Online citations, reference lists, and bibliographies.
← Back to Search

Glycosaminoglycan And Proteoglycan Biotherapeutics In Articular Cartilage Protection And Repair Strategies: Novel Approaches To Visco‐supplementation In Orthobiologics

A. J. Hayes, J. Melrose
Published 2019 · Chemistry

Cite This
Download PDF
Analyze on Scholarcy
Share
The aim of this study is to review developments in glycosaminoglycan and proteoglycan research relevant to cartilage repair biology and in particular the treatment of osteoarthritis (OA). Glycosaminoglycans decorate a diverse range of extracellular matrix and cell associated proteoglycans conveying structural organization and physico‐chemical properties to tissues. They play key roles mediating cellular interactions with bioactive growth factors, cytokines, and morphogenetic proteins, and structural fibrillar collagens, cell interactive and extracellular matrix proteoglycans, and glycoproteins which define tissue function. Proteoglycan degradation detrimentally affects tissue functional properties. Therapeutic strategies have been developed to counter these degenerative changes. Neo‐proteoglycans prepared from chondroitin sulfate or hyaluronan and hyaluronan or collagen‐binding peptides emulate the interactive, water imbibing, weight bearing, and surface lubricative properties of native proteoglycans. Many neo‐proteoglycans outperform native proteoglycans in terms of water imbibition, matrix stabilization, and resistance to proteolytic degradation. The biospecificity of recombinant proteoglycans however, provides precise attachment to native target molecules. Visco‐supplements augmented with growth factors/therapeutic cells, hyaluronan, and lubricin (orthobiologicals) have the capacity to lubricate and protect cartilage, control inflammation, and promote cartilage repair and regeneration of early cartilage lesions and may represent a more effective therapeutic approach to the treatment of mild to moderate OA and deserve further study.
This paper references
10.1371/journal.pone.0157048
Platelet Rich Plasma and Hyaluronic Acid Blend for the Treatment of Osteoarthritis: Rheological and Biological Evaluation
F. Russo (2016)
10.1002/ART.11365
Stem cell therapy in a caprine model of osteoarthritis.
J. Murphy (2003)
10.1074/JBC.M909383199
Sites of Aggrecan Cleavage by Recombinant Human Aggrecanase-1 (ADAMTS-4)*
M. Tortorella (2000)
10.1115/1.2894880
A triphasic theory for the swelling and deformation behaviors of articular cartilage.
W. M. Lai (1991)
10.1016/S1063-4584(96)80018-5
Hyaluronate on heat shock protein and synovial cells in a canine model of osteoarthritis.
A. Asari (1996)
10.1074/jbc.M111.243626
Endorepellin, the Angiostatic Module of Perlecan, Interacts with Both the α2β1 Integrin and Vascular Endothelial Growth Factor Receptor 2 (VEGFR2)
A. Goyal (2011)
10.1186/1472-6750-12-60
Perlecan domain 1 recombinant proteoglycan augments BMP-2 activity and osteogenesis
A. Decarlo (2012)
10.1042/BCJ20170820
Biodiversity of CS-proteoglycan sulphation motifs: chemical messenger recognition modules with roles in information transfer, control of cellular behaviour and tissue morphogenesis.
A. Hayes (2018)
10.1016/j.biomaterials.2018.08.045
A hyaluronic acid binding peptide-polymer system for treating osteoarthritis.
Heather J Faust (2018)
10.1074/jbc.M112.401786
Endorepellin Affects Angiogenesis by Antagonizing Diverse Vascular Endothelial Growth Factor Receptor 2 (VEGFR2)-evoked Signaling Pathways
A. Goyal (2012)
10.1126/scitranslmed.3005409
Proteoglycan 4 Expression Protects Against the Development of Osteoarthritis
M. Z. Ruan (2013)
Hassell
J R Couchman (1995)
10.1186/s13018-017-0689-6
Intra-articular injection of expanded autologous bone marrow mesenchymal cells in moderate and severe knee osteoarthritis is safe: a phase I/II study
Mahasen Al-Najar (2017)
Orthop. Trauma Surg
A. Migliore (2011)
10.1093/emboj/20.19.5342
Structural basis for the high‐affinity interaction of nidogen‐1 with immunoglobulin‐like domain 3 of perlecan
M. Kvansakul (2001)
The keratan sulfate-enriched region of bovine cartilage proteoglycan consists of a consecutively repeated hexapeptide motif.
P. Antonsson (1989)
10.1021/acs.biomac.7b00788
Thiol-Mediated Synthesis of Hyaluronic Acid-Epigallocatechin-3-O-Gallate Conjugates for the Formation of Injectable Hydrogels with Free Radical Scavenging Property and Degradation Resistance.
Chixuan Liu (2017)
10.18553/jmcp.2018.24.6-a.s2
Viscosupplementation for Osteoarthritis of the Knee: A Key Opinion Leader Panel Discussion.
J. Bert (2018)
10.1016/S0076-6879(94)47027-8
Syntheses and functions of neoproteoglycans: lipid-derivatized chondroitin sulfate with antiadhesion activity.
N. Sugiura (1994)
10.46582/JSRM.1202011
Randomized controlled trial comparing hyaluronic acid, platelet-rich plasma and the combination of both in the treatment of mild and moderate osteoarthritis of the knee
J. F. S. D. Lana (2016)
10.1007/978-1-4939-3130-9_17
Glycocalyx Remodeling with Glycopolymer-Based Proteoglycan Mimetics.
Mia L Huang (2016)
A prospective, randomized, double-blind, placebo controlled study to evaluate the efficacy of intraarticular hyaluronic acid for osteoarthritis of the knee.
R. Petrella (2006)
10.3109/03008207.2011.614364
Not All Lubricin Isoforms Are Substituted with a Glycosaminoglycan Chain
M. Lord (2012)
10.1002/jcp.25716
Systemic and Local Adipose Tissue in Knee Osteoarthritis
E. Belluzzi (2017)
10.1007/s00264-002-0330-z
Highly viscous sodium hyaluronate and joint lubrication
S. Mori (2002)
10.1055/s-0037-1603677
Early Efficacy of Intra-Articular HYADD® 4 (Hymovis®) Injections for Symptomatic Knee Osteoarthritis
Ferdinando Priano (2017)
10.1001/ARCHINTE.162.3.292
Effects of hyaluronate sodium on pain and physical functioning in osteoarthritis of the knee: a randomized, double-blind, placebo-controlled clinical trial.
R. Petrella (2002)
10.1007/s11626-015-9908-9
Effects of low molecular weight hyaluronan combined with carprofen on canine osteoarthritis articular chondrocytes and cartilage explants in vitro
T. Euppayo (2015)
10.1002/jor.24193
Biomimetic proteoglycans can molecularly engineer early osteoarthritic cartilage in vivo
Evan R Phillips (2019)
10.1007/s00011-017-1084-9
Hyaluronan in the experimental injury of the cartilage: biochemical action and protective effects
A. Avenoso (2017)
10.2147/OARRR.S128675
Single-arm open-label study of Durolane (NASHA nonanimal hyaluronic acid) for the treatment of osteoarthritis of the thumb
E. Velasco (2017)
10.1007/s10495-012-0705-6
Zinc oxide nanoparticles induce oxidative DNA damage and ROS-triggered mitochondria mediated apoptosis in human liver cells (HepG2)
Vyom Sharma (2012)
Effect of Different Crosslinking Technologies on Hyaluronic Acid Behavior: A Visual and Microscopic Study of Seven Hyaluronic Acid Gels.
P. Micheels (2016)
10.1016/j.actbio.2017.01.028
Enhanced articular cartilage by human mesenchymal stem cells in enzymatically mediated transiently RGDS-functionalized collagen-mimetic hydrogels
Paresh A. Parmar (2017)
10.1093/JNCI/DJJ441
Endorepellin in vivo: targeting the tumor vasculature and retarding cancer growth and metabolism.
G. Bix (2006)
10.1016/J.BIOMATERIALS.2006.04.018
The effect of hyaluronic acid and phospholipid based lubricants on friction within a human cartilage damage model.
Richard W. Forsey (2006)
Fe3O4 nanoparticle redox system modulation via cell‐cycle progression and gene expression in human mesenchymal stem cells
Vaiyapuri Subbarayan Periasamy (2016)
10.1359/jbmr.2002.17.1.48
Chondrogenic Activity of the Heparan Sulfate Proteoglycan Perlecan Maps to the N‐terminal Domain I
M. M. French (2002)
10.1016/j.nano.2017.12.017
Redox-responsive micelles from disulfide bond-bridged hyaluronic acid-tocopherol succinate for the treatment of melanoma.
J. Xia (2018)
10.1186/s12891-015-0842-5
Cartilage boundary lubrication synergism is mediated by hyaluronan concentration and PRG4 concentration and structure
T. Ludwig (2015)
10.1016/j.curtheres.2018.04.001
Hyaluronic Acid Single Intra-Articular Injection in Knee Osteoarthritis: A Multicenter Open Prospective Study (ART-ONE 75) with Placebo Post Hoc Comparison
D. Baron (2018)
10.1016/J.APMR.2003.08.095
Changes in sagittal ground reaction forces after intra-articular hyaluronate injections for knee osteoarthritis.
S. F. Tang (2004)
10.1016/S1063-4584(05)80024-X
High molecular weight sodium hyaluronate (hyalectin) in osteoarthritis of the knee: a 1 year placebo-controlled trial.
M. Dougados (1993)
10.1016/j.carres.2014.06.030
Hyaluronic acid-modified multiwalled carbon nanotubes for targeted delivery of doxorubicin into cancer cells.
Xueyan Cao (2015)
10.1016/j.arthro.2012.05.011
A randomized clinical trial evaluating plasma rich in growth factors (PRGF-Endoret) versus hyaluronic acid in the short-term treatment of symptomatic knee osteoarthritis.
M. Sanchez (2012)
10.1097/00003086-199402000-00039
Effect of high-molecular-weight sodium hyaluronate on immobilized rabbit knee.
Y. Sakakibara (1994)
10.1111/febs.13963
Proteoglycan neofunctions: regulation of inflammation and autophagy in cancer biology
L. Schaefer (2017)
10.1074/jbc.M006700200
Effect of Collagen Turnover on the Accumulation of Advanced Glycation End Products*
N. Verzijl (2000)
10.1186/s12891-016-0920-3
Intra-articular injection of photo-activated platelet-rich plasma in patients with knee osteoarthritis: a double-blind, randomized controlled pilot study
K. Paterson (2016)
10.1016/j.joca.2017.05.008
Stepwise preconditioning enhances mesenchymal stem cell-based cartilage regeneration through epigenetic modification.
S. Lin (2017)
10.1053/JOCA.1998.0207
The effects of hyaluronan on matrix metalloproteinase-3 (MMP-3), interleukin-1beta(IL-1beta), and tissue inhibitor of metalloproteinase-1 (TIMP-1) gene expression during the development of osteoarthritis.
K. Takahashi (1999)
10.1016/j.actbio.2011.12.029
Synthesis and characterization of an aggrecan mimic.
Jonathan C. Bernhard (2012)
10.3390/cells8040324
The Importance of the Knee Joint Meniscal Fibrocartilages as Stabilizing Weight Bearing Structures Providing Global Protection to Human Knee-Joint Tissues
J. Melrose (2019)
10.1007/s10856-018-6132-7
Biological performance of a promising Kefiran-biopolymer with potential in regenerative medicine applications: a comparative study with hyaluronic acid
Hajer Radhouani (2018)
10.1016/j.matbio.2016.01.005
Syndecan-4 in intervertebral disc and cartilage: Saint or synner?
A. L. A. Binch (2016)
10.1089/TEN.2006.12.2009
Chondrogenic differentiation on perlecan domain I, collagen II, and bone morphogenetic protein-2-based matrices.
Weidong Yang (2006)
10.2147/IJN.S155383
Paclitaxel-loaded redox-sensitive nanoparticles based on hyaluronic acid-vitamin E succinate conjugates for improved lung cancer treatment
Yu Song (2018)
10.1016/J.BONE.2004.12.010
Effects of hyaluronan on three-dimensional microarchitecture of subchondral bone tissues in guinea pig primary osteoarthrosis.
M. Ding (2005)
10.1186/ar3286
Intraarticular injection of hyaluronan prevents cartilage erosion, periarticular fibrosis and mechanical allodynia and normalizes stance time in murine knee osteoarthritis
A. Plaas (2011)
10.1016/j.matbio.2017.10.005
Decorin is a devouring proteoglycan: Remodeling of intracellular catabolism via autophagy and mitophagy.
Simone Buraschi (2019)
10.1186/s13287-015-0011-7
Pullulan: a new cytoadhesive for cell-mediated cartilage repair
Sarah E Bulman (2015)
10.1007/s12325-018-0688-y
A Comparison Between Rheological Properties of Intra-articular Hyaluronic Acid Preparations and Reported Human Synovial Fluid
Mat Nicholls (2018)
10.1074/jbc.270.44.26109
Specific Regulation of Procoagulant Activity on Monocytes
M. Mcgee (1995)
Cancer Inst. 2006, 98, 1634; b)
G Bix (2012)
10.3892/ijmm.2012.1091
Glycosaminoglycan chains of biglycan promote bone morphogenetic protein-4-induced osteoblast differentiation.
Y. Ye (2012)
10.1016/j.arthro.2013.09.006
The efficacy of platelet-rich plasma in the treatment of symptomatic knee osteoarthritis: a systematic review with quantitative synthesis.
A. Khoshbin (2013)
10.1016/J.ORTHRES.2005.05.003.1100230619
Apoptosis and nitric oxide in an experimental model of osteoarthritis in rabbit after hyaluronic acid treatment
L. Díaz-Gállego (2005)
10.1166/JNN.2017.12647
Multiwalled Carbon Nanotubes Inhibit Steroidogenesis by Disrupting Steroidogenic Acute Regulatory Protein Expression and Redox Status.
Y. Qu (2017)
10.1016/j.biomaterials.2013.12.076
The amelioration of cartilage degeneration by ADAMTS-5 inhibitor delivered in a hyaluronic acid hydrogel.
Pengfei Chen (2014)
Alzheimer's Dis
C L Parham (2016)
10.2165/00063030-200519010-00003
Non-Animal Stabilized Hyaluronic Acid
B. Ågerup (2012)
10.2147/CCID.S35251
STYLAGE®: a range of hyaluronic acid dermal fillers containing mannitol. Physical properties and review of the literature
M. Ramos-E-Silva (2013)
97, e13049; b)
Y H Han (2018)
10.1007/BF01987905
The effect of hyaluronan on interleukin-1α-induced prostaglandin E2 production in human osteoarthritic synovial cells
T. Yasui (2005)
10.1111/J.1432-1033.1995.0551D.X
Structural properties of recombinant domain III-3 of perlecan containing a globular domain inserted into an epidermal-growth-factor-like motif.
B. Schulze (1995)
10.1002/cne.23965
Extracellular matrix protein expression is brain region dependent
Stephanie Dauth (2016)
10.1016/j.actbio.2010.03.025
Molecular resurfacing of cartilage with proteoglycan 4.
K. Chawla (2010)
10.3109/10717544.2015.1108374
Liver-targeting self-assembled hyaluronic acid-glycyrrhetinic acid micelles enhance hepato-protective effect of silybin after oral administration
Xiaofeng Han (2016)
10.1016/j.biomaterials.2009.09.009
Perlecan domain I-conjugated, hyaluronic acid-based hydrogel particles for enhanced chondrogenic differentiation via BMP-2 release.
A. K. Jha (2009)
10.1016/S0268-0033(97)00004-1
Increased friction of animal joints by experimental degeneration and recovery by addition of hyaluronic acid.
Takeo Obara (1997)
10.1006/ABBI.2001.2694
Iron autoxidation and free radical generation: effects of buffers, ligands, and chelators.
K. Welch (2002)
10.1083/JCB.142.1.285
Cartilage Fibrils of Mammals are Biochemically Heterogeneous: Differential Distribution of Decorin and Collagen IX
R. Hagg (1998)
10.1021/BM0603746
Fibrillogenesis of collagen types I, II, and III with small leucine-rich proteoglycans decorin and biglycan.
T. Douglas (2006)
10.1074/jbc.M112371200
Effect of Hyaluronan Oligosaccharides on the Expression of Heat Shock Protein 72*
H. Xu (2002)
10.1055/s-0038-1675170
The Use of Platelet‐Rich Plasma in Symptomatic Knee Osteoarthritis
T. Southworth (2019)
10.1016/j.bbagen.2008.11.008
Conserved sequence in the aggrecan interglobular domain modulates cleavage by ADAMTS-4 and ADAMTS-5.
H. E. Miwa (2009)
10.1007/s11010-007-9612-5
Protective effect of hyaluronic acid on interleukin-1-induced deregulation of β1-integrin and insulin-like growth factor-I receptor signaling and collagen biosynthesis in cultured human chondrocytes
E. Karna (2007)
10.1006/SCDB.2000.0244
Hyaluronan in morphogenesis.
B. Toole (1997)
10.1016/j.matbio.2016.09.009
Decorin interacting network: A comprehensive analysis of decorin-binding partners and their versatile functions.
Maria A. Gubbiotti (2016)
10.1007/s10067-006-0504-y
Effects of hyaluronan on nitric oxide levels and superoxide dismutase activities in synovial fluid in knee osteoarthritis
Aydiner Kalaci (2006)
10.1016/J.RBO.2017.04.014
Viscossuplementação intra-articular de ácidos hialurônicos em modelo experimental de osteoartrite
Marcello Zaia Oliveira (2018)
10.1016/j.joca.2008.11.013
Intra-articular injections of hyaluronan solutions of different elastoviscosity reduce nociceptive nerve activity in a model of osteoarthritic knee joint of the guinea pig.
A. Gomis (2009)
10.1002/ajmg.a.33372
Lrp4: A novel modulator of extracellular signaling in craniofacial organogenesis
A. Ohazama (2010)
10.1113/expphysiol.1991.sp003474
Turnover of hyaluronan in synovial joints: elimination of labelled hyaluronan from the knee joint of the rabbit
T. Brown (1991)
430, 531; c) H. Oshita
A Struglics (2004)
10.1016/S1063-4584(11)60535-9
508 VISCOELASTIC PROPERTIES AND MOLECULAR WEIGHT OF HYLAN G-F 20 COMPARED WITH OTHER COMMERCIAL HYALURONAN BASED VISCOSUPPLEMENTS
Liping Yu (2011)
10.1016/j.arthro.2018.02.022
Injections for Knee Osteoarthritis: Corticosteroids, Viscosupplementation, Platelet-Rich Plasma, and Autologous Stem Cells.
D. Levy (2018)
10.1074/JBC.M105818200
Appican, the Proteoglycan Form of the Amyloid Precursor Protein, Contains Chondroitin Sulfate E in the Repeating Disaccharide Region and 4-O-Sulfated Galactose in the Linkage Region*
K. Tsuchida (2001)
10.1007/s00418-010-0730-x
Comparative immunolocalisation of perlecan with collagen II and aggrecan in human foetal, newborn and adult ovine joint tissues demonstrates perlecan as an early developmental chondrogenic marker
S. Smith (2010)
10.1097/00003086-199401000-00039
Effects of high-molecular-weight sodium hyaluronate on experimental osteoarthrosis induced by the resection of rabbit anterior cruciate ligament.
T. Yoshimi (1994)
10.1186/ar3394
Evaluation of long-term antinociceptive properties of stabilized hyaluronic acid preparation (NASHA) in an animal model of repetitive joint pain
M. Boettger (2011)
10.1007/s10555-006-9006-2
Transforming growth factor-β in cancer and metastasis
S. Jakowlew (2006)
10.1055/S-0038-1653468
GAGs-potentiated inhibition of thrombin, factor Xa and plasmin in plasma and in a purified system containing antithrombin III - correlation with total charge density.
E. Cofrancesco (1981)
10.1089/ten.teb.2008.0047
The interface of functional biotribology and regenerative medicine in synovial joints.
C. Neu (2008)
10.1681/ASN.2010070722
Circulating bone morphogenetic protein 1-3 isoform increases renal fibrosis.
L. Grgurević (2011)
10.1016/j.biomaterials.2011.06.077
Hyaluronan-modified magnetic nanoclusters for detection of CD44-overexpressing breast cancer by MR imaging.
Eun-Kyung Lim (2011)
10.1371/journal.pone.0098770
Cartilage Regeneration by Chondrogenic Induced Adult Stem Cells in Osteoarthritic Sheep Model
C. C. Ude (2014)
10.1021/ACSBIOMATERIALS.5B00458
Biomimetic molecules lower catabolic expression and prevent chondroitin sulfate degradation in an osteoarthritic ex vivo model.
S. Sharma (2016)
10.1016/j.actbio.2012.03.021
Sulfated hyaluronan and chondroitin sulfate derivatives interact differently with human transforming growth factor-β1 (TGF-β1).
V. Hintze (2012)
Carson
M C Farach-Carson (2008)
10.5435/JAAOS-D-17-00695
Arthritis Gene Therapy Approved in Korea.
C. Evans (2018)
10.1177/43.9.7543915
Antibody mapping and tissue localization of globular and cysteine-rich regions of perlecan domain III.
J. Couchman (1995)
10.1006/BBRC.1999.0377
Expression of human perlecan domain I as a recombinant heparan sulfate proteoglycan with 20-kDa glycosaminoglycan chains.
L. Graham (1999)
10.4172/1758-4272.1000191
“Cellular matrix™ PRP-HA”: A new treatment option with platelet-rich plasma and hyaluronic acid for patients with osteoarthritis having had an unsatisfactory clinical response to hyaluronic acid alone: Results of a pilot, multicenter French study with long-term follow-up
Jean-Luc Renevier (2018)
10.1002/sctm.16-0271
Concise Review: Mesenchymal Stem Cells for Functional Cartilage Tissue Engineering: Taking Cues from Chondrocyte‐Based Constructs
A. Tan (2017)
10.1016/j.joca.2009.04.018
Desirable effect of combination therapy with high molecular weight hyaluronate and NSAIDs on MMP production.
M. Hashizume (2009)
10.1016/S0940-9602(01)80007-8
Effects of hyaluronic acid on the morphology and proliferation of human chondrocytes in primary cell culture.
E. M. Ehlers (2001)
10.1093/OXFORDJOURNALS.JBCHEM.A022166
Roles of aggrecan, a large chondroitin sulfate proteoglycan, in cartilage structure and function.
H. Watanabe (1998)
10.1016/j.ijbiomac.2017.07.019
Examination of In vitro and In vivo biocompatibility of alginate-hyaluronic acid microbeads As a promising method in cell delivery for kidney regeneration.
Jhaleh Amirian (2017)
10.1002/(SICI)1097-4636(19980605)40:3<414::AID-JBM11>3.0.CO;2-J
Comparison of the boundary-lubricating ability of bovine synovial fluid, lubricin, and Healon.
G. Jay (1998)
10.1016/S1875-5364(15)30097-2
Improved anti-tumor activity and safety profile of a paclitaxel-loaded glycyrrhetinic acid-graft-hyaluronic acid conjugate as a synergistically targeted drug delivery system.
L. Zhang (2015)
10.1111/J.1432-1033.1996.00827.X
Expression and characterization of human perlecan domains I and II synthesized by baculovirus-infected insect cells.
A. Groffen (1996)
10.1369/0022155417751880
Proteoglycans as Immunomodulators of the Innate Immune Response to Lung Infection
I. Kang (2018)
10.1016/j.matbio.2018.08.007
Matrix modeling and remodeling: A biological interplay regulating tissue homeostasis and diseases.
N. Karamanos (2019)
10.1517/17425247.2016.1112374
Recent developments in hyaluronic acid-based nanomedicine for targeted cancer treatment
N. V. Rao (2016)
10.3899/jrheum.130378
Potential Role of Hyaluronic Acid on Bone in Osteoarthritis: Matrix Metalloproteinases, Aggrecanases, and RANKL Expression are Partially Prevented by Hyaluronic Acid in Interleukin 1-stimulated Osteoblasts
Z. Mladenovic (2014)
10.1016/j.actbio.2011.04.018
Heparin-decorated, hyaluronic acid-based hydrogel particles for the controlled release of bone morphogenetic protein 2.
Xian Xu (2011)
10.3109/s101650300009
Extracellular matrix recovery by human articular chondrocytes after treatment with hyaluronan hexasaccharides or Streptomyces hyaluronidase
Y. Nishida (2003)
10.1007/s11095-012-0672-1
Hyaluronan Oligomers-HPMA Copolymer Conjugates for Targeting Paclitaxel to CD44-Overexpressing Ovarian Carcinoma
Gal Journo-Gershfeld (2012)
10.1177/1947603518783521
EUROVISCO Guidelines for the Design and Conduct of Clinical Trials Assessing the Disease-Modifying Effect of Knee Viscosupplementation
Y. Henrotin (2018)
29, 354; d)
K A Hiraoka (2011)
10.1002/JEMT.1070280505
Cartilage proteoglycans: Structure and potential functions
P. Roughley (1994)
10.1007/5584_2018_205
A Comprehensive Review of Stem Cells for Cartilage Regeneration in Osteoarthritis.
Gauthaman Kalamegam (2018)
10.1007/s10637-015-0291-x
Fibrin gels loaded with cisplatin and cisplatin-hyaluronate complexes tested in a subcutaneous human melanoma model
M. Viale (2015)
10.1371/journal.pone.0045257
Perlecan Domain V Induces VEGf Secretion in Brain Endothelial Cells through Integrin α5β1 and ERK-Dependent Signaling Pathways
Douglas N. Clarke (2012)
10.3389/fbioe.2017.00036
Synergistic Interactions of a Synthetic Lubricin-Mimetic with Fibronectin for Enhanced Wear Protection
Roberto C Andresen Eguiluz (2017)
10.1016/j.carbpol.2018.04.021
Grafting of steroids to hyaluronan towards the design of delivery systems for antioxidants: The role of hydrophobic core.
Gloria Huerta-Ángeles (2018)
10.1016/j.ejpb.2015.09.005
Efficacy study of two novel hyaluronic acid-based formulations for viscosupplementation therapy in an early osteoarthrosic rabbit model.
S. Kaderli (2015)
10.1089/ten.TEC.2016.0033
Autologous Bone Marrow Concentrate in a Sheep Model of Osteoarthritis: New Perspectives for Cartilage and Meniscus Repair.
G. Desando (2016)
Rheological Properties of Several Hyaluronic Acid-Based Gels: A Comparative Study.
P. Micheels (2018)
The effect of sodium hyaluronate treating knee osteoarthritis on synovial fluid interleukin -1β and clinical treatment mechanism.
L. Yang (2015)
Inflamma-tion2013, 10, 26; g) T. Yasuda
M M Smith
10.5792/ksrr.16.061
Hylan GF-20 Viscosupplementation in the Treatment of Symptomatic Osteoarthritis of the Knee: Clinical Effect Survivorship at 5 Years
T. Boutefnouchet (2017)
10.1111/j.1742-4658.2010.07797.x
Proteoglycans in health and disease: novel regulatory signaling mechanisms evoked by the small leucine‐rich proteoglycans
R. Iozzo (2010)
10.1002/glia.21227
Perlecan domain V modulates astrogliosis In vitro and after focal cerebral ischemia through multiple receptors and increased nerve growth factor release
Abraham J Alahmad (2011)
10.1007/s10719-017-9773-8
Heparan sulfate proteoglycans as key regulators of the mesenchymal niche of hematopoietic stem cells
D. Papy-Garcia (2017)
10.1016/j.carbpol.2016.08.100
Design, synthesis and evaluation of multi-functional tLyP-1-hyaluronic acid-paclitaxel conjugate endowed with broad anticancer scope.
W. Wang (2017)
10.1021/acsami.8b09342
Free Adriamycin-Loaded pH/Reduction Dual-Responsive Hyaluronic Acid-Adriamycin Prodrug Micelles for Efficient Cancer Therapy.
Tingjie Yin (2018)
10.1016/j.joca.2013.10.005
Chondroprotective effects of high-molecular-weight cross-linked hyaluronic acid in a rabbit knee osteoarthritis model.
S. Elmorsy (2014)
10.1016/j.bmc.2009.12.053
Synthesis and optimization of hyaluronic acid-methotrexate conjugates to maximize benefit in the treatment of osteoarthritis.
Akie Homma (2010)
10.1039/c8bm00079d
Synergistic effects of hyaluronate - epidermal growth factor conjugate patch on chronic wound healing.
Yun Seop Kim (2018)
10.5999/aps.2015.42.6.721
A Phase III, Randomized, Multi-Center, Double-Masked, Matched-Pairs, Active-Controlled Trial to Compare the Efficacy and Safety between Neuramis Deep and Restylane in the Correction of Nasolabial Folds
Changsik Pak (2015)
10.1016/j.semarthrit.2015.04.013
Assessment of clinical practice guideline methodology for the treatment of knee osteoarthritis with intra-articular hyaluronic acid.
R. D. Altman (2015)
10.1615/CRITREVIMMUNOL.V26.I1.30
Cell surface glycans: the why and how of their functionality as biochemical signals in lectin-mediated information transfer.
H. Gabius (2006)
10.1136/ard.52.11.817
Effects of the molecular weight of hyaluronic acid and its action mechanisms on experimental joint pain in rats.
S. Gotoh (1993)
10.1115/1.4000942
A triphasic orthotropic laminate model for cartilage curling behavior: fixed charge density versus mechanical properties inhomogeneity.
L. Wan (2010)
10.1016/j.matbio.2014.08.009
The structure and function of the pericellular matrix of articular cartilage.
R. E. Wilusz (2014)
10.1167/iovs.14-14366
Preservation of the structure of enzymatically-degraded bovine vitreous using synthetic proteoglycan mimics.
Qianru Zhang (2014)
10.1007/s11095-016-1976-3
Intratracheal Administration of Hyaluronan-Cisplatin Conjugate Nanoparticles Significantly Attenuates Lung Cancer Growth in Mice
Susumu Ishiguro (2016)
10.1021/acs.molpharmaceut.7b00636
Receptor-Mediated Attachment and Uptake of Hyaluronan Conjugates by Breast Cancer Cells.
K. Shah (2017)
13, R110; b)
M K Boettger (2009)
10.1177/1179544117725026
Comparison of the 3 Different Injection Techniques Used in a Randomized Controlled Study Evaluating a Cross-Linked Sodium Hyaluronate Combined With Triamcinolone Hexacetonide (Cingal) for Osteoarthritis of the Knee: A Subgroup Analysis
R. Mccormack (2017)
59, 519; d)
E Maneiro (2003)
10.2217/rme-2017-0012
Glycosaminoglycan-based resorbable polymer composites in tissue refurbishment.
Khushboo Gulati (2017)
10.1002/mabi.201500082
Injectable Hyaluronan Hydrogels with Peptide-Binding Dendrimers Modulate the Controlled Release of BMP-2 and TGF-β1.
Ryan J Seelbach (2015)
10.7150/ntno.17896
Novel Hyaluronic Acid Conjugates for Dual Nuclear Imaging and Therapy in CD44-Expressing Tumors in Mice In Vivo
R. Dubey (2017)
10.1177/0363546511417792
Growth Factor and Catabolic Cytokine Concentrations Are Influenced by the Cellular Composition of Platelet-Rich Plasma
E. Sundman (2011)
Trauma: Inj., Infect
T. L. Huang (2010)
10.1038/nrrheum.2013.109
Mesenchymal stem cells in joint disease and repair
F. Barry (2013)
10.1186/1746-6148-9-68
Injectable hyaluronic-acid-doxycycline hydrogel therapy in experimental rabbit osteoarthritis
Hsien-Tsung Lu (2013)
Tissue Eng
W. Yang (2009)
The effects of intraarticular hyaluronan on cartilage and subchondral bone changes in an ovine model of early osteoarthritis.
S. Armstrong (1994)
10.1177/0363546513507766
The Anti-inflammatory and Matrix Restorative Mechanisms of Platelet-Rich Plasma in Osteoarthritis
E. Sundman (2014)
10.4155/fsoa-2016-0034
Use of FGF-2 and FGF-18 to direct bone marrow stromal stem cells to chondrogenic and osteogenic lineages
C. Shu (2016)
10.2165/00002018-200023020-00003
A Risk-Benefit Assessment of Injections of Hyaluronan and its Derivatives in the Treatment of Osteoarthritis of the Knee
M. E. Adams (2000)
10.1073/pnas.1121605109
Bioinspired nanofibers support chondrogenesis for articular cartilage repair
J. Coburn (2012)
10.1007/s11626-016-0022-4
In vitro effects of triamcinolone acetonide and in combination with hyaluronan on canine normal and spontaneous osteoarthritis articular cartilage
T. Euppayo (2016)
10.1182/BLOOD.V91.1.134.134_134_141
Platelet-derived interleukin-1 induces cytokine production, but not proliferation of human vascular smooth muscle cells.
H. Loppnow (1998)
10.1002/JOR.1100170611
Hyaluronan suppresses fibronectin fragment‐mediated damage to human cartilage explant cultures by enhancing proteoglycan synthesis
Y. Kang (1999)
10.1074/jbc.M111826200
Not All Perlecans Are Created Equal
S. Knox (2002)
10.1007/s11011-014-9576-6
The potential role of perlecan domain V as novel therapy in vascular dementia
A. Marcelo (2014)
10.1074/jbc.M709885200
Collagen Turnover in Normal and Degenerate Human Intervertebral Discs as Determined by the Racemization of Aspartic Acid*
Sarit-Sara Sivan (2008)
10.1002/art.37900
Transcriptomics of wild-type mice and mice lacking ADAMTS-5 activity identifies genes involved in osteoarthritis initiation and cartilage destruction.
J. Bateman (2013)
10.2147/DDDT.S37330
Preliminary study of highly cross-linked hyaluronic acid-based combination therapy for management of knee osteoarthritis-related pain
B. Palmieri (2013)
10.1016/j.joca.2011.07.010
Abundance of calpain and aggrecan-cleavage products of calpain in degenerated human intervertebral discs.
S. Fukuta (2011)
10.1016/j.actbio.2016.08.030
Structural and functional insights into the interaction of sulfated glycosaminoglycans with tissue inhibitor of metalloproteinase-3 - A possible regulatory role on extracellular matrix homeostasis.
S. Rother (2016)
10.1186/1476-9255-10-26
A hexadecylamide derivative of hyaluronan (HYMOVIS®) has superior beneficial effects on human osteoarthritic chondrocytes and synoviocytes than unmodified hyaluronan
M. Smith (2012)
10.1097/TA.0b013e3181a92cf8
Effect of different molecular weight hyaluronans on osteoarthritis-related protein production in fibroblast-like synoviocytes from patients with tibia plateau fracture.
Teng-Le Huang (2010)
15, 435; b)
J P Salier (1990)
10.1002/stem.2475
Allogeneic Mesenchymal Stem Cells Stimulate Cartilage Regeneration and Are Safe for Single‐Stage Cartilage Repair in Humans upon Mixture with Recycled Autologous Chondrons
T. S. de Windt (2017)
10.1080/14740338.2017.1344211
The safety of intra-articular injections for the treatment of knee osteoarthritis: a critical narrative review
C. Nguyen (2017)
10.1074/jbc.271.32.19578
Recombinant Decorin Glycoforms
P. Ramamurthy (1996)
10.1016/j.arthro.2016.09.024
Efficacy of Platelet-Rich Plasma in the Treatment of Knee Osteoarthritis: A Meta-analysis of Randomized Controlled Trials.
Wen-li Dai (2017)
10.1055/s-0033-1343425
Safety and efficacy findings from a non-interventional study of a new hyaluronic acid/sorbitol formulation (GO-ON® matrix) for intra-articular injection to relieve pain and disability in osteoarthritis patients.
J. Heisel (2013)
10.1007/s10067-018-3985-6
Comparison of hyaluronic acid and PRP intra-articular injection with combined intra-articular and intraosseous PRP injections to treat patients with knee osteoarthritis
Ke Su (2018)
10.1186/s12917-015-0611-6
Effects of corticosteroids and their combinations with hyaluronanon on the biochemical properties of porcine cartilage explants
P. Siengdee (2015)
10.3109/03009748309102899
Molecular weight distribution of hyaluronic acid of human synovial fluid in rheumatic diseases.
A. Bjelle (1983)
53, 293; d)
B Mazieres (2002)
10.1016/S0022-2836(83)80142-9
Chondroitin 4-sulfate: comparison of the structures of the potassium and sodium salts.
R. P. Millane (1983)
10.1007/s00296-003-0428-7
Does hyaluronan affect inflammatory cytokines in knee osteoarthritis?
M. Sezgin (2003)
10.5966/sctm.2013-0207
Concise Review: Unraveling Stem Cell Cocultures in Regenerative Medicine: Which Cell Interactions Steer Cartilage Regeneration and How?
T. S. de Windt (2014)
10.1016/j.jconrel.2017.08.016
A hyaluronic acid conjugate engineered to synergistically and sequentially deliver gemcitabine and doxorubicin to treat triple negative breast cancer
Douglas R. Vogus (2017)
10.1093/GLYCOB/10.3.329
Glycosaminoglycan conformation: do aqueous molecular dynamics simulations agree with x-ray fiber diffraction?
A. Almond (2000)
10.1016/j.joca.2011.10.002
Zonal differences in meniscus matrix turnover and cytokine response.
E. Fuller (2012)
10.1097/BOR.0b013e32835aa28d
Stem cell-based therapies for osteoarthritis: challenges and opportunities
B. O. Diekman (2013)
10.1016/j.matbio.2012.05.002
A biomechanical role for perlecan in the pericellular matrix of articular cartilage.
R. E. Wilusz (2012)
10.1016/j.colsurfb.2017.07.081
Synthesis and characterization of hyaluronic acid coated manganese dioxide microparticles that act as ROS scavengers.
J. Bizeau (2017)
25, 509; c) A. Khoshbin
O Guler
10.1177/0363546516665809
Hyaluronic Acid Versus Platelet-Rich Plasma: A Prospective, Double-Blind Randomized Controlled Trial Comparing Clinical Outcomes and Effects on Intra-articular Biology for the Treatment of Knee Osteoarthritis
B. Cole (2017)
10.1098/rstb.2013.0545
Extracellular distribution of diffusible growth factors controlled by heparan sulfate proteoglycans during mammalian embryogenesis
I. Matsuo (2014)
10.1016/j.sbi.2018.03.011
Deciphering functional glycosaminoglycan motifs in development.
R. Townley (2018)
10.1016/j.jcyt.2018.05.005
Epigenetic changes in umbilical cord mesenchymal stromal cells upon stimulation and culture expansion.
Samantha F H de Witte (2018)
10.1016/j.carres.2010.02.011
Periodate oxidation of polysaccharides for modification of chemical and physical properties.
K. A. Kristiansen (2010)
10.1007/s00776-009-1329-8
Effects of hyaluronan on vascular endothelial growth factor and receptor-2 expression in a rabbit osteoarthritis model
Jian-lin Zhou (2009)
10.1016/j.jconrel.2015.01.012
Reversibly crosslinked hyaluronic acid nanoparticles for active targeting and intelligent delivery of doxorubicin to drug resistant CD44+ human breast tumor xenografts.
Yinan Zhong (2015)
10.1111/jocd.12085
A prospective, open-label, multicenter, observational, postmarket study of the use of a 15 mg/mL hyaluronic acid dermal filler in the lips
W. Philipp-Dormston (2014)
10.1016/j.bmc.2009.04.063
Novel hyaluronic acid-methotrexate conjugates for osteoarthritis treatment.
Akie Homma (2009)
10.1093/glycob/cww022
Nanoscale materials for probing the biological functions of the glycocalyx.
Mia L Huang (2016)
10.1172/JCI46358
Perlecan domain V is neuroprotective and proangiogenic following ischemic stroke in rodents.
B. Lee (2011)
10.1186/s13075-014-0432-1
Mesenchymal stem cells in the treatment of traumatic articular cartilage defects: a comprehensive review
Troy D. Bornes (2014)
10.1186/ar3887
Hyaluronan injection in murine osteoarthritis prevents TGFbeta 1-induced synovial neovascularization and fibrosis and maintains articular cartilage integrity by a CD44-dependent mechanism
J. Li (2012)
10.1074/jbc.M114.636258
Heavy Chain Transfer by Tumor Necrosis Factor-stimulated Gene 6 to the Bikunin Proteoglycan*
Elliott Lamkin (2015)
10.1007/s00296-011-2339-3
The effect of hyaluronic acid on osteopontin and CD44 mRNA of fibroblast-like synoviocytes in patients with osteoarthritis of the knee
F. Zhang (2011)
10.1021/bm501045k
Synthesis and characterization of proteoglycan-mimetic graft copolymers with tunable glycosaminoglycan density.
Laura W. Place (2014)
The Glycosaminoglycan/Glycan Interactome: A Bioinformatic Platform
J. Melrose (2016)
10.1002/1529-0131(200108)44:8<1800::AID-ART317>3.0.CO;2-1
Anti-Fas-induced apoptosis in chondrocytes reduced by hyaluronan: evidence for CD44 and CD54 (intercellular adhesion molecule 1) invovement.
G. Lisignoli (2001)
10.1007/978-1-4939-0320-7_27
Investigating the role of perlecan domain V in post-ischemic cerebral angiogenesis.
A. Marcelo (2014)
10.1243/095441105X69060
Influence of hyaluronic acid on the time-dependent friction response of articular cartilage under different conditions
C. J. Bell (2006)
10.1021/acsami.7b17718
Hyaluronic Acid-Shelled Disulfide-Cross-Linked Nanopolymersomes for Ultrahigh-Efficiency Reactive Encapsulation and CD44-Targeted Delivery of Mertansine Toxin.
Y. Zhang (2018)
10.1002/adhm.201701042
Glycosaminoglycan and Proteoglycan‐Based Biomaterials: Current Trends and Future Perspectives
J. Rnjak-Kovacina (2018)
10.1007/s10856-017-5974-8
Alginate/hyaluronic acid hydrogel delivery system characteristics regulate the differentiation of periodontal ligament stem cells toward chondrogenic lineage
S. Ansari (2017)
10.1093/rheumatology/ken219
Significant synovial pathology in a meniscectomy model of osteoarthritis: modification by intra-articular hyaluronan therapy
M. Smith (2008)
10.1016/S1063-4584(05)80063-9
Intra-articular hyaluronic acid in osteoarthritis of the knee: an investigation into mechanisms of action.
P. Creamer (1994)
10.1089/ten.TEC.2017.0336
Short-Term Homing of Hyaluronan-Primed Cells: Therapeutic Implications for Osteoarthritis Treatment.
G. Desando (2018)
10.1021/ACS.BIOMAC.6B00980
Sulfated Hyaluronan Alters the Interaction Profile of TIMP-3 with the Endocytic Receptor LRP-1 Clusters II and IV and Increases the Extracellular TIMP-3 Level of Human Bone Marrow Stromal Cells.
S. Rother (2016)
10.1016/j.colsurfb.2016.02.040
The influence of hyaluronan on the structure of a DPPC-bilayer under high pressures.
T. Zander (2016)
10.1021/cn300197y
Perlecan domain V therapy for stroke: a beacon of hope?
G. Bix (2013)
10.1016/j.joca.2013.10.013
High molecular weight hyaluronic acid regulates osteoclast formation by inhibiting receptor activator of NF-κB ligand through Rho kinase.
W. Ariyoshi (2014)
10.1039/C7BM01158J
Harnessing chondroitin sulphate in composite scaffolds to direct progenitor and stem cell function for tissue repair.
B. Farrugia (2018)
10.1007/s00441-019-02996-x
The use of PRP injections in the management of knee osteoarthritis
B. O’Connell (2019)
10.18632/oncotarget.15363
Hyaluronic acid-serum albumin conjugate-based nanoparticles for targeted cancer therapy
R. Edelman (2017)
10.1089/ten.TEA.2013.0519
GFOGER-modified MMP-sensitive polyethylene glycol hydrogels induce chondrogenic differentiation of human mesenchymal stem cells.
R. Mhanna (2014)
23, 2109; b)
J Cherian (2015)
10.1007/s40744-014-0001-8
Mannitol Preserves the Viscoelastic Properties of Hyaluronic Acid in an In Vitro Model of Oxidative Stress
T. Conrozier (2014)
10.1038/nrrheum.2017.182
Native joint-resident mesenchymal stem cells for cartilage repair in osteoarthritis
D. McGonagle (2017)
10.1016/J.JOCA.2003.11.007
Intra-articular hyaluronate in experimental rabbit osteoarthritis can prevent changes in cartilage proteoglycan content.
D. Hulmes (2004)
10.3899/jrheum.111427
Preventing Friction-induced Chondrocyte Apoptosis: Comparison of Human Synovial Fluid and Hylan G-F 20
Kimberly A. Waller (2012)
10.1016/J.JOCA.2004.03.005
The effects of intraarticularly injected sodium hyaluronate on levels of intact aggrecan and nitric oxide in the joint fluid of patients with knee osteoarthritis.
K. Kobayashi (2004)
10.1002/ART.21022
ADAMTS-1-knockout mice do not exhibit abnormalities in aggrecan turnover in vitro or in vivo.
C. Little (2005)
10.2147/IJN.S113469
GE11 peptide modified and reduction-responsive hyaluronic acid-based nanoparticles induced higher efficacy of doxorubicin for breast carcinoma therapy
Danrong Hu (2016)
10.1016/J.JOCA.2012.02.181
The effect of high molecular hyaluronic acid on the induction of matrix degradation enzymes By IL-6, IL-1β and TNF-α
M. Mihara (2012)
10.1016/j.matbio.2015.02.003
Proteoglycan form and function: A comprehensive nomenclature of proteoglycans
R. Iozzo (2015)
10.1074/JBC.270.1.404
Recombinant Domain III of Perlecan Promotes Cell Attachment through Its RGDS Sequence (*)
S. Chakravarti (1995)
10.1074/jbc.R800020200
Biological Functions of the Small Leucine-rich Proteoglycans: From Genetics to Signal Transduction*
L. Schaefer (2008)
Polymers 2014
M. Rinaudo (1948)
10.1042/BJ20040113
Mature bovine articular cartilage contains abundant aggrecan that is C-terminally truncated at Ala719-Ala720, a site which is readily cleaved by m-calpain.
Hidefumi Oshita (2004)
10.1186/s13287-017-0728-6
A comparative study of chondroitin sulfate and heparan sulfate for directing three-dimensional chondrogenesis of mesenchymal stem cells
Tianyi Wang (2017)
10.1016/J.JOCA.2005.11.013
Hyaluronate effects on synovium and synovial fluid. A prospective blinded study in patients with osteoarthritis of the knee.
H. Schumacher (2006)
10.1016/j.biomaterials.2014.07.058
Synergistic anabolic actions of hyaluronic acid and platelet-rich plasma on cartilage regeneration in osteoarthritis therapy.
Wei-hong Chen (2014)
10.1016/j.rehab.2016.02.008
Evidence and recommendations for use of intra-articular injections for knee osteoarthritis.
C. Nguyen (2016)
10.1074/jbc.271.32.19571
Eukaryotic Expression of Recombinant Biglycan
A. M. Hocking (1996)
10.1016/j.actbio.2017.11.021
Biomaterials for articular cartilage tissue engineering: Learning from biology.
A. R. Armiento (2018)
10.1016/S8756-3282(03)00206-0
Hyaluronic acid reverses the abnormal synthetic activity of human osteoarthritic subchondral bone osteoblasts.
D. Lajeunesse (2003)
10.1016/j.abb.2011.12.005
Inhibition of hyaluronan synthesis reduced inflammatory response in mouse synovial fibroblasts subjected to collagen-induced arthritis.
G. M. Campo (2012)
Complete coding sequence and deduced primary structure of the human cartilage large aggregating proteoglycan, aggrecan. Human-specific repeats, and additional alternatively spliced forms.
K. Doege (1991)
10.1021/BM060287D
Solution structure and dynamics of cartilage aggrecan.
A. Papagiannopoulos (2006)
10, 4; b)
B Chen (2014)
10.1016/S0945-053X(96)90138-9
Structural and cell-adhesive properties of three recombinant fragments derived from perlecan domain III.
B. Schulze (1996)
10.1016/J.JBSPIN.2007.01.037
Medicoeconomic evaluation of hyaluronic acid for knee osteoarthritis in everyday practice: the MESSAGE study.
B. Mazières (2007)
10.1016/j.matbio.2012.01.007
New insights into cartilage repair - the role of migratory progenitor cells in osteoarthritis.
Regina Gerter (2012)
10.1007/s12178-018-9527-7
Current Clinical Recommendations for Use of Platelet-Rich Plasma
Adrian D K Le (2018)
10.1088/1748-6041/7/2/024109
Injectable perlecan domain 1-hyaluronan microgels potentiate the cartilage repair effect of BMP2 in a murine model of early osteoarthritis.
P. P. Srinivasan (2012)
10.1046/J.1432-1327.1999.00127.X
Recombinant domain IV of perlecan binds to nidogens, laminin-nidogen complex, fibronectin, fibulin-2 and heparin.
M. Hopf (1999)
10.2147/CCID.S181964
Treatment of facial lipoatrophy, morphological asymmetry, or debilitating scars with the hyaluronic acid dermal filler Princess® FILLER
D. Kopera (2018)
10.3109/00016488709102834
Rheology of hyaluronate.
H. Bothner (1987)
10.1186/s40634-014-0008-7
The role of aggrecan in normal and osteoarthritic cartilage
P. Roughley (2014)
10.1016/j.actbio.2015.08.029
Intracellular delivery and antitumor effects of a redox-responsive polymeric paclitaxel conjugate based on hyaluronic acid.
Shaoping Yin (2015)
10.1074/JBC.270.35.20516
N- and O-Linked Keratan Sulfate on the Hyaluronan Binding Region of Aggrecan from Mature and Immature Bovine Cartilage (*)
F. Barry (1995)
10.1146/ANNUREV.BIOCHEM.67.1.609
Matrix proteoglycans: from molecular design to cellular function.
R. Iozzo (1998)
10.1002/mabi.201400135
A novel crosslinked hyaluronic acid nanogel for drug delivery.
S. Pedrosa (2014)
10.1016/S0140-6736(10)60668-X
Regeneration of the articular surface of the rabbit synovial joint by cell homing: a proof of concept study
C. H. Lee (2010)
10.1111/j.1742-4658.2010.07800.x
Proteoglycans in health and disease: novel roles for proteoglycans in malignancy and their pharmacological targeting
A. Theocharis (2010)
10.1016/j.joca.2013.08.024
The clinical status of cartilage tissue regeneration in humans.
B. Mollon (2013)
10.1016/J.BIOMATERIALS.2004.02.002
A novel hyaluronan-based biomaterial (Hyaff-11) as a scaffold for endothelial cells in tissue engineered vascular grafts.
N. Turner (2004)
10.1002/stem.1833
Human Embryonic Stem Cells Prevent T‐Cell Activation by Suppressing Dendritic Cells Function via TGF‐Beta Signaling Pathway
Lucy Leshansky (2014)
10.1089/ten.tea.2018.0065
Effect of Platelet-Rich Plasma on Chondrogenic Differentiation of Adipose- and Bone Marrow-Derived Mesenchymal Stem Cells.
Jr-Jiun Liou (2018)
10.1177/1753193414529046
Hyaluronic acid scaffold for skin defects in congenital syndactyly release surgery: a novel technique based on the regenerative model
A. Landi (2014)
10.1089/ten.TEA.2011.0711
Hyaluronic acid-binding scaffold for articular cartilage repair.
Shimon A. Unterman (2012)
10.1006/BBRC.1998.0104
Articular cartilage superficial zone protein (SZP) is homologous to megakaryocyte stimulating factor precursor and Is a multifunctional proteoglycan with potential growth-promoting, cytoprotective, and lubricating properties in cartilage metabolism.
C. Flannery (1999)
10.1016/j.jconrel.2015.08.015
Hyaluronidase-incorporated hyaluronic acid-tyramine hydrogels for the sustained release of trastuzumab.
Keming Xu (2015)
10.1016/j.pmr.2016.06.002
Platelet-Rich Plasma.
P. Wu (2016)
10.1002/bies.201800166
Proteoglycan 4: From Mere Lubricant to Regulator of Tissue Homeostasis and Inflammation
Nabangshu Das (2019)
10.1093/glycob/cwy003
Keratan sulfate, a complex glycosaminoglycan with unique functional capability
B. Caterson (2018)
10.1016/s1063-4584(97)80019-2
Hyaluronic acid suppresses fibronectin fragment mediated cartilage chondrolysis: II. In vivo.
J. M. Williams (1997)
10.1016/S0925-5710(98)00034-6
The effect of cell surface glycosaminoglycans (GAGs) on the inactivation of factor VIIa--tissue factor activity by antithrombin III.
T. Hamamoto (1998)
10.1021/acsnano.5b05524
Quantitative Profiling of Protein S-Glutathionylation Reveals Redox-Dependent Regulation of Macrophage Function during Nanoparticle-Induced Oxidative Stress.
J. Duan (2016)
10.1016/j.ijpharm.2011.04.049
A novel tumor-targeted delivery system with hydrophobized hyaluronic acid-spermine conjugates (HHSCs) for efficient receptor-mediated siRNA delivery.
Y. Shen (2011)
10.1016/j.matbio.2014.04.005
Matrilysin/matrix metalloproteinase-7(MMP7) cleavage of perlecan/HSPG2 creates a molecular switch to alter prostate cancer cell behavior.
B. Grindel (2014)
10.1016/j.arthro.2011.05.011
Platelet-rich plasma intra-articular injection versus hyaluronic acid viscosupplementation as treatments for cartilage pathology: from early degeneration to osteoarthritis.
E. Kon (2011)
10.1016/j.actbio.2013.11.010
Injectable hydrogels with high fixed charge density and swelling pressure for nucleus pulposus repair: biomimetic glycosaminoglycan analogues.
S. Sivan (2014)
10.1007/BF00270463
The synthesis of hyaluronic acid by human synovial fibroblasts is influenced by the nature of the hyaluronate in the extracellular environment
M. M. Smith (2004)
10.1016/j.neurobiolaging.2010.10.018
Perlecan domain V inhibits α2 integrin-mediated amyloid-β neurotoxicity
S. Wright (2012)
10.1016/0009-8981(63)90013-5
FINGERPRINTING THE HYALURONIC ACID COMPONENT OF NORMAL AND PATHOLOGICAL SYNOVIAL FLUIDS.
S. A. Barker (1963)
10.1016/B978-0-12-385950-1.00007-9
Serpin-glycosaminoglycan interactions.
Chantelle M. Rein (2011)
10.1186/s13018-017-0521-3
The temporal effect of platelet-rich plasma on pain and physical function in the treatment of knee osteoarthritis: systematic review and meta-analysis of randomized controlled trials
L. Shen (2017)
10.1021/acs.biomac.7b00032
Biomimetic Proteoglycans Mimic Macromolecular Architecture and Water Uptake of Natural Proteoglycans.
K. Prudnikova (2017)
10.1016/j.jprot.2014.01.016
Proteomic analysis of osteoarthritic chondrocyte reveals the hyaluronic acid-regulated proteins involved in chondroprotective effect under oxidative stress.
C. Yu (2014)
10.1016/S1063-4584(02)00352-7
The effect of hyaluronan on CD44-mediated survival of normal and hydroxyl radical-damaged chondrocytes.
P. Brun (2003)
Interactions of macromolecules with the mammalian cell surface.
J. Wall (1995)
10.1016/j.joca.2012.07.004
Hylan G-F 20 maintains cartilage integrity and decreases osteophyte formation in osteoarthritis through both anabolic and anti-catabolic mechanisms.
P. Li (2012)
10.1053/SARH.2002.33720
Potential mechanism of action of intra-articular hyaluronan therapy in osteoarthritis: are the effects molecular weight dependent?
P. Ghosh (2002)
10.1016/J.CBPA.2007.05.002
Deciphering the glycocode: the complexity and analytical challenge of glycomics.
K. Pilobello (2007)
10.1002/ART.1780100407
Hyaluronic acid in synovial fluid. I. Molecular parameters of hyaluronic acid in normal and arthritis human fluids.
E. Balazs (1967)
10.1080/03008207.2017.1284824
The biology of meniscal pathology in osteoarthritis and its contribution to joint disease: beyond simple mechanics
J. Melrose (2017)
10.1016/S0142-9612(01)00360-X
Comparison of the antioxidant properties of HYAFF-11p75, AQUACEL and hyaluronan towards reactive oxygen species in vitro.
R. Moseley (2002)
10.1021/bm301538k
Growth and differentiation of prechondrogenic cells on bioactive self-assembled peptide nanofibers.
Seher Ustun (2013)
10.1016/j.actbio.2017.02.015
Sulfated hyaluronic acid hydrogels with retarded degradation and enhanced growth factor retention promote hMSC chondrogenesis and articular cartilage integrity with reduced hypertrophy.
Q. Feng (2017)
10.1089/ten.TEA.2014.0281
Multivalent Conjugates of Sonic Hedgehog Accelerate Diabetic Wound Healing.
Bruce W. Han (2015)
10.1021/bi8013938
Diverse cell signaling events modulated by perlecan.
J. Whitelock (2008)
10.2147/IJN.S121642
Thermosensitive hydrogel based on chitosan and its derivatives containing medicated nanoparticles for transcorneal administration of 5-fluorouracil
A. Fabiano (2017)
10.3390/ijms20030579
Catabolism of Fibromodulin in Developmental Rudiment and Pathologic Articular Cartilage Demonstrates Novel Roles for MMP-13 and ADAMTS-4 in C-terminal Processing of SLRPs
C. Shu (2019)
10.1016/j.exger.2012.03.018
The potential of intra-articular injection of chondrogenic-induced bone marrow stem cells to retard the progression of osteoarthritis in a sheep model
Hamoud Al Faqeh (2012)
Effect of intraarticular hyaluronan injection on synovial fluid hyaluronan in the early stage of canine post-traumatic osteoarthritis.
G. Smith (2001)
10.1016/S1286-4579(99)00250-6
TGF- and fibrosis
M. H. Branton (1999)
10.1016/j.jconrel.2014.05.008
A hyaluronic acid-salmon calcitonin conjugate for the local treatment of osteoarthritis: chondro-protective effect in a rabbit model of early OA.
A. Mero (2014)
10.1007/s12975-013-0266-1
Perlecan Domain V Is Neuroprotective and Affords Functional Improvement in a Photothrombotic Stroke Model in Young and Aged Mice
G. Bix (2013)
10.1177/2325967117690131
Cell-Based Meniscus Repair and Regeneration: At the Brink of Clinical Translation?
J. V. Korpershoek (2017)
10.1007/s00441-012-1339-2
Musculoskeletal tissue engineering by endogenous stem/progenitor cells
Hemin Nie (2012)
10.1002/art.24143
Modulation of lubricin biosynthesis and tissue surface properties following cartilage mechanical injury.
A. R. Jones (2009)
10.1016/J.JOCA.2014.02.544
Mechanisms involved in inhibition of inflammation in THP-1 cells by the hexadecylamide derivative of hyaluronic acid.
F. Oliviero (2014)
10.1016/J.CBPA.2005.10.003
Chemical approaches to deciphering the glycosaminoglycan code.
Cristal I Gama (2005)
10.1038/s41598-017-13558-y
Lubricin binds cartilage proteins, cartilage oligomeric matrix protein, fibronectin and collagen II at the cartilage surface
S. Flowers (2017)
10.1021/ED054P218
The Donnan Equilibrium and Osmotic Pressure.
Raymond C Chang (1977)
The complete sequence of perlecan, a basement membrane heparan sulfate proteoglycan, reveals extensive similarity with laminin A chain, low density lipoprotein-receptor, and the neural cell adhesion molecule.
D. Noonan (1991)
10.1515/BC.2003.100
Cleavage Site Specificity of Cathepsin K toward Cartilage Proteoglycans and Protease Complex Formation
W. Hou (2003)
10.1002/jbm.a.35729
l-Glutathione enhances antioxidant capacity of hyaluronic acid and modulates expression of pro-inflammatory cytokines in human fibroblast-like synoviocytes.
Kai-Chiang Yang (2016)
10.1089/scd.2016.0054
The CS Sulfation Motifs 4C3, 7D4, 3B3[-]; and Perlecan Identify Stem Cell Populations and Their Niches, Activated Progenitor Cells and Transitional Areas of Tissue Development in the Fetal Human Elbow.
A. Hayes (2016)
10.1136/annrheumdis-2015-207316
Agrin mediates chondrocyte homeostasis and requires both LRP4 and α-dystroglycan to enhance cartilage formation in vitro and in vivo
S. Eldridge (2016)
10.1016/S0142-9612(02)00540-9
Comparison of the antioxidant properties of wound dressing materials--carboxymethylcellulose, hyaluronan benzyl ester and hyaluronan, towards polymorphonuclear leukocyte-derived reactive oxygen species.
R. Moseley (2003)
10.1007/PL00000690
Lecticans: organizers of the brain extracellular matrix
Y. Yamaguchi (2000)
10.1302/2058-5241.2.160004
Platelet-rich plasma (PRP) for knee disorders
Mohammad Shahid (2017)
10.1002/stem.2860
Concise Review: Stem/Progenitor Cell Proteoglycans Decorated with 7‐D‐4, 4‐C‐3, and 3‐B‐3(‐) Chondroitin Sulfate Motifs Are Morphogenetic Markers of Tissue Development
A. Hayes (2018)
10.1016/S0736-0266(01)00141-3
Effects of hyaluronan on proteoglycan content of osteoarthritic chondrocytes in vitro
J. Stöve (2002)
10.1136/ard.2007.086884
Hyaluronan inhibits expression of ADAMTS4 (aggrecanase-1) in human osteoarthritic chondrocytes
T. Yatabe (2009)
10.1097/BCR.0000000000000140
Local Delivery of Antitumor Necrosis Factor-&agr; Through Conjugation to Hyaluronic Acid: Dosing Strategies and Early Healing Effects in a Rat Burn Model
E. Friedrich (2015)
10.1016/j.actbio.2018.04.015
Protective therapeutic effects of peptide nanofiber and hyaluronic acid hybrid membrane in in vivo osteoarthritis model.
E. Arslan (2018)
10.1016/j.carbpol.2017.09.017
Conjugation of paclitaxel to C-6 hexanediamine-modified hyaluronic acid for targeted drug delivery to enhance antitumor efficacy.
Yangjian Chen (2018)
10.3390/ph10020054
The Good the Bad and the Ugly of Glycosaminoglycans in Tissue Engineering Applications
Bethanie I. Ayerst (2017)
10.1089/hum.2018.106
Combinatorial Prg4 and Il-1ra Gene Therapy Protects Against Hyperalgesia and Cartilage Degeneration in Post-Traumatic Osteoarthritis.
Adrianne Stone (2019)
10.1007/s00264-009-0793-2
The regenerative effect of platelet-rich plasma on healing in large osteochondral defects
Y. Sun (2009)
10.1097/01.PHM.0000156899.18885.06
Hyaluronic Acid for the Treatment of Knee Osteoarthritis: Long-Term Outcomes from a Naturalistic Primary Care Experience
R. Petrella (2005)
10.1053/JOCA.2002.0864
The effects of hyaluronic acid on fibronectin fragment mediated cartilage chondrolysis in skeletally mature rabbits.
J. M. Williams (2003)
10.1007/s10067-010-1376-8
Intra-articular hyaluronic acid increases cartilage breakdown biomarker in patients with knee osteoarthritis
Alexandra M. Gonzalez-Fuentes (2010)
10.1007/978-1-4939-3130-9_7
Preparation of Proteoglycan Mimetic Graft Copolymers.
M. Kipper (2016)
10.1186/1471-2091-11-43
Soluble perlecan domain i enhances vascular endothelial growth factor-165 activity and receptor phosphorylation in human bone marrow endothelial cells
Arivalagan Muthusamy (2010)
10.1002/mabi.201300112
Biomimetic aggrecan reduces cartilage extracellular matrix from degradation and lowers catabolic activity in ex vivo and in vivo models.
S. Sharma (2013)
10.1016/j.ymeth.2015.03.019
Biodynamic performance of hyaluronic acid versus synovial fluid of the knee in osteoarthritis.
Michael Corvelli (2015)
10.1177/1947603516684588
Review of the Mechanism of Action for Supartz FX in Knee Osteoarthritis
R. Altman (2018)
10.1186/ar1898
Proteoglycan 4 downregulation in a sheep meniscectomy model of early osteoarthritis
A. Young (2006)
10.1002/jbm.a.35956
Injectable uncrosslinked biomimetic hydrogels as candidate scaffolds for neural stem cell delivery.
K. Farrell (2017)
10.1016/j.bbrc.2014.07.125
LRP4 induces extracellular matrix productions and facilitates chondrocyte differentiation.
N. Asai (2014)
10.1016/j.jss.2008.02.048
Intralymphatic chemotherapy using a hyaluronan-cisplatin conjugate.
S. Cai (2008)
10.1002/cbic.201800569
Recent Advances in Artificially Sulfated Polysaccharides for Applications in Cell Growth and Differentiation, Drug Delivery, and Tissue Engineering
Kui Zeng (2019)
10.1074/JBC.271.17.10079
The Degradation of Human Endothelial Cell-derived Perlecan and Release of Bound Basic Fibroblast Growth Factor by Stromelysin, Collagenase, Plasmin, and Heparanases (*)
J. Whitelock (1996)
10.2147/OARRR.S162127
Systematic clinical evidence review of NASHA (Durolane hyaluronic acid) for the treatment of knee osteoarthritis
R. Leighton (2018)
10.1002/jbm.b.32771
In vitro response of osteoarthritic chondrocytes and fibroblast-like synoviocytes to a 500-730 kDa hyaluronan amide derivative.
P. Brun (2012)
10.1074/jbc.M510330200
Identification and Characterization of Versican/PG-M Aggregates in Cartilage*
K. Matsumoto (2006)
10.3109/03008209309032926
Comparison of the proteoglycanolytic activities of human leukocyte elastase and human cathepsin G in vitro and in vivo.
J. McDonnell (1993)
10.1016/j.actbio.2014.07.033
Thermoresponsive hyaluronic acid nanogels as hydrophobic drug carrier to macrophages.
Talitha Fernandes Stefanello (2014)
10.1016/j.biomaterials.2016.08.027
Targeted systemic mesenchymal stem cell delivery using hyaluronate - wheat germ agglutinin conjugate.
Yun Seop Kim (2016)
10.1016/j.matbio.2014.05.001
Proteoglycans, key regulators of cell-matrix dynamics.
L. Schaefer (2014)
10.2106/00004623-200207000-00008
Granulomatous Inflammation After Hylan G-F 20 Viscosupplementation of the Knee: A Report of Six Cases
A. Chen (2002)
10.1016/S1008-1275(08)60059-0
Influence of sodium hyaluronate on iNOS expression in synovium and NO content in synovial fluid of rabbits with traumatic osteoarthritis.
B. Qiu (2008)
10.1186/s12891-015-0513-6
Safety and performance of Hydros and Hydros-TA for knee osteoarthritis: a prospective, multicenter, randomized, double-blind feasibility trial
R. Petrella (2015)
10.1002/ART.22321
Reduced expression and proteolytic susceptibility of lubricin/superficial zone protein may explain early elevation in the coefficient of friction in the joints of rats with antigen-induced arthritis.
K. Elsaid (2007)
10.1177/0885328216669475
Production and characterization of hyaluronic acid microparticles for the controlled delivery of growth factors using a spray/dehydration method
P. Babo (2016)
10.1002/jor.22362
Atomic force microscopy reveals regional variations in the micromechanical properties of the pericellular and extracellular matrices of the meniscus
Johannah Sanchez-Adams (2013)
10.1016/j.actbio.2012.08.041
Incorporation of an aggrecan mimic prevents proteolytic degradation of anisotropic cartilage analogs.
S. Sharma (2013)
10.1038/nmat4048
Enhanced Lubrication on Tissue and Biomaterial Surfaces through Peptide-mediated Binding of Hyaluronic Acid
A. Singh (2014)
10.1016/J.MATBIO.2007.09.007
A novel peptide sequence in perlecan domain IV supports cell adhesion, spreading and FAK activation.
M. Farach-Carson (2008)
10.1042/BJ20100591
Calpain is involved in C-terminal truncation of human aggrecan.
A. Struglics (2010)
10.1007/s00296-004-0547-9
Suppressive effects of hyaluronan on MMP-1 and RANTES production from chondrocytes
M. Tanaka (2004)
10.3899/jrheum.110777
Aggravation of ADAMTS and Matrix Metalloproteinase Production and Role of ERK1/2 Pathway in the Interaction of Osteoarthritic Subchondral Bone Osteoblasts and Articular Cartilage Chondrocytes — Possible Pathogenic Role in Osteoarthritis
I. Prasadam (2012)
10.1186/ar2453
Fragmentation of decorin, biglycan, lumican and keratocan is elevated in degenerate human meniscus, knee and hip articular cartilages compared with age-matched macroscopically normal and control tissues
J. Melrose (2008)
10.1016/j.biomaterials.2018.08.009
A synthetic polymeric biolubricant imparts chondroprotection in a rat meniscal tear model.
Michel Wathier (2018)
10.1016/S0736-0266(03)00007-X
Hyalgan® has a dose‐dependent differential effect on macrophage proliferation and cell death
Kyle M Sheehan (2003)
10.1096/fasebj.6.3.1740236
Proteoglycans: many forms and many functions
T. Hardingham (1992)
10.4049/jimmunol.1300856
Mast Cell–Restricted, Tetramer-Forming Tryptases Induce Aggrecanolysis in Articular Cartilage by Activating Matrix Metalloproteinase-3 and -13 Zymogens
Natalia J. Magarinos (2013)
10.3233/JAD-160290
Perlecan Domain V Inhibits Amyloid-β Induced Activation of the α2β1 Integrin-Mediated Neurotoxic Signaling Cascade.
Christi L. Parham (2016)
10.1620/TJEM.215.321
Intra-articular injection of hyaluronan diminishes loss of chondrocytes in a rat immobilized-knee model.
A. Ando (2008)
10.22203/ECM.V022A13
Fibronectin- and collagen-mimetic ligands regulate bone marrow stromal cell chondrogenesis in three-dimensional hydrogels.
J. Connelly (2011)
10.2217/IJR.09.54
Synvisc-One™ for the treatment of knee osteoarthritis
J. Radecki (2009)
10.1074/JBC.M412047200
Glycosaminoglycans Modulate Activation, Activity, and Stability of Tripeptidyl-peptidase I in Vitro and in Vivo*
A. Golabek (2005)
10.3233/JAD-130683
Perlecan domain V inhibits amyloid-β induced brain endothelial cell toxicity and restores angiogenic function.
Christi L. Parham (2014)
10.2478/intox-2013-0019
Hyaluronan and synovial joint: function, distribution and healing
T. Tamer (2013)
10.1016/0968-0004(90)90282-G
Inter-alpha-trypsin inhibitor: emergence of a family within the Kunitz-type protease inhibitor superfamily.
J. Salier (1990)
10.1016/S0049-0172(10)80015-0
The kinetics of hyaluronan in normal and acutely inflamed synovial joints: observations with experimental arthritis in sheep.
J. E. Fraser (1993)
10.22203/ECM.V015A02
ADAMTS-5: the story so far.
A. Fosang (2008)
10.1007/s00402-010-1165-5
Viscosupplementation in the management of ankle osteoarthritis: a review
A. Migliore (2010)
10.1002/art.39529
Ablation of Perlecan Domain 1 Heparan Sulfate Reduces Progressive Cartilage Degradation, Synovitis, and Osteophyte Size in a Preclinical Model of Posttraumatic Osteoarthritis
C. Shu (2016)
10.3109/17453679108994462
The effect of hyaluronic acid on cartilage in the immobilized rabbit knee.
E. B. Olsen (1991)
10.1016/j.jot.2017.03.005
Cartilage repair by mesenchymal stem cells: Clinical trial update and perspectives
W. Y. Lee (2017)
10.1016/j.colsurfb.2016.08.039
Silk biomaterials functionalized with recombinant domain V of human perlecan modulate endothelial cell and platelet interactions for vascular applications.
J. Rnjak-Kovacina (2016)
10.1053/JOCA.2000.0372
Hyaluronan does not affect cytokine and chemokine expression in osteoarthritic chondrocytes and synoviocytes.
G. Lisignoli (2001)
10.1038/nrrheum.2012.178
Syndecans in cartilage breakdown and synovial inflammation
T. Pap (2013)
10.1002/acr.21596
American College of Rheumatology 2012 recommendations for the use of nonpharmacologic and pharmacologic therapies in osteoarthritis of the hand, hip, and knee
M. Hochberg (2012)
The biological action of hyaluronan on human osteoartritic articular chondrocytes: the importance of molecular weight.
E. Maneiro (2004)
10.1007/s00018-005-5217-x
Aggrecan, aging and assembly in articular cartilage
J. Dudhia (2005)
10.1007/s11095-014-1393-4
Hyaluronan-Based Nanocarriers with CD44-Overexpressed Cancer Cell Targeting
Shuangshuang Song (2014)
10.1074/jbc.M412145200
N-Linked Keratan Sulfate in the Aggrecan Interglobular Domain Potentiates Aggrecanase Activity*
C. J. Poon (2005)
10.1016/j.biomaterials.2015.08.035
Tumor-specific penetrating peptides-functionalized hyaluronic acid-d-α-tocopheryl succinate based nanoparticles for multi-task delivery to invasive cancers.
D. Liang (2015)
10.1053/JOCA.1997.0086
Long-term effects of hyaluronan on experimental osteoarthritis in the rabbit knee.
C. Shimizu (1998)
10.1016/j.arth.2014.12.012
No difference between intra-articular injection of hyaluronic acid and placebo for mild to moderate knee osteoarthritis: a randomized, controlled, double-blind trial.
W. van der Weegen (2015)
10.1016/j.colsurfb.2016.03.019
Preparation of HIFU-triggered tumor-targeted hyaluronic acid micelles for controlled drug release and enhanced cellular uptake.
S. Zheng (2016)
10.1016/bs.ircmb.2016.02.009
Heparan Sulfate: Biosynthesis, Structure, and Function.
J. Li (2016)
Arthritis Rheum. 1998, 41, 1019; b)
A Guerassimov (1996)
Intra-articular hyaluronate, tenoxicam and vitamin E in a rat model of osteoarthritis: evaluation and comparison of chondroprotective efficacy.
F. Ozkan (2015)
10.1006/JMBI.2001.4878
Mapping of binding sites for nidogens, fibulin-2, fibronectin and heparin to different IG modules of perlecan.
M. Hopf (2001)
10.1016/j.matbio.2016.09.003
A current view of perlecan in physiology and pathology: A mosaic of functions.
Maria A. Gubbiotti (2017)
10.1371/journal.pone.0149835
Allogeneic Mesenchymal Stem Cells in Combination with Hyaluronic Acid for the Treatment of Osteoarthritis in Rabbits
En-Rung Chiang (2016)
10.1016/J.JOCA.2006.05.009
High molecular weight hyaluronic acid down-regulates the gene expression of osteoarthritis-associated cytokines and enzymes in fibroblast-like synoviocytes from patients with early osteoarthritis.
C. Wang (2006)
10.1096/fj.10-176305
Chondrogenesis by chemotactic homing of synovium, bone marrow, and adipose stem cells in vitro
A. Mendelson (2011)
10.1002/term.2331
Investigating cellulose derived glycosaminoglycan mimetic scaffolds for cartilage tissue engineering applications
G. P. Huang (2018)
10.1177/1941738109350438
The Basic Science of Articular Cartilage
Alice J. Sophia Fox (2009)
10.1016/S0049-0172(10)80017-4
The effects of intraarticular administration of hyaluronan in a model of early osteoarthritis in sheep. II. Cartilage composition and proteoglycan metabolism.
P. Ghosh (1993)
10.1055/s-0037-1606549
Comparative Analysis of Gene Expression between Cartilage and Menisci in Early‐Phase Osteoarthritis of the Knee—An Animal Model Study
J. Endo (2018)
10.1007/s00011-014-0742-4
Sorbitol-modified hyaluronic acid reduces oxidative stress, apoptosis and mediators of inflammation and catabolism in human osteoarthritic chondrocytes
John-Max Mongkhon (2014)
10.1111/1523-1747.EP12712140
Pentoxifylline inhibits normal human dermal fibroblast in vitro proliferation, collagen, glycosaminoglycan, and fibronectin production, and increases collagenase activity.
B. Berman (1989)
10.1002/bies.201800215
A Perspective on the Potential Utility of a Viscosupplement Multifunctional Biotherapeutic
J. Melrose (2019)
10.1111/exd.12771
All is balanced: inter‐α‐trypsin inhibitors as unseen extracellular matrix proteins in epidermal morphology and differentiation
H. Hennies (2015)
10.1016/j.carbpol.2016.10.089
Dual pH/redox responsive and CD44 receptor targeting hybrid nano-chrysalis based on new oligosaccharides of hyaluronan conjugates.
D. Chen (2017)
10.1021/acs.bioconjchem.7b00126
Hyaluronate-Peanut Agglutinin Conjugates for Target-Specific Bioimaging of Colon Cancer.
Songeun Beack (2017)
10.1016/j.jconrel.2015.04.031
Synergistic antitumor activity of camptothecin-doxorubicin combinations and their conjugates with hyaluronic acid.
K. Camacho (2015)
10.1186/s13075-017-1301-5
The autocrine role of proteoglycan-4 (PRG4) in modulating osteoarthritic synoviocyte proliferation and expression of matrix degrading enzymes
Ali Alquraini (2017)
10.1177/1947603516670709
PRP for Degenerative Cartilage Disease: A Systematic Review of Clinical Studies
L. Laver (2017)
10.1016/j.matbio.2014.01.016
The role of vascular-derived perlecan in modulating cell adhesion, proliferation and growth factor signaling.
M. Lord (2014)
10.1111/febs.12145
Biological interplay between proteoglycans and their innate immune receptors in inflammation
H. Frey (2013)
10.4161/cib.4.2.14547
Evolution of glycosaminoglycans
S. Yamada (2011)
10.1097/BLO.0b013e31815873f9
Hyaluronan Suppresses IL-1β-induced Metalloproteinase Activity from Synovial Tissue
D. Waddell (2007)
10.1006/ABBI.1994.1219
A novel proteoglycan synthesized and secreted by chondrocytes of the superficial zone of articular cartilage.
B. Schumacher (1994)
10.1021/bc300632w
Hyaluronic acid-based nanogel-drug conjugates with enhanced anticancer activity designed for the targeting of CD44-positive and drug-resistant tumors.
Xin Wei (2013)
Clinical evaluation of a cross-linked hyaluronic Acid dermal filler applied for facial augmentation.
Scott Km Barr (2015)
10.1002/jor.24126
High molecular weight hyaluronan protects cartilage from degradation by inhibiting aggrecanase expression
T. Ohtsuki (2018)
10.1089/ten.TEA.2008.0669
Perlecan domain IV peptide stimulates salivary gland cell assembly in vitro.
S. Pradhan (2009)
10.1074/jbc.M112.404186
Sulfation of the Bikunin Chondroitin Sulfate Chain Determines Heavy Chain·Hyaluronan Complex Formation*
M. Lord (2013)
10.1186/s40064-016-1762-z
Steroids, lidocain and ioxaglic acid modify the viscosity of hyaluronic acid: in vitro study and clinical implications
T. Conrozier (2016)
10.1002/ART.20937
Hyaluronan oligosaccharide-induced activation of transcription factors in bovine articular chondrocytes.
S. Ohno (2005)
10.3349/ymj.2009.50.6.832
The Protective Effect of Sodium Hyaluronate on the Cartilage of Rabbit Osteoarthritis by Inhibiting Peroxisome Proliferator-Activated Receptor-Gamma Messenger RNA Expression
Jian-lin Zhou (2009)
10.1021/bc8000485
Hyaluronic acid-paclitaxel conjugate micelles: synthesis, characterization, and antitumor activity.
H. Lee (2008)
10.1097/DSS.0000000000001634
Effacement of Transverse Neck Lines With VYC-15L and Cohesive Polydensified Matrix Hyaluronic Acid.
A. Minokadeh (2018)
10.1016/S1063-4584(97)80021-0
The effects of hyaluronan during the development of osteoarthritis.
M. Yoshioka (1997)
10.3233/BME-171643
Chitosan: A promising polymer for cartilage repair and viscosupplementation.
F. Comblain (2017)
10.1186/s40634-016-0057-1
Sustained delivery of recombinant human bone morphogenetic protein-2 from perlecan domain I - functionalized electrospun poly (ε-caprolactone) scaffolds for bone regeneration
Yu-Chieh Chiu (2016)
10.3390/ph11010027
Glycosaminoglycans and Proteoglycans
V. Pomin (2018)
10.1002/1097-0282(20011005)59:4<191::AID-BIP1018>3.0.CO;2-M
Comparative rheological behavior of hyaluronan from bacterial and animal sources with cross-linked hyaluronan (hylan) in aqueous solution.
M. Milas (2001)
10.1097/MD.0000000000013049
Comparison of platelet-rich plasma vs hyaluronic acid injections in patients with knee osteoarthritis
Yan-hong Han (2018)
10.1016/j.actbio.2018.05.039
A hybrid injectable hydrogel from hyperbranched PEG macromer as a stem cell delivery and retention platform for diabetic wound healing.
Q. Xu (2018)
10.1006/scdb.2000.0243
Cartilage proteoglycans.
C. Knudson (2001)
10.1007/s00011-010-0156-x
Hyaluronic acid inhibits nitric oxide-induced apoptosis and dedifferentiation of articular chondrocytes in vitro
H. Peng (2010)
10.1089/WOUND.2013.0464
Proteoglycans in Normal and Healing Skin.
M. Smith (2015)
10.1074/jbc.M602750200
Hyaluronan Oligosaccharides Induce Matrix Metalloproteinase 13 via Transcriptional Activation of NFκB and p38 MAP Kinase in Articular Chondrocytes*
S. Ohno (2006)
10.1038/srep18910
Lubricin/Proteoglycan 4 binds to and regulates the activity of Toll-Like Receptors In Vitro
S. M. Iqbal (2016)
10.1016/j.matbio.2014.08.008
The biology of lubricin: near frictionless joint motion.
G. Jay (2014)
Alzheimer's Dis
C Parham (2014)
10.1038/cdd.2009.9
Insights on a new path of pre-mitochondrial apoptosis regulation by a glycosaminoglycan mimetic
Xl Yue (2009)
10.1016/j.ijbiomac.2016.01.051
The collaggrecan: Synthesis and visualization of an artificial proteoglycan.
M. Raspanti (2016)
10.18999/NAGJMS.62.3-4.115
Effects of sodium hyaluronate on experimental osteoarthritis in rabbit knee joints.
F. Han (1999)
10.1177/0363546516686965
Intra-articular Recombinant Human Proteoglycan 4 Mitigates Cartilage Damage After Destabilization of the Medial Meniscus in the Yucatan Minipig
Kimberly A. Waller (2017)
10.1021/acs.biochem.5b00653
Decoding the Matrix: Instructive Roles of Proteoglycan Receptors.
T. Neill (2015)
10.1021/ACS.BIOMAC.6B01216
Hyaluronate-Epidermal Growth Factor Conjugate for Skin Wound Healing and Regeneration.
H. Kim (2016)
10.1002/ardp.201300177
Synthesis and Optimization of a Bifunctional Hyaluronan‐Based Camptothecin Prodrug
Zaiyang Xu (2014)
10.1042/bj3350491
Cathepsin B: an alternative protease for the generation of an aggrecan 'metalloproteinase' cleavage neoepitope.
J. Mort (1998)
264, 16170; b)
P Antonsson (1989)
Primary structure of the human heparan sulfate proteoglycan from basement membrane (HSPG2/perlecan). A chimeric molecule with multiple domains homologous to the low density lipoprotein receptor, laminin, neural cell adhesion molecules, and epidermal growth factor.
A. Murdoch (1992)
10.1021/acs.biomac.5b01637
Glycosaminoglycan-Mimetic Signals Direct the Osteo/Chondrogenic Differentiation of Mesenchymal Stem Cells in a Three-Dimensional Peptide Nanofiber Extracellular Matrix Mimetic Environment.
E. Arslan (2016)
10.2147/CCID.S141906
Cohesive Polydensified Matrix® hyaluronic acid volumizer injected for cheek augmentation has additional positive effect on nasolabial folds
G. Gauglitz (2017)
10.1021/ac400439a
An approach for separation and complete structural sequencing of heparin/heparan sulfate-like oligosaccharides.
Rongrong Huang (2013)
10.1016/0945-053X(94)90198-8
Length variation in the keratan sulfate domain of mammalian aggrecan.
F. P. Barry (1994)
10.1254/JJP.60.79
Inhibitory effects of hyaluronan on [14C]arachidonic acid release from labeled human synovial fibroblasts.
K. Tobetto (1992)
10.1111/J.1432-1033.1997.T01-1-00039.X
The C-terminal domain V of perlecan promotes beta1 integrin-mediated cell adhesion, binds heparin, nidogen and fibulin-2 and can be modified by glycosaminoglycans.
J. Brown (1997)
10.1007/s00011-004-1276-y
The role of insulin-like growth factor-I in hyaluronan mediated repair of cultured cartilage explants
G. Homandberg (2004)
10.1016/j.carbpol.2012.06.071
Hyaluronan regulates PPARγ and inflammatory responses in IL-1β-stimulated human chondrosarcoma cells, a model for osteoarthritis.
C. Chang (2012)
10.1007/s10439-015-1390-8
Full-Length Recombinant Human Proteoglycan 4 Interacts with Hyaluronan to Provide Cartilage Boundary Lubrication
S. Abubacker (2015)
10.1016/0014-5793(96)01082-4
Structural characterization of recombinant domain II of the basement membrane proteoglycan perlecan
M. Costell (1996)
10.1166/JBN.2014.1781
Hyaluronic acid-based drug conjugates: state-of-the-art and perspectives.
B. Chen (2014)
10.1385/1-59259-209-0:427
Interaction of proteoglycans with receptor tyrosine kinases.
D. Moscatello (2001)
10.1007/s00590-014-1517-x
Comparison of short-term results of intraarticular platelet-rich plasma (PRP) and hyaluronic acid treatments in early-stage gonarthrosis patients
O. Guler (2014)
10.1369/jhc.7A7320.2007
Chondroitin Sulfate Sulfation Motifs as Putative Biomarkers for Isolation of Articular Cartilage Progenitor Cells
A. Hayes (2008)
10.1136/ard.44.12.817
Concentration and molecular weight of sodium hyaluronate in synovial fluid from patients with rheumatoid arthritis and other arthropathies.
L. Dahl (1985)
10.1166/JBN.2014.1761
Hyaluronic acid-based conjugates for tumor-targeted drug delivery and imaging.
G. Saravanakumar (2014)
10.22203/ECM.V012A11
The structure and function of cartilage proteoglycans.
P. Roughley (2006)
10.2174/138920108785161596
Hyaluronan as an ophthalmic viscoelastic device.
E. Balazs (2008)
10.1021/acs.biomac.7b00445
Reduction- and pH-Sensitive Hyaluronan Nanoparticles for Delivery of Iridium(III) Anticancer Drugs.
Z. Cai (2017)
10.1021/acs.biomac.7b01664
pH-Sensitive Coiled-Coil Peptide-Cross-Linked Hyaluronic Acid Nanogels: Synthesis and Targeted Intracellular Protein Delivery to CD44 Positive Cancer Cells.
L. Ding (2018)
The small proteoglycan biglycan is associated with thick collagen fibrils in the mouse decidua.
S. San Martín (2003)
10.1016/0003-9861(92)90014-N
Cleavage of proteoglycan aggregate by leucocyte elastase.
M. T. Mok (1992)
10.1021/bc8000479
Hyaluronan-tethered opioid depots: synthetic strategies and release kinetics in vitro and in vivo.
Diego A. Gianolio (2008)
10.1016/j.joca.2014.04.019
Pharmacological effects of novel cross-linked hyaluronate, Gel-200, in experimental animal models of osteoarthritis and human cell lines.
K. Yoshioka (2014)
10.1021/acs.biomac.7b00553
Biopolymer Molecular Weight Can Modulate the Wound Healing Efficacy of Multivalent Sonic Hedgehog-Hyaluronic Acid Conjugates.
Taylor A. Holstlaw (2017)
10.1111/febs.12164
Endorepellin laminin‐like globular 1/2 domains bind Ig3–5 of vascular endothelial growth factor (VEGF) receptor 2 and block pro‐angiogenic signaling by VEGFA in endothelial cells
C. D. Willis (2013)
10.1016/S0304-3959(02)00260-9
Elastoviscous substances with analgesic effects on joint pain reduce stretch-activated ion channel activity in vitro
E. D. L. Peña (2002)
10.1038/nature03417
ADAMTS5 is the major aggrecanase in mouse cartilage in vivo and in vitro
H. Stanton (2005)
10.19082/2115
Efficacy of Platelet-Rich Plasma versus Hyaluronic Acid for treatment of Knee Osteoarthritis: A systematic review and meta-analysis
Hassan Niroomand Sadabad (2016)
10.1016/0006-8993(95)00775-L
Heparan sulfate and chondroitin sulfate glycosaminoglycan attenuate β-amyloid(25–35) induced neurodegeneration in cultured hippocampal neurons
A. G. Woods (1995)
10.2165/00003495-199447030-00009
Hyaluronic Acid
K. Goa (2012)
10.1002/jor.20683
The effect of hyaluronic acid on IL‐1β‐induced chondrocyte apoptosis in a rat model of osteoarthritis
Pang-Hu Zhou (2008)
10.1177/1179544117751622
Rheological Properties of Commercially Available Hyaluronic Acid Products in the United States for the Treatment of Osteoarthritis Knee Pain
Mathew Nicholls (2018)
10.1016/j.actbio.2016.01.011
Targeted intracellular protein delivery based on hyaluronic acid-green tea catechin nanogels.
Kun Liang (2016)
10.1016/j.bbrc.2012.08.124
Fibroblast growth factor 2 enhances the kinetics of mesenchymal stem cell chondrogenesis.
T. Cheng (2012)
10.2106/JBJS.M.00058
Adult human mesenchymal stem cells delivered via intra-articular injection to the knee following partial medial meniscectomy: a randomized, double-blind, controlled study.
C. Vangsness (2014)
10.1016/j.toxlet.2015.05.021
Deciphering the underlying mechanisms of oxidation-state dependent cytotoxicity of graphene oxide on mammalian cells.
Wendi Zhang (2015)
10.1007/s00011-009-0147-y
Hyaluronan reversed proteoglycan synthesis inhibited by mechanical stress: possible involvement of antioxidant effect
Y. Miki (2009)
10.1016/j.oraloncology.2011.07.029
Hyaluronic acid-paclitaxel conjugate inhibits growth of human squamous cell carcinomas of the head and neck via a hyaluronic acid-mediated mechanism.
C. Galer (2011)
271, 10079; b)
J M Whitelock (1996)
10.1016/S1063-4584(05)80013-5
The role of viscosupplementation with hylan G-F 20 (Synvisc) in the treatment of osteoarthritis of the knee: a Canadian multicenter trial comparing hylan G-F 20 alone, hylan G-F 20 with non-steroidal anti-inflammatory drugs (NSAIDs) and NSAIDs alone.
M. E. Adams (1995)
10.1093/glycob/cws218
Hypotheses on the evolution of hyaluronan: A highly ironic acid
A. B. Csóka (2013)
10.1016/j.ydbio.2009.10.026
The extracellular matrix in development and morphogenesis: a dynamic view.
Tania Rozario (2010)
10.1038/s41598-017-18382-y
Surface functionalization of electrospun scaffolds using recombinant human decorin attracts circulating endothelial progenitor cells
S. Hinderer (2017)
10.1089/ten.TEA.2017.0235
Articular Cartilage Repair with Mesenchymal Stem Cells After Chondrogenic Priming: A Pilot Study.
Troy D. Bornes (2018)
10.1016/j.biomaterials.2015.09.012
Synthesis and characterization of a lubricin mimic (mLub) to reduce friction and adhesion on the articular cartilage surface.
A. Lawrence (2015)
10.1021/acs.chemrev.8b00354
Proteoglycan Chemical Diversity Drives Multifunctional Cell Regulation and Therapeutics.
N. Karamanos (2018)
10.1186/s12891-015-0775-z
The mechanism of action for hyaluronic acid treatment in the osteoarthritic knee: a systematic review
R. Altman (2015)
10.1002/1529-0131(199806)41:6<1019::AID-ART8>3.0.CO;2-X
Cellular immunity to the G1 domain of cartilage proteoglycan aggrecan is enhanced in patients with rheumatoid arthritis but only after removal of keratan sulfate.
A. Guerassimov (1998)
10.1053/RVSC.1999.0328
In vitro stimulation of equine articular cartilage proteoglycan synthesis by hyaluronan and carprofen.
S. Frean (1999)
10.1042/BCJ20180283
Glycans and glycosaminoglycans in neurobiology: key regulators of neuronal cell function and fate.
A. Hayes (2018)
8, 902; b) L. Sundblad
S A Barker (1963)
10.1111/febs.12187
Neoproteoglycans in tissue engineering
Amanda Weyers (2013)
10.1679/AOHC.61.125
Molecular weight-dependent effects of hyaluronate on the arthritic synovium.
A. Asari (1998)
10.1016/j.matbio.2016.01.008
The cartilage extracellular matrix as a transient developmental scaffold for growth plate maturation.
J. Melrose (2016)
10.3390/molecules19033193
Hyaluronic Acid Conjugates as Vectors for the Active Targeting of Drugs, Genes and Nanocomposites in Cancer Treatment
S. Arpicco (2014)
10.1177/0363546515582027
Platelet-Rich Plasma Intra-articular Knee Injections Show No Superiority Versus Viscosupplementation
G. Filardo (2015)
10.1007/s00418-012-0968-6
Chondroitin sulphate and heparan sulphate sulphation motifs and their proteoglycans are involved in articular cartilage formation during human foetal knee joint development
J. Melrose (2012)
10.1016/J.JOCA.2006.02.006
Biochemical effects of two different hyaluronic acid products in a co-culture model of osteoarthritis.
D. D. Greenberg (2006)
10.1016/j.ejpb.2014.10.016
A novel oxido-viscosifying Hyaluronic Acid-antioxidant conjugate for osteoarthritis therapy: biocompatibility assessments.
S. Kaderli (2015)
10.1186/s40814-018-0288-2
Platelet-rich plasma (PRP) therapy for knee arthritis: a feasibility study in primary care
L. Glynn (2018)
10.1016/j.ymeth.2008.01.011
Antibodies and immunohistochemistry in extracellular matrix research.
A. Hayes (2008)
10.1073/pnas.1219289110
Role of lubricin and boundary lubrication in the prevention of chondrocyte apoptosis
Kimberly A. Waller (2013)
10.1097/DSS.0000000000001417
Long-Term Correction of Iatrogenic Lipoatrophy With Volumizing Hyaluronic Acid Filler.
Amelia K Hausauer (2018)
Bone Tissue Repair
J. Melrose (2016)
10.1021/BM061003S
Coating electrospun collagen and gelatin fibers with perlecan domain I for increased growth factor binding.
Cheryl L. Casper (2007)
10.1074/jbc.M600296200
Aggrecan Turnover in Human Intervertebral Disc as Determined by the Racemization of Aspartic Acid*
S. Sivan (2006)
10.1016/J.JOCA.2006.06.009
Differential cartilaginous tissue formation by human synovial membrane, fat pad, meniscus cells and articular chondrocytes.
A. Marsano (2007)
10.1177/2309499017731627
Randomized controlled trial comparing efficacy of conventional and new single larger dose of intra-articular viscosupplementation in management of knee osteoarthritis
Vijaya Kumar L Suppan (2017)
10.1007/s11999-012-2659-y
Adding Triamcinolone Improves Viscosupplementation: A Randomized Clinical Trial
G. C. Campos (2013)
10.1016/j.actbio.2017.04.019
Regulation of human nucleus pulposus cells by peptide-coupled substrates.
D. Bridgen (2017)
39, 17; b)
G D Jay (2007)
10.1016/J.JOCA.2004.04.010
Efficacy and safety of a single intra-articular injection of non-animal stabilized hyaluronic acid (NASHA) in patients with osteoarthritis of the knee.
R. Altman (2004)
10.3892/mmr.2012.1240
Chondrogenesis of myoblasts in biodegradable poly-lactide-co-glycolide scaffolds.
Yanglin Gu (2013)
10.1016/J.CHEMBIOL.2006.12.009
Profiling the sulfation specificities of glycosaminoglycan interactions with growth factors and chemotactic proteins using microarrays.
Eric L Shipp (2007)
10.1016/S0925-4773(99)00238-5
Synthesis of hyaluronan of distinctly different chain length is regulated by differential expression of Xhas1 and 2 during early development of Xenopus laevis
M. Köprunner (2000)
10.1186/ar4446
Intra-articular hyaluronic acid injection versus oral non-steroidal anti-inflammatory drug for the treatment of knee osteoarthritis: a multi-center, randomized, open-label, non-inferiority trial
M. Ishijima (2014)
10.1016/J.BBAGEN.2006.01.013
Glycosaminoglycan-binding properties and aggrecanase activities of truncated ADAMTSs: comparative analyses with ADAMTS-5, -9, -16 and -18.
W. Zeng (2006)
10.1016/j.ijpharm.2013.06.066
A new highly viscoelastic hyaluronic acid gel: rheological properties, biocompatibility and clinical investigation in esthetic and restorative surgery.
T. Iannitti (2013)
10.1002/biot.201700196
Recombinant Domain V of Human Perlecan Is a Bioactive Vascular Proteoglycan.
J. Rnjak-Kovacina (2017)
10.3109/1061186X.2014.921924
Cellular uptake and internalization of hyaluronan-based doxorubicin and cisplatin conjugates
S. Cai (2014)
10.1080/21691401.2017.1416390
Multifunctional redox-responsive and CD44 receptor targeting polymer-drug nanomedicine based curcumin and alendronate: synthesis, characterization and in vitro evaluation
Xue Dong (2018)
10.1016/j.joca.2013.10.009
NASHA hyaluronic acid vs. methylprednisolone for knee osteoarthritis: a prospective, multi-centre, randomized, non-inferiority trial.
R. Leighton (2014)
10.1074/mcp.M114.045856
GAG-ID: Heparan Sulfate (HS) and Heparin Glycosaminoglycan High-Throughput Identification Software*
Yulun Chiu (2015)
10.1016/j.cca.2017.03.020
Therapeutic targets in the selective killing of cancer cells by nanomaterials.
M. Akhtar (2017)
10.1111/febs.12197
Recombinant production of proteoglycans and their bioactive domains
M. Lord (2013)
10.3389/fnint.2017.00033
A Sweet Talk: The Molecular Systems of Perineuronal Nets in Controlling Neuronal Communication
Heleen van ‘t Spijker (2017)
10.1016/j.ijbiomac.2015.12.003
Hyaluronic acid alkyl derivative: A novel inhibitor of metalloproteases and hyaluronidases.
M. Pavan (2016)
10.1177/0363546512461902
Comparison Between Hyaluronic Acid and Platelet-Rich Plasma, Intra-articular Infiltration in the Treatment of Gonarthrosis
F. Cerza (2012)
10.1016/S0736-0266(00)90024-X
Hyaluronan suppressed nitric oxide production in the meniscus and synovium of rabbit osteoarthritis model
K. Takahashi (2001)
10.5966/sctm.2015-0166
Priming Dental Pulp Stem Cells With Fibroblast Growth Factor‐2 Increases Angiogenesis of Implanted Tissue‐Engineered Constructs Through Hepatocyte Growth Factor and Vascular Endothelial Growth Factor Secretion
C. Gorin (2016)
10.1371/journal.pone.0143415
Elastoviscous Transitions of Articular Cartilage Reveal a Mechanism of Synergy between Lubricin and Hyaluronic Acid
E. Bonnevie (2015)
10.1002/BIP.1968.360060603
Rheology of hyaluronic acid
D. Gibbs (1968)
10.1016/j.febslet.2005.07.090
Perlecan from human epithelial cells is a hybrid heparan/chondroitin/keratan sulfate proteoglycan
S. Knox (2005)
10.1096/fasebj.10.5.8621059
Proteoglycans of the extracellular environment: clues from the gene and protein side offer novel perspectives in molecular diversity and function
R. Iozzo (1996)
10.4137/CMAMD.S39432
Standardized Follow-up of Patients with Symptomatic Knee Osteoarthritis Treated with a Single Intra-articular Injection of a Combination of Cross-Linked Hyaluronic Acid and Mannitol
T. Conrozier (2016)
10.1002/art.27436
Loss of Cartilage Structure, Stiffness, and Frictional Properties in Mice Lacking PRG4
Jeffrey M. Coles (2010)
Iron and free radical oxidations in cell membranes.
F. Q. Schafer (2000)
10.1021/acs.biomac.6b01022
Hyaluronate-Death Receptor 5 Antibody Conjugates for Targeted Treatment of Liver Metastasis.
H. Lee (2016)
10.1111/cbdd.12288
CD44‐Targeted Docetaxel Conjugate for Cancer Cells and Cancer Stem‐Like Cells: A Novel Hyaluronic Acid‐Based Drug Delivery System
N. Goodarzi (2014)
10.1002/jor.21216
Hyaluronan inhibits matrix metalloproteinase‐13 in human arthritic chondrocytes via CD44 and P38
S. Julovi (2011)
10.1177/0022034514521237
Recombinant Biglycan Promotes Bone Morphogenetic Protein-induced Osteogenesis
P. Miguez (2014)
10.1074/mcp.R112.026294
Glycosaminoglycan Glycomics Using Mass Spectrometry*
J. Zaia (2013)
10.1053/JOCA.1999.0310
The long-term effects of hyaluronan during development of osteoarthritis following partial meniscectomy in a rabbit model.
K. Kobayashi (2000)
10.1016/j.addr.2015.11.011
Hyaluronic acid for anticancer drug and nucleic acid delivery.
F. Dosio (2016)
50, 832; ap)
F J Jiang (2009)
10.1038/nprot.2010.48
High-performance liquid chromatography-mass spectrometry for mapping and sequencing glycosaminoglycan-derived oligosaccharides
N. Volpi (2010)
10.1073/pnas.1703856114
Knee osteoarthritis has doubled in prevalence since the mid-20th century
Ian J. Wallace (2017)
10.1371/journal.pone.0194679
TGF-β1/CD105 signaling controls vascular network formation within growth factor sequestering hyaluronic acid hydrogels
Shane Browne (2018)
10.1016/S0955-0674(00)00135-6
Hyaluronan: a multifunctional, megaDalton, stealth molecule.
J. Lee (2000)
10.1016/S0955-0674(89)80072-9
The extended family of proteoglycans: social residents of the pericellular zone.
J. Gallagher (1989)
10.2147/IJN.S120847
Hyaluronic acid–nimesulide conjugates as anticancer drugs against CD44-overexpressing HT-29 colorectal cancer in vitro and in vivo
You-Sin Jian (2017)
10.1016/j.nbt.2014.07.004
Use of a chronic model of articular cartilage and meniscal injury for the assessment of long-term effects after autologous mesenchymal stromal cell treatment in sheep.
M. Caminal (2014)
10.1016/j.yexmp.2016.09.001
Interleukin-1α induces focal degradation of biglycan and tissue degeneration in an in-vitro ovine meniscal model.
E. Fuller (2016)
10.1097/DSS.0000000000001462
Cohesive Polydensified Matrix Hyaluronic Acid for the Treatment of Etched-In Fine Facial Lines: A 6-Month, Open-Label Clinical Trial
J. Black (2018)
10.1016/S0945-053X(01)00168-8
Cathepsin D cleaves aggrecan at unique sites within the interglobular domain and chondroitin sulfate attachment regions that are also cleaved when cartilage is maintained at acid pH.
C. Handley (2001)
10.1002/jor.21240
Intra‐articular injection of hyaluronan restores the aberrant expression of matrix metalloproteinase‐13 in osteoarthritic subchondral bone
N. Hiraoka (2011)
10.3390/ijms17040411
Intra-Articular Injection of Cross-Linked Hyaluronic Acid-Dexamethasone Hydrogel Attenuates Osteoarthritis: An Experimental Study in a Rat Model of Osteoarthritis
Z. Zhang (2016)
10.1089/ten.TEA.2017.0039
Efficacy and Persistence of Allogeneic Adipose-Derived Mesenchymal Stem Cells Combined with Hyaluronic Acid in Osteoarthritis After Intra-articular Injection in a Sheep Model.
C. Feng (2018)
10.1002/bies.20748
Perlecan, the "jack of all trades" proteoglycan of cartilaginous weight-bearing connective tissues.
J. Melrose (2008)
10.2147/JPR.S132497
Long-term clinical benefit and cost-effectiveness of an 8-week multimodal knee osteoarthritis management program incorporating intra-articular sodium hyaluronate (Hyalgan®) injections
L. Miller (2017)
10.3349/YMJ.1991.32.2.139
Effect of sodium hyaluronate on prevention of osteoarthritis.
N. H. Kim (1991)
84-A, 1142; c) W. van der Weegen
A L Chen (2002)
10.1053/j.jfas.2018.10.003
Nonanimal Hyaluronic Acid for the Treatment of Ankle Osteoarthritis: AProspective, Single‐Arm Cohort Study
A. Younger (2019)
10.1172/JCI118458
Immunity to the G1 globular domain of the cartilage proteoglycan aggrecan can induce inflammatory erosive polyarthritis and spondylitis in BALB/c mice but immunity to G1 is inhibited by covalently bound keratan sulfate in vitro and in vivo.
J. Y. Leroux (1996)
Critical roles of glycosaminoglycan side chains of cartilage proteoglycan (aggrecan) in antigen recognition and presentation.
T. Glant (1998)
10.1021/acsnano.6b05113
Gold-Nanoclustered Hyaluronan Nano-Assemblies for Photothermally Maneuvered Photodynamic Tumor Ablation.
H. Han (2016)
10.1016/j.ijpharm.2015.07.069
Self-assembled nanoparticles from hyaluronic acid-paclitaxel prodrugs for direct cytosolic delivery and enhanced antitumor activity.
Chaoran Xu (2015)
10.3233/BIR-180174
Characterization of the visco-elastic properties of hyaluronic acid.
B. Lázaro (2018)
10.1021/acs.analchem.6b04122
Label-Free Discovery Array Platform for the Characterization of Glycan Binding Proteins and Glycoproteins.
C. Gray (2017)
10.1016/J.TCB.2007.02.006
Tinkering with heparan sulfate sulfation to steer development.
Bushra Gorsi (2007)
10.1002/ART.20004
Inhibition of interleukin-1β-stimulated production of matrix metalloproteinases by hyaluronan via CD44 in human articular cartilage
S. Julovi (2004)
10.1021/bm401736c
Aggrecan-mimetic, glycosaminoglycan-containing nanoparticles for growth factor stabilization and delivery.
Laura W. Place (2014)
10.1016/j.expneurol.2015.08.015
Sugar-dependent modulation of neuronal development, regeneration, and plasticity by chondroitin sulfate proteoglycans
G. Miller (2015)
Arden
R D Altman (2004)
10.1186/s12891-015-0599-x
Type II collagen and glycosaminoglycan expression induction in primary human chondrocyte by TGF-β1
H. J. Yoon (2015)
10.1177/1947603517703732
Intraarticular Injection of a Cross-Linked Sodium Hyaluronate Combined with Triamcinolone Hexacetonide (Cingal) to Provide Symptomatic Relief of Osteoarthritis of the Knee: A Randomized, Double-Blind, Placebo-Controlled Multicenter Clinical Trial
L. Hangody (2018)
31, 693; b)
P S Babo (2012)
10.3390/POLYM6071948
Effect of Mannitol on Hyaluronic Acid Stability in Two in Vitro Models of Oxidative Stress
M. Rinaudo (2014)
10.1016/j.sbi.2017.12.011
Specificity of glycosaminoglycan-protein interactions.
L. Kjellén (2018)
10.1016/j.colsurfb.2014.10.025
Hyaluronic acid-quercetin conjugate micelles: synthesis, characterization, in vitro and in vivo evaluation.
Xin Pang (2014)
10.1038/NCHEMBIO810
Sulfation patterns of glycosaminoglycans encode molecular recognition and activity
Cristal I Gama (2006)
10.1038/sj.cr.7290106
Structure and function of aggrecan
Chris G Kiani (2002)
10.1016/j.biomaterials.2008.04.001
In vitro chondrogenic differentiation of human mesenchymal stem cells in collagen microspheres: influence of cell seeding density and collagen concentration.
T. Y. Hui (2008)
10.1016/j.matbio.2008.11.001
Keratan sulphate in the interglobular domain has a microstructure that is distinct from keratan sulphate elsewhere on pig aggrecan.
A. Fosang (2009)
10.1053/JOCA.2000.0395
Effects of high molecular weight hyaluronan on the distribution and movement of proteoglycan around chondrocytes cultured in alginate beads.
T. Kikuchi (2001)
10.3390/ijms20030497
A Retrospective Analysis of the Cartilage Kunitz Protease Inhibitory Proteins Identifies These as Members of the Inter-α-Trypsin Inhibitor Superfamily with Potential Roles in the Protection of the Articulatory Surface
S. Smith (2019)
10.3109/14764172.2011.613478
Benefits of adding lidocaine to a hyaluronic gel – Stylage® M
B. Môle (2011)
10.1016/j.carbpol.2017.07.063
Injectable glycosaminoglycan-protein nano-complex in semi-interpenetrating networks: A biphasic hydrogel for hyaline cartilage regeneration.
J. Radhakrishnan (2017)
10.1016/j.biomaterials.2010.03.017
Biofunctionalization of electrospun PCL-based scaffolds with perlecan domain IV peptide to create a 3-D pharmacokinetic cancer model.
O. Hartman (2010)
10.1016/j.carbpol.2018.04.052
Enhanced delivery of doxorubicin to the liver through self-assembled nanoparticles formed via conjugation of glycyrrhetinic acid to the hydroxyl group of hyaluronic acid.
Xiaodan Wang (2018)
10.1016/j.bbcan.2015.03.006
Insights into the key roles of proteoglycans in breast cancer biology and translational medicine.
A. Theocharis (2015)
Bone Tissue Repair Insights
J Melrose (2016)
10.1055/s-0036-1597685
Hyaluronic Acid Fillers in Soft Tissue Regeneration
Arianna Fallacara (2017)
10.1006/ABBI.1997.0492
Aggrecan turnover in human articular cartilage: use of aspartic acid racemization as a marker of molecular age.
A. Maroudas (1998)
10.1186/s12889-019-6465-2
Spatiotemporal evolution of global population ageing from 1960 to 2017
J. Li (2019)
10.1016/j.actbio.2018.08.029
Cartilage regeneration using arthroscopic flushing fluid-derived mesenchymal stem cells encapsulated in a one-step rapid cross-linked hydrogel.
J. Li (2018)
10.1016/j.carres.2017.10.008
Characterization of structural motifs for interactions between glycosaminoglycans and proteins.
Jiyuan Yang (2017)
10.1016/j.colsurfb.2017.07.073
Injectable hydrogels for treatment of osteoarthritis - A rheological study.
Benjamin von Lospichl (2017)
10.1620/TJEM.204.99
Hyaluronate inhibits the interleukin-1beta-induced expression of matrix metalloproteinase (MMP)-1 and MMP-3 in human synovial cells.
A. Sasaki (2004)
10.1097/WNR.0b013e3283554c5c
Perlecan domain V is upregulated in human brain arteriovenous malformation and could mediate the vascular endothelial growth factor effect in lesional tissue
Michael P. Kahle (2012)
10.1016/j.msec.2017.12.013
Hydrazone crosslinked hyaluronan-based hydrogels for therapeutic delivery of adipose stem cells to treat corneal defects.
L. Koivusalo (2018)
10.1021/ja505012a
Glycocalyx Remodeling with Proteoglycan Mimetics Promotes Neural Specification in Embryonic Stem Cells
Mia L Huang (2014)
10.1074/JBC.R300039200
Inter-α-trypsin Inhibitor, a Covalent Protein-Glycosaminoglycan-Protein Complex*
L. Zhuo (2004)
Longterm effects of intraarticular hyaluronan on synovial fluid in osteoarthritis of the knee.
Hanish Bagga (2006)
10.1074/jbc.M608462200
The Structure, Location, and Function of Perlecan, a Prominent Pericellular Proteoglycan of Fetal, Postnatal, and Mature Hyaline Cartilages*
J. Melrose (2006)
8, 359; q)
M Ehlers
10.1007/s10735-019-09823-1
Type XI collagen–perlecan–HS interactions stabilise the pericellular matrix of annulus fibrosus cells and chondrocytes providing matrix stabilisation and homeostasis
S. Smith (2019)
10.1016/j.biomaterials.2011.11.022
Redox-sensitive micelles self-assembled from amphiphilic hyaluronic acid-deoxycholic acid conjugates for targeted intracellular delivery of paclitaxel.
J. Li (2012)
10.1016/J.JOCA.2010.03.001
Bone morphogenetic proteins and articular cartilage: To serve and protect or a wolf in sheep clothing's?
P. Kraan (2010)
10.1016/0301-4622(94)85024-0
The cartilage proteoglycan aggregate: assembly through combined protein-carbohydrate and protein-protein interactions.
M. Mörgelin (1994)
10.1074/jbc.M804178200
Effects of Hyaluronic Acid on Mitochondrial Function and Mitochondria-driven Apoptosis following Oxidative Stress in Human Chondrocytes
V. Grishko (2009)
23, 398; b) M. Koprunner
A B Csoka (2000)
10.1039/C0SC00271B
End-functionalized glycopolymers as mimetics of chondroitin sulfate proteoglycans.
S. Lee (2010)
10.22203/ECM.V032A03
Pericellular colocalisation and interactive properties of type VI collagen and perlecan in the intervertebral disc.
A. Hayes (2016)
10.1021/acs.molpharmaceut.8b00473
Hyaluronic Acid-Methotrexate Conjugates Coated Magnetic Polydopamine Nanoparticles for Multimodal Imaging-Guided Multistage Targeted Chemo-Photothermal Therapy.
Q. Li (2018)
10.1016/j.bbagen.2014.01.035
Key roles for the small leucine-rich proteoglycans in renal and pulmonary pathophysiology.
M. V. Nastase (2014)
10.1016/j.ajpath.2012.04.029
Decorin: a guardian from the matrix.
T. Neill (2012)
10.1016/S1063-4584(97)80035-0
Hyaluronic acid suppresses fibronectin fragment mediated cartilage chondrolysis: I. In vitro.
G. Homandberg (1997)
10.1016/j.ijbiomac.2018.09.188
Hyaluronic acid, a promising skin rejuvenating biomedicine: A review of recent updates and pre-clinical and clinical investigations on cosmetic and nutricosmetic effects.
S. Bukhari (2018)
10.1002/wsbm.149
Heparan sulfate proteoglycans in healthy and diseased systems
J. Whitelock (2011)
10.1016/S1063-4584(09)60186-2
164 HYALURONAN AND INTERMITTENT HYDROSTATIC PRESSURE SYNERGISTICALLY SUPPRESSED MMP-13 AND IL-6 EXPRESSIONS IN OSTEOBLASTS FROM OA SUBCHONDRAL BONE
N. Hiraoka (2009)
10.1111/febs.13940
Syndecans – key regulators of cell signaling and biological functions
N. Afratis (2017)
10.1016/j.joca.2015.06.019
Preliminary results of a phase II randomized study to determine the efficacy and safety of genetically engineered allogeneic human chondrocytes expressing TGF-β1 in patients with grade 3 chronic degenerative joint disease of the knee.
J. J. Cherian (2015)
10.1038/ncprheum0216
Technology Insight: adult stem cells in cartilage regeneration and tissue engineering
F. Chen (2006)



This paper is referenced by
Semantic Scholar Logo Some data provided by SemanticScholar