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Robust Chemical Preservation Of Digital Information On DNA In Silica With Error-correcting Codes.

Robert N. Grass, Reinhard Heckel, Michela Puddu, Daniela Paunescu, Wendelin J Stark
Published 2015 · Chemistry, Medicine
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Information, such as text printed on paper or images projected onto microfilm, can survive for over 500 years. However, the storage of digital information for time frames exceeding 50 years is challenging. Here we show that digital information can be stored on DNA and recovered without errors for considerably longer time frames. To allow for the perfect recovery of the information, we encapsulate the DNA in an inorganic matrix, and employ error-correcting codes to correct storage-related errors. Specifically, we translated 83 kB of information to 4991 DNA segments, each 158 nucleotides long, which were encapsulated in silica. Accelerated aging experiments were performed to measure DNA decay kinetics, which show that data can be archived on DNA for millennia under a wide range of conditions. The original information could be recovered error free, even after treating the DNA in silica at 70 °C for one week. This is thermally equivalent to storing information on DNA in central Europe for 2000 years.



This paper is referenced by
10.1145/3383972.3383999
Next Generation Information Storage Technology: DNA Data Storage
Shuguang Liu (2020)
I T ] 2 3 M ay 2 01 9 Coded Trace Reconstruction
Mahdi Cheraghchi (2019)
10.1109/ITW44776.2019.8989171
Reconstruction and Error-Correction Codes for Polymer-Based Data Storage
Srilakshmi Pattabiraman (2019)
10.1101/770032
Improved read/write cost tradeoff in DNA-based data storage using LDPC codes
Shubham Chandak (2019)
10.1101/2019.12.20.871939
Overcoming High Nanopore Basecaller Error Rates for DNA Storage Via Basecaller-Decoder Integration and Convolutional Codes
Shubham Chandak (2019)
10.1080/10357718.2019.1584154
Mapping the potential impact of synthetic biology on Australian foreign policy
Thom Dixon (2019)
10.1038/s41598-019-45832-6
A Characterization of the DNA Data Storage Channel
Reinhard Heckel (2019)
10.4191/kcers.2019.56.5.01
Info-Convergence Ceramic Nanosystems
Wenji Jin (2019)
Coding for Polymer-Based Data Storage
Srilakshmi Pattabiraman (2020)
Proof That Theoretical Computer Science Isn ' t Dead
Toby Tobkin (2015)
Survey of Information Encoding Techniques for DNA
Thomas Heinis (2019)
The Collapse of Metaphor in Biohacking
Oliver Alexander Tafdrup (2018)
The Error Probability of Maximum-Likelihood Decoding over Two Deletion Channels
Omer Sabary (2020)
10.1038/s41570-018-0051-5
Encoding information into polymers
Martin G. T. A. Rutten (2018)
10.1109/ISIT.2016.7541780
On the number of DNA sequence profiles for practical values of read lengths
Zuling Chang (2016)
10.1109/TETC.2019.2932685
DNA Molecular Storage System: Transferring Digitally Encoded Information through Bacterial Nanonetworks
Federico Tavella (2018)
10.1109/ISIT.2019.8849687
Sequence-Subset Distance and Coding for Error Control for DNA-based Data Storage
Wentu Song (2019)
10.1002/anie.202001162
Genomic encryption of digital data stored in synthetic DNA.
Robert N. Grass (2020)
10.1016/J.SNB.2017.05.046
An expedient multiple information processing pattern-generating chromophore
Bhimsen Rout (2017)
10.1109/INIS.2016.039
Post CMOS Computing Beyond Si: DNA Computer as Future Alternative
Mayukh Sarkar (2016)
10.1038/s41598-017-16535-7
On-Chip Fluorescence Switching System for Constructing a Rewritable Random Access Data Storage Device
Hoang Hiep Nguyen (2017)
10.1007/s11042-018-6817-4
BIIGA: Bioinformatics inspired image grouping approach
Abhimanyu Singh Garhwal (2018)
10.1038/ncomms8237
Design and synthesis of digitally encoded polymers that can be decoded and erased
Raj Kumar Roy (2015)
10.15439/2019F313
Cryptographic keys management system based on DNA strands
Marek Miskiewicz (2019)
10.1109/ic-ETITE47903.2020.62
A Survey Paper on DNA-Based Data Storage
Shubham Taluja (2020)
Storing movies in DNA
Meinolf Blawat (2016)
10.1109/INMIC48123.2019.9022799
DNA Compression using an innovative Index based Coding Algorithm
Shan e Zahra (2019)
10.1101/565150
Experimental Assessment of PCR Specificity and Copy Number for Reliable Data Retrieval in DNA Storage
Lee Organick (2019)
Achievable Rates of Concatenated Codes in DNA Storage under Substitution Errors
Andreas Lenz (2020)
10.1002/ANGE.201707976
Vom Design der Moleküle des Lebens zum Design von Leben: Zukünftige Anwendungen von DNA‐Technologien
Richie E. Kohman (2018)
10.3791/59936
High-Density DNA and RNA microarrays - Photolithographic Synthesis, Hybridization and Preparation of Large Nucleic Acid Libraries.
Jory Lietard (2019)
10.1016/j.jbiotec.2016.03.044
Aims and methods of biosteganography.
Tyler D. P. Brunet (2016)
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