Online citations, reference lists, and bibliographies.

Synthesis And Antioxidant Capacities Of Some New Benzimidazole Derivatives

G. Ayhan-Kilcigil, C. Kuş, Elçin D. Özdamar, B. Can-Eke, M. Işcan
Published 2007 · Chemistry, Medicine

Cite This
Download PDF
Analyze on Scholarcy
Share
In this study, we prepared some new oxadiazolyl benzimidazole derivatives and investigated their antioxidant properties by determination of microsomal NADPH‐dependent inhibition of lipid peroxidation levels (LP assay) and microsomal ethoxyresorufin O‐deethylase activity (EROD assay). Some of these compounds 20, 23 had slightly inhibitory effects (28%) on the lipid peroxidation levels at 10–3 M concentration lower than standard BHT (65%). 5‐[2‐(Phenyl)‐benzimidazol‐1‐yl‐methyl]‐2‐mercapto‐[1,3,4]‐oxadiazole 16 was found to be more active than caffeine on the ethoxyresorufin O‐deethylase activity with an IC50 value of 2.0 6 10–4 M.
This paper references
10.1002/jhet.5570020424
A new synthesis of benzimidazoles and aza‐analogs
H. F. Ridley (1965)
Synthesis of 1,2-disubstituted benzimidazole-5(6)-carboxamides and evaluation of their antimicrobial activity.
H. Göker (1996)
10.1080/14756360500287086
Synthesis, antioxidant and radical scavenging activities of novel benzimidazoles
G. Ayhan-Kilcigil (2005)
Synthesis and Characterization of New Triheterocyclic Compounds Consisting of 1,2,4-Triazol-3-one, 1,3,4-Thiadiazole and 1,3,4-Oxadiazole Rings
N. Demirbaş (2005)
10.1042/bj0990667
Mechanisms of lipid peroxide formation in animal tissues.
E. D. Wills (1966)
10.1080/1475636042000202017
Synthesis and Antioxidant Properties of Novel Benzimidazole Derivatives
G. Ayhan-Kilcigil (2004)
10.1039/P19730000499
N-alkylation of indole and pyrroles in dimethyl sulphoxide
H. Heaney (1973)
10.1007/BF02980099
Synthesis and antioxidant properties of some novel benzimidazole derivatives on lipid peroxidation in the rat liver
C. Kuş (2004)
10.1111/j.1471-4159.1971.tb12020.x
Lipid peroxide formation in rat brain.
S. Bishayee (1971)
10.1080/14756360500131706
Synthesis and antioxidant properties of novel benzimidazoles containing substituted indole or 1,1,4,4-tetramethyl-1,2,3,4-tetrahydro-naphthalene fragments
Zeynep Ateş-Alagöz (2005)
10.1042/bj1130333
Lipid peroxide formation in microsomes. Relationship of hydroxylation to lipid peroxide formation.
E. D. Wills (1969)
10.1016/0006-2952(85)90355-7
Ethoxy-, pentoxy- and benzyloxyphenoxazones and homologues: a series of substrates to distinguish between different induced cytochromes P-450.
M. D. Burke (1985)



This paper is referenced by
10.1016/j.saa.2012.01.069
Structural and spectroscopic characterization of 2-mesityl-1H-benzo[d]imidazol-3-ium chloride: a combined experimental and theoretical analysis.
N. Merve Özdemir (2012)
Evaluation of Antioxidant Activity of Some Imines Containing 1H-Benzimidazoles 1H-Benzimidazoller İçeren Bazı İminlerin Antioksidan
Rahman Başaran (2020)
X-Rays, Spectroscopic and Molecular Docking Studies on Single Crystal Compounds Containing Schiff Base
Seher Meral (2019)
SYNTHESIS AND ANTI-INFLAMATORY ACTIVITY OF 2-((1H-BENZIMIDAZOLE-2YL METHYL) SULFONYL) -N- (PHENYL METHYLIDINE) ACETOHYDRAZIDE DERIVATIVES
Manjula Samudrala (2011)
10.3184/146867813X13738207456613
1H NMR Kinetic Investigation of the Equilibrium between the Z- and E-Isomers in a Stable Phosphorus Ylide Involving 2-Mercaptobenzimidazole
S. Mostafa Habibi Khorassani (2013)
10.1111/j.1747-0285.2012.01347.x
Synthesis and Evaluation of Antioxidant Properties of Novel 2‐[2‐(4‐chlorophenyl) benzimidazole‐1‐yl]‐N‐(2‐arylmethylene amino) acetamides and 2‐[2‐(4‐chlorophenyl) benzimidazole‐1‐yl]‐N‐(4‐oxo‐2‐aryl‐thiazolidine‐3‐yl) acetamides‐I
G. Ayhan-Kilcigil (2012)
10.1016/J.MOLSTRUC.2012.07.014
Structure, spectroscopy, and theory calculations on 1,3-bis((5,6-dimethyl-1H-benzo[d]imidazol-1-yl)methyl)benzene
G. Li (2013)
SYNTHESIS AND ANTIMICROBIAL ACTIVITIES OF NOVEL BENZIMIDAZOLE DERIVATIVES
Monika (2018)
10.1107/S2056989019015779
Crystal structure, Hirshfeld surface analysis and interaction energy and DFT studies of 1-methyl-3-(prop-2-yn-1-yl)-2,3-dihydro-1H-1,3-benzodiazol-2-one
Asmaa Aly Saber (2019)
10.1080/00268970903476688
Experimental and ab initio computational studies on 4-(1H-benzo[d]imidazol-2-yl)-N,N-dimethylaniline
N. Merve Özdemir (2010)
10.1107/S2053229618013475
Investigation of the molecular structure of 4-(3-methyl-3-phenylcyclobutyl)-2-[2-(3-methylbenzylidene)hydrazinyl]thiazole in the gas and solid phases.
Tuncay Karakurt (2018)
10.1111/cbdd.12462
Comprehensive Review in Current Developments of Benzimidazole‐Based Medicinal Chemistry
Rangappa S Keri (2015)
10.1016/J.JKSUS.2010.08.009
Synthesis, spectral and biological evaluation of some new heterocyclic derivatives incorporating dihydroanthracene moiety
Jumat Salimon (2011)
10.1016/j.ejmech.2019.04.012
Design, synthesis and docking studies of benzimidazole derivatives as potential EGFR inhibitors.
Ismail Çelik (2019)
10.1107/S2056989018016298
Crystal structure and Hirshfeld surface analysis of 1-benzyl-3-(prop-2-yn-1-yl)-2,3-dihydro-1H-1,3-benzodiazol-2-one
Asmaa Aly Saber (2018)
10.1002/ardp.201300324
Identification of a Novel Series of N‐Phenyl‐5‐[(2‐phenylbenzimidazol‐1‐yl)methyl]‐1,3,4‐oxadiazol‐2‐amines as Potent Antioxidants and Radical Scavengers
G. Ayhan-Kilcigı̇l (2014)
10.2478/s11696-011-0048-8
Synthesis and in vitro antimicrobial activity of new 3-(2-morpholinoquinolin-3-yl) substituted acrylonitrile and propanenitrile derivatives
Jigar A. Makawana (2011)
10.2174/1570180815666180827124956
Synthesis, Antioxidant and Antiurease Activities of Some New 5,6- dichloro-2-(4-fluorobenzyl)-1H-benzimidazole Derivatives Containing Furan, Oxadiazole, Triazole and Thiadiazole Moieties
Hakan Bektaş (2019)
10.1007/978-94-007-1485-4_10
Benzimidazoles, Benzothiazoles and Benzoxazoles
Abdul Rauf (2012)
10.1016/j.molstruc.2019.127174
Syntheses of N-substituted benzimidazolone derivatives: DFT calculations, Hirshfeld surface analysis, molecular docking studies and antibacterial activities
Asmaa Saber (2020)
10.1134/S1063774515070111
Crystal structures and intermolecular interactions of two novel antioxidant triazolyl-benzimidazole compounds
Arzu Karayel (2015)
10.1107/S2056989018015219
Crystal structure and Hirshfeld surface analysis of 1-{[2-oxo-3-(prop-1-en-2-yl)-2,3-dihydro-1H-1,3-benzodiazol-1-yl]methyl}-3-(prop-1-en-2-yl)-2,3-dihydro-1H-1,3-benzodiazol-2-one
Asmaa Aly Saber (2018)
10.1002/QUA.22697
Quantum‐chemical, IR, NMR, and X‐ray diffraction studies on 2‐(4‐chlorophenyl)‐1‐methyl‐ 1H‐benzo[d]imidazole
N. Merve Özdemir (2011)
10.1002/JHET.1886
Synthesis of Some New Benzimidazole–Thiazole Derivatives as Anticancer Agents
Z. M. Nofal (2014)
10.1016/j.bioorg.2019.103396
Synthesis and evaluation of antioxidant and antiproliferative activity of 2-arylbenzimidazoles.
A. Baldisserotto (2019)
10.3390/ijms131216472
1-Benzyl-2-Phenylbenzimidazole (BPB), a Benzimidazole Derivative, Induces Cell Apoptosis in Human Chondrosarcoma through Intrinsic and Extrinsic Pathways
J. Liu (2012)
10.17776/csj.349326
Synthesis, Characterization and In Vitro Antioxidant Activities of New Benzimidazole Ruthenium- (II) Complexes
Serap Şahin Bölükbaşı (2017)
10.1007/S12039-009-0114-8
Synthesis and biological activity of some heterocyclic compounds containing benzimidazole and beta-lactam moiety
K. Ansari (2009)
10.1080/00268976.2020.1718224
Structure of 2-(2-(anthracen-9-ylmethylene)hydrazinyl)-4-(3-methyl-3-phenylcyclobutyl)thiazole by combined X-Ray crystallographic and molecular modelling studies
T. Karakurt (2020)
10.1002/jccs.201900452
Novel [1,2,4]triazolo[3,4‐b][1,3,4]thiadiazine derivatives embedded with benzimidazole moiety as potent antioxidants
Reshma Sathyanarayana (2020)
10.1007/S13538-017-0540-X
Resonance Energy Transfer Studies from Derivatives of Thiophene Substituted 1,3,4-Oxadiazoles to Coumarin-334 Dye in Liquid and Dye-Doped Polymer Media
Lohit Naik (2018)
Isolation and Identification of Bioactive Compounds from Irpex Lacteus Wild Fleshy Fungi
R. Chaudhary (2015)
See more
Semantic Scholar Logo Some data provided by SemanticScholar