Online citations, reference lists, and bibliographies.
← Back to Search

Archaeal Membrane Lipids And Applications

G. Sprott
Published 2011 · Biology

Cite This
Download PDF
Analyze on Scholarcy
Share
Membrane lipids of Archaea are unique and distinct from those found in Eukarya and Bacteria. The polar lipids consist of isoprenoid chains, 20–40 carbons in length and usually saturated, which are attached via stable ether bonds to the glycerol carbons at the sn-2,3 positions. Polar head groups differ at the genus level of diversity and consist of mixtures of glyco groups (mainly disaccharides), and/or phospho groups primarily phosphoglycerol, phosphoserine, phosphoethanolamine or phosphoinositol. Phosphocholine headgroups are rarely found. Extremely halophilic archaea are characterised by headgroups consisting of phosphoglycerolphosphate-O-methyl, and sulfated-sugars. Some of these archaea synthesise cardiolipin analogues. The inherent stability and unique features of archaeal lipids makes them a useful biomarker for Archaea within environmental samples, including ocean sediments. The polar lipids of Archaea can be used to make liposomes (closed vesicles referred to as archaeosomes) with characteristics that are useful for applications in biotechnology. Archaeal-like polar lipids are being synthesised to optimise the properties of archaeosomes to serve as next-generation adjuvants and drug delivery systems. Key Concepts: Archaeol (2,3-diphytanyl-sn-glycerol), and variations thereof, define the polar lipids of the domain of life, Archaea. The structures of polar lipids biosynthesised provide a useful taxonomic feature to assign an isolate to the Genus level of classification. New polar lipid structures are being reported as the field expands to encompass novel isolates. These unique polar and neutral isoprenyl lipids can be used as biomarkers of archaea in environmental samples. Archaeal lipids can serve as a rich source for novel molecules not commonly found in nature, such as β-l-gulose. Archaeal polar lipid mixtures hydrate to form lipid membrane vesicles (archaeosomes) with bilayer, unilayer or a combination of uni and bilayer structure. Archaeosomes are generally nonfusogenic in vitro, but fusion can be dramatic for certain compositions by exposure to the combination of acidic pH, calcium and glycosidase. Archaeosomes function as safe vaccine adjuvants in mammals imparting long-lasting CD8+ T-cell immunity and antibody responses. Isoprenoid lipids that retain the key archaeal-lipid features are being synthesised to optimise their properties as vaccine adjuvants and delivery systems. Keywords: archaea; membrane lipids; archaeol; caldarchaeol; biomarkers; archaeosomes; adjuvants; drug delivery
This paper references
10.3109/08982109609039925
Uptake of Archaeobacterial Liposomes and Conventional Liposomes by Phagocytic Cells
D. L. Tolson (1996)
10.1139/M97-066
Structural features of ether lipids in the archaeobacterial thermophiles Pyrococcus furiosus, Methanopyrus kandleri, Methanothermus fervidus, and Sulfolobus acidocaldarius
G. Sprott (1997)
10.1128/JB.173.12.3907-3910.1991
Proportions of diether, macrocyclic diether, and tetraether lipids in Methanococcus jannaschii grown at different temperatures.
G. Sprott (1991)
10.1016/S0040-4039(00)00283-5
The synthesis of archaebacterial lipid analogues
B. Raguse (2000)
10.1016/S0040-6090(96)08832-3
Archaeal lipids: structural features and supramolecular organization
M. Rosa (1996)
10.1016/j.bbamem.2009.05.010
The cardiolipin analogues of Archaea.
A. Corcelli (2009)
10.1093/glycob/cwn129
Glycosidase-induced fusion of isoprenoid gentiobiosyl lipid membranes at acidic pH.
G. Sprott (2009)
10.1016/S0169-409X(98)00014-3
Targeting immune response induction with cochleate and liposome-based vaccines.
Mannino (1998)
10.1128/AEM.00924-09
Archaeal Diversity and Distribution along Thermal and Geochemical Gradients in Hydrothermal Sediments at the Yonaguni Knoll IV Hydrothermal Field in the Southern Okinawa Trough
T. Nunoura (2009)
10.1016/j.carres.2008.06.021
Synthesis of archaeal glycolipid adjuvants-what is the optimum number of sugars?
Dennis M. Whitfield (2008)
10.1016/0005-2736(94)90160-0
Stability and proton-permeability of liposomes composed of archaeal tetraether lipids.
M. Elferink (1994)
10.1016/S0264-410X(01)00041-X
Immunization of mice with lipopeptide antigens encapsulated in novel liposomes prepared from the polar lipids of various Archaeobacteria elicits rapid and prolonged specific protective immunity against infection with the facultative intracellular pathogen, Listeria monocytogenes.
J. Conlan (2001)
10.1021/JO9822028
Synthetic Approaches to Novel Archaeal Tetraether Glycolipid Analogues.
Grégory Lecollinet (1999)
10.1016/S0040-4039(97)10186-1
Synthesis of archaebacterial lipid C20 chirons
W. Berkowitz (1997)
10.3109/08982100903402962
Archaeosomes as carriers for topical delivery of betamethasone dipropionate: in vitro skin permeation study
Ana González‐Paredes (2010)
10.1016/S0005-2760(96)00163-4
Identification of β-l-gulose as the sugar moiety of the main polar lipid of Thermoplasma acidophilum
M. Swain (1997)
10.1016/0163-7827(88)90011-2
The lipids of archaebacteria.
M. De Rosa (1988)
10.1093/glycob/cwn038
Adjuvant potential of archaeal synthetic glycolipid mimetics critically depends on the glyco head group structure.
G. Sprott (2008)
10.1016/J.BIOCHI.2009.01.006
Archaeal tetraether bipolar lipids: Structures, functions and applications.
A. Jacquemet (2009)
10.1016/j.carres.2009.10.011
Development of new glycosylation methodologies for the synthesis of archaeal-derived glycolipid adjuvants.
D. Whitfield (2010)
10.1016/0079-6832(77)90011-8
The phytanyl ether-linked polar lipids and isoprenoid neutral lipids of extremely halophilic bacteria.
M. Kates (1978)
10.1186/1472-6750-9-71
Archaeosomes made of Halorubrum tebenquichense total polar lipids: a new source of adjuvancy
Raul O Gonzalez (2009)
10.1016/S0376-7388(01)00771-2
Structure and permeability properties of biomimetic membranes of bolaform archaeal tetraether lipids
A. Gliozzi (2002)
10.1080/08982100802129232
Structural Characterization of Archaeal Lipid Mucosal Vaccine Adjuvant and Delivery (AMVAD) Formulations Prepared by Different Protocols and Their Efficacy Upon Intranasal Immunization of Mice
G. B. Patel (2008)
10.1081/LPR-120016712
SAFETY OF ARCHAEOSOME ADJUVANTS EVALUATED IN A MOUSE MODEL*
G. B. Patel (2002)
10.1111/j.1462-2920.2009.01999.x
Detection of microbial biomass by intact polar membrane lipid analysis in the water column and surface sediments of the Black Sea.
F. Schubotz (2009)
10.1016/0005-2760(94)90069-8
Tetraether lipids of Methanospirillum hungatei with head groups consisting of phospho-N,N-dimethylaminopentanetetrol, phospho-N,N,N-trimethylaminopentanetetrol, and carbohydrates.
G. Sprott (1994)
10.1016/j.vaccine.2008.02.026
Archaeosome adjuvants: immunological capabilities and mechanism(s) of action.
L. Krishnan (2008)
10.1016/0031-9422(80)85120-X
Effects of temperature on ether lipid composition of Caldariella acidophila
M. Rosa (1980)
10.1016/S0009-3084(98)00004-8
Calorimetry of archaeal tetraether lipid—indication of a novel metastable thermotropic phase in the main phospholipid from Thermoplasma acidophilum cultured at 59°C
M. Ernst (1998)
10.1016/0005-2760(77)90042-X
Long-chain diglycerol tetraethers from Thermoplasma acidophilum.
T. Langworthy (1977)
10.1074/jbc.M600369200
Salt Tolerance of Archaeal Extremely Halophilic Lipid Membranes*
B. Tenchov (2006)
10.3109/08982100903544151
Isopranoid- and dipalmitoyl-aminophospholipid adjuvants impact differently on longevity of CTL immune responses
C. Dicaire (2010)
10.1016/j.bbrc.2010.03.041
Investigation of archaeosomes as carriers for oral delivery of peptides.
Z. Li (2010)
10.1007/s00253-009-2102-9
Structural and physicochemical properties of polar lipids from thermophilic archaea
N. P. Ulrih (2009)
10.1139/M96-027
Heat sterilization of archaeal liposomes
C. Choquet (1996)
10.1080/0738-859991229170
Archaeobacterial ether lipid liposomes (archaeosomes) as novel vaccine and drug delivery systems.
Patel Gb (1999)
10.1007/BF01929909
Biology of halophilic bacteria, Part II
M. Kates (2005)
10.1128/JB.186.24.8508-8515.2004
Cold adaptation in the Antarctic Archaeon Methanococcoides burtonii involves membrane lipid unsaturation.
D. Nichols (2004)
10.1016/0005-2760(87)90029-4
Structures of diether lipids of Methanospirillum hungatei containing novel head groups N,N-diniethylamino- and N,N,N-trimethylaminopentanetetrol
G. Ferrante (1987)
10.1074/JBC.M103265200
Molecular Mechanisms of Water and Solute Transport across Archaebacterial Lipid Membranes*
J. Mathai (2001)
10.1007/BF00762348
Structures of archaebacterial membrane lipids
G. Sprott (1992)
10.1128/JB.175.4.1191-1197.1993
Freeze-fracture planes of methanogen membranes correlate with the content of tetraether lipids.
T. Beveridge (1993)
10.1080/10611860410001670044
Archaeosomes as Self-adjuvanting Delivery Systems for Cancer Vaccines*
L. Krishnan (2003)
10.1016/S0005-2760(98)00157-X
A novel phosphoglycolipid archaetidyl(glucosyl)inositol with two sesterterpanyl chains from the aerobic hyperthermophilic archaeon Aeropyrum pernix K1.
H. Morii (1999)
10.1016/S0009-3084(97)00044-3
Slow fusion of liposomes composed of membrane-spanning lipids.
M. Elferink (1997)
10.1093/OXFORDJOURNALS.JBCHEM.A121942
Structure determination of a quartet of novel tetraether lipids from Methanobacterium thermoautotrophicum.
M. Nishihara (1987)
10.1016/j.chemphyslip.2011.01.005
Stability of diether C(25,25) liposomes from the hyperthermophilic archaeon Aeropyrum pernix K1.
D. Gmajner (2011)
10.1016/0005-2760(88)90277-9
Structure of the major polar lipids isolated from the aceticlastic methanogen, Methanothrix concilii GP6
G. Ferrante (1988)



This paper is referenced by
ORF79 - a putative regulator of gene expression in ɸCH1 and analysis of gp3452 as a tail fibre protein of Nab. magadii
Judith Beraha (2013)
Dynamic Regulation of Metabolism in Archaea
Horia Todor (2015)
10.13016/NZHS-QLT5
LIPID FORCE FIELD PARAMETERIZATION FOR IMPROVED MODELING OF ION-LIPID INTERACTIONS AND ETHER LIPIDS, AND EVALUATION OF THE EFFECTS OF LONG-RANGE LENNARD-JONES INTERACTIONS ON ALKANES
Alison N Leonard (2019)
PROKARYOTIC MICROORGANISMS, VIRUSES, AND ANTIMICROBIAL AGENTS FROM HYPERSALINE ENVIRONMENTS
Nina S. Atanasova (2013)
10.1134/S1990747814050067
Isoprenoid lipid chains increase membrane resistance to pore formation
P. V. Panov (2014)
Temperature and salinity controls on methanogenesis in an artificial freshwater lake (Cardiff Bay, Wales)
Miriam Frances Olivier (2016)
Title Water Permeability and Elastic Properties of an Archaea Inspired Lipid Synthesized by Click Chemistry Permalink
Steven Nguyen (2018)
10.1002/9781118391815.CH3
Microbial Natural Products
S. Sánchez (2012)
10.1371/journal.pone.0150185
Ultradeformable Archaeosomes for Needle Free Nanovaccination with Leishmania braziliensis Antigens
L. Higa (2016)
10.1098/rsif.2014.0232
Biomimetic interfaces based on S-layer proteins, lipid membranes and functional biomolecules
B. Schuster (2014)
10.1016/bs.aivir.2014.11.005
Comparison of lipid-containing bacterial and archaeal viruses.
Nina S. Atanasova (2015)
10.1016/B978-0-12-800047-2.00002-4
The Lipids of Biological Membranes
P. Yeagle (2016)
10.1201/9781315381909-14
The Diversity of Microbial Extremophiles
Thiago Bruce Rodrigues (2016)
10.1371/journal.pone.0155287
Biological Membranes in Extreme Conditions: Simulations of Anionic Archaeal Tetraether Lipid Membranes
Luis Felipe Pineda De Castro (2016)
10.1139/CJC-2016-0252
A membrane-spanning macrocyclic bolaamphiphile lipid mimic of archaeal lipids
G. Mitchell (2017)
Semantic Scholar Logo Some data provided by SemanticScholar