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The Nature Of 12‐O‐tetradecanoylphorbol‐13‐acetate (TPA)‐stimulated Hemopoiesis, Colony Stimulating Factor (CSF) Requirement For Colony Formation, And The Effect Of TPA On [125I]CSF‐1 Binding To Macrophages

L. Guilbert, D. Nelson, J. Hamilton, N. Williams
Published 1983 · Biology, Medicine

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The tumor‐promoting phorbol diester, 12‐O‐tetradecanoylphorbol‐13‐acetate (TPA) was found to act both independently of and synergistically with the mononuclear phagocyte specific colony stimulating factor (CSF‐1) to stimulate the formation of macrophage colonies in cultures of mouse bone marrow cells. In contrast, TPA did not synergize with other CSF subclasses that stimulate the formation of eosinophil, eosinophil‐neutrophil, neutrophil, neutrophil‐macrophage, and macrophage colonies, nor with either of the two factors required for megakaryocyte colony formation, megakaryocyte CSF, and megakaryocyte colony potentiator. In serum‐free mouse bone marrow cell cultures TPA retained the ability to independently stimulate macrophage colony formation. However, TPA‐stimulated colony formation was suboptimal and delayed in serum‐free cultures that could support optimal colony formation in the presence of CSF‐1. In addition, TPA did not directly compete with [125I]CSF‐1 at 4°C for its specific, high‐affinity receptor on mouse peritoneal exudate macrophages. However, a 2‐hour preincubation of the cells with TPA at 37° caused almost complete loss of the receptor. Thus, TPA is able to mimic CSF‐1 in its effects on CSF‐1 responsive cells in some aspects (the spectrum of target cells, the morphology of resulting colonies, and the ability to down‐regulate the CSF‐1 receptor) but it is not able to mimic CSF‐1 in other ways (TPA alone cannot stimulate the full CSF‐1 response, TPA does not stimulate the most primitive CSF‐1 responsive cells, and TPA does not bind to the CSF‐1 receptor).
This paper references
10.1083/JCB.85.1.153
Specific interaction of murine colony-stimulating factor with mononuclear phagocytic cells
L. Guilbert (1980)
10.1007/978-94-009-8793-7_15
Regulation of Macrophage Production by a Colony-Stimulating Factor
E. R. Stanley (1980)
10.1002/JCP.1041100116
Two‐factor requirement for murine megakaryocyte colony formation
N. Williams (1982)
Resolution of high and low affinity epidermal growth factor receptors. Inhibition of high affinity component by low temperature, cycloheximide, and phorbol esters.
A. C. King (1982)
10.1002/JCP.1041060314
Induction of Macrophage DNA Synthesis by phorbol esters
J. Hamilton (1981)
10.1038/276723A0
Stimulation of DNA synthesis by tumour promoter and pure mitogenic factors
Phillip Dicker (1978)
Detection of a new type of mouse eosinophil colony by Luxol-fast-blue staining.
G. Johnson (1980)
10.1002/JCP.1041040309
Discrimination of a colony stimulating factor subclass by a specific receptor on a macrophage cell line
S. Das (1980)
10.1016/0022-1759(81)90156-3
Methods for the purification, assay, characterization and target cell binding of a colony stimulating factor (CSF-1).
E. R. Stanley (1981)
10.1073/PNAS.76.6.2969
Colony-stimulating factor (CSF) radioimmunoassay: detection of a CSF subclass stimulating macrophage production.
E. R. Stanley (1979)
10.1016/0092-8674(77)90086-1
Macrophage plasminogen activator: induction by concanavalin A and phorbol myristate acetate
Jean-Dominique Vassalli (1977)
Stimulation of macrophage prostaglandin and neutral protease production by phorbol esters as a model for the induction of vascular changes associated with tumor promotion.
J. Hamilton (1980)
10.1007/978-1-4757-1732-7_6
Colony Stimulating Factors
E. R. Stanley (1981)
10.1073/PNAS.78.7.4402
Tumor-promoting phorbol esters stimulate myelopoiesis and suppress erythropoiesis in cultures of mouse bone marrow cells.
F. Sieber (1981)
10.1073/PNAS.77.7.4152
Tumor promoters enhance myeloid and erythroid colony formation by normal mouse hemopoietic cells.
E. Fibach (1980)
10.1038/263594A0
Partial replacement of serum by selenite, transferrin, albumin and lecithin in haemopoitec cell cultures
L. Guilbert (1976)
10.1182/BLOOD.V57.6.1032.BLOODJOURNAL5761032
Regulation of myelopoiesis in vitro: partial replacement of colony-stimulating factors by tumor-promoting phorbol esters.
R. Stuart (1981)
10.1126/SCIENCE.6245446
Tumor-promoting phorbol esters stimulate hematopoietic colony formation in vitro.
R. Stuart (1980)
10.1016/0014-4827(80)90476-0
Complete replacement of serum in primary cultures of erythropoietin-dependent red cell precursors (CFU-E) by albumin, transferrin, iron, unsaturated fatty acid, lecithin and cholesterol.
N. Iscove (1980)
10.1083/JCB.91.3.848
Distribution of cells bearing receptors for a colony-stimulating factor (CSF-1) in murine tissues
P. Byrne (1981)
10.1002/JCP.1041130412
Molecules stimulating early red cell, granulocyte, macrophage, and megakaryocyte precursors in culture: Similarity in size, hydrophobicity, and charge
N. Iscove (1982)
Epidermal growth factor. Ability of tumor promoter to alter its degradation, receptor affinity and receptor number.
B. Magun (1980)
10.1038/274168A0
Induction of macrophage production and proliferation by a purified colony stimulating factor
E. Stanley (1978)
10.1111/J.1432-0436.1978.TB00970.X
Differentiation of mouse bone marrow precursor cells into neutrophil granulocytes by an activity separation from WEHI-3 cell-conditioned medium.
N. Williams (1978)
10.1084/JEM.147.3.923
Complete replacement of serum by albumin, transferrin, and soybean lipid in cultures of lipopolysaccharide-reactive B lymphocytes
N. Iscove (1978)



This paper is referenced by
10.1007/978-94-009-5020-7_24
Mononuclear phagocyte progenitors and growth factors
L. Guilbert (1985)
10.1182/BLOOD.V64.2.526.BLOODJOURNAL642526
The effects of tumor-promoting phorbol esters on human granulopoiesis in vitro.
R. Sullivan (1984)
10.1002/jlb.47.1.79
Control of Lipoprotein Lipase Secretion by Macrophages: Effect of Macrophage Differentiation Agents
R. Goldman (1990)
10.1016/0022-1759(84)90027-9
Modulation of receptors for the colony-stimulating factor, CSF-1, by bacterial lipopolysaccharide and CSF-1.
L. Guilbert (1984)
10.1182/BLOOD.V85.6.1496.BLOODJOURNAL8561496
High expression of c-kit in K562YO cells due to the prolonged half-life of its mRNA: the effects of modification with serine/threonine kinase signals.
K. Ogawa (1995)
10.1007/978-1-4613-2253-5_35
Production of Colony-Stimulating Factor (CSF) by Bone Marrow Cells Stimulated with Lipopolysaccharide (LPS) and Phorbol Esters
D. H. Pluznik (1986)
10.1016/0167-5699(91)90067-4
Signalling through CSF receptors.
G. Vairo (1991)
10.1182/BLOOD.V73.1.307.BLOODJOURNAL731307
Synergistic stimulation of macrophage proliferation by the monokines tumor necrosis factor-alpha and colony-stimulating factor 1.
A. R. Turner (1989)
10.1385/0-89603-441-0:301
Murine bone marrow-derived macrophages.
E. R. Stanley (1997)
10.1007/BF02918783
Macrophage-directed lymphokines
D. Liu (1984)
10.1002/JCP.1041230221
Enhancement of colony‐stimulating‐factor–dependent clonal growth of murine macrophage progenitors and their phagocytic activity by retinoic acid
R. Goldman (1985)
10.1007/978-3-642-70956-2_10
Effect of the Phorbol Esters on the Receptors for LDL on U-937 Monocyte-Like Cells and Acetyl-LDL on Mouse Peritoneal Macrophages
S. Goldstein (1986)
Hemopoietic growth factors: a review.
G. Morstyn (1988)
Enhancement of clonal proliferation of mouse mast cells by a tumor-promoting phorbol ester.
H. Saito (1984)
10.1016/0304-419X(89)90038-3
Myeloid haemopoietic growth factors.
A. Whetton (1989)
10.1002/STEM.5530090404
Hematopoietic growth factor receptors.
M. Brizzi (1991)
Isolation of 12-O-tetradecanoylphorbol-13-acetate-resistant mutants of a macrophage-like cell line: evidence for induction by 12-O-tetradecanoylphorbol-13-acetate of a non-colony-stimulating growth factor.
A. A. Yashruti (1987)
10.1007/978-1-4612-3210-0_15
Colony-Stimulating Factor 1 (Macrophage Colony-Stimulating-Factor)
C. Sherr (1991)
10.3324/haematol.2017.187278
Fetal hemoglobin induction during decitabine treatment of elderly patients with high-risk myelodysplastic syndrome or acute myeloid leukemia: a potential dynamic biomarker of outcome
Julia Stomper (2018)
10.1182/blood.v71.6.1574.1574
Activation and proliferation signals in murine macrophages: synergistic interactions between the hematopoietic growth factors and with phorbol ester for DNA synthesis.
J. Hamilton (1988)
10.1002/JCP.1041210313
Phorbol esters inhibit the binding of low‐density lipoproteins (LDL) to U‐937 monocytelike cells
M. Rouis (1984)
10.1016/0005-2760(89)90137-9
Control of lipoprotein lipase secretion in mouse macrophages.
R. Goldman (1989)
10.1007/978-3-642-77377-8_5
The biology of CSF-1 and its receptor.
P. Roth (1992)
10.1016/J.IMBIO.2005.05.004
LPS regulates a set of genes in primary murine macrophages by antagonising CSF-1 action.
D. Sester (2005)
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