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Nickel-catalyzed Kumada Reaction Of Tosylalkanes With Grignard Reagents To Produce Alkenes And Modified Arylketones.

Ji-cheng Wu, Lu-Bing Gong, Y. Xia, Ren-Jie Song, Ye-Xiang Xie, Jin-Heng Li
Published 2012 · Chemistry, Medicine

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Open a new door: The first example of alkene synthesis from alkyl electrophiles with Grignard reagents using the Kumada cross-coupling reaction strategy is reported. This method opens a new door for the Kumada cross-coupling reaction, allowing alkenes to be prepared from the reaction of tosylalkanes with Grignard reagents.
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