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A Synthesis Of (–)‐(R)‐ And (+)‐(S)‐Lavandulol, (+)‐Lavandulyl 2‐Methylbutanoate, And (+)‐Lavandulyl Senecioate Through Ortho­ester Johnson–Claisen Rearrangement

R. A. Fernandes, Asim K. Chowdhury
Published 2013 · Chemistry

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An efficient synthesis of (–)-(R)- and (+)-(S)-lavandulol, (+)-lavandulyl 2-methylbutanoate and (+)-lavandulyl senecioate is presented in this paper. The synthetic strategy features a chiral-pool approach to an allyl alcohol intermediate, and an orthoester Johnson–Claisen rearrangement as the key step.
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