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Synthesis And In Vitro Antimicrobial Activity Screening Of New 3-Acetyl-2,5-disubstituted-1,3,4-oxadiazoline Derivatives.

Łukasz Popiołek, Anna Biernasiuk, Kinga Paruch, Anna Malm, Monika Wujec
Published 2019 · Chemistry, Medicine
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Thirteen new 3-acetyl-2,5-disubstituted-1,3,4-oxadiazoline derivatives were synthesized from corresponding hydrazide-hydrazones of isonicotinic acid in the reaction with acetic anhydride. The obtained compounds were identified with the use of spectral methods (IR, 1 H-NMR, 13 C-NMR, MS). In vitro antimicrobial activity screening of synthesized compounds against a panel of bacteria and fungi revealed interesting antibacterial and antifungal activity of tested 1,3,4-oxadiazoline derivatives, which is comparable to that of commonly used antimicrobial agents.
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