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Renal-clearable Macromolecular Reporter For Near-infrared Fluorescence Imaging Of Bladder Cancer.

Kanyi Pu, Jiaguo Huang, Yuyan Jiang, Jingchao Li, Shasha He, Jingsheng Huang
Published 2019 · Chemistry, Medicine
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Bladder cancer (BC) is a prevalent disease with high morbidity and mortality; however, in vivo optical imaging of BC remains challenging because of the lack of cancer-specific optical agents with high renal clearance. Herein, a macromolecular reporter (CyP1) is synthesized for real-time near-infrared fluorescence (NIRF) imaging and urinalysis of BC in living mice. Having a high renal clearable (~94% injection dosage at 24 h post-injection) and a cancer biomarker (APN: aminopeptidase N) specificity, CyP1 can efficiently go to the bladder and specially turn on its NIRF signal to report the detection of BC in living mice. Moreover, CyP1 can be used for optical urinalysis, permitting ex vivo tracking of tumor progression for therapeutic evaluation and easy translation of CyP2 as in vitro diagnostic assay. Thus, this study not only provides new opportunities for non-invasive diagnosis of BC, but also reveals useful guidelines to development of molecular reporters for detection of bladder diseases.
This paper references
10.1038/S41551-016-0010
Near-infrared fluorophores for biomedical imaging
Guosong Hong (2017)
10.1038/s41585-018-0092-z
Intravesical device-assisted therapies for non-muscle-invasive bladder cancer
Wei Shen Tan (2018)
10.1039/c8sc01865k
Near-infrared fluorescence probes to detect reactive oxygen species for keloid diagnosis† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c8sc01865k
Penghui Cheng (2018)
10.1038/nrurol.2013.24
Proteomic studies of urinary biomarkers for prostate, bladder and kidney cancers
Steven L. Wood (2013)
10.1038/s41563-019-0378-4
Molecular optical imaging probes for early diagnosis of drug-induced acute kidney injury
Jiaguo Huang (2019)
10.1002/adma.201902672
An Organic Afterglow Protheranostic Nanoassembly.
Shasha He (2019)
Urine protein biomarkers for the detection, surveillance, and treatment response prediction of bladder cancer.
Ashish Chakraborty (2019)
10.1038/s41467-019-10119-x
A generic approach towards afterglow luminescent nanoparticles for ultrasensitive in vivo imaging
Yuyan Jiang (2019)
10.1038/nrclinonc.2016.188
Systemic, perioperative management of muscle-invasive bladder cancer and future horizons
Samuel A. Funt (2017)
Comparison of the 5637 human urothelial cancer cell line with a second-generation 5637 cell line for cancer therapy
Weiguo Jian (2008)
10.1186/1741-7015-11-104
Advances in bladder cancer imaging
Shaista Hafeez (2013)
10.1038/nbt.3987
Molecular afterglow imaging with bright, biodegradable polymer nanoparticles
Qingqing Miao (2017)
10.1002/ANGE.201905643
NIR‐II Fluorescent Self‐Assembled Peptide Nanochain for Ultrasensitive Detection of Peritoneal Metastasis
Qiuxiang Wen (2019)
10.3892/mmr.2018.8402
Ubenimex, an APN inhibitor, could serve as an anti-tumor drug in RT112 and 5637 cells by operating in an Akt-associated manner
Xiaoqing Wang (2018)
10.1002/anie.201812878
Precise In Vivo Inflammation Imaging Using In Situ Responsive Cross-linking of Glutathione-Modified Ultra-Small NIR-II Lanthanide Nanoparticles.
Mengyao Zhao (2019)
10.1002/anie.201909560
Renal-clearable Molecular Semiconductor for Second Near-Infrared Fluorescence Imaging of Kidney Dysfunction.
Kanyi Pu (2019)
10.1002/adma.201801331
Self-Assembled Semiconducting Polymer Nanoparticles for Ultrasensitive Near-Infrared Afterglow Imaging of Metastatic Tumors.
Chen Xie (2018)
10.1021/acs.analchem.9b01220
Near-Infrared Fluorescent Furin Probe for Revealing the Role of Furin in Cellular Carcinogenesis and Specific Cancer Imaging.
Longmin Zhu (2019)
10.2174/092986707780059571
The structure and main functions of aminopeptidase N.
Yepeng Luan (2007)
10.1039/c8cs00001h
Development of organic semiconducting materials for deep-tissue optical imaging, phototherapy and photoactivation.
Jingchao Li (2019)
10.1016/j.biomaterials.2015.10.049
A porphyrin-PEG polymer with rapid renal clearance.
Haoyuan Huang (2016)
10.1002/adma.201601101
Renal Clearable Organic Nanocarriers for Bioimaging and Drug Delivery.
Homan Kang (2016)
10.1002/prca.201300118
Aminopeptidase activities as prospective urinary biomarkers for bladder cancer.
Jennifer M. Taylor (2014)
10.1002/cncr.28905
Novel endoscopic diagnosis for bladder cancer.
Seth P. Lerner (2015)
10.1126/scitranslmed.3009457
Endoscopic molecular imaging of human bladder cancer using a CD47 antibody
Ying Pan (2014)
10.1038/nrurol.2014.130
Landmarks in non-muscle-invasive bladder cancer
Laura S. Mertens (2014)
10.1016/j.urology.2019.01.011
The Prevalence of Bladder Cancer During Cystoscopy for Asymptomatic Microscopic Hematuria.
Ashley N. Gonzalez (2019)
10.1038/nnano.2017.170
Glomerular Barrier Behaves As an Atomically Precise Bandpass Filter in a Sub-nanometer Regime
Bujie Du (2017)
10.1002/anie.201511148
Noninvasive Staging of Kidney Dysfunction Enabled by Renal-Clearable Luminescent Gold Nanoparticles.
Mengxiao Yu (2016)
10.1038/nmat2986
Porphysome nanovesicles generated by porphyrin bilayers for use as multimodal biophotonic contrast agents.
Jonathan F. Lovell (2011)
10.1007/s11547-010-0567-3
64-Slice CT urography: 30 months of clinical experience
Paola Martingano (2010)
10.1021/cr100154p
Fluoro- and chromogenic chemodosimeters for heavy metal ion detection in solution and biospecimens.
Tuan Quang Duong (2010)
10.1021/jacs.9b02580
Unimolecular Chemo-fluoro-luminescent Reporter for Crosstalk-Free Duplex Imaging of Hepatotoxicity.
Penghui Cheng (2019)
10.1038/nrurol.2015.231
Targeted therapies in bladder cancer: an overview of in vivo research
Kim E. van Kessel (2015)
10.1038/nbt1340
Renal clearance of quantum dots
Hak Soo Choi (2007)
10.1002/anie.201805162
Tandem Payne/Dakin Reaction: A New Strategy for Hydrogen Peroxide Detection and Molecular Imaging.
Sen Ye (2018)
10.1039/c9cc04736k
Engineering dithiobenzoic acid lactone-decorated Si-rhodamine as a highly selective near-infrared HOCl fluorescent probe for imaging drug-induced acute nephrotoxicity.
Jinping Wang (2019)
10.1039/c7cc05142e
Design, synthesis and application of a near-infrared fluorescent probe for in vivo imaging of aminopeptidase N.
Xinyuan He (2017)
10.1038/s41585-019-0199-x
Organ preservation in bladder cancer: an opportunity for truly personalized treatment
Yee Pei Song (2019)
10.1016/j.cancergencyto.2010.01.007
Clinical usefulness of fluorescence in situ hybridization for diagnosis and surveillance of bladder cancer.
Min-Jung Song (2010)
10.1021/nl803405h
Fluorescent silica nanoparticles with efficient urinary excretion for nanomedicine.
Andrew A. Burns (2009)
10.1158/0008-5472.CAN-12-1668
De novo design of a tumor-penetrating peptide.
Luca Alberici (2013)
10.1007/BF03262330
The health economics of bladder cancer
Marc F Botteman (2012)
10.1002/jmri.26294
Update on multiparametric MRI of urinary bladder cancer
Christian B van der Pol (2018)
10.1117/1.2978059
High-resolution imaging diagnosis and staging of bladder cancer: comparison between optical coherence tomography and high-frequency ultrasound.
Zhijia Yuan (2008)
10.1002/anie.201803321
Macrotheranostic Probe with Disease-Activated Near-Infrared Fluorescence, Photoacoustic, and Photothermal Signals for Imaging-Guided Therapy.
Xu Zhen (2018)
10.1200/JCO.2010.28.7052
Clinical value of fluorine-18 2-fluoro-2-deoxy-D-glucose positron emission tomography/computed tomography in bladder cancer.
Andrea B. Apolo (2010)
10.1038/s41585-018-0105-y
T1 bladder cancer: current considerations for diagnosis and management
Brian Jordan (2018)
10.1002/anie.201710727
Near-Infrared Fluorescent Molecular Probe for Sensitive Imaging of Keloid.
Qingqing Miao (2018)
10.1111/j.1349-7006.2010.01826.x
Aminopeptidase N (CD13) as a target for cancer chemotherapy
Malin Wickström (2011)
10.1073/pnas.0913667107
Paradoxical glomerular filtration of carbon nanotubes
Alessandro Ruggiero (2010)
10.1021/acs.analchem.7b00021
Ultrasensitive Detection of Aminopeptidase N Activity in Urine and Cells with a Ratiometric Fluorescence Probe.
Xinyuan He (2017)



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