Renal-clearable Macromolecular Reporter For Near-infrared Fluorescence Imaging Of Bladder Cancer.
Kanyi Pu, Jiaguo Huang, Yuyan Jiang, Jingchao Li, Shasha He, Jingsheng Huang
Published 2019 · Chemistry, Medicine
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Bladder cancer (BC) is a prevalent disease with high morbidity and mortality; however, in vivo optical imaging of BC remains challenging because of the lack of cancer-specific optical agents with high renal clearance. Herein, a macromolecular reporter (CyP1) is synthesized for real-time near-infrared fluorescence (NIRF) imaging and urinalysis of BC in living mice. Having a high renal clearable (~94% injection dosage at 24 h post-injection) and a cancer biomarker (APN: aminopeptidase N) specificity, CyP1 can efficiently go to the bladder and specially turn on its NIRF signal to report the detection of BC in living mice. Moreover, CyP1 can be used for optical urinalysis, permitting ex vivo tracking of tumor progression for therapeutic evaluation and easy translation of CyP2 as in vitro diagnostic assay. Thus, this study not only provides new opportunities for non-invasive diagnosis of BC, but also reveals useful guidelines to development of molecular reporters for detection of bladder diseases.
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