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DYSBOT: A Single‐blind, Randomized Parallel Study To Determine Whether Any Differences Can Be Detected In The Efficacy And Tolerability Of Two Formulations Of Botulinum Toxin Type A—Dysport And Botox—assuming A Ratio Of 4:1

C. Sampaio, J. Ferreira, F. Simões, M. Rosas, M. Magalhães, A. P. Correia, A. Bastos-Lima, R. Martins, A. Castro-Caldas
Published 1997 · Medicine

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Background: Elston and Russell discovered a difference in the biological potency of the English formulation of botulinum toxin type A or BTX‐A (Dysport) and the American formulation (Botox). Potency of both is expressed in LD50 mouse units, but because of assay differences, these units are not equivalent. Since the first warning by Quinn and Hallet on the clinical importance of this issue, it has been impossible to reach a consensus on the conversion factor for the potency of these formulations.
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