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Gestational Age And Autism Spectrum Disorder: Trends In Risk Over Time.

Hjördís Ósk Atladóttir, Diana E. Schendel, Tine Brink Henriksen, Lene Hjort, Erik T Parner
Published 2016 · Medicine
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Autism Spectrum Disorder (ASD) is a serious neurodevelopmental disorder. Several previous studies have identified preterm birth as a risk factor for ASD but none has studied whether the association between gestational age and ASD has changed over time. This is a Danish population-based follow-up study including live-born singletons born in Denmark between 1980 and 2009, identified in the Danish Medical Birth Registry, a study population of 1,775,397 children. We used a Cox regression model combined with spline to study the risk for ASD by gestational age across three decades of birth cohorts. We included 19,020 children diagnosed with ASD. Across all birth year cohorts, we found that the risk of being diagnosed with ASD increased with lower gestational age (P-value: <0.01). Across all gestational weeks, we found a statistically significant higher risk estimates in birth cohort 1980 to 1989, compared to birth cohorts 1990 to 1999 and 2000 to 2009, respectively. No statistically significant difference in risk estimates was observed between birth cohort 1990 to 1999 and 2000 to 2009. The observed time trend in risk of ASD after preterm birth may reflect: (1) a change in the risk profile of persons with ASD due to the broadening of ASD diagnostic criteria over time; or (2) improved neonatal care for low GA infants, which has reduced risk of adverse outcomes like ASD in preterm children.
This paper references
10.1001/jamapsychiatry.2013.2107
Preterm birth and mortality and morbidity: a population-based quasi-experimental study.
Brian M. D’Onofrio (2013)
10.1023/A:1025054610557
Epidemiological Surveys of Autism and Other Pervasive Developmental Disorders: An Update
Eric Fombonne (2003)
10.1016/j.annepidem.2011.08.009
Have secular changes in perinatal risk factors contributed to the recent autism prevalence increase? Development and application of a mathematical assessment model.
Laura A Schieve (2011)
10.1016/S0895-4356(02)00443-2
Hazard rate ratio and prospective epidemiological studies.
Michael J. Symons (2002)
10.1177/1403494810395825
The Danish Psychiatric Central Research Register
Ole Mors (2011)
10.1007/s10803-009-0818-0
Validity of Childhood Autism in the Danish Psychiatric Central Register: Findings from a Cohort Sample Born 1990–1999
Marlene Briciet Lauritsen (2010)
The Danish Medical Birth Registry.
L B Knudsen (1998)
10.1016/j.jpeds.2012.07.040
Gestational age at birth and risk of autism spectrum disorders in Alberta, Canada.
Anna Leavey (2013)
Prevalence of autism spectrum disorder among children aged 8 years - autism and developmental disabilities monitoring network, 11 sites, United States, 2010.
Jon Baio (2014)
10.1542/peds.2011-3028
Mortality and Neonatal Morbidity Among Infants 501 to 1500 Grams From 2000 to 2009
Jeffrey D. Horbar (2012)
10.1542/peds.2008-3582
Can Association Between Preterm Birth and Autism be Explained by Maternal or Neonatal Morbidity?
Susanne Buchmayer (2009)
10.1034/j.1600-0412.1999.780406.x
Epidemiological studies of obstetric ultrasound examinations in Denmark 1989-1990 versus 1994-1995.
F S Jørgensen (1999)
10.1001/jama.289.1.49
Prevalence of autism in a US metropolitan area.
Marshalyn Yeargin-Allsopp (2003)
10.1542/peds.110.1.143
Trends in mortality and morbidity for very low birth weight infants, 1991-1999.
Jeffrey D. Horbar (2002)
10.1176/appi.ajp.2011.10101532
Prevalence of autism spectrum disorders in a total population sample.
Young Shin Kim (2011)
10.1136/bmj.38751.524132.2F
Spontaneous preterm delivery in primiparous women at low risk in Denmark: population based study
Jens Langhoff-Roos (2006)
10.1007/s10803-015-2408-7
A Descriptive Study on the Neonatal Morbidity Profile of Autism Spectrum Disorders, Including a Comparison with Other Neurodevelopmental Disorders
Hjördís Ósk Atladóttir (2015)
10.1017/S0033291704002387
The incidence and prevalence of pervasive developmental disorders: a Danish population-based study.
Marlene Briciet Lauritsen (2004)
10.1002/0471721182
Finite Mixture Models
Geoffrey J. McLachlan (2000)
10.1007/s00787-014-0553-8
The increasing prevalence of reported diagnoses of childhood psychiatric disorders: a descriptive multinational comparison
Hjördis O. Atladottir (2014)
10.1097/01.aoa.0000350603.68744.9e
Long-Term Medical and Social Consequences of Preterm Birth
Dag Moster (2009)
10.1016/0895-4356(96)00018-2
Validation of the Danish Birth Registration.
J Kristensen (1996)
10.1016/j.jpeds.2013.09.021
Prevalence and neonatal factors associated with autism spectrum disorders in preterm infants.
Michael W. Kuzniewicz (2014)



This paper is referenced by
A comparative acoustic examination of infant cries: Children at high risk versus low risk for autism spectrum disorder development
Ildiko Eva Bruz (2015)
10.3390/ijms20092270
Sex-Dependent Effects of Perinatal Inflammation on the Brain: Implication for Neuro-Psychiatric Disorders
Maryam Ardalan (2019)
10.1111/ppe.12413
Prevalence of Autism Spectrum Disorders with and without Intellectual Disability by Gestational Age at Birth in the Stockholm Youth Cohort: a Register Linkage Study
Sherlly Xie (2017)
10.1080/03004430.2017.1301934
Early identification of learners with autism spectrum disorder: drawing on developmental histories
S. van Biljon (2019)
10.1016/B978-0-323-42876-7.00016-8
Encephalopathy of Prematurity: Clinical-Neurological Features, Diagnosis, Imaging, Prognosis, Therapy
Jeffrey J. Neil (2018)
10.1007/s10803-019-04229-0
Perinatal Factors Associated with Autism Spectrum Disorder in Jamaican Children.
Sepideh Saroukhani (2019)
10.1007/978-3-319-53889-1_4
Epigenetics of Autism Spectrum Disorder.
Michelle T. Siu (2017)
10.1016/j.earlhumdev.2016.05.001
Reduced growth during early infancy in very low birth weight children with autism spectrum disorder.
Kana Ikejiri (2016)
Developmental Regression in Children with Autism Spectrum Disorder: Associated Factors and Outcomes
Jasper A Estabillo (2019)
10.1016/B978-0-323-42876-7.00014-4
Encephalopathy of Prematurity: Neuropathology
Hannah C. Kinney (2018)
10.1038/s41372-019-0452-4
Neonatal jaundice in association with autism spectrum disorder and developmental disorder
Christina Cordero (2019)
10.1080/1034912X.2019.1653449
Onset of intervention for learners in autism-specific government-funded schools in South Africa
Sumari Erasmus (2019)
10.1093/ije/dyw284
Gestational age at birth and academic performance: population-based cohort study.
Kathryn Abel (2017)
10.1002/dneu.22512
Neonatal infection produces significant changes in immune function with no associated learning deficits in juvenile rats.
Brittany F Osborne (2017)
Aplicação do M-Chat para avaliação de sinais indicativos de risco para transtorno do espectro autista em crianças nascidas prematuras extremas
Mariana Talgati (2019)
10.3889/oamjms.2017.153
Association between Beta-Sympathomimetic Tocolysis and Risk of Autistic Spectrum Disorders, Behavioural and Developmental Outcome in Toddlers
Mengühan Araz Altay (2017)
10.1038/mp.2016.213
Gestational vitamin D deficiency and autism-related traits: the Generation R Study
Anna A. E. Vinkhuyzen (2018)
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