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Hyperbaric Oxygen Potentiates Doxil Antitumor Efficacy By Promoting Tumor Penetration And Sensitizing Cancer Cells
X. Wu, Y. Zhu, W. Huang, Jing-qiu Li, B. Zhang, Zifu Li, X. Yang
Published 2018 · Medicine
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Abstract Hypoxia is a fundamental hallmark of solid tumors and helps contribute to chemotherapy resistance. Hyperbaric oxygen (HBO) therapy can overcome tumor hypoxia and promote chemotherapy antitumor efficacy; however, the simultaneous administration of some conventional chemotherapies, including doxorubicin (DOX), with HBO is considered an absolute contraindication. Here, DOX‐loaded liposome (Doxil) is coadministered with HBO to assess the safety and efficacy of this combination treatment. By overcoming tumor hypoxia, HBO not only improves Doxil tumor penetration by decreasing the collagen deposition but also sensitizes tumor cells to Doxil. As a result, the combination treatment synergistically inhibits H22 tumor growth, with a tumor inhibition rate of 91.5%. The combination of HBO with Doxil shows neither extra side effects nor promotion of tumor metastasis. These results collectively reveal that the combination of HBO with Doxil is an effective and safe treatment modality. As both HBO and Doxil are routinely used, their combination could quickly translate to clinical trials for patients with hypoxic solid tumors.
This paper references
Tumor Priming Enhances Delivery and Efficacy of Nanomedicines
D. Lu (2007)
Identification of the molecular basis of doxorubicin-induced cardiotoxicity
Sui Zhang (2012)
Stimuli-responsive nanoparticles for targeting the tumor microenvironment.
Jin-Zhi Du (2015)
An Implantable Depot That Can Generate Oxygen in Situ for Overcoming Hypoxia-Induced Resistance to Anticancer Drugs in Chemotherapy.
Chieh-Cheng Huang (2016)
Light‐Triggered Clustered Vesicles with Self‐Supplied Oxygen and Tissue Penetrability for Photodynamic Therapy against Hypoxic Tumor
J. Li (2017)
Otolaryngol., Head Neck Surg
D. B. Headley (1991)
Tumor-Penetrating Nanoparticles for Enhanced Anticancer Activity of Combined Photodynamic and Hypoxia-Activated Therapy.
Yazhe Wang (2017)
Pharmacokinetics of Pegylated Liposomal Doxorubicin
A. Gabizon (2003)
High interstitial fluid pressure — an obstacle in cancer therapy
C. Heldin (2004)
Quercetin Remodels the Tumor Microenvironment To Improve the Permeation, Retention, and Antitumor Effects of Nanoparticles.
K. Hu (2017)
Hypoxia‐induced resistance to doxorubicin and methotrexate in human melanoma cell lines in vitro
K. Sanna (1994)
Nanocarriers as an emerging platform for cancer therapy.
D. Peer (2007)
Hypoxia — a key regulatory factor in tumour growth
A. Harris (2002)
Severe hypoxia induces complete antifolate resistance in carcinoma cells due to cell cycle arrest
S. Raz (2014)
Functionalized nanoscale micelles improve drug delivery for cancer therapy in vitro and in vivo.
Tuo Wei (2013)
Smart Superstructures with Ultrahigh pH-Sensitivity for Targeting Acidic Tumor Microenvironment: Instantaneous Size Switching and Improved Tumor Penetration.
Hong-Jun Li (2016)
Matrix stiffness modulates proliferation, chemotherapeutic response, and dormancy in hepatocellular carcinoma cells
J. Schrader (2011)
Effects of hyperbaric oxygen on growth and metastases of the C3HBA tumor in the mouse
J. McCredie (1966)
Hypoxia promotes fibrogenesis in vivo via HIF-1 stimulation of epithelial-to-mesenchymal transition.
D. Higgins (2007)
Hypoxia-inducible Factor-1α Is a Positive Factor in Solid Tumor Growth
H. Ryan (2000)
Angiotensin inhibition enhances drug delivery and potentiates chemotherapy by decompressing tumour blood vessels
Vikash P. Chauhan (2013)
Confluence-dependent resistance to doxorubicin in human MDA-MB-231 breast carcinoma cells requires hypoxia-inducible factor-1 activity.
Yu Fang (2007)
Polyoxometalate-Based Radiosensitization Platform for Treating Hypoxic Tumors by Attenuating Radioresistance and Enhancing Radiation Response.
Yuan Yong (2017)
Hypoxia in cancer: significance and impact on clinical outcome
P. Vaupel (2007)
60, 2497; b) A. I. Minchinton, I. F. Tannock
P A Netti (2000)
Epithelial derived CTGF promotes breast tumor progression via inducing EMT and collagen I fibers deposition
X. Zhu (2015)
The effect of hyperbaric oxygen on growth of human squamous cell carcinoma xenografts.
Don B. Headley (1991)
The role of hypoxia-inducible factors in tumorigenesis
E. Rankin (2008)
Dual-Stage Light Amplified Photodynamic Therapy against Hypoxic Tumor Based on an O2 Self-Sufficient Nanoplatform.
Li-Han Liu (2017)
Hyperbaric oxygenation for tumour sensitisation to radiotherapy: a systematic review of randomised controlled trials.
M. Bennett (2008)
Analysis of nanoparticle delivery to tumours
Stefan Wilhelm (2016)
The impact of O2 availability on human cancer
Jessica A. Bertout (2008)
Cancer Cell Membrane‐Biomimetic Oxygen Nanocarrier for Breaking Hypoxia‐Induced Chemoresistance
H. Tian (2017)
HIF-1 activation induces doxorubicin resistance in MCF7 3-D spheroids via P-glycoprotein expression: a potential model of the chemo-resistance of invasive micropapillary carcinoma of the breast
S. Doublier (2011)
Role of the microenvironment in hepatocellular carcinoma development and progression.
Sheng-di Wu (2012)
The mechanisms by which hyperbaric oxygen and carbogen improve tumour oxygenation.
D. Brizel (1995)
Hyperoxia increases the uptake of 5-fluorouracil in mammary tumors independently of changes in interstitial fluid pressure and tumor stroma
Ingrid Moen (2009)
Antiangiogenesis strategies revisited: from starving tumors to alleviating hypoxia.
Rakesh K. Jain (2014)
Exposure to hyperbaric oxygen induces cell cycle perturbation in prostate cancer cells
J. E. Kalns (1999)
Liposomal drug delivery systems: from concept to clinical applications.
T. Allen (2013)
Hypoxia-specific ultrasensitive detection of tumours and cancer cells in vivo.
Xianchuang Zheng (2015)
Hyperbaric Oxygen Therapy for Malignancy: A Review
J. Daruwalla (2006)
Effects of hypoxia on human cancer cell line chemosensitivity
Sara Strese (2013)
Preservation of tumour oxygen after hyperbaric oxygenation monitored by magnetic resonance imaging
Yoshimasa Kinoshita (2000)
Photodynamic Therapy for Treatment of Solid Tumors — Potential and Technical Challenges
Z. Huang (2008)
Hypoxia induces resistance to 5-fluorouracil in oral cancer cells via G(1) phase cell cycle arrest.
Sayaka Yoshiba (2009)
Role of extracellular matrix assembly in interstitial transport in solid tumors.
P. A. Netti (2000)
Hyperbaric oxygen and photodynamic therapy in the treatment of advanced carcinoma of the cardia and the esophagus
A. Maier (2000)
The tumor microenvironment in hepatocellular carcinoma: current status and therapeutic targets.
J. Yang (2011)
Investigating the optimal size of anticancer nanomedicine
L. Tang (2014)
Prolonged circulation time and enhanced accumulation in malignant exudates of doxorubicin encapsulated in polyethylene-glycol coated liposomes.
A. Gabizon (1994)
Reduced cardiotoxicity and comparable efficacy in a phase III trial of pegylated liposomal doxorubicin HCl (CAELYX/Doxil) versus conventional doxorubicin for first-line treatment of metastatic breast cancer.
M. O'Brien (2004)
Losartan inhibits collagen I synthesis and improves the distribution and efficacy of nanotherapeutics in tumors
B. Diop-Frimpong (2011)
Hypoxia-inducible factor-1-dependent regulation of the multidrug resistance (MDR1) gene.
K. Comerford (2002)
Drug penetration in solid tumours
A. Minchinton (2006)
TaOx decorated perfluorocarbon nanodroplets as oxygen reservoirs to overcome tumor hypoxia and enhance cancer radiotherapy.
G. Song (2017)
Multifunctional albumin-MnO₂ nanoparticles modulate solid tumor microenvironment by attenuating hypoxia, acidosis, vascular endothelial growth factor and enhance radiation response.
P. Prasad (2014)
Drug resistance and the solid tumor microenvironment.
O. Trédan (2007)
Cancer nanomedicine: progress, challenges and opportunities
J. Shi (2017)
Nanomedicine: a great first year and, with your help, a bright future ahead
C. Martin (2007)
Tumor-specific antibody-mediated targeted delivery of Doxil reduces the manifestation of auricular erythema side effect in mice.
T. Elbayoumi (2008)
Molecular mechanisms of cardioprotection by a novel grape seed proanthocyanidin extract.
D. Bagchi (2003)
Stimuli-responsive clustered nanoparticles for improved tumor penetration and therapeutic efficacy
Hong-Jun Li (2016)
322, 80; c) B. Diop-Frimpong
K L Hu (2007)
Increased nanoparticle penetration in collagenase-treated multicellular spheroids
Thomas T. Goodman (2007)
Use of 5-FU plus hyperbaric oxygen for treating malignant tumors: evaluation of antitumor effect and measurement of 5-FU in individual organs
N. Takiguchi (2001)
Hypoxia-inducible Factor 1 (HIF-1) Promotes Extracellular Matrix Remodeling under Hypoxic Conditions by Inducing P4HA1, P4HA2, and PLOD2 Expression in Fibroblasts*
Daniele M Gilkes (2013)
Delivering nanomedicine to solid tumors
R. Jain (2010)
Targeting hypoxia in cancer therapy
W. Wilson (2011)
Hyperbaric Oxygen and Radiotherapy
Ramona Mayer (2005)
Improving drug delivery to solid tumors: priming the tumor microenvironment.
Iftikhar Ali Khawar (2015)
Multistage nanoparticle delivery system for deep penetration into tumor tissue
Cliff R. Wong (2011)
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