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Advances In The Synthesis Of Methylated Products Through Indirect Approaches

Yantao Chen
Published 2020 · Chemistry

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10.1021/jacs.8b04479
Intermediacy of Ni-Ni Species in sp2 C-O Bond Cleavage of Aryl Esters: Relevance in Catalytic C-Si Bond Formation.
Rosie J Somerville (2018)
10.1248/CPB.28.1648
A Novel Synthesis of 2, 3-Dimethoxy-5-methyl-p-benzoquinone
N. Minami (1980)
10.1002/anie.201611813
B(C6 F5 )3 -Catalyzed Chemoselective Defunctionalization of Ether-Containing Primary Alkyl Tosylates with Hydrosilanes.
Indranil Chatterjee (2017)
10.3987/COM-14-13077
The Reaction of 2-((Trimethylsilyl)methyl)-2H-tetrazoles with Aldehydes and Ketones in the Presence of 1,8-Diazabicyclo[5.4.0]undec-7-ene
Hideaki Umemoto (2014)
10.1016/J.ENZMICTEC.2006.06.002
Biotransformations of Mannich bases and propiophenones by Brazilian microorganisms and enzymatic resolution of phenylpropanols by lipase from Candida antarctica (Novozym 435)
Cristiano Raminelli (2007)
10.1002/CJOC.200990224
Highly Efficient N‐Monomethylation of Primary Aryl Amines
Yiyuan Peng (2009)
10.1248/CPB.14.1007
Reaction of Amide Homologs. XIV. N-Monomethylation of Aromatic Primary Amines
M. Sekiya (1966)
10.1021/ACS.OPRD.7B00171
(Chloromethyl)dimethylchlorosilane–KF: A Two-Step Solution to the Selectivity Problem in the Methylation of a Pyrimidone Intermediate en Route to Raltegravir
Christos I. Stathakis (2017)
10.1002/cctc.201100076
A Palladium‐Catalyzed Multicascade Reaction: Facile Low‐Temperature Hydrogenolysis of Activated Nitriles and Related Functional Groups
Aaron J. Yap (2011)
10.1055/S-0037-1610185
Divergent Syntheses of Carbazole Alkaloids
Feixiang Ji (2018)
10.1021/acs.joc.8b00205
Organocatalyzed, Visible-Light Photoredox-Mediated, One-Pot Minisci Reaction Using Carboxylic Acids via N-(Acyloxy)phthalimides.
Trevor C Sherwood (2018)
10.1021/ACS.IECR.9B01274
Hydrotreating the Low-Boiling-Point Fraction of Biocrude in Hydrogen Donor Solvents for Production of Trace-Sulfur Liquid Fuel
Zhicong Wang (2019)
10.1021/OP100257R
Development of a Second-Generation, Highly Efficient Manufacturing Route for the HIV Integrase Inhibitor Raltegravir Potassium
G. Humphrey (2011)
10.1021/ja5007838
C–H Methylation of Heteroarenes Inspired by Radical SAM Methyl Transferase
Jinghan Gui (2014)
10.1002/ANGE.201303207
Ausgeprägte Methyleffekte in der Wirkstoff‐Forschung und der Bedarf an neuen C‐H‐Methylierungsreaktionen
Heike Schoenherr (2013)
10.1002/anie.201612045
Enantioselective Formal α‐Methylation and α‐Benzylation of Aldehydes by Means of Photo‐organocatalysis
G. Filippini (2017)
10.1021/JO020057Z
A convenient synthesis of 2-(alkylamino)pyridines.
Douglas M. Krein (2002)
10.1002/EJOC.201300657
Reductive Deoxygenation of Alcohols: Catalytic Methods Beyond Barton–McCombie Deoxygenation
J. M. Herrmann (2013)
10.1002/ANGE.201611813
B(C6F5)3‐katalysierte chemoselektive Defunktionalisierung von etherhaltigen primären Alkyltosylaten mit Hydrosilanen
Indranil Chatterjee (2017)
10.1007/978-1-62703-544-6_10
Synthesis of N-methylated peptides: on-resin methylation and microwave-assisted couplings.
R. Roodbeen (2013)
10.1039/C1MD00134E
Minisci reactions: Versatile CH-functionalizations for medicinal chemists
M. Duncton (2011)
10.1021/jo2018558
Synthesis of the reported structure of trans-africanan-1α-ol.
D. Taber (2011)
10.1016/J.TETLET.2011.08.144
Application of flow chemistry to the reduction of nitriles to aldehydes
J. M. Muñoz (2011)
10.1002/anie.200705797
Improving oral bioavailability of peptides by multiple N-methylation: somatostatin analogues.
Eric Biron (2008)
10.1021/acs.orglett.7b03537
Generation of All-Carbon Quaternary Stereocenters at the C-3 Carbon of Lactams via [3,3]-Sigmatropic Rearrangement and Revision of Absolute Configuration: Total Synthesis of (-)-Physostigmine.
G. Pandey (2018)
10.1055/S-0032-1318220
A Highly Stereoselective Organocatalytic Approach to Lilial® and Muguesia
A. Gualandi (2013)
10.1016/J.FUPROC.2015.07.016
Effect of cyclohexane as hydrogen-donor in ultradispersed catalytic upgrading of heavy oil
A. Hart (2015)
10.1016/J.TET.2004.09.064
Synthesis of new N-aryl oxindoles as intermediates for pharmacologically active compounds
M. Acemoglu (2004)
10.1039/C7QO01079F
Recent advances in the intramolecular Mannich reaction in natural products total synthesis
Y. Shi (2018)
10.1002/cssc.201402610
A catalytic reactor for the organocatalyzed enantioselective continuous flow alkylation of aldehydes.
R. Porta (2014)
10.1021/JA01246A005
Hydrogenolysis of Sulfur Compounds by Raney Nickel Catalyst
R. Mozingo (1943)
10.1002/anie.201801919
Noncanonical RNA Nucleosides as Molecular Fossils of an Early Earth-Generation by Prebiotic Methylations and Carbamoylations.
C. Schneider (2018)
10.1039/c2cc17482k
A general stereoselective enamine mediated alkylation of α-substituted aldehydes.
A. Gualandi (2012)
10.1002/ADSC.201300250
A Straightforward Organocatalytic Alkylation of 2-Arylacetaldehydes: An Approach towards Bisabolanes
A. Gualandi (2014)
10.1002/anie.201301741
A catalytic asymmetric synthesis of polysubstituted piperidines using a rhodium(I)-catalyzed [2+2+2] cycloaddition employing a cleavable tether.
T. J. Martin (2013)
10.5012/BKCS.2010.31.9.2453
Studies of Silyl-Transfer Photochemical Reactions of N-[(Trimethylsilyl)alkyl]saccharins
D. Cho (2010)
10.1021/acs.jmedchem.8b01721
Binding to an Unusual Inactive Kinase Conformation by Highly Selective Inhibitors of Inositol-Requiring Enzyme 1α Kinase-Endoribonuclease
Giampiero Colombano (2019)
10.1039/C5GC00556F
Conversion of biomass-derived fatty acids and derivatives into hydrocarbons using a metal-free hydrodeoxygenation process
Xingyu Li (2015)
10.3390/molecules24020330
TiO2 Photocatalysis for Transfer Hydrogenation
D. Ma (2019)
10.1002/chem.201604904
Direct Catalytic Hydrogenation of Simple Amides: A Highly Efficient Approach from Amides to Amines and Alcohols.
Liyang Shi (2017)
10.1016/j.bmc.2017.08.031
Improving oral bioavailability of cyclic peptides by N-methylation.
Andreas F B Räder (2018)
10.1002/CBER.19140470108
Über eine allgemeine Methode zur Reduktion der Carbonylgruppe in Aldehyden und Ketonen zur Methylengruppe
Erik Clemmensen (1914)
10.1016/j.copbio.2017.07.007
Strategies for transitioning macrocyclic peptides to cell-permeable drug leads.
L. Walport (2017)
10.1002/CHEM.200600815
Total solid-phase synthesis of the azathiocoraline class of symmetric bicyclic peptides.
N. Bayó-Puxan (2006)
10.1002/cmdc.201500572
Hitting a Moving Target: How Does an N‐Methyl Group Impact Biological Activity?
Y. C. Koay (2016)
10.1021/ja9050586
Enantiospecific photochemical Norrish/Yang type II reaction of nonbiaryl atropchiral alpha-oxoamides in solution--axial to point chirality transfer.
A. J. Ayitou (2009)
10.1021/ACSCATAL.8B02902
Highly Selective, Efficient Deoxygenative Hydrogenation of Amides Catalyzed by a Manganese Pincer Complex via Metal–Ligand Cooperation
You‐Quan Zou (2018)
10.1021/JO061749G
N-H carbazole synthesis from 2-chloroanilines via consecutive amination and C-H activation.
R. Bedford (2006)
10.1021/acs.joc.7b03139
An Additive-Free, Base-Catalyzed Protodesilylation of Organosilanes.
Wubing Yao (2018)
10.1016/j.ejmech.2016.03.014
Systematic comparison of the mono-, dimethyl- and trimethyl 3-hydroxy-4(1H)-pyridones - Attempted optimization of the orally active iron chelator, deferiprone.
Yuanyuan Xie (2016)
10.1002/POLA.26939
BF3·OEt2 in alcoholic media, an efficient initiator in the cationic polymerization of phenyl-1,3-benzoxazines
R. Andreu (2013)
10.1021/ol502956j
Synthesis of syn-1,3-aminoalcohols via a Ru-catalyzed N-demethylative rearrangement of isoxazolidines and its application in a three-step total synthesis of HPA-12.
Chuan-Zhi Yao (2014)
10.1021/acs.joc.8b00061
Strategy for O-Alkylation of Serine and Threonine from Serinyl and Threoninyl Acetic Acids by Photoinduced Decarboxylative Radical Reactions: Connection between Serine/Threonine and Carbohydrates/Amino Acids at the Side Chain.
T. Yamamoto (2018)
10.1016/j.ejps.2017.09.007
Impact of N‐methylation of the substance P 1–7 amide on anti‐allodynic effect in mice after peripheral administration
A. Skogh (2017)
10.1016/0022-328X(89)85379-3
The reaction of N-trimethylsilyl-amides and -lactams with dimethyl(chloromethyl)chlorosilane. Kinetically controlled formation of (NSi) chelate intermediates, O-[(dimethylchlorosilyl)methyl]imidates and their rearrangement to final(OSi) chelate N-[(dimethylchlorosilyl)methyl]amides and lactams
I. Kalikhman (1989)
10.1248/CPB.22.1256
Reductive Cleavage Reaction of N, N'-, N, O- and N, S-Linked Alkylidene Compounds by Sodium Borohydride
K. Shimizu (1974)
10.1002/anie.201708800
Catalytic Reduction of Alkyl and Aryl Bromides Using Propan-2-ol.
Michael C Haibach (2017)
10.1002/cctc.201501243
Palladium Supported on Nanodiamonds as an Efficient Catalyst for the Hydrogenating Deamination of Benzonitrile and Related Compounds
N. Gupta (2016)
10.1073/PNAS.78.3.1321
Hydrogenative deoxygenation of organic compounds: Direct conversion of amides to alkanes.
E. E. van Tamelen (1981)
10.1016/0040-4020(95)01016-5
Directed aminomethylation of 3-hydroxy-2(1H)-pyridinones and 3-hydroxy-4(1H)-pyridinones: Synthesis of iso-deferiprone
M. K. Patel (1996)
10.3390/CATAL9060490
Base Metal Catalysts for Deoxygenative Reduction of Amides to Amines
Andrey Y Khalimon (2019)
10.1002/chem.201803642
Recent Advances in Methylation: A Guide for Selecting Methylation Reagents.
Yantao Chen (2019)
10.1039/C4MD00409D
The effect of N-methylation on transition state mimetic inhibitors of the Plasmodium protease, plasmepsin V
Michelle Gazdik (2015)
10.1002/JHET.3275
Interaction of Fused 1,2,4-Triazinone with Diborane/Oxidation: A New Route for the Synthesis of Partially Saturated and Aromatic Pyrazolo[5,1-c][1,2,4]triazines: A New Route for the Synthesis of Partially Saturated and Aromatic Pyrazolo[5,1-c][1,2,4]triazines
S. Ivanov (2018)
10.1016/J.CES.2019.03.011
PdCl2-catalyzed hydrodeoxygenation of 5-hydroxymethylfurfural into 2,5-dimethylfuran at room-temperature using polymethylhydrosiloxane as the hydrogen donor
Jun Zhang (2019)
10.1016/j.bmc.2014.11.034
Improving the passive permeability of macrocyclic peptides: Balancing permeability with other physicochemical properties.
P. Thansandote (2015)
10.1016/j.bmc.2016.01.036
A new GLP-1 analogue with prolonged glucose-lowering activity in vivo via backbone-based modification at the N-terminus.
Xiaohui Bai (2016)
10.1021/ACSCATAL.7B01133
Visible Light-Mediated Direct Decarboxylative C–H Functionalization of Heteroarenes
R. A. Garza‐Sanchez (2017)
10.1002/EJOC.201701278
Selective Generation of (1H‐1,2,4‐Triazol‐1‐yl)methyl Carbanion and Condensation with Carbonyl Compounds
P. Lassalas (2017)
10.1002/anie.201900801
Diastereo‐ and Enantioselective Access to Stereotriads through a Flexible Coupling of Substituted Aldehydes and Alkenes
Jing Li (2019)
10.1002/anie.201905021
Palladium-Catalyzed Dearomative syn-1,4-Carboamination with Grignard Reagents.
C. Tang (2019)
10.1021/JM00170A026
Synthesis and biological evaluation of 4-fluoro-, 7-fluoro-, and 4,7-difluoro-5,6-dihydroxytryptamines.
M. Kawase (1990)
10.1021/JA01157A143
1,3-Anhydro-2,4-methylene-D,L-xylitol and Related Compounds
R. M. Hann (1950)
10.1007/s00044-018-2183-z
Synthesis of new C-dimethylated chalcones as potent antitubercular agents
Rambabu Anandam (2018)
10.1039/c8ob03088j
Continuous-flow protocol for the synthesis of enantiomerically pure intermediates of anti epilepsy and anti tuberculosis active pharmaceutical ingredients.
R. Aguiar (2019)
10.1021/acs.joc.8b03266
Pd/Cu Cocatalyzed Oxidative Tandem C-H Aminocarbonylation and Dehydrogenation of Tryptamines: Synthesis of Carbolinones.
H. Han (2019)
10.1016/j.ejmech.2013.07.037
Development of potent dipeptide-type SARS-CoV 3CL protease inhibitors with novel P3 scaffolds: Design, synthesis, biological evaluation, and docking studies
P. Thanigaimalai (2013)
10.1021/ar8000603
N-methylation of peptides: a new perspective in medicinal chemistry.
J. Chatterjee (2008)
10.1016/J.TET.2009.10.086
SmI2/H2O/amine promoted reductive cleavage of benzyl-heteroatom bonds: optimization and mechanism
T. Ankner (2009)
10.1021/ACS.OPRD.7B00098
Cp2TiCl: An Ideal Reagent for Green Chemistry?
M. C. Rodríguez (2017)
10.1039/c5cs00628g
The medicinal chemist's toolbox for late stage functionalization of drug-like molecules.
Tim Cernak (2016)
10.1021/acs.orglett.5b03082
Unified Approach to the Spiro(pyrrolidinyl-oxindole) and Hexahydropyrrolo[2,3-b]indole Alkaloids: Total Syntheses of Pseudophrynamines 270 and 272A.
S. De (2015)
10.1039/c7cc09201f
N terminal N-methylation modulates chiral centre induced helical (CIH) peptides' biophysical properties.
Wenjun Li (2018)
10.1039/c6ob02610a
Synthesis, SAR and biological studies of sugar amino acid-based almiramide analogues: N-methylation leads the way.
Dipendu Das (2017)
10.1021/acs.jmedchem.5b00919
Going Out on a Limb: Delineating The Effects of β-Branching, N-Methylation, and Side Chain Size on the Passive Permeability, Solubility, and Flexibility of Sanguinamide A Analogues.
Andrew T. Bockus (2015)
10.1002/ANGE.200705797
Die Verbesserung der oralen Bioverfügbarkeit von Peptiden durch multiple N‐Methylierung: Somatostatin‐Analoga
Eric Biron (2008)
10.1021/ja906083c
Weakening C-O bonds: Ti(III), a new reagent for alcohol deoxygenation and carbonyl coupling olefination.
Horacio R. Dieguez (2010)
10.1021/ACSCATAL.7B01729
Manganese-Catalyzed Direct Deoxygenation of Primary Alcohols
J. Bauer (2017)
10.1038/nchembio.2393
Autocatalytic backbone N-methylation in a family of ribosomal peptide natural products.
N. S. J. van der Velden (2017)
10.1021/acs.orglett.8b00190
Inexpensive Radical Methylation and Related Alkylations of Heteroarenes.
Q. Huang (2018)
10.1021/acs.joc.9b00114
Conversion of "Customizable Units" into N-Alkyl Amino Acids and Generation of N-Alkyl Peptides.
Carlos J Saavedra (2019)
10.1016/j.bmcl.2019.01.029
Identification of highly potent competence stimulating peptide-based quorum sensing activators in Streptococcus mutans through the utilization of N-methyl and reverse alanine scanning.
Chowdhury Raihan Bikash (2019)
10.1021/acs.orglett.7b03456
Enantioselective Synthesis of Spliceostatin G and Evaluation of Bioactivity of Spliceostatin G and Its Methyl Ester.
A. Ghosh (2018)
10.1021/ACS.JOC.6B01699
Deoxygenation of Unhindered Alcohols via Reductive Dealkylation of Derived Phosphate Esters.
Sarwat Chowdhury (2016)
10.1039/P19810001569
Sodium borohydride reduction of adducts of primary amines with aldehydes and p-thiocresol. The alkylation of heterocyclic and aromatic amino-compounds
Öznur Kemal (1981)
10.1039/c6sc03374a
Photoredox radical conjugate addition of dithiane-2-carboxylate promoted by an iridium(iii) phenyl-tetrazole complex: a formal radical methylation of Michael acceptors† †Electronic supplementary information (ESI) available: Experimental procedures, product characterizations, NMR spectra, compound pr
A. Gualandi (2017)
10.1021/acs.chemrev.6b00838
Orally Absorbed Cyclic Peptides.
D. S. Nielsen (2017)
10.1016/S0022-328X(00)82874-0
Reactions of the ambidentate substrate chloromethyldimethylchlorosilane with amines and amides
C. H. Yoder, (1980)
10.1021/acs.joc.7b00116
Access to Imidazolidine-Fused Sulfamidates and Sulfamides Bearing a Quaternary Center via 1,3-Dipolar Cycloaddition of Nonstabilized Azomethine Ylides.
Joydev K Laha (2017)
10.1038/nchembio.664
On-resin N-methylation of cyclic peptides for discovery of orally bioavailable scaffolds
T. White (2011)
10.1016/J.TET.2013.05.016
Diastereoselective synthesis of cyclic β2,3-amino acids utilizing 4-substituted-1,3-oxazinan-6-ones
Brad E. Sleebs (2013)
10.1016/J.TET.2011.04.004
1,1′-Methylene-bis(1,1′,2,2′,3,3′,4,4′-octahydroisoquinoline): synthesis, reaction, resolution, and application in catalytic enantioselective transformations
Qiong Yao (2011)
10.1002/0471264180.OR046.03
Reductions with Samarium(II) Iodide
G. Molander (2004)
10.1055/S-0036-1591624
Synthesis of Raltegravir
P. Kocieński (2017)
10.1016/j.chom.2017.04.011
SMYD2-Mediated Histone Methylation Contributes to HIV-1 Latency.
D. Boehm (2017)
10.1016/j.ejmech.2018.12.063
Design, biological evaluation and X-ray crystallography of nanomolar multifunctional ligands targeting simultaneously acetylcholinesterase and glycogen synthase kinase-3.
Killian Oukoloff (2019)
10.1021/cr200060g
The methylation effect in medicinal chemistry.
E. Barreiro (2011)
10.3762/bjoc.9.316
Modulating NHC catalysis with fluorine
Yannick P. Rey (2013)
10.1021/acs.joc.7b03080
Visible-Light-Mediated Decarboxylative Alkylation Cascade Cyano Insertion/Cyclization of N-Arylacrylamides under Transition-Metal-Free Conditions.
Y. Yu (2018)
10.1016/J.TETLET.2013.10.065
Reduction of nitriles into aldehydes using a TMDS/V(O)(OiPr)3 reducing system
S. Laval (2014)
10.1080/00397918808060912
The Reduction of Mannich Bases and Their Derivatives by Tri-N-Butyltin Hydride
H. Chao (1988)
10.1002/ANGE.201900801
Eine flexible Kupplung von Aldehyden und Alkenen ermöglicht die diastereo‐ und enantioselektive Herstellung von Stereotriaden
J. Li (2019)
10.1039/c4cc00117f
N-Methyl and peptoid scans of an autoinducing peptide reveal new structural features required for inhibition and activation of AgrC quorum sensing receptors in Staphylococcus aureus.
Yftah Tal-Gan (2014)
10.1039/c4cc09780g
Facile synthesis of mono- and bis-methylated Fmoc-Dap, -Dab and -Orn amino acids.
Fredrik Lindahl (2015)
10.1021/acschembio.5b00682
N-Methylation as a Strategy for Enhancing the Affinity and Selectivity of RNA-binding Peptides: Application to the HIV-1 Frameshift-Stimulating RNA
Thomas A. Hilimire (2016)
10.1016/S0040-4020(01)80441-5
Reductions of carboxylic acids and their derivatives using samarium diiodide-acid system
Y. Kamochi (1992)
10.1002/chem.201602416
Design and Synthesis of 2,2'-Diindolylmethanes to Selectively Target Certain G-Quadruplex DNA Structures.
Madeleine Livendahl (2016)
10.1016/j.bmcl.2016.03.073
Natural products as sources of new fungicides (III): Antifungal activity of 2,4-dihydroxy-5-methylacetophenone derivatives.
W. Shi (2016)
10.1021/JA00388A069
Protodesilylation reactions of simple .beta.-hydroxysilanes (and .alpha.-hydroxysilanes). Homo-Brook rearrangements
P. F. Hudrlik (1982)
10.1002/EJOC.201100537
Biocatalyzed Enantioselective Reduction of Activated C=C Bonds: Synthesis of Enantiomerically Enriched α-Halo-β-arylpropionic Acids
E. Brenna (2011)
10.1002/ADSC.201200832
Efficient Palladium-Catalyzed CO Hydrogenolysis of Benzylic Alcohols and Aromatic Ketones with Polymethylhydrosiloxane
H. Wang (2013)
10.1016/j.bmc.2017.02.045
Identification of a novel hormone sensitive lipase inhibitor with a reduced potential of reactive metabolites formation.
Tomoko Ogiyama (2017)
10.1039/C5MD00309A
Insights into the impact of N- and O-methylation on aqueous solubility and lipophilicity using matched molecular pair analysis
T. J. Ritchie (2015)
10.1021/acs.joc.6b00689
Visible-Light-Promoted (Phenylsulfonyl)methylation of Electron-Rich Heteroarenes and N-Arylacrylamides.
F. Liu (2016)
10.1002/cmdc.201300173
Effect of Ester to Amide or N‐Methylamide Substitution on Bacterial Membrane Depolarization and Antibacterial Activity of Novel Cyclic Lipopeptides
Nina Bionda (2013)
10.1002/anie.201402023
Late-stage functionalization of biologically active heterocycles through photoredox catalysis.
D. DiRocco (2014)
10.1016/J.MOLSTRUC.2016.03.019
N4-methylation changes the conformation of (3S,6S)-3-alkyl-6-benzylpiperazine-2,5-diones from folded to extended
M. Nakao (2016)
10.1016/S0040-4020(01)91972-6
Modern methods for the radical deoxygenation of alcohols
W. Hartwig (1983)
10.1021/JO00221A010
Synthetic application of cyanoaminosilanes as azomethine ylide equivalents
A. Padwa (1985)
10.1002/anie.201500062
Lewis acid promoted ruthenium(II)-catalyzed etherifications by selective hydrogenation of carboxylic acids/esters.
Y. Li (2015)
10.1021/acs.joc.7b01393
Rh(III)-Catalyzed C-H Cyclization of Arylnitrones with Diazo Compounds: Access to 3-Carboxylate Substituted N-Hydroxyindoles.
Yazhou Li (2017)
10.1002/chem.201501600
cis-Peptide Bonds: A Key for Intestinal Permeability of Peptides? .
U. K. Marelli (2015)
10.1021/cb300515u
Getting in shape: controlling peptide bioactivity and bioavailability using conformational constraints.
J. Bock (2013)
10.2174/138527208783743697
Peptide Backbone Modifications
Uli Kazmaier and Jan Deska (2008)
10.1246/CL.1983.1131
A SILYL-FUNCTIONALIZED ALKYL AZIDE, TRIMETHYLSILYLMETHYL AZIDE; SYNTHESIS AND CYCLOADDITION REACTION TO ACETYLENIC DIPOLAROPHILES
O. Tsuge (1983)
10.1021/JM000361P
N-Methyl scan of somatostatin octapeptide agonists produces interesting effects on receptor subtype specificity.
W. Rajeswaran (2001)
10.1039/C5RA01545F
An unprecedented deoxygenation protocol of benzylic alcohols using bis(1-benzotriazolyl)methanethione
D. Kumar (2015)
10.1021/ja505964r
Carboxylic Acids as A Traceless Activation Group for Conjugate Additions: A Three-Step Synthesis of (±)-Pregabalin
L. Chu (2014)
10.1002/anie.201303207
Profound methyl effects in drug discovery and a call for new C-H methylation reactions.
Heike Schoenherr (2013)
10.1021/acs.jmedchem.5b01501
The Importance of Being Me: Magic Methyls, Methyltransferase Inhibitors, and the Discovery of Tazemetostat.
K. Kuntz (2016)
10.1021/jacs.9b03862
Rhodium-Catalyzed Atroposelective C-H Arylation: Efficient Synthesis of Axially Chiral Heterobiaryls.
Q. Wang (2019)
10.1016/j.ejmech.2014.10.076
Mannich bases in medicinal chemistry and drug design
G. Roman (2015)
10.1021/jacs.6b02344
En Route to a Practical Primary Alcohol Deoxygenation.
Xi-Jie Dai (2016)
10.1016/J.TET.2016.03.102
The role of naked fluoride ion as base or catalyst in organic synthesis
Abdul Hameed (2016)
10.1021/acs.jmedchem.6b01873
Topical Intestinal Aminoimidazole Agonists of G-Protein-Coupled Bile Acid Receptor 1 Promote Glucagon Like Peptide-1 Secretion and Improve Glucose Tolerance.
M. Lasalle (2017)
10.1002/EJOC.201800207
Highly Efficient Synthesis and Structure–Activity Relationships of a Small Library of Substituted 1,4‐Naphthoquinones
N. Bao (2018)
10.1002/ANGE.201801919
Nicht‐kanonische RNA‐Nukleoside als molekulare Fossilien einer frühen Erde – Generierung durch präbiotische Methylierungen und Carbamoylierungen
C. Schneider (2018)
10.1016/S0040-4039(00)88452-X
A cyanide promoted Michael reaction: the use of an aminonitrile as an enamine equivalent for the Michael reacton
C. Mitch (1988)
10.1002/chir.22303
A practical and stereoselective organocatalytic alkylation of aldehydes with benzodithiolylium tetrafluoroborate.
A. Gualandi (2014)
10.1016/S0040-4020(01)89752-0
Further advances in the chemistry of mannich bases
M. Tramontini (1990)
10.1055/S-1987-27963
Facile Syntheses of Ethyl 2-Alkylindole-3-carboxylates: Reinvestigation of an Earlier Synthesis of Ethyl 3-Methylindole-2-carboxylates
M. S. Wadia (1987)
10.1021/ACSCATAL.5B02171
Heterogeneous Catalytic Transfer Hydrogenation as an Effective Pathway in Biomass Upgrading
Matthew J. Gilkey (2016)



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