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Real Time Quaking‐induced Conversion Analysis Of Cerebrospinal Fluid In Sporadic Creutzfeldt–Jakob Disease

Lynne McGuire, A. Peden, Christina D Orrú, Jason M. Wilham, Nigel E. J. Appleford, G. Mallinson, Mary Andrews, M. Head, B. Caughey, R. Will, R. Knight, A. Green
Published 2012 · Medicine

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Current cerebrospinal fluid (CSF) tests for sporadic Creutzfeldt–Jakob disease (sCJD) are based on the detection of surrogate markers of neuronal damage such as CSF 14‐3‐3, which are not specific for sCJD. A number of prion protein conversion assays have been developed, including real time quaking‐induced conversion (RT‐QuIC). The objective of this study is to investigate whether CSF RT‐QuIC analysis could be used as a diagnostic test in sCJD.
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