies, the methodological quality of studies, and small sample sizes, no recommendation can be advanced regarding the use of B6-Mg as a treatment for autism.

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The Levels of Vitamin D, Vitamin D Receptor, Homocysteine and Complex B Vitamin in Children with Autism Spectrum Disorders
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Potential identification of vitamin B6 responsiveness in autism spectrum disorder utilizing phenotype variables and machine learning methods
Taku Obara (2018)
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Senthilkumar Sivanesan (2017)
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Larissa Lyra (2017)
Urinary metabolomics of young Italian autistic children supports abnormal tryptophan and purine metabolism
Federica Gevi (2016)
Complementary and Alternative Therapies for Autism Spectrum Disorder
N. Brondino (2015)
Autism Spectrum Disorders
B. Maria (2015)
Systematic review of tools to measure outcomes for young children with autism spectrum disorder.
H. McConachie (2015)
Interventions for Autism Spectrum Disorders
J. Ganz (2014)
Educating pharmacists and the public about the role of over-the-counter medications in the management of Autism Spectrum Disorders
Jillian M. Bankoff (2014)
Autism and nutrition: the role of the gut–brain axis
Marijke M H van De Sande (2014)
Mothers' experiences of a primary specialist provision for autism attended by their child
E. Read (2013)
Complementary and alternative medicine for autism spectrum disorders: Rationale, safety and efficacy
A. Whitehouse (2013)
A Review of Complementary and Alternative Treatments for Autism Spectrum Disorders
Nicholas Lofthouse (2012)
Intervention Models in Children with Autism Spectrum Disorders
G. R. Cervera (2011)
PNS1100324 14..26
David Benton (2011)
Autism spectrum disorders
H. Faras (2010)
Incidence of Gastrointestinal Symptoms in Children With Autism: A Population-Based Study
S. Ibrahim (2009)
Aberrations in folate metabolic pathway and altered susceptibility to autism
Naushad Shaik Mohammad (2009)
The practice and regulatory requirements of naturopathy and western herbal medicine in Australia
V. Lin (2009)
Interventions for Autism Spectrum Disorders: State of the Evidence
Mph Lindsey Tweed Md (2009)
Micronutrient status, cognition and behavioral problems in childhood
D. Benton (2008)
The status of pharmacotherapy for autism spectrum disorders
S. M. Myers (2007)
Systematic review of the effectiveness of pharmacological treatments for adolescents and adults with autism spectrum disorder
M. Broadstock (2007)
Management of Children With Autism Spectrum Disorders
S. Myers (2007)
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