Online citations, reference lists, and bibliographies.
← Back to Search

The Integration Of Flow Reactors Into Synthetic Organic Chemistry

I. Baxendale
Published 2013 · Engineering

Save to my Library
Download PDF
Analyze on Scholarcy Visualize in Litmaps
Share
Reduce the time it takes to create your bibliography by a factor of 10 by using the world’s favourite reference manager
Time to take this seriously.
Get Citationsy
The material presented in this review is based upon discussions and interactions with members of the Department of Chemistry and Biochemistry within the University of Windsor, Ontario, Canada. This article explores the changing face of chemical synthesis with regard to the impact of flow based chemical processing technologies. Highlighted works from the Innovative Technology Centre (ITC), Cambridge, UK, are used to illustrate the alternative synthetic practices available to modern research chemists. The dominant theme of the review is the synergistic effects encountered by combining the advantages of continuous processing regimes with the power of immobilized reagents and scavenger systems for multi-step organic chemistry. © 2012 Society of Chemical Industry
This paper references
10.1021/JA01347A511
IS THE NUTRILITE FOR “GEBRÜDE MAYER” YEAST OF UNIVERSAL BIOLOGICAL IMPORTANCE?
R. Williams (1932)
10.1021/JA01347A509
DEHYDRATION OF DIETHYLCARBINOL
F. A. Karnatz (1932)
10.1080/08327823.1988.11688033
Microwave Enhanced Diffusion in Polymeric Materials
C. Gibson (1988)
10.1021/CR00092A006
Considerations of chiral recognition relevant to the liquid chromatography separation of enantiomers
W. H. Pirkle (1989)
10.1021/JM00078A002
Synthesis and antimicrobial evaluation of a series of 7-[3-amino (or aminomethyl)-4-aryl (or cyclopropyl)-1-pyrrolidinyl]-4-quinolone- and -1,8-naphthyridone-3-carboxylic acids.
R. Bucsh (1993)
10.1016/0021-9673(94)01021-6
Modified poly(glycidyl methacrylate-co-ethylene dimethacrylate) continuous rod columns for preparative-scale ion-exchange chromatography of proteins.
F. Švec (1995)
10.1002/BIT.260480509
"Molded" rods of macroporous polymer for preparative separations of biological products.
F. Švec (1995)
10.1080/00304949709355247
SYNTHESIS OF AMINOTOLUENESULFONAMIDE DERIVATIVES USING CONVENTIONAL HEATING OR MICROWAVE-ASSISTED METHODS
R. Pérez (1997)
10.1016/S0021-9673(97)00254-9
Rigid porous polyacrylamide-based monolithic columns containing butyl methacrylate as a separation medium for the rapid hydrophobic interaction chromatography of proteins.
S. Xie (1997)
10.1039/CS9972600417
Polymer-supported organic reactions: what takes place in the beads?
P. Hodge (1997)
10.1055/S-1997-1021
Microwave-Assisted Facile Synthesis of Imines and Enamines using Envirocat EPZGR as a Catalyst
R. Varma (1997)
10.1063/1.370432
Permeability and electromagnetic-interference characteristics of Fe–Si–Al alloy flakes–polymer composite
S. Yoshida (1999)
10.1016/S0014-3057(99)00153-6
Microwave irradiation effect on diffusion of organic molecules in polymer
J. Y. Jeon (2000)
10.1002/1521-3765(20001215)6:24<4445::AID-CHEM4445>3.0.CO;2-W
The "resin-capture-release" hybrid technique: a merger between solid- and solution-phase synthesis.
A. Kirschning (2000)
10.1039/B006588I
Multi-step organic synthesis using solid-supported reagents and scavengers: a new paradigm in chemical library generation
S. Ley (2000)
10.1016/S0040-4020(01)00906-1
Microwave assisted organic synthesis-a review
P. Lidström (2001)
10.1002/1521-3773(20020617)41:12<2194::AID-ANIE2194>3.0.CO;2-4
Total synthesis of the amaryllidaceae alkaloid (+)-plicamine and its unnatural enantiomer by using solid-supported reagents and scavengers in a multistep sequence of reactions.
I. Baxendale (2002)
10.1039/B203388G
A concise synthesis of carpanone using solid-supported reagents and scavengers
I. Baxendale (2002)
10.2174/1386207024607220
Synthesis of trifluoromethyl ketones using polymer-supported reagents.
I. Baxendale (2002)
10.1055/S-2002-25333
A Clean Conversion of Aldehydes to Nitriles Using a Solid-Supported Hydrazine
I. Baxendale (2002)
10.1038/nrd871
New tools and concepts for modern organic synthesis
S. Ley (2002)
10.1016/S0040-4020(02)00628-2
Total synthesis of the amaryllidaceae alkaloid (+)-plicamine using solid-supported reagents
I. Baxendale (2002)
10.1016/S1367-5931(02)00306-X
High-speed combinatorial synthesis utilizing microwave irradiation.
C. O. Kappe (2002)
10.1055/S-2002-34249
Application of polymer-supported enzymes and reagents in the synthesis of γ-aminobutyric acid (GABA) analogues
I. Baxendale (2002)
10.1016/S1367-5931(03)00052-8
Organic synthesis using polymer-supported reagents, catalysts and scavengers in simple laboratory flow systems.
P. Hodge (2003)
10.1002/CHEM.200305212
Continuous flow techniques in organic synthesis.
G. Jas (2003)
10.1039/B301432K
Out of the oil bath and into the oven--microwave-assisted combinatorial chemistry heats up.
H. Blackwell (2003)
10.1021/OP034181B
Development and Applications of a Practical Continuous Flow Microwave Cell
N. Wilson (2004)
10.1002/CHEM.200305669
Multi-step application of immobilized reagents and scavengers: a total synthesis of epothilone C.
R. I. Storer (2004)
10.1007/s11030-005-3302-6
Advances in organic synthesis using polymer-supported reagents and scavengers under microwave irradiation
S. Bhattacharyya (2005)
10.1039/B509540A
Non-metal-catalysed intramolecular alkyne cyclotrimerization reactions promoted by focussed microwave heating in batch and flow modes.
S. Saaby (2005)
10.1016/J.TET.2005.03.062
The rapid preparation of 2-aminosulfonamide-1,3,4-oxadiazoles using polymer-supported reagents and microwave heating
I. Baxendale (2005)
10.1021/CC049826D
Formation of 4-aminopyrimidines via the trimerization of nitriles using focused microwave heating.
I. Baxendale (2005)
10.1021/IE048822I
Synthesis of the Alkaloid Natural Products (+)-Plicane and (-)-Obliquine, Using Polymer-Supported Reagents and Scavengers
I. Baxendale (2005)
10.2174/138527205774370513
Synthesis of Alkaloid Natural Products Using Solid-Supported Reagents and Scavengers
I. Ley (2005)
10.1021/IE040285E
Synthesis of Organic Compounds Using Polymer-Supported Reagents, Catalysts, and/or Scavengers in Benchtop Flow Systems†
P. Hodge (2005)
10.1002/ANIE.200502387
Controlled autocatalytic nitration of phenol in a microreactor.
L. Ducry (2005)
10.1021/OL061975C
Fully automated continuous flow synthesis of 4,5-disubstituted oxazoles.
M. Baumann (2006)
10.1002/CHEM.200600596
Microreactors as tools for synthetic chemists-the chemists' round-bottomed flask of the 21st century?
K. Geyer (2006)
10.1007/2789_2007_027
Microreactors as new tools for drug discovery and development.
S. Wong-Hawkes (2006)
10.1039/B600382F
A flow process for the multi-step synthesis of the alkaloid natural product oxomaritidine: a new paradigm for molecular assembly.
I. Baxendale (2006)
10.1039/B612197G
A flow reactor process for the synthesis of peptides utilizing immobilized reagents, scavengers and catch and release protocols.
I. Baxendale (2006)
10.1002/CHEM.200600236
Combining enabling techniques in organic synthesis: continuous flow processes with heterogenized catalysts.
A. Kirschning (2006)
10.1002/CHIN.200626245
Polyurea‐Encapsulated Palladium Catalysts: The Development and Application of a New and Versatile Immobilized Homogeneous Catalyst Technology
D. Pears (2006)
10.1055/S-2006-926244
Preparation of the neolignan natural product grossamide by a continuous-flow process
I. Baxendale (2006)
10.1002/CHEM.200501400
Microwave-assisted Suzuki coupling reactions with an encapsulated palladium catalyst for batch and continuous-flow transformations.
I. Baxendale (2006)
10.1002/CHIN.200710272
Microwave flow chemistry: the next evolutionary step in synthetic chemistry?
I. Baxendale (2006)
10.1016/J.BMCL.2007.07.081
(3R,4S)-4-(2,4,5-Trifluorophenyl)-pyrrolidin-3-ylamine inhibitors of dipeptidyl peptidase IV: synthesis, in vitro, in vivo, and X-ray crystallographic characterization.
S. W. Wright (2007)
10.1021/OL070527H
Efficient conversion of aromatic amines into azides: a one-pot synthesis of triazole linkages.
K. Barral (2007)
10.1039/B702995K
[3 + 2] Cycloaddition of acetylenes with azides to give 1,4-disubstituted 1,2,3-triazoles in a modular flow reactor.
Christopher D. Smith (2007)
10.1002/MARC.200600665
Microwave‐Assisted Synthesis under Continuous‐Flow Conditions
Toma Glasnov (2007)
10.2174/138620707783220374
Microwave reactions under continuous flow conditions.
I. Baxendale (2007)
10.1002/9780470171974.CH3
Application of Principal Component Analysis in Organic Chemistry
R. I. Zalewski (2007)
10.1007/S00706-007-0616-3
Applications of Polymeric Reagents in Organic Synthesis
H. Salimi (2007)
10.1002/CHIN.200745236
Solid-Supported Reagents and Catch-and-Release Techniques in Organic Synthesis
A. Solinas (2007)
10.1016/J.BMC.2006.10.037
Synthesis of novel quinolone and quinoline-2-carboxylic acid (4-morpholin-4-yl-phenyl)amides: a late-stage diversification approach to potent 5HT1B antagonists.
Carey L Horchler (2007)
10.1002/cmdc.200700008
Pharmaceutical Strategy and Innovation: An Academics Perspective
I. Baxendale (2007)
10.1039/B609428G
Recent advances in synthetic micro reaction technology.
P. Watts (2007)
10.1039/B709043A
Flow and batch mode focused microwave synthesis of 5-amino-4-cyanopyrazoles and their further conversion to 4-aminopyrazolopyrimidines.
C. J. Smith (2007)
10.2533/CHIMIA.2008.162
The Changing Face of Organic Synthesis
S. Ley (2008)
10.1021/cc800070a
A bifurcated pathway to thiazoles and imidazoles using a modular flow microreactor.
I. Baxendale (2008)
10.1055/S-2008-1078026
The Use of Diethylaminosulfur Trifluoride (DAST) for Fluorination in a Continuous-Flow Microreactor
M. Baumann (2008)
10.1021/JO7022697
Nonthermal microwave effects revisited: on the importance of internal temperature monitoring and agitation in microwave chemistry.
M. A. Herrero (2008)
10.1039/b801634h
Azide monoliths as convenient flow reactors for efficient Curtius rearrangement reactions.
M. Baumann (2008)
10.1039/b801631n
A modular flow reactor for performing Curtius rearrangements as a continuous flow process.
M. Baumann (2008)
10.1039/b803584a
E factors, green chemistry and catalysis: an odyssey.
R. Sheldon (2008)
10.1177/1087057109350114
Review Article: High-Throughput Affinity-Based Technologies for Small-Molecule Drug Discovery
Z. Zhu (2009)
10.3762/bjoc.5.1
Reduction of arenediazonium salts by tetrakis(dimethylamino)ethylene (TDAE): Efficient formation of products derived from aryl radicals
M. Mahesh (2009)
10.1002/anie.200904185
Microwave chemistry in silicon carbide reaction vials: separating thermal from nonthermal effects.
David Obermayer (2009)
10.1021/cr8004444
Organic polymer supports for synthesis and for reagent and catalyst immobilization.
J. Lu (2009)
10.1016/J.TETLET.2009.03.059
Functionalized fluoroalkyl heterocycles by 1,3-dipolar cycloadditions with γ-fluoro-α-nitroalkenes
Serena Bigotti (2009)
10.1016/J.TET.2009.05.083
Development of fluorination methods using continuous-flow microreactors
M. Baumann (2009)
10.1002/anie.200900970
Multistep synthesis using modular flow reactors: Bestmann-Ohira reagent for the formation of alkynes and triazoles.
I. Baxendale (2009)
10.1039/b917289k
Synthesis of acetal protected building blocks using flow chemistry with flow I.R. analysis: preparation of butane-2,3-diacetal tartrates.
C. Carter (2009)
10.1021/OP8002739
Development of a Sequential Tetrahydropyran and Tertiary Butyl Deprotection: High-Throughput Experimentation, Mechanistic Analysis, and DOE Optimization
J. Kuethe (2009)
10.3762/bjoc.5.23
Continuous flow based catch and release protocol for the synthesis of α-ketoesters
A. Palmieri (2009)
10.1002/EJOC.200900344
Pd‐EnCatTM TPP30 as a Catalyst for the Generation of Highly Functionalized Aryl‐ and Alkenyl‐Substituted Acetylenes via Microwave‐Assisted Sonogashira Type Reactions
Joerg Sedelmeier (2009)
10.1038/nrd2961
Lessons from 60 years of pharmaceutical innovation
B. Munos (2009)
10.1246/CL.2009.1060
Generations and Reactions of N-(t-Butylsulfonyl)aziridinyllithiums Using Microreactors
Aiichiro Nagaki (2009)
10.1055/S-0029-1219344
Synthesis of 3-Nitropyrrolidinesvia Dipolar Cycloaddition Reactions Using a Modular Flow Reactor
M. Baumann (2010)
10.1002/chem.200902906
Multi-step synthesis by using modular flow reactors: the preparation of yne--ones and their use in heterocycle synthesis.
I. Baxendale (2010)
10.1007/s11030-010-9282-1
The flow synthesis of heterocycles for natural product and medicinal chemistry applications
M. Baumann (2010)
10.1039/b924309g
The continuous flow synthesis of butane-2,3-diacetal protected building blocks using microreactors.
C. Carter (2010)
10.1007/7081_2009_22
Microreactor Technology as an Efficient Tool for Multicomponent Reactions
A. Cukalovic (2010)
10.1039/C0SC00381F
Continuous flow multi-step organic synthesis
Damien Webb (2010)
10.1002/anie.201005092
Real-time product switching using a twin catalyst system for the hydrogenation of furfural in supercritical CO2.
James G. Stevens (2010)
10.3987/com-10-s(e)77
Synthesis of highly substituted nitropyrrolidines, nitropyrrolizines and nitropyrroles via multicomponent-multistep sequences within a flow reactor
S. Ley (2010)
10.1021/OP900287J
Exploring the Scope for Scale-Up of Organic Chemistry Using a Large Batch Microwave Reactor
Jason R Schmink (2010)
10.1055/S-0029-1219358
A Flow Process Using Microreactorsfor the Preparation of a Quinolone Derivative as a Potent5HT1B Antagonist
Zizheng Qian (2010)
10.1016/j.chroma.2010.10.100
Hypercrosslinking: new approach to porous polymer monolithic capillary columns with large surface area for the highly efficient separation of small molecules.
J. Urban (2010)
10.1021/OP900305V
ReactIR Flow Cell: A New Analytical Tool for Continuous Flow Chemical Processing
C. Carter (2010)
10.1002/chem.201002147
A continuous flow process using a sequence of microreactors with in-line IR analysis for the preparation of N,N-diethyl-4-(3-fluorophenylpiperidin-4-ylidenemethyl)benzamide as a potent and highly selective δ-opioid receptor agonist.
Zizheng Qian (2010)
10.1002/tcr.201000020
Flash chemistry: flow microreactor synthesis based on high-resolution reaction time control.
Jun-Ichi Yoshida (2010)
10.1016/j.bmc.2010.03.073
Flow chemistry using milli- and microstructured reactors-from conventional to novel process windows.
T. Illg (2010)
10.1039/b925327k
The application of flow microreactors to the preparation of a family of casein kinase I inhibitors.
Francesco Venturoni (2010)
10.3390/molecules15096306
Recent Applications of Polymer Supported Organometallic Catalysts in Organic Synthesis
N. Kann (2010)
10.1039/c001550d
A flow-based synthesis of imatinib: the API of Gleevec.
Mark D. Hopkin (2010)
10.1055/S-0030-1260573
An Integrated Flow and Batch-BasedApproach for the Synthesis of O-Methyl Siphonazole
M. Baumann (2011)
10.1002/JCTB.2482
Development of microfluidic devices for biomedical and clinical application
A. Webster (2011)
Flow chemistry today: Practical approaches for optimisation and scale-up
R. Becker (2011)
10.1002/anie.201006107
Intelligent microflow: development of self-optimizing reaction systems.
Munawwer Rasheed (2011)
10.1002/JHET.568
Continuous-flow syntheses of heterocycles
Toma Glasnov (2011)
10.1021/la200009w
Aspects of heterogeneous enantioselective catalysis by metals.
G. Kyriakou (2011)
10.1039/c0ob00815j
A fully automated, multistep flow synthesis of 5-amino-4-cyano-1,2,3-triazoles.
C. J. Smith (2011)
10.3762/bjoc.7.194
The application of a monolithic triphenylphosphine reagent for conducting Appel reactions in flow microreactors
Kimberley A Roper (2011)
10.1002/cssc.201000271
Green and sustainable chemical synthesis using flow microreactors.
Jun-Ichi Yoshida (2011)
10.1021/OP200109T
Adaptive Process Optimization for Continuous Methylation of Alcohols in Supercritical Carbon Dioxide
R. Bourne (2011)
10.1016/j.tibtech.2011.03.005
Biotransformations in microstructured reactors: more than flowing with the stream?
Juan M Bolivar (2011)
10.1039/c0cc05060a
Ten key issues in modern flow chemistry.
J. Wegner (2011)
10.1021/co2000357
Synthesis of a drug-like focused library of trisubstituted pyrrolidines using integrated flow chemistry and batch methods.
M. Baumann (2011)
Novel process windows, part 1: Boosted micro process technology
V. Hessel (2011)
10.1002/anie.201100412
Self-optimizing continuous reactions in supercritical carbon dioxide.
Andrew J Parrott (2011)
10.1021/ol2010006
A new enabling technology for convenient laboratory scale continuous flow processing at low temperatures.
D. L. Browne (2011)
10.1002/anie.201004637
Deciding whether to go with the flow: evaluating the merits of flow reactors for synthesis.
R. Hartman (2011)
10.1002/chem.201102065
The microwave-to-flow paradigm: translating high-temperature batch microwave chemistry to scalable continuous-flow processes.
Toma Glasnov (2011)
10.1055/S-0030-1259923
Oxidation Reactions in Segmented and Continuous Flow Chemical Processing Using an N-(tert-Butyl)phenylsulfinimidoyl Chloride Monolith
Heiko Lange (2011)
10.1002/AIC.12598
From batch to continuous flow processing in chemicals manufacturing
Gary S. Calabrese (2011)
10.1016/J.CES.2010.08.018
Novel process windows – Concept, proposition and evaluation methodology, and intensified superheated processing
V. Hessel (2011)
10.1039/c0ob00813c
Flow synthesis of organic azides and the multistep synthesis of imines and amines using a new monolithic triphenylphosphine reagent.
C. J. Smith (2011)
10.1016/j.jala.2009.01.002
A Review of Electronic Laboratory Notebooks Available in the Market Today
Michael Rubacha (2011)
10.1021/OP100257R
Development of a Second-Generation, Highly Efficient Manufacturing Route for the HIV Integrase Inhibitor Raltegravir Potassium
G. Humphrey (2011)
10.1038/nrd3462
US academic drug discovery
S. Frye (2011)
10.3390/molecules16108368
Microfluidic Devices: Useful Tools for Bioprocess Intensification
M. Marques (2011)
10.1002/chem.201003148
Diastereoselective chain-elongation reactions using microreactors for applications in complex molecule assembly.
C. Carter (2011)
10.3390/molecules16097522
Recent Advances in Microflow Photochemistry
M. Oelgemöller (2011)
10.1039/c1cc00089f
Recent advances in micro reaction technology.
C. Wiles (2011)
10.1002/cssc.201200061
Flow chemistry: enabling technology in drug discovery and process research.
T. Wirth (2012)
10.1039/C1GC16022B
Continuous flow reactors: a perspective
C. Wiles (2012)
10.1002/asia.201101019
Cross-coupling of aryllithiums with aryl and vinyl halides in flow microreactors.
Aiichiro Nagaki (2012)
10.1073/pnas.1115623109
The molecular basis for selective inhibition of unconventional mRNA splicing by an IRE1-binding small molecule
Benedict C S Cross (2012)
10.1055/S-0031-1289676
Scale-Up of Flow-Assisted Synthesisof C2-Symmetric Chiral PyBoxLigands
Claudio Battilocchio (2012)
10.5740/JAOACINT.SGE_EL-GINDY
Chemometrics in pharmaceutical analysis: an introduction, review, and future perspectives.
A. El-Gindy (2012)
10.1021/OP200331S
Selective Continuous Flow Processes Using Fluorine Gas
Christopher B. McPake (2012)
10.1002/chem.201201039
Establishing a flow process to coumarin-8-carbaldehydes as important synthetic scaffolds.
J. Žák (2012)
10.1021/cr2003147
Homochiral metal-organic frameworks for asymmetric heterogeneous catalysis.
M. Yoon (2012)
10.1021/OP300084Z
A Flow-Based Synthesis of 2-Aminoadamantane-2-carboxylic Acid
C. Battilocchio (2012)
10.1021/ol301673q
A "catch-react-release" method for the flow synthesis of 2-aminopyrimidines and preparation of the Imatinib base.
Richard J. Ingham (2012)
10.1038/nrd3681
Diagnosing the decline in pharmaceutical R&D efficiency
J. Scannell (2012)
10.1002/ADSC.201100584
Flow Chemistry – A Key Enabling Technology for (Multistep) Organic Synthesis
J. Wegner (2012)
10.1039/c2ob27002a
An expeditious synthesis of imatinib and analogues utilising flow chemistry methods.
Mark D. Hopkin (2013)
10.1039/C2SC21850J
Flow chemistry synthesis of zolpidem, alpidem and other GABAA agonists and their biological evaluation through the use of in-line frontal affinity chromatography
Lucie Guetzoyan (2013)
10.1071/CH12365
Flow Microwave Technology and Microreactors in Synthesis
I. Baxendale (2013)
10.1039/c2ob27003j
The synthesis of Bcr-Abl inhibiting anticancer pharmaceutical agents imatinib, nilotinib and dasatinib.
Benjamin J. Deadman (2013)



This paper is referenced by
10.1039/d0re00352b
Selective oxidation of bio-based platform molecules and their conversion products over metal nanoparticle catalysts: a review
K. Timofeev (2021)
10.3390/CATAL11040501
Continuous 2-Methyl-3-butyn-2-ol Selective Hydrogenation on Pd/γ-Al2O3 as a Green Pathway of Vitamin A Precursor Synthesis
A. J. Fernández-Ropero (2021)
10.1002/aic.17067
Photo isomerization of cis‐cyclooctene to trans‐cyclooctene: Integration of a micro‐flow reactor and separation by specific adsorption
E. Shahbazali (2021)
10.1021/acs.oprd.0c00167
Preparation of Mono- and Diisocyanates in Flow from Renewable Carboxylic Acids
Thien An Phung Hai (2020)
10.1002/anie.202006720
Tandem Photoredox Catalysis: Enabling Carbonylative Amidation of Aryl and Alkylhalides.
J. A. Forni (2020)
10.1016/j.cattod.2020.07.014
Flow grams-per-hour production enabled by hierarchical bimodal porous silica gel supported palladium column reactor having low pressure drop
Yosuke Ashikari (2020)
10.1007/s41981-020-00113-6
Telescoped continuous flow synthesis of phenyl acrylamide
J. Salaklang (2020)
10.1039/d0re00087f
Continuous one-flow multi-step synthesis of active pharmaceutical ingredients
Victor R. L. J. Bloemendal (2020)
10.1021/jacs.0c06370
A Synthetic Approach to Dimetallated Arenes Using Flow Microreactors and the Switchable Application to Chemoselective Cross-Coupling Reactions.
Yosuke Ashikari (2020)
10.1016/b978-0-12-819539-0.00005-1
Biocatalysis in green organic synthesis
S. Malini (2020)
10.1002/ejoc.201901729
Synthesis of Biaryls Having a Piperidylmethyl Group Based on Space Integration of Lithiation, Borylation, and Suzuki-Miyaura Coupling
Yusuke Takahashi (2020)
10.1021/acsomega.0c02390
Integrated Batch and Continuous Flow Process for the Synthesis of Goniothalamin
J. C. Pastre (2020)
10.1002/chem.202002063
A Visible‐Light‐Powered Polymerization Method for the Immobilization of Enantioselective Organocatalysts into Microreactors
R. Warias (2020)
10.1039/d0py00276c
Rapid production of block copolymer nano-objects via continuous-flow ultrafast RAFT dispersion polymerisation
Sam Parkinson (2020)
10.1021/acs.joc.0c00656
A rearrangement of 3-hydroxyazetidines into 2-oxazolines.
Michele Ruggeri (2020)
10.1007/978-3-030-41524-2_13
Safety Guidelines for Continuous Processing
Martin D Johnson (2020)
10.1039/D0RE00329H
Harnessing interrupted Fischer in continuous flow: sustainable synthesis of (spiro)indolenine and (spiro)indoline privileged scaffolds
A. Alfano (2020)
10.1039/d0re00076k
Recent advances in continuous-flow organocatalysis for process intensification
Carmela De Risi (2020)
10.1002/ange.202003831
Fluoro‐Substituted Methyllithium Chemistry: External Quenching Method Using Flow Microreactors
Marco Colella (2020)
10.1246/cl.190831
Tf2O-mediated Reaction of Alkenyl Sulfoxides with Unprotected Anilines in Flow Microreactors
Alexandre Baralle (2020)
10.1038/s41598-020-73957-6
Memory of chirality in a room temperature flow electrochemical reactor
Tomas Hardwick (2020)
10.1002/anie.202003831
Fluoro-substituted Methyllithium Chemistry Based on A Novel External Quenching Method Using Flow Microreactors.
Marco Colella (2020)
10.1007/s41981-019-00050-z
Translating batch electrochemistry to single-pass continuous flow conditions: an organic chemist’s guide
Snjezana Maljuric (2020)
10.1002/chem.201900743
Synthesis of Functionalized Ketones from Acid Chlorides and Organolithiums by Extremely Fast Micromixing.
Aiichiro Nagaki (2019)
10.1002/chem.201902867
Generation and Reaction of Functional Alkyllithiums Using Microreactors and Their Application to Heterotelechelic Polymer Synthesis.
Aiichiro Nagaki (2019)
10.1002/CEAT.201900057
Monolithiation of 5,5′‐Dibromo‐2,2′‐bithiophene Using Flow Microreactors: Mechanistic Implications and Synthetic Applications
Aiichiro Nagaki (2019)
10.1002/ejoc.201901335
Flow Chemistry: Towards A More Sustainable Heterocyclic Synthesis
Pedro Brandão (2019)
10.1002/CEAT.201900160
Practical Continuous‐Flow Controlled/Living Anionic Polymerization
Yuichi Nakahara (2019)
10.1002/9781119600800.CH16
DESIGN AND SELECTION OF CONTINUOUS REACTORS FOR PHARMACEUTICAL MANUFACTURING
M. D. Johnson (2019)
10.1002/chem.201903426
Oxo-Thiolation of Cationically Polymerizable Alkenes Using Flow Microreactors.
Aiichiro Nagaki (2019)
10.1002/anie.201814088
Alkyllithium Compounds Bearing Electrophilic Functional Groups: A Flash Chemistry Approach.
Aiichiro Nagaki (2019)
10.3390/CATAL9030300
Suzuki–Miyaura Coupling Using Monolithic Pd Reactors and Scaling-Up by Series Connection of the Reactors
Aiichiro Nagaki (2019)
See more
Semantic Scholar Logo Some data provided by SemanticScholar