Online citations, reference lists, and bibliographies.
← Back to Search

Some Non-mucin Components Of Mucus And Their Possible Biological Roles.

J. Clamp, J. M. Creeth
Published 1984 · Chemistry, Medicine

Cite This
Download PDF
Analyze on Scholarcy
Share
Non-mucin components have essential roles in the protective functions of mucous secretions. Secretory IgA (SIgA) antibodies probably act by blocking the attachment of pathogenic microorganisms to mucosal cells. In addition SIgA1 may render bacteria more 'mucophilic', possibly by virtue of the 'mucus-like' stretch that the immunoglobulin molecule possesses. Lysozyme will attack cell walls of susceptible bacteria. As the enzyme associates strongly with mucus glycoproteins the mucus layer is provided with powerful bactericidal properties. Lactoferrin, normally unsaturated, sequesters any free iron in secretions, so exerting a bacteriostatic action on iron-requiring microorganisms. In addition it may protect mucus glycoproteins from iron-catalysed active oxygen species. This mucoprotective action would be overcome during infections. Attention is also directed towards a possible copper-mediated limited degradation by hydrogen peroxide. Surfactants and free lipid have long been recognized as components of normal bronchial mucus. For example, some lipid is tightly but non-covalently bound to a hydrophobic region of bronchial mucin. More intriguing is the presence of small amounts of covalently bound lipid in normal human gastric mucin. In addition, normal human gastric mucus contains significant amounts of a galactose-rich polysaccharide. The function of this is not known but it may act as a cross-linking strand in the mucus gel structure or as a renewable cell membrane component, perhaps interacting between glycocalyx and the mucus layer.
This paper references
10.1016/0005-2795(72)90283-8
Lactoferrin and transferrin: a comparative study.
P. Aisen (1972)
10.1136/jcp.26.11.852
Quantitative immunoelectrophoretic analysis of the plasma proteins in the sol phase of sputum from patients with chronic bronchitis
H. Ryley (1973)
10.1016/0304-4165(83)90005-3
Activation of bronchial mucin proteolysis by 4-aminophenylmercuric acetate and disulphide bond reducing agents.
N. Houdret (1983)
Mucosal barrier mechanisms. Interplay between secretory IgA (SIgA), IgG and mucins on the surface properties and association of salmonellae with intestine and granulocytes.
K. Magnusson (1982)
10.1021/JA00901A029
Cleavage of Histidyl Peptide Bonds by N-Bromosuccinimide
Shmuel. Shaltiel (1963)
10.1016/0304-4165(73)90280-8
Iron binding of gastric mucins.
A. Bella (1973)
Mucosal and glandular distribution of immunoglobulin components: differential localization of free and bound SC in secretory epithelial cells.
P. Brandtzaeg (1974)
10.1021/BI00533A017
Isolation, purification, and properties of respiratory mucus glycoproteins.
H. Woodward (1982)
The interaction of ribonuclease with metal ions. I. Studies of cupric and zinc ions and the effect of cytidylic acid.
E. Breslow (1966)
Intestinal goblet cell mucus release. II. In vivo stimulation by antigen in the immunized rat.
A. Lake (1979)
10.1177/00220345820610120101
Adherence of Streptococcus sanguis to salivary mucin bound to glass.
M. Stinson (1982)
10.1136/gut.20.2.121
Absorption of antigens after oral immunisation and the simultaneous induction of specific systemic tolerance.
E. T. Swarbrick (1979)
10.3109/00365516509077057
Studies on the Serum γA-Globulin Level III. The Frequency of A-γA-Globulinemia
R. Bachmann (1965)
10.1016/0006-291X(83)90464-3
Isolation of fatty acids covalently bound to the gastric mucus glycoprotein of normal and cystic fibrosis patients.
A. Slomiany (1983)
10.1016/S0065-2776(08)60550-7
Cellular aspects of immunoglobulin A.
M. Lamm (1976)
10.1084/JEM.153.4.968
Role of serum IgA. Hepatobiliary transport of circulating antigen
M. Russell (1981)
Differences in inhibition of the growth of commensal and enteropathogenic strains of Escherichia coli by lactotransferrin and secretory immunoglobulin A isolated from human milk.
S. Stephens (1980)
10.1042/BJ2150421
The presence of polysaccharide in normal human gastric mucus.
J. Clamp (1983)
Protection against enteric bacterial infection by secretory IgA antibodies.
E. S. Fubara (1973)
Pulmonary host defenses. I. Analysis of protein and lipids in bronchial secretions and antibody responses after vaccination with pseudomonas aeruginosa.
H. Reynolds (1973)
10.1056/NEJM197803232981205
Oxygen-Dependent Microbial Killing by Phagocytes
B. Babior (1978)
Secretory component-dependent hepatic transport of IgA antibody-antigen complexes.
D. Socken (1981)
10.1021/JA00776A047
Metal catalysis in the depolymerization of hyaluronic acid by autoxidants.
M. Harris (1972)
10.1073/PNAS.74.6.2301
Location and structural significance of the oligosaccharides in human Ig-A1 and IgA2 immunoglobulins.
A. Toraño (1977)
Immune exclusion and mucus trapping during the rapid expulsion of Nippostrongylus brasiliensis from primed rats.
H. Miller (1981)
Character of azurophil and specific granules purified from human polymorphonuclear leukocytes.
J. Spitznagel (1974)
10.1016/0006-2952(82)90136-8
The role of the superoxide and hydroxyl radicals in the degradation of DNA and deoxyribose induced by a copper-phenanthroline complex.
J. Gutteridge (1982)
10.1152/PHYSREV.1951.31.2.131
Mucoproteins in relation to virus action.
F. Burnet (1951)
10.1084/JEM.158.2.559
Identification of an active disaccharide unit of a glycoconjugate receptor for pneumococci attaching to human pharyngeal epithelial cells
B. Andersson (1983)
10.1007/978-1-4615-9254-9_38
The intestinal mucus barrier to parasites and bacteria.
G. B. Lee (1982)
The lateral nasal gland of dog: its structure and secretory content.
D. R. Adams (1981)
10.1016/S0016-5085(76)80046-7
Studies on Translocation of Immunoglobulins Across Intestinal Epithelium: II. Immunoelectron-microscopic localization of immunoglobulins and secretory component in human intestinal mucosa
W. R. Brown (1976)
10.1128/IAI.41.1.339-344.1983
Evidence for mucins and sialic acid as receptors for Pseudomonas aeruginosa in the lower respiratory tract.
R. Ramphal (1983)
10.1177/29.6.6788837
Localization of low molecular weight protease inhibitor in serous secretory cells of the respiratory tract.
J. Kramps (1981)
10.1126/SCIENCE.877559
Stimulation by immune complexes of mucus release from goblet cells of the rat small intestine.
W. Walker (1977)
Different cell-surface receptor determinants of antigenically similar influenza virus hemagglutinins.
S. M. Carroll (1981)
10.1016/S0016-5085(19)34231-3
Pattern of Secretion of Paneth Cells of the Small Intestine of Mice
J. Trier (1967)
10.1515/BCHM2.1977.358.1.583
Isolation and partial characterization of a low molecular weight acid stable protease inhibitor from human bronchial secretion.
K. Ohlsson (1977)
10.1042/BST0051579
The relationship between secretory immunoglobulin A and mucus [proceedings].
J. Clamp (1977)
10.1042/BJ1810717
An interaction between lysozyme and mucus glycoproteins. Implications for density-gradient separations.
J. M. Creeth (1979)
Anaphylactic release of intestinal goblet cell mucus.
A. Lake (1980)
10.1042/BJ1990263
Superoxide-dependent formation of hydroxyl radicals in the presence of iron salts. Detection of 'free' iron in biological systems by using bleomycin-dependent degradation of DNA.
J. Gutteridge (1981)
10.3109/00365518009095588
The importance of lysozyme for the viscosity of sputum from patients with chronic obstructive lung disease.
A. O. Jenssen (1980)
10.1016/0014-5793(78)80116-1
Superoxide‐dependent production of hydroxyl radical catalyzed by iron—EDTA complex
J. McCord (1978)
10.1177/22.6.401
ULTRASTRUCTURAL IMMUNOCYTOCHEMICAL LOCALIZATION OF LYSOZYME IN THE PANETH CELLS OF MAN
S. Erlandsen (1974)
10.1515/bchm2.1972.353.1.221
Isolierung und Charakterisierung eines Proteaseninhibitors aus menschlichem Bronchialsekret
K. Hochstrasser (1972)
10.1016/0006-291X(83)90328-5
Escherichia coli strains binding neuraminyl α2–3 galactosides
J. Parkkinen (1983)
10.1042/BJ2110323
Studies of the limited degradation of mucus glycoproteins. The effect of dilute hydrogen peroxide.
J. M. Creeth (1983)
10.1016/0003-9861(72)90086-0
Rat small intestinal mucin: isolation and characterization of a water-soluble mucin fraction.
A. Bella (1972)
10.1172/JCI110042
Lactoferrin enhances hydroxyl radical production by human neutrophils, neutrophil particulate fractions, and an enzymatic generating system.
D. Ambruso (1981)
10.3109/01902148009065462
Inactivation of bronchial mucous proteinase inhibitor by cigarette smoke and phagocyte-derived oxidants.
H. Carp (1980)
10.1016/0014-5793(78)80409-8
Superoxide‐dependent formation of hydroxyl radicals in the presence of iron salts
B. Halliwell (1978)



This paper is referenced by
Interactions of Mucins with Biopolymers and Drug Delivery Particles
O. Svensson (2008)
Bacterial Adaptation and Mucosal Defenses
M. S. Cohen (1992)
Immunological study of proteins and mucosubstance in saline soluble human ocular mucus.
C. Chao (1987)
10.1007/s00345-004-0436-6
Mucus production after transposition of intestinal segments into the urinary tract
J. N'dow (2004)
10.1167/iovs.61.12.9
Lactoferrin Concentration in Human Tears and Ocular Diseases: A Meta-Analysis
Erika Ponzini (2020)
10.1080/17471060801931211
Role of intestinal mucus and pancreatic proteases in the pathogenesis of trauma–hemorrhagic shock-induced gut barrier failure and multiple organ dysfunction syndrome
Susan M. Sharpe (2008)
Prasanna Sakha Development of Microfluidic Applications to Study the Role of Kainate Receptors in Synaptogenesis
Neha Shrestha (2016)
10.1016/0308-8146(94)90189-9
Mechanisms of gastrointestinal absorption: dietary minerals and the influence of beverage ingestion
J. Powell (1994)
10.1007/BF01923598
A study of macromolecular diffusion through native porcine mucus
M. Desai (2005)
10.1016/J.EARLHUMDEV.2007.09.009
Gastrointestinal maturation and implications for infant feeding.
J. Neu (2007)
10.1016/B978-0-12-805417-8.00008-1
Immune Responses in the Upper Respiratory Tract in Health and Disease
Derek B McMahon (2018)
10.1007/BF00305724
Keratin-like components of gland thread cells modulate the properties of mucus from hagfish (Eptatretus stouti)
E. Koch (2004)
10.3109/9780203008966-12
Nerve–Mast Cell Interactions—Partnership in Health and Disease
J. Bienenstock (2003)
10.1016/s0079-6336(96)80006-4
Carbohydrate histochemistry of vertebrate taste organs.
M. Witt (1996)
10.1053/J.SEMPEDSURG.2005.05.001
Intestinal innate immunity: how does it relate to the pathogenesis of necrotizing enterocolitis.
J. Neu (2005)
Regulation of metal absorption in the
R P Thompson M W Whitehead ()
10.1097/ICO.0000000000000435
Lactoferrin-Loaded Contact Lenses: Eye Protection Against Oxidative Stress
V. Pastori (2015)
10.1002/ar.1092310310
Immunohistochemical localization of components of the immune barrier in the olfactory mucosae of salamanders and rats
M. L. Getchell (1991)
10.1007/BF01644188
The role of bacterial adhesion in cystic fibrosis including the Staphylococcal aspect
R. Ramphal (2005)
10.1016/0169-409X(93)90010-2
The effect of gastro-intestinal mucus on drug absorption
A. Macadam (1993)
10.1016/S0928-0987(99)00032-9
Chitosans as absorption enhancers of poorly absorbable drugs. 3: Influence of mucus on absorption enhancement.
N. G. Schipper (1999)
10.1016/J.FREERADBIOMED.2007.05.023
Action of reactive oxygen species on colonic mucus secretions.
I. Brownlee (2007)
Oxidative Stress and Dry Eye in Cross-Sectional Clinical Studies
Sophia Seen (2018)
10.1111/j.1699-0463.1990.tb01002.x
Adhesion of Yersinia enterocolitica to human epithelial cell lines and to rabbit and human small intestinal tissue
A. Pærregaard (1990)
10.1128/IAI.64.12.5417-5420.1996
Adhesion of Pseudomonas aeruginosa to respiratory mucins and expression of mucin-binding proteins are increased by limiting iron during growth.
A. Scharfman (1996)
10.1136/gut.39.5.625
Regulation of metal absorption in the gastrointestinal tract.
M. Whitehead (1996)
10.1016/S0095-5108(03)00064-2
Update on host defense and immunonutrients.
J. Neu (2002)
10.1111/aos.13526
Dry eye disease and oxidative stress
Sophia Seen (2018)
10.1146/ANNUREV.PH.52.030190.000525
The serous cell.
C. Basbaum (1990)
10.2508/CHIKUSAN.71.329
Lactoferrin: A Marvelous Protein in Milk
K. Shimazaki (2000)
10.1002/9781118794203.CH04
Gastrointestinal Mucosa and Mucus
F. J. O. Varum (2014)
10.1016/j.jaci.2015.10.009
Chronic rhinosinusitis pathogenesis.
W. Stevens (2015)
See more
Semantic Scholar Logo Some data provided by SemanticScholar