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Bulky Chiral Carbene Ligands And Their Application In The Palladium-catalyzed Asymmetric Intramolecular Alpha-arylation Of Amides.

E. P. Kuendig, T. M. Seidel, Y. Jia, G. Bernardinelli
Published 2007 · Chemistry, Medicine

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Bring on the big cats: New, C2-symmetric bulky N-heterocyclic carbene ligands bring major improvements in the palladium-catalyzed asymmetric intramolecular α-arylation of amides to give oxindoles (see picture, dba=trans,trans-dibenzylideneacetone), which are formed in high yield and excellent enantiomeric purity.
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