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Odorless Isocyanide Chemistry: An Integrated Microfluidic System For A Multistep Reaction Sequence.

S. Sharma, Ram Awatar Maurya, Kyoung-Ik Min, Guan-Young Jeong, D. Kim
Published 2013 · Chemistry, Medicine

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Can't smell this: An integrated continuous-flow microfluidic setup enables in situ generation, extraction, separation, and reaction of foul-smelling isocyanides with little exposure to the surroundings. Isocyanides were generated by dehydration of the corresponding N-substituted formamides, and several representative isocyanide-based organic reactions were successfully performed. DIPEA = N,N-diisopropylethylamine.
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