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Localized Template-driven Functionalization Of Nanoparticles By Dynamic Combinatorial Chemistry.

P. Nowak, Vittorio Saggiomo, Fatemeh Salehian, Mathieu Colomb-Delsuc, Yang Han, Sijbren Otto
Published 2015 · Medicine, Chemistry

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We have developed a method for the localized functionalization of gold nanoparticles using imine-based dynamic combinatorial chemistry. By using DNA templates, amines were grafted on the aldehyde-functionalized nanoparticles only if and where the nanoparticles interacted with the template molecules. Functionalization of the nanoparticles was controlled solely by the DNA template; only amines capable of interacting with DNA were bound to the surface. Interestingly, even though our libraries contained only a handful of simple amines, the DNA sequence influenced their attachment to the surface. Our method opens up new opportunities for the synthesis of multivalent, nanoparticle-based receptors for biomacromolecules.
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