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Rational Design Of A New Self‐Codelivery System From Redox‐Sensitive Camptothecin–Cytarabine Conjugate Assembly For Effectively Synergistic Anticancer Therapy
Wenxiu He, Xu Hu, Wei Jiang, R. Liu, Di Zhang, J. Zhang, Z. Li, Y. Luan
Published 2017 · Chemistry, Medicine
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Herein, two careful selected anticancer drugs camptothecin (CPT) and cytarabine (Ara-C) with different biological action mechanisms and different water solubility are conjugated together through a glutathione (GSH) cleavable disulfide bond to construct a redox-sensitive drug-drug conjugate, which can self-assemble into nanoparticles, thus notably improving the water solubility of CPT and the cell membrane permeability of Ara-C. Compared with free drugs, the self-assembled CPT-ss-Ara nanoparticles can concentrate in tumor tissues through the enhanced permeability and retention (EPR) effect, then they can be rapidly internalized by tumor cells and degrade into free drugs for killing the tumor cells when exposed to the reductive environment (GSH) of tumor cells, thereby reducing the injury to normal cells. Meanwhile, the CPT-ss-Ara nanoparticles can effectively protect CPT and Ara-C molecules from biological inactivation before their arrival in tumor microenvironment since free CPT and Ara-C are easy to partly lose their therapy efficacy due to their structure degradation in blood circulation. The in vitro and in vivo anticancer experimental results indicate that simultaneous release of free CPT and Ara-C can realize synergistic chemotherapy effects, thus markedly improve their anticancer activity. Therefore, our designed carrier-free, redox-sensitive CPT-ss-Ara nanoparticles might have promising clinical application to combat cancers.
This paper references
Cytosine arabinoside and 6‐thioguanine in refractory acute lymphocytic leukemia
J. H. Bryan (1974)
KB cell culture I. Role in discovery of antitumor agents from higher plants.
R. E. Purdue (1982)
Preparation, characterization and properties of sterically stabilized paclitaxel-containing liposomes.
P. Crosasso (2000)
Identification and Characterization of a Deletion Mutant of DNA Topoisomerase I mRNA in a Camptothecin‐resistant Subline of Human Colon Carcinoma
K. Yanase (2000)
Relation between intracellular acidification and camptothecin-induced apoptosis in leukemia cells.
J. Goossens (2000)
Block copolymer micelles for drug delivery: design, characterization and biological significance.
K. Kataoka (2001)
Modulation of camptothecin analogs in the treatment of cancer: a review
D. Kehrer (2001)
The role of glutathione in cancer
G. K. Balendiran (2004)
Dendrimers and dendritic polymers in drug delivery.
E. Gillies (2005)
Overcoming multidrug resistance of small-molecule therapeutics through conjugation with releasable octaarginine transporters
Elena A. Dubikovskaya (2008)
A phase II study of continuous infusion homoharringtonine and cytarabine in newly diagnosed patients with chronic myeloid leukemia: CALGB study 19804
R. Stone (2008)
Antitumoral activity of PEG-gemcitabine prodrugs targeted by folic acid.
G. Pasut (2008)
Thermo-sensitive polymeric micelles based on poly(N-isopropylacrylamide) as drug carriers
Hua Wei (2009)
Disassemblable micelles based on reduction-degradable amphiphilic graft copolymers for intracellular delivery of doxorubicin.
Y. Sun (2010)
Cancer therapies utilizing the camptothecins: a review of the in vivo literature.
Vincent J Venditto (2010)
Global cancer statistics
A. Jemal (2011)
Improved outcome of patients with low‐ and intermediate‐risk cytogenetics acute myeloid leukemia (AML) in first relapse with gemtuzumab and cytarabine versus cytarabine
T. Prebet (2011)
Cisplatin@US-tube carbon nanocapsules for enhanced chemotherapeutic delivery.
A. Guven (2012)
Self-assembled plasmonic vesicles of SERS-encoded amphiphilic gold nanoparticles for cancer cell targeting and traceable intracellular drug delivery.
Jibin Song (2012)
Self-assembled Tat nanofibers as effective drug carrier and transporter.
P. Zhang (2013)
Tumor redox heterogeneity-responsive prodrug nanocapsules for cancer chemotherapy.
J. Wang (2013)
Clinical application of drug delivery systems in cancer chemotherapy: review of the efficacy and side effects of approved drugs.
T. Iwamoto (2013)
Supramolecular nanostructures formed by anticancer drug assembly.
A. G. Cheetham (2013)
Combination of small molecule prodrug and nanodrug delivery: amphiphilic drug-drug conjugate for cancer therapy.
Ping Huang (2014)
Synthesis and Self-Assembly of a Mikto-Arm Star Dual Drug Amphiphile Containing both Paclitaxel and Camptothecin.
A. G. Cheetham (2014)
Disulfide Bond Bridge Insertion Turns Hydrophobic Anticancer Prodrugs into Self-Assembled Nanomedicines
Y. Wang (2014)
Folate-decorated and reduction-sensitive micelles assembled from amphiphilic polymer-camptothecin conjugates for intracellular drug delivery.
Chaoyu Liu (2014)
Layer-by-layer nanoencapsulation of camptothecin with improved activity.
Gaurav Parekh (2014)
Self-assembled PEG-IR-780-C13 micelle as a targeting, safe and highly-effective photothermal agent for in vivo imaging and cancer therapy.
A. Yuan (2015)
Dual‐Stage‐Light‐Guided Tumor Inhibition by Mitochondria‐Targeted Photodynamic Therapy
K. Han (2015)
Hao Su (2015)
Enzymatically and reductively degradable α-amino acid-based poly(ester amide)s: synthesis, cell compatibility, and intracellular anticancer drug delivery.
H. Sun (2015)
Cancer statistics, 2015
R. Siegel (2015)
Spiral assembly of amphiphilic cytarabine prodrug assisted by probe sonication: Enhanced therapy index for leukemia.
J. Liu (2015)
Supramolecular nanostructures as drug carriers
R. Lin (2015)
Synergistic Combination Chemotherapy of Camptothecin and Floxuridine through Self-Assembly of Amphiphilic Drug-Drug Conjugate.
Minxi Hu (2015)
Facile Fabrication of Tumor Redox-Sensitive Nanoassemblies of Small-Molecule Oleate Prodrug as Potent Chemotherapeutic Nanomedicine.
C. Luo (2016)
Reduction-Sensitive Polymeric Micelles Based on Docetaxel-Polymer Conjugates Via Disulfide Linker for Efficient Cancer Therapy.
Y. Guo (2016)
A small molecule nanodrug consisting of amphiphilic targeting ligand-chemotherapy drug conjugate for targeted cancer therapy.
Quanbing Mou (2016)
Reduction Responsive Self-Assembled Nanoparticles Based on Disulfide-Linked Drug-Drug Conjugate with High Drug Loading and Antitumor Efficacy.
Q. Song (2016)
IR-780 Loaded Phospholipid Mimicking Homopolymeric Micelles for Near-IR Imaging and Photothermal Therapy of Pancreatic Cancer.
Yangjun Chen (2016)
Supramolecular Crafting of Self-Assembling Camptothecin Prodrugs with Enhanced Efficacy against Primary Cancer Cells
H. Su (2016)
Self-Assembled Redox Dual-Responsive Prodrug-Nanosystem Formed by Single Thioether-Bridged Paclitaxel-Fatty Acid Conjugate for Cancer Chemotherapy.
Cong Luo (2016)
Highly enhanced leukemia therapy and oral bioavailability from a novel amphiphilic prodrug of cytarabine
Jing Liu (2016)
Mitochondria-Targeted Chimeric Peptide for Trinitarian Overcoming of Drug Resistance.
Kai Han (2016)
Disulfide-Linked Amphiphilic Polymer-Docetaxel Conjugates Assembled Redox-Sensitive Micelles for Efficient Antitumor Drug Delivery.
Pei Zhang (2016)
Paclitaxel dimers assembling nanomedicines for treatment of cervix carcinoma
Q. Pei (2017)
Synergistic antitumor activity of a self‐assembling camptothecin and capecitabine hybrid prodrug for improved efficacy
Wang Ma (2017)
This paper is referenced by
Polymeric blends of okra gum/gelatin prepared by aqueous polymerization technique: their characterization and toxicological evaluation
Shayan Maryam (2021)
Redox-sensitive carrier-free nanoparticles self-assembled by disulfide-linked paclitaxel-tetramethylpyrazine conjugate for combination cancer chemotherapy
Liang Zou (2021)
Antitumour Properties based on the Self-assembly of Camptothecin and Carbamoylmannose Conjugates.
Jiali Wang (2020)
Disulfide based prodrugs for cancer therapy
Q. Wang (2020)
Studies on interaction potency model based on drug synergy and therapeutic potential of triple stimuli-responsive delivery of doxorubicin and 5-fluoro-2-deoxyuridine against lymphoma using disulfide-bridged cysteine over mesoporous silica nanoparticles.
P. Srivastava (2020)
A GSH-Responsive Nanoprodrug System Based on Self-Assembly of Lactose Modified Camptothecin for Targeted Drug Delivery and Combination Chemotherapy
Chenxi Hou (2020)
Co-delivery system of chemotherapy drugs and active ingredients from natural plants: a brief overview of preclinical research for cancer treatment
Pu Guo (2020)
Redox-responsive amphiphilic camptothecin prodrug nanoparticles for targeted liver tumor therapy.
Lu Lu (2020)
Research progress on nanotechnology for delivery of active ingredients from traditional Chinese medicines.
Li Qiao (2020)
Self‐Assembled Nanoparticles as Cancer Therapeutic Agents
W. Ge (2020)
Controlled drug delivery with nanoassemblies of redox-responsive prodrug and polyprodrug amphiphiles.
Z. Deng (2020)
Self-assembling prodrug nanotherapeutics for synergistic tumor targeted drug delivery
Zhiren Wang (2020)
ROS-sensitive thioketal-linked polyphosphoester-doxorubicin conjugate for precise phototriggered locoregional chemotherapy.
Pei Pei (2019)
Acid sensitive ROS-triggered dextran-based drug delivery system for advanced chemo-photodynamic synergistic therapy.
Y. Bao (2019)
Mitochondria-targeting nanomedicine self-assembled from GSH-responsive paclitaxel-ss-berberine conjugate for synergetic cancer treatment with enhanced cytotoxicity.
Y. Cheng (2019)
Intracellular GSH-responsive camptothecin delivery systems
Dan Zhang (2019)
Redox-sensitive lipophilic prodrugs: delivering unstable chemotherapeutant for improved cancer therapy
F. Li (2019)
Targeted co-delivery of the aldose reductase inhibitor epalrestat and chemotherapeutic doxorubicin via a redox-sensitive prodrug approach promotes synergistic tumor suppression.
V. T. Banala (2019)
A versatile strategy to create an active tumor-targeted chemo-photothermal therapy nanoplatform: A case of an IR-780 derivative co-assembled with camptothecin prodrug.
Wenxiu He (2019)
Tailored graphene oxide-doxorubicin nanovehicles via near-infrared dye-lactobionic acid conjugates for chemo-photothermal therapy.
Chunzhi Huang (2019)
Liposomal Cytarabine as Cancer Therapy: From Chemistry to Medicine
B. Salehi (2019)
Redox-sensitive dimeric camptothecin phosphatidylcholines-based liposomes for improved anticancer efficacy.
W. He (2019)
Reduction‐responsive poly (ethylene glycol)‐dexamethasone biarm conjugate and its self‐assembled nanomicelles: Preparation, physicochemical characterization, and thiol‐triggered drug release
Ngoc Dung Tran Thi (2019)
Combretastatin A4-camptothecin micelles as combination therapy for effective anticancer activity
M. Assali (2019)
Lactoferrin-conjugated pH and redox-sensitive polymersomes based on PEG-S-S-PLA-PCL-OH boost delivery of bacosides to the brain.
Kritika Goyal (2018)
IR780 based nanomaterials for cancer imaging and photothermal, photodynamic and combinatorial therapies
Cátia G Alves (2018)
pH- and Enzyme-Sensitive IR820-Paclitaxel Conjugate Self-Assembled Nanovehicles for Near-Infrared Fluorescence Imaging-Guided Chemo-Photothermal Therapy.
D. Zhang (2018)
Preparation of pH- and reductive-responsive prodrug nanoparticles via polymerization-induced self-assembly
M. Chen (2018)
A preclinical evaluation of cytarabine prodrug nanofibers assembled from cytarabine‐lauric acid conjugate toward solid tumors
R. Liu (2018)
Rational Design of IR820- and Ce6-Based Versatile Micelle for Single NIR Laser-Induced Imaging and Dual-Modal Phototherapy.
X. Hu (2018)
Synthesis of non-ionic bolaamphiphiles and study of their self-assembly and transport behaviour for drug delivery applications
Preparation and in vitro/in vivo evaluation of 6-Gingerol TPGS/PEG-PCL polymeric micelles
Lijun Zhen (2018)See more