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Natural Killer Cells Infiltrating Human Nonsmall‐cell Lung Cancer Are Enriched In CD56brightCD16− Cells And Display An Impaired Capability To Kill Tumor Cells
P. Carrega, B. Morandi, R. Costa, G. Frumento, G. Forte, G. Altavilla, G. B. Ratto, M. Mingari, L. Moretta, G. Ferlazzo
Published 2008 · Biology, Medicine
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Despite natural killer (NK) cells being originally identified and named because of their ability to kill tumor cells in vitro, only limited information is available on NK cells infiltrating malignant tumors, especially in humans.
This paper references
NK cells and the tumour microenvironment: implications for NK-cell function and anti-tumour activity.
P. Albertsson (2003)
Prognostic significance of tumor infiltrating natural killer cells subset CD57 in patients with squamous cell lung cancer.
F. Villegas (2002)
CD4+ T cells in cancer stroma, not CD8+ T cells in cancer cell nests, are associated with favorable prognosis in human non‐small cell lung cancers
O. Wakabayashi (2003)
The Abundant NK Cells in Human Secondary Lymphoid Tissues Require Activation to Express Killer Cell Ig-Like Receptors and Become Cytolytic1
G. Ferlazzo (2004)
CD 56 bright cells differ in their KIR repertoire and cytotoxic features from CD 56 dim NK cells
R Jacobs (2001)
A role for IFN-gamma in primary and secondary immunity generated by NK cell-sensitive tumor-expressing CD80 in vivo
JM Kelly (2002)
The IL-12 Signature: NK Cell Terminal CD56+high Stage and Effector Functions 1
M. Loza (2004)
CD41 T cells in cancer stroma, not CD81 T cells in cancer cell nests, are associated with favorable prognosis in human nonsmall cell lung cancers
O Wakabayashi (2003)
Tumor structure and extracellular matrix as a possible barrier for therapeutic approaches using immune cells or adenoviruses in colorectal cancer
P. Kuppen (2001)
Cytolytic granule polarization and degranulation controlled by different receptors in resting NK cells
Y. Bryceson (2005)
The microscopic anatomy of experimental rat CC531 colon tumour metastases: Consequences for immunotherapy?
M. Hagenaars (2004)
Immediate Cytotoxicity But Not Degranulation Distinguishes Effector and Memory Subsets of CD8+ T Cells
P. Wolint (2004)
Prognostic significance of tumor infiltrating natural killer cells subset CD 57 in patients with squamous cell
FR Villegas (2002)
Biology of Natural Killer Cells
G. Trinchieri (1989)
Infiltration of CD8+ T cells in non-small cell lung cancer is associated with dedifferentiation of cancer cells, but not with prognosis.
M. Mori (2000)
Sensitive and viable identification of antigen-specific CD8+ T cells by a flow cytometric assay for degranulation.
M. Betts (2003)
The Ly-49 and NKR-P1 gene families encoding lectin-like receptors on natural killer cells: the NK gene complex.
W. Yokoyama (1993)
Unique subpopulations of CD561 NK and NK-T peripheral blood lymphocytes identified by chemokine receptor expression repertoire
JJ Campbell (2001)
Structure and function of the CD94 C‐type lectin receptor complex involved in recognition of HLA class I molecules
M. López‐Botet (1997)
Receptors for HLA class-I molecules in human natural killer cells.
A. Moretta (1996)
Effector and regulatory events during natural killer–dendritic cell interactions
L. Moretta (2006)
IL-18–induced CD83+CCR7+ NK helper cells
R. Mailliard (2005)
Cancer Statistics, 2005
A. Jemal (2005)
Unique Subpopulations of CD56+ NK and NK-T Peripheral Blood Lymphocytes Identified by Chemokine Receptor Expression Repertoire1
J. Campbell (2001)
Melanoma immunotherapy: a battle against radicals?
K. Hellstrand (2003)
Chemo - therapy in non - small cell lung cancer : a meta - analysis using updated data on individual patients from 52 randomised clinical trials
A Jemal (1995)
Role of tumor-associated macrophages in lung cancer.
S. Takeo (1986)
Biology and clinical relevance of human natural killer cells.
M. Robertson (1990)
Sticky moments with sticky molecules.
C. Buckley (2000)
NK Cells Inhibit T Cell Proliferation via p21-Mediated Cell Cycle Arrest1
Prachi P Trivedi (2005)
Receptors for HLAclass I-molecules in human natural killer cells
A Moretta (1996)
Induction of tumor-specific T cell memory by NK cell–mediated tumor rejection
J. Kelly (2002)
Human NK cell education by inhibitory receptors for MHC class I.
N. Anfossi (2006)
Natural killer cells activated by MHC class I(low) targets prime dendritic cells to induce protective CD8 T cell responses.
R. Mocikat (2003)
Characteristics of tumor infiltration by adoptively transferred and endogenous natural‐killer cells in a syngeneic rat model: Implications for the mechanism behind anti‐tumor responses
M. Hagenaars (1998)
Prognostic value of intratumoral natural killer cells in gastric carcinoma
S. Ishigami (2000)
Human natural killer cells: their origin, receptors and function
L. Moretta (2002)
Natural killer and dendritic cell liaison: recent insights and open questions.
G. Ferlazzo (2005)
The role of tumor stroma in the interaction between tumor and immune system.
T. Blankenstein (2005)
The regulatory effect of natural killer cells: do "NK-reg cells" exist?
C. Zhang (2006)
CD56brightCD16− Killer Ig-Like Receptor− NK Cells Display Longer Telomeres and Acquire Features of CD56dim NK Cells upon Activation1
C. Romagnani (2007)
Human natural killer cells : a unique innate immunoregulatory role for the CD 56 bright subset
M. Cooper (2001)
Natural Killer Cells Activated by MHC Class ILow Targets Prime Dendritic Cells to Induce Protective CD8 T Cell Responses
R. Mocikat (2003)
Human natural killer cells: a unique innate immunoregulatory role for the CD56bright subset
M. Cooper (2001)
The effects of extracellular pH on immune function
A. Lardner (2001)
Regulation of immune responses through inhibitory receptors.
Eric O Long (1999)
Cytotoxic Markers and Frequency Predict Functional Capacity of Natural Killer Cells Infiltrating Renal Cell Carcinoma
J. Schleypen (2006)
Chemotherapy in non-small cell lung cancer: a meta-analysis using updated data on individual patients from 52 randomised clinical trials
W. Alberti (1995)
[Chemotherapy of lung cancer].
M. Bychkov (1972)
NK cell receptors.
L. Lanier (1998)
CD 56 bright CD 16 2 KIR 2 NK cells display longer telomeres and acquire features of CD 56 dim NK cells upon activation
C Romagnani (2007)
Human natural killer cells: a unique innate immunoregulatory role for the CD56
MA Cooper (2001)
CD56bright Human NK Cells Differentiate into CD56dim Cells: Role of Contact with Peripheral Fibroblasts
A. Chan (2007)
The prognostic value of natural killer cell infiltration in resected pulmonary adenocarcinoma.
I. Takanami (2001)
Ex vivo identification, isolation and analysis of tumor-cytolytic T cells
V. Rubio (2003)
The prognostic significance of intratumoral natural killer cells in patients with colorectal carcinoma
S. Coca (1997)
Activating receptors and coreceptors involved in human natural killer cell-mediated cytolysis.
A. Moretta (2001)
Natural-killer cells and dendritic cells: "l'union fait la force".
T. Walzer (2005)
CD56 cells differ in their KIR repertoire and cytotoxic features from CD56 NK cells
R Jacobs (2001)
CD56bright cells differ in their KIR repertoire and cytotoxic features from CD56dim NK cells
R. Jacobs (2001)
CD56 CD162 KIR2 NK cells display longer telomeres and acquire features of CD56 NK cells upon activation
C Romagnani (2007)
Human natural killer cell function and their interactions with dendritic cells.
L. Moretta (2003)
Renal cell carcinoma‐infiltrating natural killer cells express differential repertoires of activating and inhibitory receptors and are inhibited by specific HLA class I allotypes
J. Schleypen (2003)
NK cells: elusive players in autoimmunity.
S. Johansson (2005)
A Role for IFN-γ in Primary and Secondary Immunity Generated by NK Cell-Sensitive Tumor-Expressing CD80 In Vivo1
J. Kelly (2002)
This paper is referenced by
NK cells from malignant pleural effusions are not anergic but produce cytokines and display strong antitumor activity on short‐term IL‐2 activation
P. Vacca (2013)
NK cells from pleural effusions are potent antitumor effector cells
M. Terme (2013)
© 2012 Landes Bioscience. Do not distribute. NK cells sense tumors, course of disease and treatments Consequences for NK-based therapies
G. Fregni (2012)
Expanded CD56superbrightCD16+ NK Cells from Ovarian Cancer Patients Are Cytotoxic against Autologous Tumor in a Patient-Derived Xenograft Murine Model
Sophie M. Poznanski (2018)
Natural Killer Cells as Key Players of Tumor Progression and Angiogenesis: Old and Novel Tools to Divert Their Pro-Tumor Activities into Potent Anti-Tumor Effects
B. Bassani (2019)
Beta-2-microglobulin gene transfer in hla class i deficient tumor cells using recombinant adenovirus
C. Alonso (2014)
Distribution of several activating and inhibitory receptors on CD3(-)CD56(+) NK cells in regional lymph nodes of melanoma patients.
A. Vuletić (2013)
Increased Tim-3 expression in peripheral NK cells predicts a poorer prognosis and Tim-3 blockade improves NK cell-mediated cytotoxicity in human lung adenocarcinoma.
L. Xu (2015)
Innate Lymphoid Cells in Mucosal Immunity
Santosh K. Panda (2019)
PD-1+ natural killer cells in human non-small cell lung cancer can be activated by PD-1/PD-L1 blockade
Marcel P. Trefny (2020)
Renal cell tumors convert natural killer cells to a proangiogenic phenotype
Yue Guan (2020)
Extravillous trophoblast and decidual natural killer cells: a remodelling partnership.
A. Wallace (2012)
Development of model system to study NC cell hyporesponsiveness
Gema Cárdenas (2014)
Killers 2.0: NK cell therapies at the forefront of cancer control.
Jonathan Hodgins (2019)
Gemcitabine sensitizes lung cancer cells to Fas/FasL system‐mediated killing
L. Siena (2014)
A Think Tank of TINK/TANKs: Tumor-Infiltrating/Tumor-Associated Natural Killer Cells in Tumor Progression and Angiogenesis
A. Bruno (2014)
Dendritic Cell Derived Cytokines in Human Natural Killer Cell Differentiation and Activation
O. Chijioke (2013)
Aging Immunity and the Impact of Physical Exercise
G. Spielmann (2014)
Differential killing of CD56-expressing cells by drug-conjugated human antibodies targeting membrane-distal and membrane-proximal non-overlapping epitopes
Y. Feng (2016)
Profound coordinated alterations of intratumoral NK cell phenotype and function in lung carcinoma.
S. Platonova (2011)
Comparative Network Analysis of Patients with Non-Small Cell Lung Cancer and Smokers for Representing Potential Therapeutic Targets
Mehrdad Pazhouhandeh (2017)
PD-L1 blockade enhances anti-tumor efficacy of NK cells
Jeremiah L Oyer (2018)
Altered phenotype in peripheral blood and tumor-associated NK cells from colorectal cancer patients
Y. S. Rocca (2013)
Intrahepatic and peripheral blood phenotypes of natural killer and T cells: differential surface expression of killer cell immunoglobulin‐like receptors
A. Podhorzer (2018)
About causes of early-stage asymptomatic prostate cancer
Ilarion Draguta (2017)
Enhanced adaptive immune responses in lung adenocarcinoma through natural killer cell stimulation
L. Schmidt (2019)
Future approaches in immunotherapy.
B. Rini (2014)
Methods to improve adoptive T-cell therapy for melanoma: IFN-γ enhances anticancer responses of cell products for infusion.
M. Donia (2013)
Monocytes control natural killer cell differentiation to effector phenotypes.
Katrina Soderquest (2011)
CD16 cross-linking induces increased expression of CD56 and production of IL-12 in peripheral NK cells.
M. Márquez (2010)
Characterization of tumor infiltrating Natural Killer cell subset
I. Levi (2015)
Receptors, cells & mechanisms responsible for antibody-induced tumor therapy
M. Albanesi (2012)See more