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Direct Genetic Analysis Of Ten Cancer Cells: Tuning Sensor Structure And Molecular Probe Design For Efficient MRNA Capture.

E. Vasilyeva, B. Lam, Z. Fang, M. Minden, E. Sargent, S. Kelley
Published 2011 · Medicine

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In order to facilitate the use of biomolecular markers in clinical medicine, devices are urgently needed that are highly sensitive, specific, cost effective, and automated. [1–3] Great strides have been made in this area with elegant sensing systems employing nanomaterials, microfluidics, and increasingly sophisticated device design. [4–7] The direct analysis of most types of clinical samples requires femtomolar detection limits to sense scarce analytes with an acceptably low level of false negatives. Very high levels of specificity are required to ensure low levels of false positives. From a practical perspective, equally important is a streamlined approach to sample workup, since the need for extensive sample process
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