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Genome-Wide Association Analysis Of Eating Disorder-Related Symptoms, Behaviors, And Personality Traits
V. Boraska, O. Davis, L. Cherkas, S. Helder, J. Harris, I. Krug, Thomas Pei-Chi Liao, J. Treasure, I. Ntalla, L. Karhunen, A. Keski-Rahkonen, Danai Christakopoulou, A. Raevuori, Soyoun Shin, G. Dedoussis, J. Kaprio, N. Soranzo, T. Spector, D. Collier, E. Zeggini
Published 2012 · Medicine
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Eating disorders (EDs) are common, complex psychiatric disorders thought to be caused by both genetic and environmental factors. They share many symptoms, behaviors, and personality traits, which may have overlapping heritability. The aim of the present study is to perform a genome‐wide association scan (GWAS) of six ED phenotypes comprising three symptom traits from the Eating Disorders Inventory 2 [Drive for Thinness (DT), Body Dissatisfaction (BD), and Bulimia], Weight Fluctuation symptom, Breakfast Skipping behavior and Childhood Obsessive‐Compulsive Personality Disorder trait (CHIRP). Investigated traits were derived from standardized self‐report questionnaires completed by the TwinsUK population‐based cohort. We tested 283,744 directly typed SNPs across six phenotypes of interest in the TwinsUK discovery dataset and followed‐up signals from various strata using a two‐stage replication strategy in two independent cohorts of European ancestry. We meta‐analyzed a total of 2,698 individuals for DT, 2,680 for BD, 2,789 (821 cases/1,968 controls) for Bulimia, 1,360 (633 cases/727 controls) for Childhood Obsessive‐Compulsive Personality Disorder trait, 2,773 (761 cases/2,012 controls) for Breakfast Skipping, and 2,967 (798 cases/2,169 controls) for Weight Fluctuation symptom. In this GWAS analysis of six ED‐related phenotypes, we detected association of eight genetic variants with P < 10−5. Genetic variants that showed suggestive evidence of association were previously associated with several psychiatric disorders and ED‐related phenotypes. Our study indicates that larger‐scale collaborative studies will be needed to achieve the necessary power to detect loci underlying ED‐related traits. © 2012 Wiley Periodicals, Inc.
This paper references
Common vs. rare allele hypotheses for complex diseases.
N. Schork (2009)
Breakfast skipping and health-compromising behaviors in adolescents and adults
A. Keski-Rahkonen (2003)
Significant linkage on chromosome 10p in families with bulimia nervosa.
C. Bulik (2003)
Identification of novel candidate loci for anorexia nervosa at 1q41 and 11q22 in Japanese by a genome-wide association analysis with microsatellite markers
K. Nakabayashi (2009)
AfinebalancebetweenCCNL 1 andTIMP 1 contributes to the development of breast cancer cells
The relation among perfectionism, obsessive-compulsive personality disorder and obsessive-compulsive disorder in individuals with eating disorders.
K. Halmi (2005)
Genetic epidemiology, endophenotypes, and eating disorder classification.
C. Bulik (2007)
Does a relationship exist between body weight, concerns about weight, and smoking among adolescents? An integration of the literature with an emphasis on gender.
B. Potter (2004)
Ectopic myelinating oligodendrocytes in the dorsal spinal cord as a consequence of altered semaphorin 6D signaling inhibit synapse formation
J. Leslie (2011)
The endophenotype concept in psychiatry: etymology and strategic intentions.
I. Gottesman (2003)
Schizophrenia and vitamin D related genes could have been subject to latitude-driven adaptation
R. Amato (2010)
A cross-cultural comparison of the Eating Disorder Inventory.
I. Podar (2009)
Rm Freathy (2010)
XichenZ.2011.AfinebalancebetweenCCNL1andTIMP1contributes to the development of breast cancer cells
L Peng (2011)
An approach based on a genome-wide association study reveals candidate loci for narcolepsy
M. Shimada (2010)
Temperament and character in eating disorders: Ten years of studies
S. Fassino (2004)
Comparability of the Eating Disorder Inventory-2 Between Women and Men
N. Spillane (2004)
A Powerful Approach to Sub-Phenotype Analysis in Population-Based Genetic Association Studies
A. Morris (2010)
Body dissatisfaction and drive for thinness in young adult twins.
A. Keski-Rahkonen (2005)
Genome-wide association analysis of gender differences in major depressive disorder in the Netherlands NESDA and NTR population-based samples.
Nagesh Aragam (2011)
The role of genetic variation in the causation of mental illness: an evolution-informed framework
R. Uher (2009)
The endophenotype concept in psychiatric genetics
J. Flint (2007)
The development of the childhood retrospective perfectionism questionnaire (CHIRP) in an eating disorder sample.
L. Southgate (2008)
Epistasis and its implications for personal genetics.
J. Moore (2009)
The Tobacco and Genetics Consortium Genome-wide metaanalyses identify multiple loci associated with smoking behavior
What is the associationbetweenobsessive - compulsive disorder and eating disorders ?
ShankmanSA AltmanSE (2009)
Depressive symptomatology, perceptions of attractiveness, and body image in children.
M. McCabe (1993)
Signs of subclinical eating disorders in teenage girls.
K. Melve (1994)
The Birth Weight Lowering C-Allele of rs900400 Near LEKR1 and CCNL1 Associates with Elevated Insulin Release following an Oral Glucose Challenge
E. Andersson (2011)
A genome-wide association study on common SNPs and rare CNVs in anorexia nervosa
K. Wang (2011)
Similarities and differences between women and men on eating disorder risk factors and symptom measures.
Laura M Boerner (2004)
Linkage analysis of anorexia and bulimia nervosa cohorts using selected behavioral phenotypes as quantitative traits or covariates
S. Bacanu (2005)
Molecular mechanisms underlying anorexia nervosa: Focus on human gene association studies and systems controlling food intake
M. Rask-Andersen (2010)
Risk factors for anorexia nervosa: three integrated case-control comparisons.
C. Fairburn (1999)
Anorexia nervosa and anorexic-like syndromes in a population-based female twin sample.
E. Walters (1995)
A controlled family study of anorexia nervosa and bulimia nervosa: psychiatric disorders in first-degree relatives and effects of proband comorbidity.
L. Lilenfeld (1998)
Restraint, weight loss, and variability of body weight.
T. Heatherton (1991)
Comparison of the eating disorder inventory (EDI) in the Netherlands, Austria and Italy.
K. Waldherr (2008)
What is the association between obsessive-compulsive disorder and eating disorders?
Sarah E. Altman (2009)
Variants in ADCY 5 and near CCNL 1 are associatedwith fetal growth and birth weight
RM Freathy (2010)
Body size perception and body satisfaction in restrained and unrestrained eaters.
S. Lautenbacher (1992)
is supported by Academy of Finland. A.R. is supported by ENGAGE—European Network for Genetic and Genomic Epidemiology
Association study of 182 candidate genes in anorexia nervosa
A. Pinheiro (2010)
Controlled family study of anorexia nervosa and bulimia nervosa: evidence of shared liability and transmission of partial syndromes.
M. Strober (2000)
Genetic and Environmental Factors in Breakfast Eating Patterns
A. Keski-Rahkonen (2004)
The genetics of eating disorders.
W. Berrettini (2004)
The relation between risk factors for binge eating and bulimia nervosa: a population-based female twin study.
T. Wade (2000)
Evidence for a susceptibility gene for anorexia nervosa on chromosome 1.
D. Grice (2002)
A fine balance between CCNL1 and TIMP1 contributes to the development of breast cancer cells.
Li Peng (2011)
Genome-wide meta-analyses identify multiple loci associated with smoking behavior
H. Furberg (2010)
What is the association between obsessivecompulsive disorder and eating disorders
Sarah E. Altman (2009)
Childhood obsessive-compulsive personality traits in adult women with eating disorders: defining a broader eating disorder phenotype.
M. Anderluh (2003)
Variants in ADCY5 and
NJ Schork (2009)
Personality features of women with good outcome from restricting anorexia nervosa.
R. Casper (1990)
Identification, Characterization, and Functional Study of the Two Novel Human Members of the Semaphorin Gene Family* 210
X. Qu (2002)
Evidence-based psychiatric genetics, AKA the false dichotomy between common and rare variant hypotheses
P. Visscher (2012)
Linkage analysis of anorexia nervosa incorporating behavioral covariates.
B. Devlin (2002)
Variants in ADCY5 and near CCNL1 are associated with fetal growth and birth weight
R. Freathy (2010)
This paper is referenced by
Advances in the neurobiology of eating disorders
A. V. van Elburg (2013)
Contribution of Genetic Epidemiology to Our Understanding of Psychiatric Disorders
K. Merikangas (2016)
Behavioral and neurodevelopmental precursors to binge-type eating disorders: support for the role of negative valence systems.
A. Vannucci (2015)
Brain-directed interventions for eating disorders : the potential of repetitive transcranial magnetic stimulation in the treatment of anorexia nervosa
Jessica Kate McClelland (2015)
Overview of genetic research in anorexia nervosa: The past, the present and the future.
M. Brandys (2015)
Genetic variants in AKR1B10 associate with human eating behavior
K. Rohde (2015)
Genetic variants in dopamine pathways affect personality dimensions displayed by patients with eating disorders
L. M. Gonzalez (2019)
Association between the oxytocin receptor gene polymorphism (rs53576) and bulimia nervosa.
Y. Kim (2015)
A genome-wide association study of anorexia nervosa
V. Boraska (2014)
Energy and Nutrient Timing for Weight Control: Does Timing of Ingestion Matter?
M. McCrory (2016)
An Evolutionary Genetic Perspective of Eating Disorders
A. J. Mayhew (2017)
Statistical correction of the Winner’s Curse explains replication variability in quantitative trait genome-wide association studies
Cameron Palmer (2017)
On the Neurobiology of Physical Activity in Mice and Human : In search of Eating Disorders Determinants
Elzbieta Kostrzewa (2014)
Attachment, affect and social processing in eating disorders
Freya Corfield (2014)
The genetics of eating disorders.
S. Trace (2013)
The addictive appetite model of Bulimia Nervosa and Binge Eating Disorder : a synthesis of basic science and clinical evidence for a new maintenance model of recurrent binge eating
Monica Leslie (2019)
Genetics and Epigenetics of Eating Disorders.
S. Zerwas (2011)
Research Review: What we have learned about the causes of eating disorders - a synthesis of sociocultural, psychological, and biological research.
K. Culbert (2015)
Clinical phenotype and genetic risk factors for bipolar disorder with binge eating: an update
A. Cuellar-Barboza (2019)
Modeling anorexia nervosa: transcriptional insights from human iPSC-derived neurons
P. Negraes (2017)
Genomic and Epigenomic Insights into Nutrition and Brain Disorders
M. Dauncey (2013)
Genome‐wide association study of body mass index in subjects with alcohol dependence
R. Polimanti (2017)
Timing of Food Intake: Identifying Contributing Factors to Design Effective Interventions.
H. Dashti (2019)
Treatment of anorexia nervosa: A multimethod investigation translating experimental neuroscience into clinical practice
U. Schmidt (2017)
TITLE: Gene-asbestos interaction in malignant pleural mesothelioma susceptibility. Running: Gene-asbestos interaction in pleural mesothelioma
Sara Tunesi ()
Genome-wide association study of breakfast skipping links clock regulation with food timing.
H. Dashti (2019)
Small molecule ghrelin receptor inverse agonists and antagonists.
K. Cameron (2014)
Molecular Genetics of Eating Disorders
Melissa A Munn-Chernoff (2016)
Molecular bases of anorexia nervosa, bulimia nervosa and binge eating disorder: shedding light on the darkness
G. Cuesto (2017)
OPRD1 Genetic Variation and Human Disease.
R. Crist (2018)
Genetics and Epigenetics of Eating Disorders.
Zeynep Yilmaz (2015)
Effects of single genetic variants and polygenic obesity risk scores on disordered eating in adolescents – The HUNT study
F. S. Sardahaee (2017)See more