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Inhibition By Aphidicolin Of Cell Cycle Progression And DNA Replication In Sea Urchin Embryos

S. Ikegami, S. Amemiya, M. Oguro, H. Nagano, Y. Mano
Published 1979 · Biology, Medicine

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We have recently found that aphidicolin, a tetracyclic diterpene‐tetraol produced by several fungi, blocks DNA synthesis of sea urchin embryos by interfering with the activity of DNA polymerase α. These cells fail to proliferate in the presence of aphidicolin.
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