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The Use Of Dendrimers To Optimize The Physicochemical And Therapeutic Properties Of Drugs

N. Stieger, W. Liebenberg, M. Aucamp, M. M. Villiers
Published 2012 · Chemistry

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10.1002/JBM.A.31122
Folate coupled poly(ethyleneglycol) conjugates of anionic poly(amidoamine) dendrimer for inflammatory tissue specific drug delivery.
D. Chandrasekar (2007)
10.1158/1535-7163.MCT-05-0325
Targeted delivery of methotrexate to epidermal growth factor receptor–positive brain tumors by means of cetuximab (IMC-C225) dendrimer bioconjugates
G. Wu (2006)
10.1208/pt060367
Poly(amidoamine) (PAMAM) dendritic nanostructures for controlled sitespecific delivery of acidic anti-inflammatory active ingredient
Abhay Asthana (2008)
10.1002/jps.22428
Polyamidoamine dendrimers can improve the pulmonary absorption of insulin and calcitonin in rats.
Zhengqi Dong (2011)
10.1002/chem.200800584
Dendrimers and DNA: combinations of two special topologies for nanomaterials and biology.
A. Caminade (2008)
10.1016/j.ccr.2008.09.009
Leaving home early: reexamination of the canonical models of tumor progression.
Robert A. Weinberg (2008)
10.1021/NL005502P
Dendrimer−Silver Complexes and Nanocomposites as Antimicrobial Agents
L. Balogh (2001)
10.1021/BC060240P
Dendrimer versus linear conjugate: Influence of polymeric architecture on the delivery and anticancer effect of paclitaxel.
J. Khandare (2006)
10.2165/00003088-198005020-00003
Clinical Pharmacokinetics of Quinidine
H. Ochs (1980)
10.2174/156720107779314794
PEGylated dendritic architecture for development of a prolonged drug delivery system for an antitubercular drug.
Palanirajan Vijayaraj Kumar (2007)
10.1021/bm9000298
Unexpected in vivo anti-inflammatory activity observed for simple, surface functionalized poly(amidoamine) dendrimers.
A. Chauhan (2009)
10.1001/ARCHOPHT.1961.00960010338007
Tropicamide: comparative cycloplegic effects.
B. C. Gettes (1961)
10.1016/S1359-6446(04)03276-3
Dendrimers and dendritic polymers in drug delivery.
E. Gillies (2005)
10.1016/j.addr.2009.11.021
Surface modifications of nanocarriers for effective intracellular delivery of anti-HIV drugs.
S. Gunaseelan (2010)
10.1097/01.hjh.0000160223.94220.29
Effect of long-acting nifedipine on mortality and cardiovascular morbidity in patients with symptomatic stable angina and hypertension: the ACTION trial
J. Lubsen (2005)
10.1016/S1461-5347(00)00247-9
Recent technological advances in oral drug delivery - a review.
Sastry (2000)
10.1016/j.jconrel.2008.05.003
Recent progress in tumor pH targeting nanotechnology.
E. Lee (2008)
10.1016/S0002-9343(97)00207-6
Epidemiology of nonsteroidal anti-inflammatory drug-associated gastrointestinal injury.
M. Griffin (1998)
10.1002/JPS.21155
Enhanced oral bioavailability of doxorubicin in a dendrimer drug delivery system.
Weilun Ke (2008)
10.1002/(SICI)1521-3773(19981102)37:20<2754::AID-ANIE2754>3.0.CO;2-3
Polyvalent Interactions in Biological Systems: Implications for Design and Use of Multivalent Ligands and Inhibitors.
M. Mammen (1998)
10.1111/J.1525-1373.2000.22525.X
Nitric oxide donors.
T. Yamamoto (2000)
10.3109/10611869409015898
Selective targeting of malignant cells with cytotoxin-folate conjugates.
C. P. Leamon (1994)
Biotinylated poly(amido)amine (PAMAM) dendrimers as carriers for drug delivery to ovarian cancer cells in vitro.
V. Yellepeddi (2009)
10.1016/0005-2736(94)00235-H
Folate-mediated tumor cell targeting of liposome-entrapped doxorubicin in vitro.
R. Lee (1995)
10.1016/J.TUBE.2003.08.003
M. tuberculosis persistence, latency, and drug tolerance.
J. E. Gomez (2004)
10.1016/J.ADDR.2005.09.019
Dendrimer biocompatibility and toxicity.
R. Duncan (2005)
10.1016/S0079-6468(08)70024-9
Antimicrobial activity and action of silver.
A. Russell (1994)
10.1021/BC9500709
Synthesis, purification, and tumor cell uptake of 67Ga-deferoxamine--folate, a potential radiopharmaceutical for tumor imaging.
S. Wang (1996)
10.1158/0008-5472.CAN-04-3921
Nanoparticle targeting of anticancer drug improves therapeutic response in animal model of human epithelial cancer.
J. Kukowska-Latallo (2005)
10.1208/pt060363
Effect of polyamidoamine (PAMAM) dendrimers on the in vitro release of water-insoluble nifedipine from aqueous gels
B. Devarakonda (2008)
10.1023/A:1020398624602
Design and Function of a Dendrimer-Based Therapeutic Nanodevice Targeted to Tumor Cells Through the Folate Receptor
A. Quintana (2004)
10.1016/0169-409X(89)90013-6
Soluble macromolecular carriers for the delivery of antitumour drugs
H. Sezaki (1989)
10.1016/J.ADDR.2004.01.012
Folate receptor-mediated targeting of therapeutic and imaging agents to activated macrophages in rheumatoid arthritis.
Chrystal M. Paulos (2004)
10.1016/J.IJPHARM.2007.05.039
Effect of pH on the solubility and release of furosemide from polyamidoamine (PAMAM) dendrimer complexes.
B. Devarakonda (2007)
10.1016/S0079-6700(00)00045-9
Synthesis of polysaccharides having specific biological activities
T. Yoshida (2001)
10.1016/0091-6749(89)90381-3
Penetration of corticosteroids into the lung: evidence for a difference between methylprednisolone and prednisolone.
P. Vichyanond (1989)
10.1056/NEJM199704103361501
Malignant melanoma in patients treated for psoriasis with methoxsalen (psoralen) and ultraviolet A radiation (PUVA). The PUVA Follow-Up Study.
R. Stern (1997)
10.1097/CAD.0b013e3282f28842
Preclinical antitumor efficacy evaluation of dendrimer-based methotrexate conjugates
A. Myc (2008)
10.1016/J.ADDR.2005.09.018
Dendrimers in biomedical applications--reflections on the field.
Sönke Svenson (2005)
10.1016/S0040-4020(03)00461-7
Peptide-functionalized polyphenylene dendrimers
Andreas Herrmann (2003)
Evaluation of a novel colonic delivery device in vivo
E. Quadros (1995)
10.1016/J.IJPHARM.2005.05.014
Preparation and characterization of nanocrystals for solubility and dissolution rate enhancement of nifedipine.
J. Hecq (2005)
10.1016/S1569-2582(97)80078-5
Chapter 16 Cholinergic Agents
Vijay C. Swamy (1997)
10.1097/00005373-199706000-00003
Incidence of bacteremia after burn wound manipulation in the early postburn period.
D. Mozingo (1997)
10.1016/0006-2952(86)90769-0
Antidepressant biochemical profile of the novel bicyclic compound Wy-45,030, an ethyl cyclohexanol derivative.
E. Muth (1986)
10.1016/j.ijpharm.2010.07.019
PAMAM dendrimers as solubilizers and hosts for 8-methoxypsoralene enabling transdermal diffusion of the guest.
K. Borowska (2010)
10.1186/1477-3155-8-1
Mode of antiviral action of silver nanoparticles against HIV-1
H. H. Lara (2010)
10.1016/S0168-3659(99)00248-5
Tumor vascular permeability and the EPR effect in macromolecular therapeutics: a review.
H. Maeda (2000)
10.1007/BF02244986
Plasma protein binding of risperidone and its distribution in blood
G. Mannens (2005)
Distribution of the folate receptor GP38 in normal and malignant cell lines and tissues.
S. Weitman (1992)
10.1016/j.ijpharm.2010.04.021
Effects of polyamidoamine (PAMAM) dendrimers on the nasal absorption of poorly absorbable drugs in rats.
Zhengqi Dong (2010)
10.1038/372150A0
Oligosaccharide ligands for NKR-P1 protein activate NK cells and cytotoxicity
K. Bezouška (1994)
10.1016/S0927-7757(02)00389-8
Sulfonamide based pH-sensitive polymeric micelles: physicochemical characteristics and pH-dependent aggregation
S. K. Han (2003)
10.1016/S0169-409X(01)00184-3
Transcytosis of nanoparticle and dendrimer delivery systems: evolving vistas.
A. Florence (2001)
10.1186/AR395
Autoantibody systems in rheumatoid arthritis: specificity, sensitivity and diagnostic value
M. van Boekel (2002)
10.1021/jp9039176
Association of a weakly acidic anti-inflammatory drug (ibuprofen) with a poly(amidoamine) dendrimer as studied by molecular dynamics simulations.
I. Tanis (2009)
10.2165/00003088-199018050-00004
Furosemide (Frusemide) A Pharmacokinetic/Pharmacodynamic Review (Part I)
L. L. Boles Ponto (1990)
10.1038/nri1733
Monocyte and macrophage heterogeneity
S. Gordon (2005)
10.1007/s11095-010-0141-7
Nanoparticle-Mediated Brain-Specific Drug Delivery, Imaging, and Diagnosis
H. Yang (2010)
10.1016/J.JCIS.2004.02.012
Silver nanoparticles as antimicrobial agent: a case study on E. coli as a model for Gram-negative bacteria.
I. Sondi (2004)
10.1016/J.JINORGBIO.2004.07.009
Vitamin-mediated targeting as a potential mechanism to increase drug uptake by tumours.
G. Russell-Jones (2004)
10.2165/00003495-199753040-00008
Lamivudine. A review of its antiviral activity, pharmacokinetic properties and therapeutic efficacy in the management of HIV infection.
C. Perry (1997)
10.1016/J.CARBPOL.2010.01.031
Sulfated oligosaccharide cluster with polylysine core scaffold as a new anti-HIV dendrimer
S. Han (2010)
10.1016/J.EJMECH.2005.06.010
Dendrimers as potential drug carriers. Part I. Solubilization of non-steroidal anti-inflammatory drugs in the presence of polyamidoamine dendrimers.
Cheng Yiyun (2005)
10.1016/S0040-4020(03)00431-9
A new class of protein mimics: preparation and electrophoretic properties of polycationic β-alanine-based dendrimers
H. Chow (2003)
10.1016/J.TETLET.2006.08.110
Synthesis of salicylate dendritic prodrugs
Shengzhuang Tang (2006)
10.1073/PNAS.88.13.5572
Delivery of macromolecules into living cells: a method that exploits folate receptor endocytosis.
C. P. Leamon (1991)
10.1016/j.ejmech.2008.06.012
PEGylated PPI dendritic architectures for sustained delivery of H2 receptor antagonist.
V. Gajbhiye (2009)
10.1023/B:PHAR.0000026823.82950.ff
Nasal route and drug delivery systems
S. Türker (2004)
10.1097/00005344-199011000-00019
Quinidine/Quinine: Stereospecific Electrophysiologic and Antiarrhythmic Effects in a Canine Model of Ventricular Tachycardia
R. Sheldon (1990)
10.1007/s11095-008-9769-y
Synthesis and Evaluation of Pegylated Dendrimeric Nanocarrier for Pulmonary Delivery of Low Molecular Weight Heparin
Shuhua Bai (2008)
10.1006/SCBI.2001.0416
Critical determinants of metastasis.
I. Fidler (2002)
10.1189/jlb.0608371
Anti‐inflammatory and immunosuppressive activation of human monocytes by a bioactive dendrimer
S. Fruchon (2009)
10.1016/J.TET.2004.09.033
Synthesis of new unsymmetrical optically active (s)-(+)-naproxen dendrimers
S. K. Potluri (2004)
10.2165/00003495-198938040-00005
Ranitidine. An updated review of its pharmacodynamic and pharmacokinetic properties and therapeutic use in peptic ulcer disease and other allied diseases.
S. Grant (1989)
10.1038/nrc1098
The pathogenesis of cancer metastasis: the 'seed and soil' hypothesis revisited
I. Fidler (2003)
Silver nanoparticles inhibit hepatitis B virus replication.
L. Lu (2008)
10.1016/0163-7258(94)90006-X
Targeting of drugs and vaccines to the gut.
I. Wilding (1994)
10.1111/J.1600-0420.2007.00885.X
Topical and systemic absorption in delivery of dexamethasone to the anterior and posterior segments of the eye.
H. Sigurdsson (2007)
10.1016/j.ejmech.2010.08.006
Poly propyl ether imine (PETIM) dendrimer: a novel non-toxic dendrimer for sustained drug delivery.
S. Jain (2010)
10.1016/J.ADDR.2005.09.012
Dendrimer-drug interactions.
A. D’Emanuele (2005)
10.1039/B515624F
Molecular heterogeneity analysis of poly(amidoamine) dendrimer-based mono- and multifunctional nanodevices by capillary electrophoresis.
X. Shi (2006)
10.1016/S0939-6411(00)00075-8
HPMA copolymer-anticancer drug conjugates: design, activity, and mechanism of action.
J. Kopeček (2000)
10.1002/JPS.20745
Transdermal delivery of nonsteroidal anti-inflammatory drugs mediated by polyamidoamine (PAMAM) dendrimers.
Cheng Yiyun (2007)
10.1158/1535-7163.MCT-06-0359
Macromolecular delivery of 5-aminolaevulinic acid for photodynamic therapy using dendrimer conjugates
S. Battah (2007)
10.1021/mp100105c
Anionic amino acid dendrimer-trastuzumab conjugates for specific internalization in HER2-positive cancer cells.
Takuya Miyano (2010)
10.1016/S0168-3659(02)00461-3
Dendrimers conjugates for colonic delivery of 5-aminosalicylic acid.
R. Wiwattanapatapee (2003)
10.1016/J.BBAGEN.2006.12.007
Targeting potential and anti-HIV activity of lamivudine loaded mannosylated poly (propyleneimine) dendrimer.
T. Dutta (2007)
10.1016/S0168-3659(98)00120-5
In vitro release of 5-fluorouracil with cyclic core dendritic polymer.
R. Zhuo (1999)
10.1002/JBM.A.30220
Extended release of a novel antidepressant, venlafaxine, based on anionic polyamidoamine dendrimers and poly(ethylene glycol)-containing semi-interpenetrating networks.
H. Yang (2005)
10.1056/NEJM198601163140304
A controlled trial of methylprednisolone in the emergency treatment of acute asthma.
B. Littenberg (1986)
10.1016/S0168-3659(97)00253-8
Nasal delivery of peptides: an in vitro cell culture model for the investigation of transport and metabolism in human nasal epithelium.
T. Kissel (1998)
10.1021/bm7011746
S-nitrosothiol-modified dendrimers as nitric oxide delivery vehicles.
N. Stasko (2008)
10.1023/A:1026170830782
Starlike vs. Classic Macromolecular Prodrugs: Two Different Antibody-Targeted HPMA Copolymers of Doxorubicin Studied in Vitro and in Vivo as Potential Anticancer Drugs
M. Jelínková (2004)
10.1159/000093928
Silver in health care: antimicrobial effects and safety in use.
A. Lansdown (2006)
10.1615/CRITREVTHERDRUGCARRIERSYST.V14.I4.20
Pulmonary drug delivery: physiologic and mechanistic aspects.
J. Yu (1997)
The effect of posture on nasal clearance of bioadhesive starch microspheres
D. Ridley (1995)
10.1021/JO0344438
"Lego" chemistry for the straightforward synthesis of dendrimers.
V. Maraval (2003)
10.3109/10717549509031355
Oral colon-specific drug delivery: a review
G. Mooter (1995)
10.1016/J.JCONREL.2004.09.015
Poly(amidoamine) dendrimers as ophthalmic vehicles for ocular delivery of pilocarpine nitrate and tropicamide.
Th F Vandamme (2005)
10.1248/CPB.59.63
Drug pH-sensitive release in vitro and targeting ability of polyamidoamine dendrimer complexes for tumor cells.
Dan Liu (2011)
10.1016/j.drudis.2010.01.009
Dendrimer-based drug and imaging conjugates: design considerations for nanomedical applications.
A. R. Menjoge (2010)
10.1016/S0923-1811(96)00561-0
Psoralens percutaneous permeation across the human whole skin and the epidermis in respect to their polarity (in vitro study).
A. Saied (1997)
10.2165/00003495-200059060-00004
Clinical Pharmacology, Therapeutic Use and Potential of COMT Inhibitors in Parkinson’s Disease
S. Kaakkola (2012)
10.1016/S0168-3659(01)00331-5
PEG drugs: an overview.
R. Greenwald (2001)
10.1073/PNAS.92.8.3318
Delivery of antisense oligodeoxyribonucleotides against the human epidermal growth factor receptor into cultured KB cells with liposomes conjugated to folate via polyethylene glycol.
S. Wang (1995)
10.1056/NEJMra072367
Oncogenes and cancer.
C. Croce (2008)
10.1517/17425247.5.4.371
Advances in PEGylation of important biotech molecules: delivery aspects
S. Ryan (2008)
10.1016/0883-9441(88)90098-6
Intravenous methylprednisolone efficacy in status asthmaticus of childhood.
R. Younger (1987)
10.1039/c0cs00097c
Design of biocompatible dendrimers for cancer diagnosis and therapy: current status and future perspectives.
Y. Cheng (2011)
10.3181/00379727-99-24429
Protective Effect of Seaweed Extracts for Chicken Embryos Infected with Influenza B or Mumps Virus
P. Gerber (1958)
10.1002/jcb.21148
The role of the organ microenvironment in the biology and therapy of cancer metastasis
I. Fidler (2007)
10.1021/CR9603892
Dendrimers in Supramolecular Chemistry: From Molecular Recognition to Self-Assembly.
F. Zeng (1997)
10.1016/J.EJPS.2004.09.006
Synthesis and in vitro evaluation of macromolecular antitumour derivatives based on phenylenediamine mustard.
K. de Winne (2005)
10.1002/jps.21519
Evaluation of phenylbutazone and poly(amidoamine) dendrimers interactions by a combination of solubility, 2D-NOESY NMR, and isothermal titration calorimetry studies.
W. Yang (2009)
10.1042/CS0820589
Absorption of human calcitonin across the rat colon in vivo.
J. Hastewell (1992)
10.1023/A:1018959029186
Comparison of the Anticancer Effect of Free and HPMA Copolymer-Bound Adriamycin in Human Ovarian Carcinoma Cells
T. Minko (2004)
10.1002/ANIE.200454078
Efficiency and fidelity in a click-chemistry route to triazole dendrimers by the copper(i)-catalyzed ligation of azides and alkynes.
P. Wu (2004)
10.1053/RMED.2002.1457
Fundamentals of pulmonary drug delivery.
D. Groneberg (2003)
10.1158/0008-5472.CAN-06-2066
Dendrimer-encapsulated camptothecins: increased solubility, cellular uptake, and cellular retention affords enhanced anticancer activity in vitro.
Meredith T. Morgan (2006)
10.1016/j.ijpharm.2008.02.010
Role of a novel multifunctional excipient poly(ethylene glycol)-block-oligo(vinyl sulfadimethoxine) in controlled release of lysozyme from PLGA microspheres.
Ajay Taluja (2008)
10.1002/1097-0142(19940501)73:9<2432::AID-CNCR2820730929>3.0.CO;2-S
Differential regulation of folate receptor isoforms in normal and malignant tissues in vivo and in established cell lines. Physiologic and clinical implications
J. Ross (1994)
10.1016/j.ejmech.2010.12.021
Optimization and in vitro toxicity evaluation of G4 PAMAM dendrimer-risperidone complexes.
M. J. Prieto (2011)
10.2147/IJN.S14601
Novel peptide–dendrimer conjugates as drug carriers for targeting nonsmall cell lung cancer
J. Liu (2010)
10.1016/J.EJMECH.2005.08.002
Polyamidoamine dendrimers used as solubility enhancers of ketoprofen.
Cheng Yiyun (2005)
10.1002/jps.21603
Poly(amidoamine) dendrimers as skin penetration enhancers: Influence of charge, generation, and concentration.
V. V. Venuganti (2009)
10.1016/J.IJPHARM.2006.11.047
In vitro evaluation of dendrimer prodrugs for oral drug delivery.
M. Najlah (2007)
10.1016/j.ejps.2009.07.008
Dendrimers: emerging polymers for drug-delivery systems.
B. Nanjwade (2009)
Endocytosis of folate-protein conjugates: ultrastructural localization in KB cells.
J. Turek (1993)
10.1016/J.ADDR.2005.09.016
Nano-sized MRI contrast agents with dendrimer cores.
Hisataka Kobayashi (2005)
10.1016/j.ijpharm.2010.07.030
In vivo efficacy of dendrimer-methylprednisolone conjugate formulation for the treatment of lung inflammation.
R. Inapagolla (2010)
10.3109/03639049709148695
Colonic Drug Delivery
P. Watts (1997)
10.1021/BC015525A
In vitro gene transfection using dendritic poly(L-lysine).
M. Ohsaki (2002)
10.1016/J.POLYMER.2008.07.044
A fluorescence resonance energy transfer probe for sensing pH in aqueous solution
S. W. Hong (2008)
10.1021/OL061449L
Synthesis and characterization of water-soluble and photostable L-DOPA dendrimers.
Shengzhuang Tang (2006)
10.1016/0165-6147(90)90174-7
Overcoming barriers to the oral administration of peptide drugs.
S. Davis (1990)
10.1161/01.CIR.64.6.1089
The Mechanisms of Nitroglycerin Action: Stenosis Vasodilatation as a Major Component of the Drug Response
B. Brown (1981)
10.1111/J.1365-2125.1974.TB00203.X
Dose-response relationships in tropicamide-induced mydriasis and cycloplegia.
S. Smith (1974)
10.1016/S0168-3659(03)00200-1
Dendrimer-mediated transdermal delivery: enhanced bioavailability of indomethacin.
A. Chauhan (2003)
10.1021/cr900174j
Dendrimers as carriers for delivery of chemotherapeutic agents.
S. Medina (2009)
10.1007/S10856-007-3144-0
Stealth dendrimers for antiarrhythmic quinidine delivery
H. Yang (2007)
10.1089/JOP.1993.9.373
Topical ophthalmic beta blockers: a comparative review.
T. Zimmerman (1993)
10.1002/1097-0142(19940415)73:8<2013::AID-CNCR2820730802>3.0.CO;2-J
Apoptosis. Its significance in cancer and cancer Therapy
J. Kerr (1994)
Folate-binding protein is a marker for ovarian cancer.
I. Campbell (1991)
10.1021/jp105958j
Host-guest chemistry of dendrimer-drug complexes. 5. Insights into the design of formulations for noninvasive delivery of heparin revealed by isothermal titration calorimetry and NMR studies.
Xueyan Feng (2010)
10.1016/j.ddtec.2005.05.019
Nanoparticle uptake by the oral route: Fulfilling its potential?
A. Florence (2005)
10.1016/j.ejmech.2009.10.017
Designing dendrimers for ocular drug delivery.
G. Spataro (2010)



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