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Synthesis And Antioxidant Capacities Of Some New Benzimidazole Derivatives

G. Ayhan‐Kılcıgil, C. Kuş, E. D. Özdamar, B. Can‐Eke, M. Iscan
Published 2007 · Chemistry, Medicine

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In this study, we prepared some new oxadiazolyl benzimidazole derivatives and investigated their antioxidant properties by determination of microsomal NADPH‐dependent inhibition of lipid peroxidation levels (LP assay) and microsomal ethoxyresorufin O‐deethylase activity (EROD assay). Some of these compounds 20, 23 had slightly inhibitory effects (28%) on the lipid peroxidation levels at 10–3 M concentration lower than standard BHT (65%). 5‐[2‐(Phenyl)‐benzimidazol‐1‐yl‐methyl]‐2‐mercapto‐[1,3,4]‐oxadiazole 16 was found to be more active than caffeine on the ethoxyresorufin O‐deethylase activity with an IC50 value of 2.0 6 10–4 M.
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