Online citations, reference lists, and bibliographies.
← Back to Search

Improved Assessment Of Significant Activation In Functional Magnetic Resonance Imaging (fMRI): Use Of A Cluster‐Size Threshold

S. Forman, J. Cohen, M. Fitzgerald, W. Eddy, M. Mintun, D. Noll
Published 1995 · Psychology, Medicine, Mathematics

Cite This
Download PDF
Analyze on Scholarcy
Share
The typical functional magnetic resonance (fMRI) study presents a formidable problem of multiple statistical comparisons (i.e, > 10,000 in a 128 x 128 image). To protect against false positives, investigators have typically relied on decreasing the per pixel false positive probability. This approach incurs an inevitable loss of power to detect statistically significant activity. An alternative approach, which relies on the assumption that areas of true neural activity will tend to stimulate signal changes over contiguous pixels, is presented. If one knows the probability distribution of such cluster sizes as a function of per pixel false positive probability, one can use cluster‐size thresholds independently to reject false positives. Both Monte Carlo simulations and fMRI studies of human subjects have been used to verify that this approach can improve statistical power by as much as fivefold over techniques that rely solely on adjusting per pixel false positive probabilities.
This paper references



This paper is referenced by
10.7282/T3C8280B
The influence of social context on reward-processing and associated neural signals
Dominic S. Fareri (2013)
10.1080/00207450802333029
Neural Networks of Motor and Cognitive Inhibition are Dissociated Between Brain Hemispheres: An fMRI Study
B. Bernal (2009)
10.1002/(SICI)1522-712X(1995)1:4<191::AID-IGS1>3.0.CO;2-5
Comparison of functional magnetic resonance imaging with positron emission tomography and magnetoencephalography to identify the motor cortex in a patient with an arteriovenous malformation.
S. Baumann (1995)
10.1007/978-3-642-46992-3_4
Functional Imaging Analysis Software — Computational Olio
W. Eddy (1996)
10.26481/dis.20190410vda
Computational neuroimaging of real-life listening
V. D. Angelis (2019)
10.1073/pnas.0431053100
Predicting the practice effects on the blood oxygenation level-dependent (BOLD) function of fMRI in a symbolic manipulation task
Yulin Qin (2003)
10.1523/JNEUROSCI.0548-12.2012
Dissociable Brain Systems Mediate Vicarious Learning of Stimulus–Response and Action–Outcome Contingencies
Mimi Liljeholm (2012)
10.1523/JNEUROSCI.5010-14.2015
Altered Resting-State Functional Connectivity in Cortical Networks in Psychopathy
C. Philippi (2015)
10.1002/hbm.20898
Step‐by‐step: The effects of physical practice on the neural correlates of locomotion imagery revealed by fMRI
Silvio Ionta (2010)
10.1016/S1053-8119(00)91037-1
Anterior cingulate cortex and response conflict: Effects of response modality and processing domain
D. Barch (2000)
10.1017/S1355617704105110
Parametric manipulation of working memory load in traumatic brain injury: behavioral and neural correlates.
W. Perlstein (2004)
10.1016/j.neuroimage.2004.07.035
Simultaneous 3-T fMRI and high-density recording of human auditory evoked potentials
Carrie J. Scarff (2004)
10.1207/s15326942dn2703_7
The Functional Neuroanatomy of Spatial Attention in Autism Spectrum Disorder
F. Haist (2005)
10.1523/JNEUROSCI.4170-04.2005
Motion Class Dependency in Observers' Motor Areas Revealed by Functional Magnetic Resonance Imaging
K. Sakreida (2005)
10.1016/J.COGBRAINRES.2005.01.020
Stimulus sequence affects schizophrenia-normal differences in event processing during an auditory oddball task.
Casey S. Gilmore (2005)
10.1016/S0010-9452(08)70400-3
Functional Neuroanatomy of Segmenting Speech and Nonspeech
M. Burton (2006)
Frontal cortex, laterality, and memory: encoding versus retrieval.
V. Kavcic (2003)
10.1038/nn1072
Early ‘visual’ cortex activation correlates with superior verbal memory performance in the blind
A. Amedi (2003)
10.1016/j.neuroimage.2005.12.019
Acute opioid effects on human brain as revealed by functional magnetic resonance imaging
M. Leppä (2006)
10.1016/j.brainres.2006.02.091
Probability effects in the stop-signal paradigm: The insula and the significance of failed inhibition
J. Ramautar (2006)
10.1016/B978-012372560-8/50019-X
CHAPTER 19 – Topological Inference
K. Friston (2007)
10.1162/jocn.2007.19.5.855
Comprehending Prehending: Neural Correlates of Processing Verbs with Motor Stems
Shirley-Ann Rüschemeyer (2007)
10.1007/s11682-007-9003-2
Glucocorticoids Decrease Hippocampal and Prefrontal Activation during Declarative Memory Retrieval in Young Men
N. Oei (2007)
10.1016/j.neuron.2007.12.009
Enhanced Intersubject Correlations during Movie Viewing Correlate with Successful Episodic Encoding
U. Hasson (2008)
10.1167/iovs.07-0372
An FMRI study of saccadic and smooth-pursuit eye movement control in patients with age-related macular degeneration.
D. Little (2008)
10.1080/17470910701745858
Cognitive humor processing: Different logical mechanisms in nonverbal cartoons—an fMRI study
A. Samson (2008)
10.1016/j.neuroimage.2008.09.004
Fluctuations in electrodermal activity reveal variations in single trial brain responses to painful laser stimuli — A fMRI/EEG study
A. Mobascher (2009)
10.1016/j.brainres.2008.12.076
Aberrant functional connectivity in autism: Evidence from low-frequency BOLD signal fluctuations
Sarah K. Noonan (2009)
10.1093/CERCOR/BHL143
Event frequency modulates the processing of daily life activities in human medial prefrontal cortex.
F. Krueger (2007)
Amygdala and insula response to emotional images in patients with generalized social anxiety disorder.
S. G. Shah (2009)
10.1016/j.neuroimage.2009.04.040
An fMRI study of cytokine-induced depressed mood and social pain: The role of sex differences
N. Eisenberger (2009)
10.1016/j.neuron.2009.11.017
The Neural Circuitry of a Broken Promise
T. Baumgartner (2009)
See more
Semantic Scholar Logo Some data provided by SemanticScholar