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Biodegradation Of Poly(alkylcyanoacrylates)

C. Vauthier, P. Couvreur
Published 2002 · Chemistry

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Introduction Historical Outline Synthesis and Purification of Alkylcyanoacrylate Monomers Polymer Synthesis General Considerations Bulk Polymerization Polymerization in Organic Solvents Emulsion Polymerization: Preparation of Matricial PACA Nanoparticles (Nanospheres) Interfacial Polymerization: Preparation of Reservoir-Type PACA Nanoparticles (Nanocapsules) Synthesis of Amphiphilic Block Copolymers Containing PACA Segments World Market Characterization and Methods of Analysis Stability and Mechanism of Degradation Toxicity Application of PACA in the Design of Drug Delivery Systems Use of “Conventional” PACA Nanoparticles From “Conventional” to Targeted Systems Patent Overview Outlook and Perspectives Keywords: alkylcyanoacrylate; anionic polymerization; cancer; copolymer; degradation; drug delivery system; nanocapsule; nanoparticle; nanosphere; ocular; oligonucleotide; peptide; poly(alkylcyanoacrylate); poly(ethylene glycol); protein; radical polymerization; toxicity; zwitterionic polymerization
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