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Electrochemical Difunctionalization Of Alkenes Via Four-component Reactions Cascade Mumm Rearrangement: Rapid Access To Functionalized Imides.

Peipei Sun, X. Zhang, Ting Cui, Xin Zhao, P. Liu
Published 2019 · Chemistry, Medicine

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An electrochemical four-component reaction cascade Mumm rearrangement was developed, representing a rare example of in situ generation of O-acyl isoamides for 1,3-(O®N) acyl transfer. Inexpensive, commercially available arylethylenes, aryl or heterocyclic acids, acetonitrile, and alcohols were used as substrates. A wide range of aryl acids and alcohols were found to be tolerated and provided imides in satisfactory yields. Subsequent hydrolysis of imides could be utilized to synthesize valuable amides and β-amino alcohol derivatives.
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