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The Pivotal Role Of Ferritin In Cellular Iron Homeostasis
E. Mattia, J. van Renswoude
Published 1988 · Chemistry, Medicine
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Iron delivered by transferrin to the interior of the cell is in part utilized in biosynthetic processes and in part incorporated into ferritin, the major iron storage protein. The intracellular ferritin concentration is directly correlated to and determined by the extent of iron supply to the cell. Intracellular partitioning of iron to ferritin is suggested as forming the basis of cellular iron homeostasis.
This paper references
Uptake of transferrin by rat peritoneal macrophages
T. Nishisato (1982)
Expression of transferrin receptors in phytohemagglutinin-stimulated human T-lymphocytes. Evidence for a three-step model.
E. Pelosi (1986)
Structure and expression of ferritin genes in a human promyelocytic cell line that differentiates in vitro.
C. Chou (1986)
Effects of alterations in cellular iron on biosynthesis of the transferrin receptor in K562 cells.
K. Rao (1985)
Iron metabolism in BeWo chorion carcinoma cells. Transferrin-mediated uptake and release of iron.
A. van der Ende (1987)
Regulation of HeLa cell transferrin receptors.
J. H. Ward (1982)
Receptor-mediated endocytosis of transferrin in developmentally totipotent mouse teratocarcinoma stem cells.
M. Karin (1981)
Noncoding 3′ sequences of the transferrin receptor gene are required for mRNA regulation by iron.
D. Owen (1987)
Structure of gene and pseudogenes of human apoferritin H.
F. Costanzo (1986)
Transcriptional regulation by iron of the gene for the transferrin receptor.
K. Rao (1986)
Novel mechanism for translational control in regulation of ferritin synthesis by iron.
J. Zähringer (1976)
Cloning of the gene coding for human L apoferritin.
C. Santoro (1986)
Human ferritin gene is assigned to chromosome 19.
J. H. Caskey (1983)
Cloning, characterization, expression, and chromosomal localization of a human ferritin heavy-chain gene.
M. Hentze (1986)
Receptor-mediated endocytosis of transferrin and the uptake of fe in K562 cells: identification of a nonlysosomal acidic compartment.
J. van Renswoude (1982)
Both subunits of rat liver ferritin are regulated at a translational level by iron induction.
N. Aziz (1986)
On ferritin heterogeneity. Further evidence for heteropolymers.
P. Arosio (1978)
Iron transport and storage proteins.
P. Aisen (1980)
Multiple mechanisms of iron-induced ferritin synthesis in HeLa cells.
G. Cairo (1985)
Biosynthetic regulation of the human transferrin receptor by desferrioxamine in K562 cells.
E. Mattia (1984)
Receptor-mediated endocytosis of transferrin in K562 cells.
R. Klausner (1983)
Isolation and characterization of a cDNA clone for human ferritin heavy chain.
D. Boyd (1984)
Regulation of intracellular iron distribution in K562 human erythroleukemia cells.
E. Mattia (1986)
This paper is referenced by
Expression of Ferritin Messenger RNA in an in vitro Model of Human CD3-Mediated T-Lymphocyte Activation
L. D. Oliveira (1991)
Iron Economy in Insects: Transport, Metabolism, and Storage
M. Locke (1992)
Regulation of transferrin receptor synthesis by human cytotrophoblast cells in culture.
M. J. Kroos (1996)
Ferritin gene expression is developmentally regulated and induced by heat shock in sea urchin embryos
A. Infante (1993)
Proteins of iron storage and transport.
R. Crichton (1990)
Effect of intravenous iron-dextran (Imferon) infusion on antigen induced monarticular arthritis in rabbits.
C. Kind (1992)
Ferritin in cultured human cytotrophoblasts: synthesis and subunit distribution.
J. S. Starreveld (1995)
The Transferrin Receptor and Iron Accumulation in Erythroid Cells
K. Forsbeck (1990)
Regulation of transferrin receptor expression and ferritin content in human mononuclear phagocytes. Coordinate upregulation by iron transferrin and downregulation by interferon gamma.
T. Byrd (1993)