Online citations, reference lists, and bibliographies.
Please confirm you are human
(Sign Up for free to never see this)
← Back to Search

Multiple Testing In Clinical Trials.

P. Bauer
Published 1991 · Mathematics, Medicine

Save to my Library
Download PDF
Analyze on Scholarcy
Share
The basic ideas of multiple testing are outlined and the problem of how to control the probability of erroneous decisions is discussed. The main emphasis is on the concept of the multiple level of significance (controlling the experiment, or family error in the strong sense) which can be achieved by applying the principle of closed tests. Various practical situations encountered in multiple testing in clinical trials are considered: more than one end point; more than two treatments, such as comparisons with a single control, comparisons using ordered alternatives, all pairwise comparisons and contrast methods; and more than one trial. Tests based on global statistics, the union intersection principle and other criteria are discussed. The application of the multiple test concept in sequential sampling is investigated. Finally some comments are made on multiple power, multiple confidence intervals and directed decisions.
This paper references
10.1080/01621459.1986.10478341
Modified Sequentially Rejective Multiple Test Procedures
J. Shaffer (1986)
10.1007/BF01894765
Multiple test procedures for arbitrary dependence structures
G. Hommel (1986)
10.1002/BIMJ.4710310600
Sequential tests of hypotheses in consecutive trials
P. Bauer (1989)
10.1080/01621459.1983.10477045
Multiple comparisons by rerandomization tests
D. Petrondas (1983)
10.1093/BIOMET/63.3.655
On closed testing procedures with special reference to ordered analysis of variance
R. Marcus (1976)
10.1080/01621459.1967.10482935
Rectangular Confidence Regions for the Means of Multivariate Normal Distributions
Z. Šidák (1967)
10.1093/BIOMET/75.2.383
A stagewise rejective multiple test procedure based on a modified Bonferroni test
G. Hommel (1988)
10.1093/BIOMET/73.3.759
Approximation of discrete sequential boundaries
P. Bauer (1986)
10.1080/01621459.1983.10477046
Sequential Multiple Comparisons with the Best
J. Hsu (1983)
10.1093/BIOMET/41.1-2.133
A DISTRIBUTION-FREE k-SAMPLE TEST AGAINST ORDERED ALTERNATIVES
A. Jonckheere (1954)
10.2307/2343787
Repeated Significance Tests on Accumulating Data
P. Armitage (1969)
10.1214/AOMS/1177704570
A Sequential Procedure for Comparing Several Experimental Categories with a Standard or Control
E. Paulson (1962)
10.1080/01621459.1965.10480814
Estimation of Multiple Contrasts Using T-distributions
O. Dunn (1965)
10.1080/00029890.1965.11970533
Best Possible Inequalities for the Probability of a Logical Function of Events
T. Hailperin (1965)
10.1080/00401706.1960.10489894
A Rank Sum Test for Comparing All Pairs of Treatments
R. Steel (1960)
10.1093/BIOMET/73.3.751
An improved Bonferroni procedure for multiple tests of significance
R. Simes (1986)
10.1080/03610927508827267
Some selection rules for comparing p processes with a standard
Umesh D. Naik (1975)
10.1093/BIOMET/76.3.624
A comparison of two modified Bonferroni procedures
G. Hommel (1989)
10.1080/01621459.1990.10475325
Some New Inequalities for the Range Distribution, with Application to the Determination of Optimum Significance Levels of Multiple Range Tests
H. Finner (1990)
10.1002/BIMJ.4710290803
On the Assessment of the Performance of Multiple Test Procedures
P. Bauer (1987)
10.1080/01621459.1989.10478839
Multiple Test Procedures in Clinical Dose Finding Studies
Michael Budde (1989)
10.1214/AOS/1176345205
Control of Directional Errors with Stagewise Multiple Test Procedures
J. Shaffer (1980)
10.1080/02331888808802068
Model selection by multiple test procedures
P. Bauer (1988)
10.1007/BF02204362
Das maximale signifikanzniveau des Tests: “LehneHo ab, wennk untern gegebenen tests zur ablehnung führen”
B. Rüger (1978)
10.2307/2531158
Procedures for comparing samples with multiple endpoints.
P. C. O'Brien (1984)
10.1093/BIOMET/64.2.191
Group sequential methods in the design and analysis of clinical trials
S. Pocock (1977)
10.1007/978-3-642-83328-1
Verlaufskurven und Crossover
W. Lehmacher (1987)
10.1037/H0042478
Multiple comparison in psychological research.
T. A. Ryan (1959)
10.1214/AOMS/1177692621
On the Optimality of Some Multiple Comparison Procedures
E. Spjøtvoll (1972)
10.2307/2528930
A test for differences between treatment means when several dose levels are compared with a zero dose control.
Williams Da (1971)
10.2307/4615733
A Simple Sequentially Rejective Multiple Test Procedure
S. Holm (1979)
10.1093/BIOMET/75.4.800
A sharper Bonferroni procedure for multiple tests of significance
Y. Hochberg (1988)
10.1007/BF01894737
Multiple testing of pairs of one-sided hypotheses
P. Bauer (1986)
10.1007/978-1-4614-1412-4_55
Optimum Significance Levels for Multistage Comparison Procedures
E. L. Lehmann (1979)
10.2307/2530245
A multiple testing procedure for clinical trials.
P. C. O'Brien (1979)
10.1055/S-0038-1635488
Descriptive data analysis: a concept between confirmatory and exploratory data analysis.
K. Abt (1987)
10.1080/01621459.1981.10477635
Closure of the Newman-Keuls Multiple Comparisons Procedure
J. M. Begun (1981)
10.1080/01621459.1990.10474944
On the power of tests for multiple comparison of three normal means
J. Kunert (1990)
10.1214/AOMS/1177729029
On a Heuristic Method of Test Construction and its use in Multivariate Analysis
S. Roy (1953)
10.1093/BIOMET/67.3.651
Group sequential methods for clinical trials with a one-sided hypothesis
D. Demets (1980)
10.1093/BIOMET/40.1-2.87
A METHOD FOR JUDGING ALL CONTRASTS IN THE ANALYSIS OF VARIANCE
H. Scheffé (1953)
10.1093/BIOMET/70.3.659
Discrete sequential boundaries for clinical trials
K. Lan (1983)
10.1002/BIMJ.4710280717
Two Stage Sampling for Simultaneously Testing Main and Side Effects in Clinical Trials
P. Bauer (1986)
10.2307/2347119
Selection of the Best of K Normal Populations
G. Wetherill (1974)
10.1016/0378-3758(89)90008-6
A sequential elimination procedure for choosing the best population(s) based on multiple testing
P. Bauer (1989)
10.2307/2532142
Procedures for two-sample comparisons with multiple endpoints controlling the experimentwise error rate.
W. Lehmacher (1991)
10.2307/2527654
A multiple comparison rank sum test: Treatments versus control.
R. Steel (1959)
10.1080/00401706.1964.10490181
Multiple Comparisons Using Rank Sums
Olive Jean Dunn (1964)
10.1214/AOMS/1177697819
SIMULTANEOUS TEST PROCEDURES-SOME THEORY OF MULTIPLE COMPARISONS'
K. Gabriel (1969)
10.1214/AOMS/1177703739
A Sequential Procedure for Selecting the Population with the Largest Mean from $k$ Normal Populations
E. Paulson (1964)
10.1080/00401706.1968.10490583
Simultaneous Statistical Inference
R. G. Miller (1966)



This paper is referenced by
Advances in Multivariate Back-testing for Credit Risk Underestimation
F. Coppens (2016)
10.1016/S0002-9149(00)01268-6
Restenosis after coronary placement of various stent types.
A. Kastrati (2001)
10.1080/10543400500265660
The Fallback Procedure for Evaluating a Single Family of Hypotheses
B. Wiens (2005)
10.1080/19466315.2017.1371071
Sample Size for Multiple Hypothesis Testing in Biosimilar Development
Johanna Mielke (2018)
10.1002/acm2.12438
Second cancer risk after radiation therapy of ependymoma using the flattening filter free irradiation mode of a linear accelerator
Judit Alvarez Moret (2018)
10.1177/00912709922011836
The New Topical Steroid Ciclesonide Is Effective in the Treatment of Allergic Rhinitis
B. M. Schmidt (1999)
10.1111/j.1472-8206.2006.00437.x
How to deal with multiple endpoints in clinical trials
M. Neuhäuser (2006)
10.1016/S0140-6736(16)31637-3
Early, goal-directed mobilisation in the surgical intensive care unit: a randomised controlled trial
S. J. Schaller (2016)
10.5691/JJB.27.S64
Review of "Points to Consider on Multiplicity Issues in Clinical Trials" and Issues to be Discussed
S. Fujikoshi (2006)
10.1067/MAI.2001.118596
The phosphodiesterase 4 inhibitor roflumilast is effective in the treatment of allergic rhinitis.
B. M. Schmidt (2001)
10.1198/sbr.2010.10010
Multiple and Repeated Testing of Primary, Coprimary, and Secondary Hypotheses
W. Maurer (2011)
10.1177/009286159302700314
Internally Adaptive Designs for Parallel Group Trials
U. Gugerli (1993)
10.1023/A:1007778706354
Barnidipine, a Novel Calcium Antagonist for Once-Daily Treatment of Hypertension: A Multicenter, Double-Blind, Placebo-Controlled, Dose-Ranging Study
W. Hart (2004)
10.3978/J.ISSN.2304-3865.2014.05.03
Drug designs fulfilling the requirements of clinical trials aiming at personalizing medicine.
S. Mandrekar (2014)
10.1136/ebmh.10.2.34
p Value fetishism and use of the Bonferroni adjustment
J. Morgan (2007)
10.1186/s41747-019-0115-4
Artefact and ablation performance of an MR-conditional high-power microwave system in bovine livers: an exvivo study
Antonia Grimm (2019)
10.1111/j.1526-4610.2006.00684.x
Efficacy and Safety of Topiramate for the Treatment of Chronic Migraine: A Randomized, Double‐Blind, Placebo‐Controlled Trial
S. Silberstein (2007)
10.1016/0009-9236(95)90055-1
Effects of cisplatin on urinary thromboxane B2 excretion
B. Blöchl-Daum (1995)
10.1902/ANNALS.1997.2.1.42
Design principles and statistical considerations in periodontal clinical trials.
G. Koch (1997)
Effectiveness of occupational therapy home program intervention for children with cerebral palsy : a double blind randomised controlled trial
I. Novak (2009)
10.1002/bjs.6960
Influence of general health and degree of surgical insult on long‐term survival
R. Kennedy (2010)
10.1097/ALN.0b013e31823d010a
Ketamine Activates Breathing and Abolishes the Coupling between Loss of Consciousness and Upper Airway Dilator Muscle Dysfunction
M. Eikermann (2012)
Multiple Endpoints in Clinical Trials Guidance for Industry
Draft Guidance (2017)
10.1016/0378-3758(94)90197-X
Problems of multiplicity in clinical trials
R. Simon (1994)
10.1002/sim.5427
Multiple tests of cost-effectiveness angles.
G. Gutjahr (2013)
10.1016/J.THERAP.2015.11.001
Quelle utilisation et quelle hiérarchisation pour les critères de jugement secondaires
S. Laporte (2016)
10.1007/978-90-313-9661-0_6
Verschil in Gemiddelde tussen Twee Groepen: Behandelingen Vergelijken, Log Transformatie, Meerdere Uitkomstmaten, Twee-steekproeven t-toets of Wilcoxon-Mann–Whitney rangsom toets
H. Schouten (1999)
10.1016/j.therap.2016.01.002
Clinical research and methodology: What usage and what hierarchical order for secondary endpoints?
S. Laporte (2016)
10.1080/10543406.2011.552879
Multiple Hypotheses Testing Based on Ordered p Values—A Historical Survey with Applications to Medical Research
G. Hommel (2011)
Research Submissions Efficacy and Safety of Topiramate for the Treatment of Chronic Migraine: A Randomized, Double-Blind, Placebo-Controlled Trial
D. Dodick (2007)
10.1158/1078-0432.CCR-08-0325
Multi-Arm Clinical Trials of New Agents: Some Design Considerations
B. Freidlin (2008)
10.1007/978-1-4419-1213-8_19
Planning the Analysis
Paul R. Rosenbaum (2010)
See more
Semantic Scholar Logo Some data provided by SemanticScholar